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Aji Winanta
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ajiwinanta@umy.ac.id
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jfaps2021@gmail.com
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K.H. Sudja Building G3, 2nd Floor, Faculty of Medicine and Health Science, Universitas Muhammadiyah Yogyakarta, Jalan Brawijaya (Lingkar Selatan), Tamantirto, Kasihan, Bantul, Daerah Istimewa Yogyakarta
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INDONESIA
Journal of Fundamental and Applied Pharmaceutical Science
Published by Universitas Muhammadiyah Yogyakarta
ISSN : 27237648     EISSN : 2723763X     DOI : 10.18196
Core Subject : Health,
Medicine & Pharmacology
JFAPS focuses on various aspects of pharmaceutical sciences such as: Pharmaceutical Technology Pharmacology & Toxicology Pharmaceutical Chemistry Drug Discovery Traditional Medicine and Medicinal Herb Pharmaceutical Microbiology and Biotechnology
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 63 Documents
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Optimization of FDT Turmeric Rhizome Extract (Curcuma domestica Val.) Using a Combination of Crospovidone and Croscarmellose Sodium
Journal of Fundamental and Applied Pharmaceutical Science Vol. 5 No. 2 (2025): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v5i2.24483

Abstract

Turmeric rhizome (Curcuma domestica Val.) is a plant that has anti-diarrheal activity. To get an immediate effect and action in the treatment of diarrhea, turmeric rhizome is formulated into a fast-disintegrating tablet (FDT) dosage form. FDT is strongly influenced by super disintegrant (crushing material). Crospovidone is used as a super disintegrant, as it has a wicking effect (capillary action), while croscarmellose sodium has a swelling effect. The study aims to determine the effect of variations in the concentration of crospovidone and croscarmellose sodium on the physical properties of FDT and determine the optimal concentration of crospovidone and croscarmellose sodium. The sample used was a dry extract of turmeric rhizome. The dried extract of turmeric rhizome was made 5 runs with variations of crospovidone 2–5% and croscarmellose sodium 2–5%. Run 1 (2.75%: 4.25%), run 2 (3.5%: 3.5%), run 3 (5%: 2%), run 4 (2%: 5%), and run 5 (4.25%: 2.75%). The responses used included disintegration time, hardness, and restriction tests. The results utilized to determine the optimum formula were derived from the simplex lattice design (SLD) method. The outcomes of the optimal formula testing experiment were based on the findings from 13.0.5 predictive software experts, employing a one-sample t-test analysis at a 95% confidence level. The results of this study indicate that the combination of crospovidone and croscramellose sodium can reduce the response time of disintegration, hardness, and FDT. The optimum formula was obtained with the variation of crospovidone 3.5% and croscarmellose sodium 3.5%.
Optimization of Extraction Factors in Aerial Plantago major L. Based on RSM to TPC Levels
Journal of Fundamental and Applied Pharmaceutical Science Vol. 6 No. 1 (2025): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v6i1.26735

Abstract

Plantago major L. is known as an old medicinal plant. Some studies report that P. major has significant benefits in the world of health because of its phenolic content. Ultrasonic-assisted extraction (UAE) was chosen because it can extract faster with better yields. The best extraction conditions need to be sought to obtain optimum phenolic levels. Optimization can be done with Response Surface Methodology (RSM). This study aimed to obtain the best extraction conditions that produce optimum total phenolic levels. This study used the RSM Box-Behnken Design method. The study was conducted using 3 factors, namely the material-solvent ratio (1:5; 1:10; 1:15), ethanol-aqueous ratio (100:0; 50:50; 0:100), and extraction time (20, 40, 60) minutes, which was formulated using Design Expert 13. Total phenolic content (TPC) was measured using a UV-Vis Spectrophotometer. The analysis revealed that the quadratic polynomial model can be used to improve the extraction of P. major aerials. The best extraction conditions for TPC were a material-solvent ratio of 1:5.09; ethanol-aqueous ratio 73.27:26.73; extraction time 29.01 min, yielding a TPC value of 29.730 mg GAE/g. The experimental data were consistent with the predicted results. It demonstrates the applicability of the model and the success of the response surface methodology in optimizing the projected extraction conditions.
Cytotoxic and In Silico Evaluation of Hyrtios erectus Extract Against T47D Breast Cancer Cells: A Potential Marine-Derived Anticancer Agent
Journal of Fundamental and Applied Pharmaceutical Science Vol. 6 No. 1 (2025): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v6i1.26988

Abstract

Hyrtios erectus is a marine sponge species with promising potential as an anticancer agent. This study aimed to evaluate the cytotoxic activity of Hyrtios erectus extract against T47D breast cancer cells and assess the drug-likeness of its active compounds through in silico approaches. The investigation began with a phytochemical screening of the extract, followed by a cytotoxicity assay using the MTT method. The in silico analysis included PASS prediction, ADMET evaluation, and molecular docking. Phytochemical screening revealed the presence of flavonoids, alkaloids, terpenes, and saponins. The cytotoxicity test yielded an IC₅₀ value of 12.73 ± 1.05 µg/mL and a selectivity index (SI) of 18.16, indicating strong cytotoxic activity and high selectivity towards T47D breast cancer cells. PASS and ADMET analyses predicted that 20 identified compounds possess anticancer potential with low toxicity. Molecular docking results exhibited favorable binding energies for 2-chloro-6-phenyl-8H-quinazolino[4,3-b]-quinazolin-8-one, Echinoclerodane A, and 5-hydroxy-1H-indole-3-carboxylic-acid-methyl-ester, suggesting significant interaction with cancer-related protein targets. These findings support the potential of Hyrtios erectus extract and its bioactive compounds as promising candidates for anticancer drug development.

Page 7 of 7 | Total Record : 63

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