cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Aji Winanta
Contact Email
ajiwinanta@umy.ac.id
Phone
+6282221556698
Journal Mail Official
jfaps2021@gmail.com
Editorial Address
K.H. Sudja Building G3, 2nd Floor, Faculty of Medicine and Health Science, Universitas Muhammadiyah Yogyakarta, Jalan Brawijaya (Lingkar Selatan), Tamantirto, Kasihan, Bantul, Daerah Istimewa Yogyakarta
Location
Kab. bantul,
Daerah istimewa yogyakarta
INDONESIA
Journal of Fundamental and Applied Pharmaceutical Science
Published by Universitas Muhammadiyah Yogyakarta
ISSN : 27237648     EISSN : 2723763X     DOI : 10.18196
Core Subject : Health,
Medicine & Pharmacology
JFAPS focuses on various aspects of pharmaceutical sciences such as: Pharmaceutical Technology Pharmacology & Toxicology Pharmaceutical Chemistry Drug Discovery Traditional Medicine and Medicinal Herb Pharmaceutical Microbiology and Biotechnology
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 54 Documents
 2   3   4   5   6 
Formulation and Antioxidant Activity Analysis of Jotang Herb (Acmella paniculata) Extract Mask Cream Kholifah, Eva; Fitriani, Via; Shobah, Afifah Nur
Journal of Fundamental and Applied Pharmaceutical Science Vol 4, No 2 (2024): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i2.19341

Abstract

Pollution in the environment can increase the production of reactive oxygen species (ROS), which can reduce the amount of antioxidants in the skin. Antioxidants are compounds that can inhibit oxidation reactions by binding to free radicals and reactive molecules. Herbaceous plant jotang (Acmella paniculata) has secondary metabolites such as flavonoids, alkaloids, tannins, and saponins, which can protect the internal and external organs of the body's cells from damage caused by free radicals on the skin. One of the treatment preparations used for the skin is a cream mask, as the use or application at the final level of skin care can improve cleanliness and health and stimulate and repair skin cells. This study aims to determine a formula that has a good antioxidant value using the DPPH method (2,2-diphenyl-1-pikrilhidrazyl). In this study, preparations were made with 3 formulas, namely Formula I (1% w/w), Formula II (10%w/w), and Formula 0 (Control). Evaluation of physical properties included organoleptic tests, homogeneity tests, spreadability tests, pH tests, viscosity tests, cream-type tests, and antioxidant tests. The result showed that the organoleptic test had a cream mask dosage in the form of semi-solid, distinctive jotang odor, light and dark green, had a homogeneous dosage form, spreadability around 5.1-5.7 with an average pH value of 6, had a good viscosity value and had a type of cream M/A and a high antioxidant value in formula II (10% w/w ) with an IC50 value of 21.959 μg/ml. Based on statistical tests, significant results were obtained of 0.000p (0.05) so that it can be interpreted that there was a significant difference in each concentration of jotang herb extract to the resulting IC50 value.
Evaluation of Sarcocephalus latifoliusAfzel. ex R.Br. Rubiaceae on Reduction of Creatinine Level and Its Antioxidant In-Vitro Obika, Ogochukwu Immaculate; Oyawaluja, Aminat Asabi; Odukoya, Olukemi Abiodun; Obika-Ndiri, Ngozi Afulenu; Oiseoghaede, Joseph Oisemuzeimen
Journal of Fundamental and Applied Pharmaceutical Science Vol 5, No 1 (2024): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v5i1.22237

Abstract

Medicinal herbs are divine gifts from Mother Nature and have been used for centuries as natural remedies. Sarcocephalus latifolius has been reported to contain active substances that have therapeutic effects on the kidney. The study aims to investigate the medicinal effects of Sarcocephalus latifolius extract on creatinine levels. Phytochemical and antioxidant activity were carried out using standard methods. Vacuum Liquid chromatography and Thin Layer Chromatography were employed to separate constituents of the plant extract, which were then evaluated for their creatinine reduction ability using Jaffe’s method. Based on the IC50, which is half the maximal inhibitory concentration value, Sarcocephalus latifolius demonstrates stronger antioxidant activity at 43.34µg/ml compared to the standard ascorbic acid at 40.59µg/ml. The Two-way ANOVA Statistical analysis revealed significant differences between the patients’ urine (rows) as the P-value = 6.17×10-16 is less than 0.05 significant level, and the dose treatments (columns) as the P-value = 1.71×10-12 is less than 0.05 significant level. Fractions of Sarcocephalus latifolius at various concentrations exhibit varied effects on creatinine levels, which could be attributed to the bioactive compounds in the fractions. Sarcocephalus latifolius showed potential for creatinine reduction, especially at low doses.
Preparation and Evaluation of Mouth Dissolving Tablet of Albendazole Using Different Concentrations of Super-Disintegrant Bavaskar, Kedar Rupa; Pote, Supriya; Vidhate, Prasad; Patil, Vinit; Jain, Ashish
Journal of Fundamental and Applied Pharmaceutical Science Vol 4, No 2 (2024): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i2.19148

Abstract

Anthelmintic medications are anticipated to act more quickly and have greater absorption. Mouth-dissolving albendazole tablets were created using a direct compression approach and a mixture of super disintegrants to accomplish rapid disintegration of the tablets in the oral cavity. The preparation of ten batches of mouth-dissolving tablets using different grades of Kollidon, crospovidone, sodium starch glycolate, and croscarmellose sodium as super disintegrants produced the greatest results. For a compatibility investigation, FTIR was used to characterize the drug and physical mixture. An optimization technique was used to forecast the most effective formulation out of all the prepared combinations. All the physical characteristics of the tablet are within the limit. All preformulation results indicated good flow properties. Disintegration time and drug content of the F4 batch were found to be 28 seconds and 95.69%, respectively. In vitro release of the drug was performed in a phosphorus buffer pH 6.8 for 40 min, in which F4 shows maximum drug release. Based on the stability studies, it was confirmed that the optimized formulation remained at accelerated stability conditions. It was discovered that the mouth-dissolving tablet exhibits effective drug release.
Potential of Binahong Leaf Ethanol Extract (Anredera cordifolia (Ten.) Steenis) against Elevated HDL Levels (Rattus corvegious) Streptozonic-Induced Wistar Strain Orbayinah, Salmah; Auliya, Rizqa
Journal of Fundamental and Applied Pharmaceutical Science Vol 5, No 1 (2024): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v5i1.22496

Abstract

Diabetes mellitus is frequently associated with decreased levels of high-density lipoprotein (HDL), which are prevalent cardiovascular disease risk factors. The use of synthetic drugs substantially increases the risk of atherosclerosis since they often have severe side effects, require high costs, and have poor prescription adherence. Anredera cordifolia (Ten.) Steenis, often known as the binahong plant, is a potentially effective complementary therapy for increasing HDL levels. Flavonoid compounds present in the ethanol extract of Binahong leaf have the potential to increase HDL levels. This work aims to evaluate the action of an ethanol extract from binahong leaves in raising HDL levels in rats of the Streptozotocin-induced Wistar strain (Rattus norvegicus). In this research, the Pretest-Posttest Control Group Design was used. The study involved the grouping of five Wistar strain rats (n=5) into five distinct groups: one received binahong leaf ethanol extract at concentrations of 25 mg/kg BW, 50 mg/kg BW, and 100 mg/kg BW, which served as the positive control group and received a negative control group supplemented with atorvastatin at 0.9 mg/kg BW. The CHOD-PAP method was applied to measure HDL levels. SPSS software was used to run the normality test, Wilcoxon test, one-way ANOVA test, and paired sample t-test. No statistically significant difference in HDL levels was found between treatment groups. The 50 mg/kg BW binahong leaf extract group had significantly higher HDL levels (p-value 0.05). As a result, the ethanol extract obtained from binahong leaves presumably raises HDL levels in streptozotocin-induced Wistar rats.
Analysis of Pork Fatty Acid in Cornet in The Curug Market Using Gas Chromatography Widyatari, Ade Dwi; Rusdiana, Nita; Rasydy, Laode Akbar
Journal of Fundamental and Applied Pharmaceutical Science Vol 4, No 2 (2024): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i2.18878

Abstract

Counterfeiting of food products with non-halal ingredients is starting to become a new problem in Indonesian society, the majority of whom are Muslim. One example of processed meat that is susceptible to the addition of pork components is corned beef. This research aims to determine the content and levels of fatty acids in corned beef. The method used to analyze halal food products is the GC method. The results showed that corned beef 1, 2, and 3 had dominant fatty acids such as myristic acid (1.58), (2.08), and (1.54), palmitic acid (49.91), (48.19) and (48.67), stearic acid (9.27), (10.20) and (7.24), oleic acid (58.89), (49.37) and  (59.64), and linoleic acid (12.78), (8.16) and (11.53).
Alpha Glucosidase Inhibitory Activity of Tiger Milk Mushroom (Lignosus rhinocerus) Ethanolic Extract Ulfah, Mariam; Efirani, Like; Hadi, Ismanurrahman
Journal of Fundamental and Applied Pharmaceutical Science Vol 5, No 1 (2024): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v5i1.20299

Abstract

Tiger's milk mushroom (TMM) is a plant that can only grow in certain regions in Asia. Indonesia is the country that has the most TMM plants in the world. This plant grows wild in the forests of Kalimantan and Papua. This plant is widely used by people to treat fever, breast cancer and asthma. TMM is known to have various pharmacological activities such as anticancer. The research about TMM originate from Indonesia is still rarely carried out. So, the aim of this research is to carry out an alpha glucosidase inhibition activity test of TMM ethananolic extract. The method used for extraction the TMM is maceration method using ethanol solvent. To identify the secondary metabolite compounds from TMM, phytochemical tests and thin layer chromatography (TLC) tests were carried out.  Inhibition test of alpha glucosidase enzyme activity of TMM ethanolic extract was carried using p-nitrophenyl-alpha-D-glucopyranoside reagent. The results of this phytochemical test are the ethanol extract of TMM contains flavonoid, alkaloid, terpenoid and phenolic compounds. This is confirmed by the TLC test where this test indicates the presence of flavonoid and alkaloid compounds. The results of the alpha glucosidase enzyme inhibition activity test showed that the ethanol extract of tiger milk mushrooms had an IC 50 value of  39.96 ppm which are categorized strong antidiabetic activity. From this research can be concluded that TMM ethanlolic extract very potential as an antidiabetic drug.
Formulation and Evaluation of Formalin Washer Fluid Preparation from Garlic Peel Waste (Allium sativum L.) Burhan, Amelia Handayani; Irianto, Iramie Duma Kencana; Azizah, Shyella; Puji, Rian
Journal of Fundamental and Applied Pharmaceutical Science Vol 4, No 2 (2024): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i2.20201

Abstract

Until 2022, there will still be many salted anchovies that contain formalin. This potential danger can be reduced by reducing the levels of formalin that may be contained in salted anchovies before consumption, one of which is by utilizing the saponin content in garlic peel waste. Garlic peel waste powder is proven to be able to reduce formalin levels in salted anchovies by up to 89.12%. However, the use of powder is less practical, and in a certain period, the powder can rot and emit an unpleasant odor. Therefore, an innovation is needed to transform the powder form into a formalin washer fluid. This study aims to determine the effect of garlic peel extract variation on several parameters evaluating the physical properties of formalin washing liquid. The extraction of garlic peel was done using the maceration method and a 70% ethanol solvent. Washing liquids were prepared using glycerin, PEG400, EDTA, and distilled water with varying extract concentrations. Evaluation of physical properties included organoleptic, pH value, specific gravity, viscosity, clarity, and physical stability of formalin washer fluid. The stability test of the physical properties of the sample liquid was carried out using the cycling test method. The samples were kept in storage conditions with extreme temperatures for 3 cycles. In each cycle, the test preparation was stored for 24 hours at 4±2oC and 24 hours at 40±2oC. The formalin washer fluid produced was in the form of a liquid with a weak to pungent garlic aroma, yellow to dark brown in color, homogeneous, clear, and had a pH value of 4. The more extract is used in the formalin washer fluid, the darker the color and the more pungent the garlic aroma will be. Increasing the concentration of garlic peel extract does not affect the pH and clarity of the preparation. The higher the concentration of extract is, the higher the specific gravity and viscosity will be. The selected formula is the formula with a 1% concentration of garlic peel extract.
Formulation and Evaluation of Natural Pigmented Lipstick from Roselle Flower and Secang Wood Extracts Monica, Eva; Yoedhistira, Chresiani Destianita; Wulandari, Cindy Dwi
Journal of Fundamental and Applied Pharmaceutical Science Vol 4, No 2 (2024): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i2.19631

Abstract

Lipstick is a cosmetic product for the lips consisting of pigments, oils, waxes, and moisturizers. Natural lipstick is safe to use and contains natural nutrients to maintain lip health. The use of synthetic dyes in lipstick can have adverse effects on the skin and health; hence, the use of natural dyes from various natural sources needs to be considered. Secang wood and Rosella flowers are plants with important compound contents that have antioxidant properties. Secang wood contains brazilin, alkaloids, flavonoids, saponins, tannins, phenylpropane, and terpenoids. Meanwhile, Rosella flowers that grow in tropical areas have anthocyanin pigments as part of flavonoids that function as antioxidants. This research aims to determine the formulation of lipstick containing extracts of Secang wood and Rosella flowers and to test the antioxidant activity of the preparation. Extraction was carried out by maceration using 70% ethanol solvent. Then, a phytochemical analysis was conducted to determine the extract content, and a lipstick formula was made by comparing the ratio of Rosella and Secang extracts. The optimal formula selection was performed using the Simplex Lattice Design method with quality testing parameters, including pH, melting point, hardness, and antioxidant activity of the preparation. The data analysis showed that the optimal ratio of the two extracts was 2.5% and 7.5% for Rosella and Secang extracts, respectively. At this composition, the optimum pH value was 5, the melting point was 57˚C, the hardness was 1.87 seconds, and the antioxidant activity was classified as strong.
Analysis of Triclosan Content in Cisadane River Water Using Gc-Ms (Gas Chromatography Mass Spectrometry) Cahyowati, Merliani Nur; Rudiana, Nita; Pratiwi, Dina
Journal of Fundamental and Applied Pharmaceutical Science Vol 5, No 1 (2024): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v5i1.19096

Abstract

The Ministry of Environment and Forestry states that 75% of river water in Indonesia has been polluted by household and industrial waste. Triclosan (2,4,4-trichloro-2-hydroxydiphenyl-ether) is an antibacterial that is widely used in various health and household supply products, such as detergents, toothpaste, mouthwash, bath soap and so on. This study approach employs liquid-liquid extraction on sampels, which are subsequently subjected to SIM mode analysis untilizing the Gas Chromatography Mass Spectometry (GC-MS) method. River water samples were taken from 3 points, namely village areas, fishing and industry. The results of this study indicate that the levels of the three Cisadane river water samples are positive for Triclosan with levels less than 0.3%, namely at the fishing point 598x10-9%, industrial point 1076x10-9% and residential point 1584x10-9% with a retention time of 19, 37 minutes.
Formulation and evaluation of lip balm preparations of ethanolic extract from beetroot (Beta vulgaris L.) Hadi, Ismanurrahman; Shinta, Tiara Aries; Putra, Teguh Adiyas
Journal of Fundamental and Applied Pharmaceutical Science Vol. 6 No. 1 (2025): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v6i1.19331

Abstract

Beetroot (Beta vulgaris L.) is a source of betacyanin that could be used as a natural dye and is known as an antioxidant that can protect the skin from exposure to free radicals. Lip balm, one of the popular cosmetics, often uses natural ingredients as active compounds to enhance colour and promote healthy skin. This study aims to formulate beetroot ethanolic extract into a topical lip balm preparation. The beetroot was extracted using ethanol solvent. The phytochemical screening was carried out to identify phytochemicals of flavonoids, saponins, tannins, and alkaloids within the ethanolic extract. The extract was formulated into a lip balm preparation with extract concentrations of 0% (F1), 5% (F2), 10% (F3), and 15% (F4). After formulation, the lip balm was physically examined for organoleptic, homogeneity, acidity, spreadability, and adhesivity of the product. The phytochemical screening exhibited positive results in all phytochemical groups tested in the beetroot ethanolic extract. Meanwhile, physical evaluation of lip balm demonstrates that all formulations had a semi-solid texture, cacao scent, and red color that increased in intensity proportionate with the extracts used (F2, F3, F4). Other parameters indicate a homogeneous product with suitable acidity (pH valued at 9) and adhesivity (>4 seconds). However, the spreadability test displayed low dispersion capabilities of the lip balm. Even though the spreadability values increased with higher beetroot extract, this value remained lower than the standard minimum dispersion of lip balm, thus indicating poor spreadability of the formula. The hedonic evaluation indicates that respondents tended to like the third formulation (F3). Based on this, the best and most preferred formula is at a concentration of 10% active substance (F3).

Page 5 of 6 | Total Record : 54

 2   3   4   5   6 

Filter by Year

2020 2025


Reset
Filter By Issues
All Issue Vol. 6 No. 1 (2025): August Vol 5, No 1 (2024): August Vol 4, No 2 (2024): February Vol 4, No 1 (2023): August Vol 3, No 2 (2023): February Vol 3, No 1 (2022): August Vol 2, No 2 (2022): February Vol 2, No 1 (2021): August Vol 1, No 2 (2021): February Vol 1, No 1 (2020): August