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INDONESIA
Journal of Fundamental and Applied Pharmaceutical Science
Published by Universitas Muhammadiyah Yogyakarta
ISSN : 27237648     EISSN : 2723763X     DOI : 10.18196
Core Subject : Health,
Medicine & Pharmacology
JFAPS focuses on various aspects of pharmaceutical sciences such as: Pharmaceutical Technology Pharmacology & Toxicology Pharmaceutical Chemistry Drug Discovery Traditional Medicine and Medicinal Herb Pharmaceutical Microbiology and Biotechnology
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 54 Documents
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Antibacterial Activity of Abrus precatorius L. Leaves Against Streptococcus mutans ATCC 25175 Bacteria Nadia Aisy Andika; Kusumaningtyas Siwi Artini; Tatiana Siska Wardani
Journal of Fundamental and Applied Pharmaceutical Science Vol 3, No 2 (2023): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v3i2.16206

Abstract

One of the herbal plants that have medicinal properties is Abrus precatorius L or commonly known as Saga in Indonesia. Empirically, the boiled water of saga leaves is widely used as an ingredient in cough medicine, cancer sores and swollen tonsils. The chemical constituents of antibacterial activity in the saga leaves are glycosides (abrusoside AD and abrusgenin), flavonoids and saponins (glycerin). This study aims to determine the antibacterial activity of extracts and fractions from saga leaves and the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of the most active fraction of saga leaves on the growth of Streptococcus mutans ATCC 25175. Saga leaf powder was macerated using 96% ethanol, then fractionated using n-hexane, ethyl acetate, water as solvent, 96% ethanol extract, and n-hexane fraction. The antibacterial activity test using the diffusion method showed that the extract, n-hexane fraction, ethyl acetate fraction, and water fraction of saga leaves had antibacterial activity against Streptococcus mutans. The most active fraction was the ethyl acetate fraction, with a concentration of 50% with an average inhibition zone diameter of 12.2 mm. The ethyl acetate fraction from saga leaves had the most active antibacterial activity compared to ethanol extract, n-hexane fraction, ethyl acetate fraction, and water fraction, as seen from the average diameter of the inhibition zone obtained. The test results of the dilution method of the ethyl acetate fraction of saga leaves showed a Minimum Inhibitory Concentration of 12.5% and a Minimum Killing Concentration of 25%.
In-Vivo Anti-Inflammatory Activity of Kelubut Leaf Ethyl Acetate Extract (Passiflora foetida L.) from Samarinda City Mochtar, Chaerul Fadly; Devi, Reni Selviana; Hamzah, Hasyrul; Faradillah, Ayu; Hafidzah, Elva; Varizza, Fathiah Putri; Aisyiyah, Novia Misnawati; Husna, Qur'anni Akhwatun
Journal of Fundamental and Applied Pharmaceutical Science Vol 4, No 1 (2023): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i1.18287

Abstract

Kelubut (Passiflora foetida L.), as an anti-inflammatory, is widely found in various regions in Indonesia, including in Central Kalimantan. Its main chemical compounds include alkaloids, phenols, glycosides, flavonoids, and cyanogenic compounds. Flavonoids show more than a hundred kinds of bioactivity, including antipyretic, analgesic, and anti-inflammatory. This study aims to determine the anti-inflammatory activity of kelubut leaf extract (Passiflora foetda L.) against mice (Mus musculus). This research went through a Pretest and Posttest Control Group Design with 5 treatment groups, negative control, positive control, and ethyl acetate extract of kelubut leaves with 3 doses of 250 mg/KgBW, 125mg/KgBW and 62.5 mg/KgBB. Before being given treatment, each treatment group was induced by carrageenin by sub-planar injection into the sole of the left leg of the mouse. Then, the edema developed rapidly and persisted for 6 hours. After being induced by carrageenin, the researchers waited for 30 minutes and measured the volume of edema every 30 minutes to 120 minutes. The inhibition of all groups of ethyl acetate extract of kelubut leaves showed anti-inflammatory activity, but the resulting abilities were different. Inflammation inhibition by ethyl acetate extract at a dose of 250 mg/KgBW was 92.78%, at a dose of  125 mg/KgBW, was 91.76%, and at a dose of 62.5 mg/KgBW was 84.61%. From the results obtained, the ethyl acetate extract group of kelubut leaves at a dose of 250 mg/KgBW had the greatest inflammatory inhibition activity compared to a dose of 125 mg/KgBW and 62.5 mg/KgBW.
Evaluation of the Antithrombotic Activity of Acmella oleracea L. Flower Ethanol Extract Tiaravista, Amanda Gita; Putri, Laras Widawaty; Nurrochmad, Arief; Widyarini, Sitarina; Fakhrudin, Nanang
Journal of Fundamental and Applied Pharmaceutical Science Vol 4, No 1 (2023): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i1.19055

Abstract

Acmella oleracea L. (hereinafter abbreviated as AOE) is one of the plants with the potential for antithrombosis, one of the deadliest cardiovascular diseases in Indonesia. The antithrombotic activity test on AOE leaf extract revealed that it could lyse blood clots. However, no information regarding the AOE flower as an antithrombosis is provided. This study, thus, aims to determine the chromatography profile and the antithrombotic activity of the AOE flower ethanol extract. To identify the AOE chemical profile, thin-layer chromatography was carried out. Antithrombotic testing was performed on male rats of the Sprague-Dawley strain. Then, the antithrombotic activity was tested using the FeCl3-induced rat method, with the observed parameter being total occlusion time. The test animals were also divided into six groups: normal, solvent (CMC-Na 0.9%), comparator drug (clopidogrel 8.67 mg/kg), and AOE (doses 125, 250, and 375 mg/kg). The data obtained were then analyzed statistically using Kruskal-Wallis, followed by Tukey's. The TLC profile results confirmed the presence of the alkaloid compound in AOE. The authors also found that AOE at doses of 125, 250, and 375 mg/kg significantly prolonged the occlusion time comparable to that of clopidogrel at 8.67 mg/kg (p 0.05). This finding indicates that AOE has antithrombotic activity in FeCl3-induced rats.
Local Application of Timolol 0.5% Solution in Treating Chronic Non-Healing Ulcers – A Prospective Study Valluru, Sivaramakrishna; R, Ramachandra; Chandana, Jyothi Sasikanth
Journal of Fundamental and Applied Pharmaceutical Science Vol 4, No 1 (2023): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i1.19143

Abstract

Chronic non-healing ulcers are a variety of ulcers that occur mainly over the lower limb and are resistant to conventional therapy. There are modern treatments like various types of dressings and topical preparations available in the market. However, they are costly and may not be freely available to the general population. Topical usage of  β2-AR  antagonists like timolol may promote wound healing by enabling keratinocyte migration into the wound to initiate the re-epithelisation. The objective of this study is to assess the effectiveness of topical timolol 0.5% in accelerating the wound healing process by observing the signs of healing. It is a prospective observational study conducted in Government General Hospital, Rangaya Medical Medical College, Kakinada, after getting  Institutional Ethical Committee approval from March 2021 to March 2023. One hundred patients with Chronic non-healing foot ulcers were taken for this study. Mean age was 47.64.60% of the study population was in the 20-55 years age group. Reduction in mean ulcer area was on day 15 and day 30 with topical application of timolol.
Optimization of the Mixing of Hibiscus Flower (Hibiscus rose sinensis) Extract as a Lip Balm Color with Variations in Concentration Kumala Sari, Diah Indah; Mayangsari, Fransisca Dita; Pratiwi, Elasari Dwi
Journal of Fundamental and Applied Pharmaceutical Science Vol 4, No 1 (2023): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i1.16179

Abstract

Hibiscus rosa sinensis L. is widely used by the community to decorate the garden because of its splendor. In addition, Hibiscus flowers containing anthocyanin and flavonoids have antioxidants, which function as antioxidants against free radicals. This natural dye can be obtained by extracting Hibiscus flowers through maceration using 96% ethanol. In this research, Hibiscus flowers were obtained from Sendang Rejo Village, Lamongan Regency. In the extract process, the Hibiscus flower’s petals were blended until smooth, then added to 96% ethanol (1 liter) and stirred for 30 minutes. Filtrate results were taken, placed in a porcelain dish, and put in an oven at 60 °C for a day. Four formulas were made with varying levels of Hibiscus flower extract: F1 (0%), F2 (2%), F3 (4%), and F4 (6%). Physical evaluation included organoleptic, homogeneity, dispersibility, pH, and qualitative tests for the identification of anthocyanins. The results of the organoleptic, homogeneity, dispersion, pH, and identification of anthocyanins evaluations were then analyzed descriptively. The data from the organoleptic test indicated that F1 had an odorless white color, while F2, F3, and F4 had a red and white color with a distinctive Hibiscus flower aroma. The homogeneity test revealed that while F1 had good homogeneity, F2, F3, and F4 were not homogeneous (heterogeneous). The spreadability test on the four formulas did not fall within the range of requirements, namely 5-7 cm, with an average value of 3.53, but this was related to several significant reasons. In addition, the pH test results matched the requirements for topical preparations, namely 4.5–6.5, with an average value of 5.075. In conclusion, Hibiscus flower extract obtained through the maceration method with 96% ethanol could not give a homogeneous red color from the anthocyanin substance. Physical evaluation and anthocyanin identification tests also obtained good results.
The Effects of Heating Temperatures on Passion Fruit Juice's Ascorbic Acid and Total Phenol Levels Siswandi, Alodia Jeconiah; Prismawan, Deka; Kambira, Pretty Falena Atmanda
Journal of Fundamental and Applied Pharmaceutical Science Vol 4, No 1 (2023): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i1.18648

Abstract

The Passiflora edulis f. flavicarpa, a yellow passion fruit, is known for its distinctive aroma and tart flavor. The pulp of the yellow passion fruit can be used to make tea, jam, and syrup commercially. Commercial items are processed using oven heating, which involves prolonged exposure to high temperatures. As a result, fruit content, particularly water content, may alter. The benefit of reducing the water content is that less microbial growth medium means the product has a longer shelf life. However, fruit flesh’s nutritional composition will also change due to the ascorbic acid and phenolic compounds' thermolability and other factors. In this study, the yellow passion fruit pulp juice is heated in a controlled manner at 60°C, 70°C, and 80°C for 7 hours using an oven. The purpose is to assess changes in the amounts of ascorbic acid and total phenol that occurred. A paired T-test was used to assess the association between weight loss, ascorbic acid levels, and phenolic levels in the control and treatment groups. The amount of ascorbic acid was determined using the 2.6 dichloroindophenol titrimetry method, and the amount of phenol was determined using the Folin-Cioceltau method and UV-Vis spectrophotometry. According to this study, increasing the temperature to 60 °C or 80 °C significantly reduces weight and ascorbic acid levels. Also, the heating temperature unaffected the amount of phenol in each group.
Analysis of Calcium, Iron, Ash, Fat, and Water Content in Fresh and Processed Cow's Milk Using Atomic Absorption Spectrophotometry Methods Amalia, Rizka; Pindona, Zelvia; Rusdiana, Nita; Pratiwi, Dina
Journal of Fundamental and Applied Pharmaceutical Science Vol 4, No 1 (2023): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i1.18938

Abstract

Milk is a source of nutrition for the body's growth, containing calcium and iron minerals. This study analyzes the optimal calcium, iron, ash, water, and fat levels in fresh and processed cow's milk. This study used five samples: pure milk (S1), pasteurized pure milk (S2), pasteurized milk with sugar (S3), pasteurized milk with paste coloring and citric acid (S4), and pasteurized milk with powder coloring(S5). The results showed that the calcium content of milk 4 (S4) treated with pasteurized milk added with sugar and paste coloring and citric acid had a higher calcium content than the other four samples by 98.61 mg/kg, at levels of milk iron 5 (S5) treated with pasteurized milk added with sugar and powdered dyes had a higher iron content than the other four samples by 73.81 mg/kg. The ash content of pure milk was higher at 0.96%. The fat content of pasteurized milk, the taste of coloring paste and powder, was higher than the other three samples at 2.80%. The water content of pasteurized added sugar milk was higher than the other four samples at 88.58%. Pure milk had the most optimal calcium (Ca) and iron (Fe) levels from the other four samples.
In Vivo Antihyperuricemia Activity of Kelubut Leaf Ethyl Acetate Extract (Passiflora foetida, L.) From Samarinda City Mochtar, Chaerul Fadly; Faradillah, Ayu; Bakhtiar, Muh Irham; Devi, Reni Selviana; Husna, Qur’anni Akhwatun; Hafidzah, Elva; Varizza, Fathiah Putri; Aisyiyah, Novia Misnawati
Journal of Fundamental and Applied Pharmaceutical Science Vol 5, No 1 (2024): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v5i1.19171

Abstract

The development of the times creates shifts in lifestyle and eating patterns that trigger hyperuricemia. Hyperuricemia is generally treated with synthetic drugs, but on the other hand, it causes side effects. So the use of natural ingredients such as kelubut leaves can be an alternative treatment. The purpose of this study was to determine the ethyl acetate extract of kelubut leaves has activity as an anti-hyperuricemia. The research uses experimental research methods with a design in the form of a pretest and posttest design. Mice were used and divided into 5 groups, namely the positive control group, the negative control and the group given the extract with three different doses including doses of 250 mg/Kg BW, 125 mg/Kg BW, and 62.5 mg/Kg BW. Mice will be conditioned by hyperuricemia and given different treatments in each group. Data on uric acid levels were analyzed by Kruskal-Wallis and Mann-Whitney. The results of the study showed that administration of the extract at a concentration of 250 mg/Kg BW reduced uric acid levels as much as the positive control group at 120 minutes, but was not statistically different (p0.05) from the positive control. This study concludes that the ethyl acetate extract of kelubut leaves has anti-hyperuricemic activity at a dose of 250 mg/Kg BW showing the best-reducing activity in reducing uric acid levels in mice.
Formulation of Shampoo from Rice Bran Extract (Oryza sativa) and Essential Oil Pomelo Peel (Citrus maxima) Hadi, Ismanurrahman; Silviyani, Amerta; Ulfah, Mariam
Journal of Fundamental and Applied Pharmaceutical Science Vol 4, No 2 (2024): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i2.19328

Abstract

Rice bran (Oryza sativa) is a by-product of rice processing that contains bioactive terpenoid compounds such as oryzanol. This compound has many pharmacological effects such as antioxidant, anti-fungal, anti-bacterial, etc. On the other hand, the essential oil of pomelo peel (Citrus maxima) has a refreshing aroma and also contains a variety of phytochemicals that are efficacious as antioxidants. This study aims to identify optimal formulations of shampoo with a combination of acetone extract from rice bran and essential oil of pomelo peel. Rice bran was extracted using acetone solvent, while essential oil from pomelo peel was obtained by distillation. Phytochemical screening of acetone extract showed the presence of terpenoids, flavonoids, alkaloids, tannins, and saponins. The extracts and essential oil were formulated into shampoo into 4 groups (FI, FII, FIII, FIV), which respectively contained 0%, 10%, 15%, and 20% extract. The results showed the evaluation of the best physical shampoo in Formula III because volunteers preferred Formula III and its better foam stability. Based on these results, it can be concluded that the acetone extract of rice bran and the essential oil of pomelo  peel could be formulated into good shampoo.
Antidiabetic Activity of Diospyros mespiliformis on Alloxan-Induced Diabetic Rats Dahiru, Mubarak Muhammad; Musa, Neksumi
Journal of Fundamental and Applied Pharmaceutical Science Vol 5, No 1 (2024): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v5i1.19798

Abstract

The rate of morbidity and mortality attributed to diabetes has become a concern and challenge for individuals and governments. The availability, affordability, and efficacy of plant-based drugs make them an attractive choice for diabetic management in low-income countries and rural communities. Thus, their application in folkloric medicine for diabetic management. This study investigated the antidiabetic activity of the crude ethanol extract (CRE), ethyl acetate (EAF), and aqueous (AQF) fractions Diospyros mespiliformis (DM) in alloxan-induced diabetic rats to justify its acclaimed applications in folkloric medicine. The effect of the plant extract and its fractions on the aspartate aminotransferase, glutamyl aminotransferase, albumin, urea, creatinine, electrolytes, and lipid profile was determined by biochemical assay methods. The result showed a significant (p 0.05) decrease in fasting blood glucose for all the extracts, while the aspartate aminotransferase, gamma-glutamyl transferase, and albumin were significantly (p 0.05) decreased in the EAF only. The urea and creatinine levels of the CRE and AQF were decreased significantly (p 0.05), while K+, Cl-, and HCO3- levels decreased significantly (p 0.05) for the treatment groups. Furthermore, a significant (p 0.05) decrease in total cholesterol and triglyceride was observed for the EAF. Conclusively, DM exhibited significant hypoglycemic and hypolipidemic potential with improved lipid profile and hepato-renal function. Thus, the observed antidiabetic activity of the plant might justify its acclaimed utilization in the treatment/management of diabetes and its related ailment.    

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