cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Muhamad Thohar Arifin
Contact Email
Thohar@gmail.com
Phone
+6281325861628
Journal Mail Official
dimjoffice@gmail.com
Editorial Address
Muhamad Thohar Arifin MD. PhD. Faculty of Medicine, Diponegoro University Jl. Prof. Soedarto, Tembalang, Kec. Tembalang, Kota Semarang, Jawa Tengah 50275 Email: dimjoffice@gmail.com
Location
Kota semarang,
Jawa tengah
INDONESIA
Diponegoro International Medical Journal (DIMJ)
Published by Universitas Diponegoro
ISSN : Without     EISSN : 27455815     DOI : https://doi.org/10.14710/dimj
Core Subject : Health, Science,
Medicine & Pharmacology Neuroscience
Diponegoro International Medical Journal (DIMJ) ISSN Number: 2745-5815 welcomes contributions which promote the exchange of ideas and rational discourse between practicing educators and medical researchers all over the world. DIMJ is an international, peer review, electronic, and open access journal. DIMJ is seeking an original and high-quality manuscript. Areas of interest in all aspects of medical and physiology include but are not limited to the following topics: Modelling of diagnose and cure of human diseases The scientific underpinning of medicine and pathophysiology Biochemistry and biology molecular solution Decision support systems Biomedicine Any experimental design and statistical analysis The application of new analytical and study methods (including biomolecular studies)
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 83 Documents
 5   6   7   8   9 
The Impact of Particulate Matter Air Pollution on Coronary Heart Disease: A Systematic Review Husodho, Gabriela Valencia Putri; Siregar, Muhammad Abi Ghoffari; Faiza, Agyta Hanifa
Diponegoro International Medical Journal Vol 6, No 2 (2025): December 2025
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v6i2.29648

Abstract

Background: Coronary heart disease remains a significant global public health threat, with around 315 million patients in 2022, having risen due to global population growth, with regional disparities persisting. Air pollution, specifically fine particulate matter (PM) categorized according to size into PM2.5 and PM10, has been identified as a critical and modifiable determinant of coronary heart disease, associated with 4.2 million deaths globally in 2019, most of cardiovascular origin. Hence, a systematic review was conducted to assess the impact that PM2.5 and PM10 have on coronary heart disease. Coronary heart disease remains a significant global public health threat, with around 315 million patients in 2022, having risen due to global population growth, with regional disparities persisting. Air pollution, specifically fine particulate matter (PM) categorized according to size into PM2.5 and PM10, has been identified as a critical and modifiable determinant of coronary heart disease, associated with 4.2 million deaths globally in 2019, most of cardiovascular origin.Objective: To assess the impact that PM2.5 and PM10 have on coronary heart disease.Methods: A literature search was done to identify relevant articles using three databases (PubMed, ScienceDirect, EBSCO) between 2020-2025. Studies written in English and observational studies were included. Articles without complete data and case reports were excluded. The systematic review followed PRISMA guidelines.Results: 46 studies were included in the final synthesis. 24 studies discussed only PM2.5, 22 studies discussed both PM2.5 and PM10, while none of the studies discussed only PM10. The majority of the studies were conducted in China (21 studies). Overall, PM2.5 had higher OR, RR, and HR for coronary heart disease compared to PM10, due to its smaller size. Lower quality of life, which includes higher mortality and hospitalization rates, was also seen with higher PM exposure.Conclusion: PM exposure increases the risk of coronary heart disease occurrence and decreases quality of life in patients, with PM2.5 having a higher effect than PM10.
The Effects of Kretek Cigarettes and Ascorbic Acid-based Vape on IL-6, TNF-α Levels, and Pulmonary Histopathology: An Experimental Study on White Rats (Rattus novergicus) on Inflammatory Response and Pulmonary Histopathology Maftikhati, Dora; Prasetyo, Awal; Sadhana, Udadi; Istiadi, Hermawan
Diponegoro International Medical Journal Vol 6, No 2 (2025): December 2025
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v6i2.29825

Abstract

Background: Smoking habits remain difficult to break, with 991 million smokers worldwide in 2020. Many have switched to vaping, which is regarded as safer than clove cigarettes. Exposure to cigarette smoke can increase pro-inflammatory cytokines and damage lung tissue.Objective: This study compared the effects of kretek cigarette smoke and ascorbic acid-based vape smoke on inflammatory response and lung tissue in male white rats (Rattus norvegicus).Methods: Twenty-one 8-week-old rats were randomized into three groups: control, exposed to kretek cigarette smoke, and exposed to ascorbic acid-based vape. The kretek cigarette group was exposed to smoke from 3 cigarettes/day, while the vape group received 0.5 ml/day of vape smoke, for 12 weeks. Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-α) levels were analyzed using ELISA. The perimeter length of the alveolus, the degree of alveolar wall damage, and the extent of inflammatory cell distribution were also examined. Statistical analyses were accomplished using the ANOVA One-Way test, chi square test, and Kruskal-Wallis test.Results: Cigarette exposure significantly increased IL-6 levels (control: 8.43 ± 0.88 pg/ml; kretek cigarette: 11.45 ± 1.17 pg/ml; ascorbic acid vape: 11.83 ± 1.56 pg/ml; p = 0.000), the degree of alveolar damage (mean rank control: 6.21; kretek cigarette: 14.17; ascorbic acid vape: 11.64; p = 0.001), and the extent of inflammatory cell distribution (mean rank control: 4.00; kretek cigarette: 15.25; ascorbic acid vape: 12.93; p = 0.012). TNF-α levels increased in the kretek cigarette group, while the alveolar perimeter length increased in the ascorbic acid vape group; however, neither parameter was statistically significant (p > 0.05).Conclusion: Both kretek cigarette smoke and ascorbic acid-based vape smoke induced pulmonary inflammation and structural changes, with significant effects observed in IL-6 levels and histopathological damage, but not in TNF-α levels or alveolar perimeter length. There is a need for better regulation and increased public awareness about the dangers of smoking.
The Effect of Vitamin D Supplementation on Changes in TNF-? Levels and Exciting Frequency in Epilepsy Patients Daynuri, Riri; Kustiowati, Endang; Husni, Amin; Retnaningsih, Retnaningsih; Suryawati, Herlina; Ardhini, Rahmi
Diponegoro International Medical Journal Vol 6, No 1 (2025): July 2025
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v6i1.26585

Abstract

Background: Epilepsy, a neurological disorder, is a global public health problem. The active form of vitamin-D is 5000IU/day for 42 days, able to push inflammation and change the balance between inhibitory cytokine and excitatory cytokine, to suppress recurrent seizuresObjective: Analyze the effect of vitamin-D 5000 supplementations on changes in TNF-α levels pre-and-post-vitamin-D supplementation and changes in the frequency of seizures pre-and post-vitamin-D supplementation in epilepsy patients.Methods: This research is a quasi-experimental analytic observational study with a pre-and-post-tests approach without control. Subjects were patients diagnosed with epilepsy who had met the inclusion criteria. Previous research subjects were checked for TNF-α levels, then given vitamin-D supplementation of 5000IU/day for 42 days, then rechecked TNF-α levels. Then performed a bivariate analysis.Results:  There was a significant difference between changes in TNF-α pre-and-post-levels of vitamin-D supplementation of 5000IU/day for 42 days (p<0.001). There was a significant difference in the frequency of seizures pre-and-post-levels of vitamin D supplementation 5000IU/day for 42 days (p=0.002). There is a significant relationship between (d)TNF-α on (d)the frequency of seizures pre-and-post-vitamin-D supplementation 5000IU/day, strongly and positively related (p<0.001; r=0.661). There is no relationship between risk factors with (d)TNF-α. There is no relationship between risk factors with (d)seizure frequency.Conclusion: There is a significant difference in the levels of TNF-α pre-and-post-vitamin-D supplementation. There is a significant difference between the frequency of seizures pre-and-post-vitamin-D supplementation. There is a relationship between (d)TNF-α and (d)the frequency of seizures pre-and-post-vitamin-D supplementation.

Page 9 of 9 | Total Record : 83

 5   6   7   8   9 

Filter by Year

2020 2025


Reset
Filter By Issues
All Issue Vol 6, No 2 (2025): December 2025 Vol 6, No 1 (2025): July 2025 Vol 5, No 2 (2024): December 2024 Vol 5, No 1 (2024): July 2024 Vol 4, No 2 (2023): December 2023 Vol 4, No 1 (2023): July 2023 Vol 3, No 2 (2022): December 2022 Vol 3, No 1 (2022): July 2022 Vol 2, No 2 (2021): December Vol 2, No 1 (2021): July Vol 1, No 2 (2020): December Vol 1, No 1 (2020): July More Issue