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Muhamad Thohar Arifin
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Muhamad Thohar Arifin MD. PhD. Faculty of Medicine, Diponegoro University Jl. Prof. Soedarto, Tembalang, Kec. Tembalang, Kota Semarang, Jawa Tengah 50275 Email: dimjoffice@gmail.com
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Diponegoro International Medical Journal (DIMJ)
Published by Universitas Diponegoro
ISSN : Without     EISSN : 27455815     DOI : https://doi.org/10.14710/dimj
Core Subject : Health, Science,
Medicine & Pharmacology Neuroscience
Diponegoro International Medical Journal (DIMJ) ISSN Number: 2745-5815 welcomes contributions which promote the exchange of ideas and rational discourse between practicing educators and medical researchers all over the world. DIMJ is an international, peer review, electronic, and open access journal. DIMJ is seeking an original and high-quality manuscript. Areas of interest in all aspects of medical and physiology include but are not limited to the following topics: Modelling of diagnose and cure of human diseases The scientific underpinning of medicine and pathophysiology Biochemistry and biology molecular solution Decision support systems Biomedicine Any experimental design and statistical analysis The application of new analytical and study methods (including biomolecular studies)
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 72 Documents
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Comparison of Intravenous Ephedrine Administration of 5 mg and 10 mg Doses on Post Spinal Anesthesia Hypotension in Caesarean Section at Dr. Kariadi General Hospital Semarang Alaydrus, Husein; Rayhan, Amar; Arifin, Johan; Satoto, Hari Hendriarto
Diponegoro International Medical Journal Vol 6, No 1 (2025): July 2025
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v6i1.26813

Abstract

Background: Hypotension after spinal anesthesia or combined epidural anesthesia in caesarean section (CS) causes adverse effects on the mother and fetus/neonatal. Hypotension often occurs therefore vasopressors could be used routinely and should be used as prophylaxisMethods: Simple randomized controlled trial study of 52 patients undergoing CS at RSUP dr. Kariadi Semarang. Subjects revealed two groups, namely intravenous ephedrine at a dose of 5 mg and a dose of 10 mg. Hemodynamic variables were measured every 3 minutes until the operation was completed.Results: In the comparison of mean arterial pressure (MAP) between the ephedrine 5 mg and ephedrine 10 mg groups, a statistically significant difference was obtained at 30 minutes (P < 0.05) while in the measurement of heart rate (HR) between the ephedrine 5 group mg and ephedrine 10 mg, a statistically significant difference was obtained from 3 to 15 minutes. Hypotension was obtained in 1 patient in the ephedrine 10 mg group and 3 patients in the ephedrine 5 mg group.Conclusion: 10 mg intravenous ephedrine as a prophylactic agent after spinal anesthesia for patients undergoing CS has better hemodynamic outcomes and complications than 5 mg intravenous ephedrine. Keywords: spinal anesthesia, ephedrine, SC, hypotension
Bacteria Patterns and Antibiotic Sensitivities in Patients with Preterm Premature Rupture of Membrane: Study of Patients with PPROM ≤ 6 Hours And > 6 Hours at General Hospital Kariadi Semarang Munthe, Rio Bornfry Haro; Pramono, Besari Adi; Kristiawan, Endy Cahyono; Poerwoko, Agoes Oerip; Cahyanti, Ratnasari Dwi
Diponegoro International Medical Journal Vol 6, No 1 (2025): July 2025
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v6i1.24649

Abstract

Background: Preterm premature rupture of membranes (PPROM) has multifactorial causes. Ascending bacterial invasion can cause intrauterine infection in up to 60% of cases with PPROM. Giving antibiotics at inadequate concentrations causes bacteria to grow exponentially, which is characterized by very fast growth.Objective: This study aims to determine bacteria patterns and antibiotic sensitivity in patients with PPROM at Dr. RSUP. Kariadi, Semarang.Methods: Observational analytical research with a cross-sectional design. The research subjects were 46 pregnant women aged 20-36 weeks 6 days who experienced PPROM. The selection of research subjects was carried out using the consecutive sampling method, namely the selection of research subjects based on research criteria and the subjects signed an agreement to participate in the research. The independent variables in this study were preterm PPROM ≤ 6 hours and > 6 hours, the dependent variables in this study were bacteria patterns and antibiotic sensitivity. The data that has been obtained is analyzed using the SPSS program. Results are significant if p<0.05.Results: Escherichia coli and Candida albicans are the most found pathogens. The antibiotics vancomycin, meropenem, and amphotericin B are effective in patients with PPROM. Women who experienced PPROM ≤ 6 hours and > 6 hours did not have significant differences in bacteria patterns and antibiotic sensitivity results.Conclusion: The gram-negative rod-shaped bacteria Escherichia coli and the fungus Candida albicans are the main pathogens that cause PPROM. The administration of vancomycin, meropenem, and amphotericin B has high effectiveness in PPROM patients at RSUP dr. Kariadi Semarang.

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