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Aji Winanta
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K.H. Sudja Building G3, 2nd Floor, Faculty of Medicine and Health Science, Universitas Muhammadiyah Yogyakarta, Jalan Brawijaya (Lingkar Selatan), Tamantirto, Kasihan, Bantul, Daerah Istimewa Yogyakarta
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INDONESIA
Journal of Fundamental and Applied Pharmaceutical Science
Published by Universitas Muhammadiyah Yogyakarta
ISSN : 27237648     EISSN : 2723763X     DOI : 10.18196
Core Subject : Health,
Medicine & Pharmacology
JFAPS focuses on various aspects of pharmaceutical sciences such as: Pharmaceutical Technology Pharmacology & Toxicology Pharmaceutical Chemistry Drug Discovery Traditional Medicine and Medicinal Herb Pharmaceutical Microbiology and Biotechnology
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 70 Documents
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Formulation and Organoleptic Evaluation of Roselle (Hibiscus sabdariffa) Jamu Godog with Stability and Microbial Quality Assessment Irianto, Iramie Duma Kencana; Purwanto; Nurhaeni, Farisya; Ana Mardiyaningsih; Bangkit Ary Pratama; Fiqoh, Latifah Nisa; Febriana Ardiyanti
Journal of Fundamental and Applied Pharmaceutical Science Vol. 6 No. 1 (2025): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v6i1.22102

Abstract

Jamu is a traditional medicinal preparation proven to have many pharmacological properties and is widely used in Indonesian society. Unfortunately, many people do not like herbal medicine because of its unpleasant taste and odor. This phenomenon has driven much research in modifying the organoleptic parameters of jamu to make it more acceptable to the tongues and noses of consumers while still having a potent effect on health. This study, thus, aimed to formulate a roselle (Hibiscus sabdariffa)-enhanced jamu godog (traditional Indonesian herbal decoction) and evaluate its organoleptic properties, physical stability, and microbial quality. Jamu godog was prepared by sequentially boiling and mixing ground ginger, turmeric, lemongrass, roselle, rock sugar, and lime, with roselle concentrations set at 0%, 0.3%, and 0.6%. Organoleptic attributes and pH stability were assessed before and after storage at 4°C and 25°C for seven days. Microbial contamination was measured via total plate count (TPC) after storage at 4°C for three and seven days. A hedonic test with 40 participants across two age groups evaluated sensory acceptance. Results indicate that the addition of roselle at 0.3% concentration optimized taste and overall acceptability while maintaining pH stability and microbial safety within BPOM standards throughout the storage period. This formulation demonstrates potential as a palatable and microbiologically safe herbal preparation with enhanced consumer acceptance.  
TLC and UV-Visible Spectrophotometry Validation for Identification of Sildenafil Citrate in Aphrodisiac Herbal Medicine Azizi, Khodadad Trimawan; Haresmita, Perdana Priya; Permatasari, Desy Ayu Irma
Journal of Fundamental and Applied Pharmaceutical Science Vol. 6 No. 1 (2025): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v6i1.23627

Abstract

Traditional medicines, also known as jamu, have sometimes been found to contain medicinal chemicals to enhance the effectiveness of these products. Sildenafil citrate, which is clinically effective in improving erectile function, can cause harmful side effects when included in herbal products. This study, therefore, aims to validate the identification of sildenafil citrate in aphrodisiac herbal medicine using Thin Layer Chromatography (TLC) and UV-visible spectrophotometry. The samples were prepared by macerating 100 mg of the jamu in 96% ethanol for 24 hours. The samples were then evaluated using TLC and a UV-visible spectrophotometer, with validation parameters including linearity, precision, limit of detection (LOD), and limit of quantitation (LOQ). This study uncovered that one of the three samples tested positive for sildenafil citrate, as evidenced by similar Retention factor (Rf) values in two TLC systems. Additionally, analysis using UV-visible spectrophotometry revealed that the average content of sildenafil citrate in the sample was 23.96%, with a relative standard deviation (RSD) of 0.74% and LOD and LOQ values of 10.28 and 34.27 µg/mL, respectively. The methods of analysis, including TLC and UV-visible spectrophotometry, for sildenafil citrate identification are expected to be valuable for regulatory and supervisory agencies in monitoring the distribution of such herbal medicines.  
Reworking Potential of Polyvinylpyrrolidone K-25 as a Binder in The Production of Paracetamol Tablets Agatha Budi Susiana Lestari; Okana, Lie Dofi Ananda Madelin
Journal of Fundamental and Applied Pharmaceutical Science Vol. 6 No. 1 (2025): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v6i1.27034

Abstract

Binding agents play an important role in maintaining the bond between active and additional ingredients in tablets, especially when subjected to repeated compression. One commonly used binder is polyvinylpyrrolidone (PVP) K-25. However, issues often arise regarding the binder's potential when undergoing multiple compressions. This research, hence, aims to determine the reworking potential of PVP K-25 with different concentration levels as a binder, focusing on the physical properties of the mixtures and the resulting paracetamol tablets. The study follows a pure experimental design with a two-way completely randomized research design. Tablets were compressed and subsequently crashed again twice. Various tests, including flow properties and compressibility for the mixtures, as well as compatibility, hardness, friability, and disintegration time for the tablets, were conducted to assess their physical properties. The obtained data were subjected to statistical analysis, starting with the Shapiro-Wilk normality test, followed by Kruskal-Wallis and Post-Hoc Mann-Whitney tests. The research findings indicate that PVP K-25 can maintain its potential as a binder, as evidenced by the physical properties of both the mixtures and the resulting paracetamol tablets.
Analysis of the Entrapment Efficiency of Thymoquinone in Microcapsules of Black Cumin Seed Oil (Nigella sativa L.) Using High Performance Liquid Chromatography Ofa Suzanti Betha; Supandi, Supandi; Addina Syahida; Boy Reynaldi Noor; Nelly Suryani; Sabrina Dahlizar; Yuni Anggraeni; Barita J. Siregar; Zilhadia
Journal of Fundamental and Applied Pharmaceutical Science Vol. 6 No. 1 (2025): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v6i1.27545

Abstract

Thymoquinone is the main active compound found in black cumin seed oil (Nigella sativa). This study intends to analyze the efficiency of its absorption in microcapsules by the ionic gelation of cross-linked alginate and the CaCl2 method, and loading with black cumin seed oil in a concentration of 20%. Thymoquinone was used as a marker to establish quality standards for this microcapsule preparation. Analysis of thymoquinone in microcapsules was performed using a pre-optimized, high-performance liquid chromatography method. Method optimization utilized an Acclaim® Polar Advantage II (C18) column with a flow speed of 1.5 mL/min, a UV detector wavelength of 252 nm, and an injection volume of 20 μL with an isocratic system on a methanol eluent composition: water (70:30). This method revealed a good linearity value (r = 0.9997) in the range of 0.5 – 500 μg/ml. The detection and quantitation limits were 8.67 μg/mL and 28.9 μg/mL, (%diff) was about -1.864 to 1.562, precision (% RSD) was 0.052 to 0.113%, and the recovery was 98.135 to 101.563%. The results of this method validation were then applied to determine thymoquinone loading in black cumin seed oil microcapsules. The results of the absorption efficiency value of black cumin seed oil microcapsules by the ionic gelation alginate and CaCl2 method, which contained 20% oil concentration in the formula, were 81.769%.
ANTIOXIDANT TEST OF TONER IN SKINCARE PACKAGES CIRCULATING IN INDONESIAN SOCIETY
Journal of Fundamental and Applied Pharmaceutical Science Vol. 5 No. 2 (2025): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v5i2.19097

Abstract

Toner has the function of an antioxidant because it can shrink pores and make skin fresher to ward off symptoms of premature aging. In 2021, the use of facial care or skincare products, especially toners, has greatly increased among the public based on online sales results on e-commerce (Shopee and Tokopedia). The purpose of this study was to determine the IC50 value obtained in toner in the skincare package. This study used five toner samples with 5 concentration variations (50 ppm, 100 ppm, 150 ppm, 200 ppm, 250 ppm) and measured antioxidant activity using a UV-Vis Spectrophotometer instrument with the DPPH method. The results showed that the best IC50 value was ascorbic acid (vitamin C) as a positive control with an IC50 value of 7.768 ppm and entered the very strong category. Toner 1 had an IC50 value of 62.218 ppm and was categorised as a strong antioxidant. Toner 2 had an IC50 value of 128 ppm and was categorised as a medium antioxidant. Toner 3 IC50 value of 158.972 was categorised as a weak antioxidant, and toner 4 IC50 value of 91.017 ppm is categorised as a strong antioxidant. At the same time, the one with the lowest IC50 value is toner 5, which has an IC50 value of 170.64 and is included in the weak antioxidant category. Of the five toner samples that have the best IC50 value is toner 1, with an IC50 value of 62.218 ppm.  
Formulation and Physical Test of Hair Tonic with Mangosteen Peel Extract (Garcinia mangostana L.)
Journal of Fundamental and Applied Pharmaceutical Science Vol. 5 No. 2 (2025): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v5i2.21006

Abstract

Hair Tonic is made from the extract of mangosteen peel (Garcinia mangostana L.) and other additional ingredients, which are beneficial in addressing hair loss and nourishing the hair. Scientifically, mangosteen fruit is known to contain Xanthones and flavonoids that function as antioxidants essential for hair health. These compounds can repair damaged hair cells and promote a conducive skin environment for hair growth. The research employed an experimental method involving the creation of four formulations. The mangosteen peel was extracted through maceration using ethanol as a solvent and then evaporated using a rotary evaporator. Subsequently, it was formulated into a Hair Tonic, and the formulation underwent evaluation. Data analysis was conducted through both qualitative and quantitative analyses. Qualitative analysis included organoleptic testing and homogeneity testing, while quantitative analysis involved pH testing, viscosity testing, specific gravity testing, and stability testing using the freeze-thaw cycling method. The results of the research on the organoleptic test for four formulations showed insignificant color differences, ranging from brown, light brown, and dark brown to transparent brown. Homogeneity evaluation indicates that concentration variations in the hair tonic do not affect the stability of its homogeneity. Observations of pH changes during the cycling test (cycles 1 to 6) show an increase in pH values but still within the standard limits. The viscosity values of the Hair Tonic before and after cycling comply with the standard. In conclusion, the overall physical characteristics of the Hair Tonic are that all formulations are suitable to be used, and all of them comply with the requirements.
FORMULATION AND PHYSICAL QUALITY TESTING OF SOLID SOAP SANDALWOOD OIL (Santalum album L.) COMBINATION OF RAMBUSA LEAF EXTRACT (Passiflora foetida L.) AS AN ANTIBACTERIAL AGAINST Staphylococcus aureus
Journal of Fundamental and Applied Pharmaceutical Science Vol. 5 No. 2 (2025): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v5i2.21811

Abstract

The skin is highly susceptible to infections and other skin diseases, one of which is caused by Staphylococcus aureus bacteria. Staphylococcus aureus is a Gram-positive bacterium, with the skin surface as its natural habitat. Sandalwood and rambusa oils are plants known for their antibacterial activity. The objective of this study was to determine the characteristics and physical quality of solid soap formulations made from sandalwood oil combined with rambusa leaf extract to inhibit Staphylococcus aureus bacteria. The method used in this research is experimental. Antibacterial testing was conducted using the disc diffusion method. The results indicated that the addition of sandalwood oil and rambusa extract in solid soap formulations significantly enhanced antibacterial activity against Staphylococcus aureus, with very strong inhibition. Specifically, the diameter of the inhibition zone in formulation 2 with a 50% concentration averaged 23 mm, while formulation 3 at 50% concentration showed an average of 19.8 mm. At a 100% concentration, formulation 3 showed an average inhibition zone of 26.5 mm. Furthermore, physical quality tests of the solid soap preparations confirmed that the results met the quality standards for solid soap as regulated by the Indonesian National Standard (SNI).
FORMULATION DEVELOPMENT OF GUMMY COMPRISING GINGER (Zingiber officinale), CURCUMA (Curcuma xanthorrhiza), AND LEMONGRASS (Cymbopogon citratus)
Journal of Fundamental and Applied Pharmaceutical Science Vol. 5 No. 2 (2025): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v5i2.23051

Abstract

Ginger (Zingiber officinale), Curcuma (Curcuma xanthorriza), and lemongrass (Cymbopogon citratus) are herbal plants widely known by the public to maintain health for various ages, including children. Even though they are beneficial, children tend to find it challenging to accept herbs because of their bitter taste. A method that can reduce the bitter taste of herbs is to prepare them into a gummy. Therefore, this study aimed to formulate those herbal plant extracts into gummy using gelatin. The gummy manufacturing method involved heating, mixing, filtering, molding, and cooling. Due to the Curcuma pH stability, citric acid or tamarind was used as the acid source. Several tests were carried out to ensure the safety and quality of the gummy. They are organoleptic tests, weight uniformity, dimension uniformity, determination of water content, microbial contamination tests, and metal contamination tests. The results show that the gummy formulation meets the organoleptic requirements, weight uniformity, and the dimensions of the gummy.
Formulation & Evaluation Rosella Suspension (Hibiscus sabdariffa L.) as Immunomodulator with Variation of Carboxymethylcellulose Sodium Concentration
Journal of Fundamental and Applied Pharmaceutical Science Vol. 5 No. 2 (2025): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v5i2.23764

Abstract

Rosella flower (Hibiscus sabdariffa L.) has proven in previous studies through clinical trials and preclinical trials to be safe as an immunostimulant. The purpose of this study was to determine the stability of suspension preparation by varying the concentration of CMC Sodium as a suspending agent. The suspension preparations into 4 formulas, Formula 0 (without CMC Sodium), Formula 1 (CMC Sodium 1.5%), Formula 2 (CMC Sodium 1.75%), Formula 3 (CMC Sodium 2%). The results in the organoleptical test showed that the dosage form F0 was liquid, F1 and F2 were slightly thick liquid, F3 was thick. Density test results in F0 1.09g/mL, F1, F2 and F3 1.10g/mL. Viscosity test on F0 20.8 cps, F1 128.6 cps, F2 268.6 cps and F3 475.6 cps. The pH test of all formulas is in the acidic range. Sedimentation test F0 = 1, F1 and F2 = 0.97 and F3 = 0.99 or close to 1. Redispersion time test of all preparations <30 seconds.  The good formula based on the evaluation of suspension rosellaa preparations, namely F1 and F2 with Na CMC concentrations of 1.5% and 1.75%.
Antioxidant Activity from Glucomannan Degradation Product Using β- mannanase Enzyme with DPPH Method
Journal of Fundamental and Applied Pharmaceutical Science Vol. 6 No. 1 (2025): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v6i1.23778

Abstract

Antioxidants are defined as chemical components or compounds that can inhibit damage due to the oxidation process. Glucomannan, which is formed from a polysaccharide called mannan, has various benefits, such as anti-inflammatory, hypoglycemic, hypolipidemic, and antioxidant properties. This research aims to determine the antioxidant activity of glucomannan degradation using the β-Mannanase enzyme and the effect of temperature and pH on its antioxidant activity. Researchers carried out three degradation variations in the form of pH variations (5.5, 7, and 9) and temperature variations (45℃, 55℃, and 65℃), which resulted in 9 samples. The method used for antioxidant testing is DPPH. The antioxidant activity parameters were assessed based on the IC50 value obtained from the antioxidant test results. The best degradation results of glucomannan were pH 5.5 and a temperature of 65℃ with an IC50 value of 39.603 µg/mL due to the influence of pH and temperature on antioxidant activity, where low pH will have high antioxidants and high temperatures will cause a considerable reduction, resulting in high antioxidants.

Page 6 of 7 | Total Record : 70

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