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INDONESIA
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL
Published by Universitas 17 Agustus 1945 Jakarta
ISSN : -     EISSN : 25028413     DOI : https://doi.org/10.52447/scpij.v7i1
Core Subject : Health, Social,
Health Professions Medicine & Pharmacology Public Health Social Sciences
Social Clinical Pharmacy Indonesia Journal (SCPIJ) is a scientific journal managed by the Faculty of Pharmacy Universitas 17 Agustus 1945 Jakarta, which is published twice a year (April and October). SCPIJ is a scientific research journal in the field of community service with articles that have never been published online or in print before. SCPIJ aims to disseminate conceptual thoughts or ideas and research results that have been achieved in the fields of pharmacy and health, Regulatory Affairs and Pharmaceutical Marketing Research, Pharmaceutical Care,Pharmacotheraphy, Pharmacoepydemology, Pharmacogenetic, Rational Therapeutics, Evidence-Based Practice, Health Services Research, Medication Management, Drug Interactions, Drug Utilization, Drug Prescribing, Drug Information. The results of the service published in this journal are in the form of experimental and non-experimental service.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 124 Documents
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EVALUASI PEMANTAUAN TERAPI OBAT PADA PASIEN GERIATRI DENGAN TIA, SINDROMA DISPEPSIA, DISLIPIDEMIA, DIABETES MELITUS TIPE 2 DI RUMAH SAKIT “X” DI JAKARTA melasari, wulan panduwi
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 2 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.9022

Abstract

Pemantauan terapi obat (PTO) dilakukan untuk memastikan keamanan, efektivitas, dan ketepatan penggunaan obat pada pasien. Pelaksanaan pemantauan terapi obat terlihat pada kasus seorang pasien yang datang ke Poli Saraf dengan keluhan tidak ada nafsu makan, bicara pelo, begah, mual, muntah, dan keluarga mengatakan pasien tidak mau makan sejak pulang perawatan dari Unit Stroke. Pasien didiagnosa Transient ischemic attack (TIA), sindroma dispepsia, dislipidemia, dan diabetes melitus tipe 2.  Tujuan pemantauan terapi obat adalah untuk mengidentifikasi Drug Related Problems (DRPs) pada pasien geriatri dengan diagnosa Transient ischemic attack (TIA), sindroma dispepsia, dislipidemia, dan diabetes melitus tipe 2. Metode yang dilakukan dalam pemantauan terapi obat ini adalah secara observasional dengan pengambilan data melalui catatan perkembangan pasien terintergrasi dari Sistem Informasi Manajemen Rumah Sakit (SIMRS), analisis data menggunakan format SOAP, identifikasi Drug Related Problems (DRPs) berdasarkan klasifikasi PCNE (Pharmaceutical Care Network Europe) V9.1, dan melakukan visite secara langsung serta koordinasi profesional pemberi asuhan terkait intervensi pengobatan. Berdasarkan pemantauan terapi obat diperoleh drug related problems berupa adanya interaksi obat dengan kategori mayor antara Donepezil HCl dengan Risperidone yang dapat mengakibatkan meningkatnya risiko perpanjangan interval QT dan torsade de pointes. Setiap intervensi telah dicantumkan di catatan perkembangan pasien terintegrasi dan telah didiskusikan dengan dokter sehingga hasil intervensi dapat diimplementasikan.Kata kunci: Pemantauan terapi obat, Transient ischemic attack, Sindroma dispepsia, Dislipidemia, Diabetes melitus tipe 2
Determinan Dan Pola Konsumsi Antibiotik Pada Balita Dengan Diare di Indonesia: Analisis Data Demographic Health Survey 2017 Maylinda, Tashya Dhela; Yulianto, Rivai Endra Dwi
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 2 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.9258

Abstract

Diarrhea is still the second leading cause of death for children under five years of age. Deaths of children under five years due to diarrhea are caused by unsafe water, inadequate sanitation, and hygiene. Socio-demographic characteristics, environment, behavior, and parenting practices are factors associated with diarrhea in children under five years in Indonesia. The use of antibiotics in the treatment of diarrhea needs more attention. Antibiotic resistance can occur if its use is not based on a proper diagnosis. This study was conducted to examine the factors that influence the incidence of diarrhea in children under five years of age. This study also looked at the prevalence of treatment centers for diarrhea patients and the use of antibiotics for the treatment of diarrhea in children under five years of age. The data used is cross-sectional data on children under five living in households in Indonesia taken from the 2017 DHS survey through data collections and survey reports. Descriptive analyzes were performed on survey reports and datasets related to demographics, the prevalence of diarrheal diseases, and the use of antibiotics for the treatment of diarrhea. Significance analysis was conducted to see whether the selected variables had an effect on the incidence of diarrhea in children under five years of age. Gender, age, location of residence (urban or rural), wealth level, mother's education level and the main material of the house floor are significant factors influencing the incidence of diarrhea in children under five years. Puskesmas is a place to seek treatment for diarrhea which is most frequently visited by children under five years old (20.99%). 10.9% of pediatric patients with diarrhea visited more than one health facility. Private hospitals are the places that most often give antibiotics to children under five years of age who have diarrhea (25%). Antibiotics were given not only by licensed health care facilities but also by other places visited by respondents, namely traditional birth attendants, grocery stores, and other sources.
ANALYSIS OF CHEMOTHERAPY COSTS IN BREAST CANCER PATIENTS PARTICIPATING BPJS AT DHARMAIS CANCER HOSPITAL JAKARTA Piter, Piter; Astiani, Rangki; Monica, Kristin; Permatasari, Yuri
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 2 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.7773

Abstract

This study aims to find out how much chemotherapy costs for inpatient breast cancer chemotherapy patients participating in BPJS and whether there is a difference in real hospital costs compared to INA-CBGs rates. This research is a descriptive, observational study taken from secondary data, in the form of medical record data, laboratory data, INA-CBGs e-claim data and financial data on patient medical costs in accordance with the inclusion and exclusion criteria totaling 100 patient data. Data analysis uses One Sample T-test to see whether there is a significant difference between real costs and INA-CBGs rates. Based on the results of the One Sample T-test, it shows that there is a significant difference. According to the statistical results, a significance of p<0.005 was obtained in class 3 and there was no significant difference in class 1 or class 2. The average cost that breast cancer patients have to pay for each procedure chemotherapy, severity level I Rp. 7,129,348, severity level II Rp. 9,323,275 and severity level III Rp. 9,037,426.
REVIEW ARTIKEL: WAWASAN FARMAKOGENOMIK DAN BIOINFORMATIKA VARIAN GEN ACE DAN PENGARUHNYA TERHADAP RESPONS INHIBITOR ACE PADA HIPERTENSI Anggraeni, Ria; Astiani, Rangki
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 2 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.9109

Abstract

Respons terhadap terapi antihipertensi berbasis angiotensin-converting enzyme inhibitors (ACEIs) bervariasi antar individu, yang sebagian besar dipengaruhi oleh faktor genetik. Gen ACE memiliki sejumlah polimorfisme yang dapat memengaruhi kadar enzim dan efektivitas terapi. Penelitian ini bertujuan mengeksplorasi hubungan antara variasi genetik pada gen ACE dan respons terhadap kaptopril, lisinopril, ramipril, dan enalapril pada pasien hipertensi. Penelitian ini menggunakan pendekatan bioinformatika dan farmakogenomik dengan menganalisis data dari PharmGKB, Ensembl, dan GTEx Portal. Polimorfisme genetik dianalisis untuk mengevaluasi keterkaitannya dengan efektivitas ACEI menggunakan pendekatan statistik deskriptif. Empat polimorfisme nukleotida tunggal (SNP) pada gen ACE ditemukan berasosiasi dengan respons terhadap ACEI. Varian rs4291 dan rs1799752 dikaitkan dengan efikasi kaptopril, di mana genotipe AA menunjukkan penurunan keparahan gagal ginjal. Varian rs1799752 juga terkait dengan lisinopril dan enalapril, dengan genotipe DD memberikan penurunan tekanan darah yang lebih besar. Selain itu, rs4359 dan rs4344 berkorelasi dengan efektivitas ramipril, terutama pada genotipe CC+TT dan AA+GG. Kesimpulan: Variasi genetik pada gen ACE berperan dalam menentukan respons terhadap terapi ACEI. Pendekatan farmakogenetik berpotensi meningkatkan efikasi dan keamanan pengobatan antihipertensi
Effectiveness of Vitamin D Supplementation in Children with Attention-Deficit/Hyperactivity Disorder: A Systematic Review Puspita, Okta; Meiliana, Made Laksmi; Ardhianto, Denny; Ulandari, Syaripah
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 11, No 1 (2026)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v11i1.9367

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder that significantly affects functioning and quality of life. Emerging evidence suggests that vitamin D may contribute to neurodevelopment and behavioral regulation, and children with ADHD have been reported to exhibit lower serum 25(OH)D concentrations. However, findings regarding the clinical effectiveness of vitamin D supplementation remain inconsistent. This study systematically reviewed the effectiveness of vitamin D supplementation in children with ADHD. A systematic review was conducted in accordance with PRISMA guidelines by searching PubMed, ScienceDirect, and Scopus for randomized controlled trials (RCTs) published between January 2016 and February 2026. Eligible studies included children aged ≤18 years diagnosed with ADHD who received oral vitamin D supplementation. Study quality was assessed using the Joanna Briggs Institute Critical Appraisal Checklist, and a qualitative synthesis was performed. Six RCTs met the inclusion criteria. Across studies, vitamin D supplementation consistently increased serum 25(OH)D concentrations. However, clinical effects were heterogeneous. Although some trials reported modest improvements in specific symptom domains, particularly inattention, consistent reductions in overall ADHD severity were not observed. In conclusion, vitamin D supplementation effectively improves serum 25(OH)D levels but demonstrates variable clinical benefits in children with ADHD. Current evidence does not support its use as a definitive standalone treatment, although potential adjunctive benefits cannot be excluded. Further high-quality, large-scale RCTs are needed to clarify its clinical role. 
Pengaruh Rosmarinus officinalis dan Centella asiatica terhadap kadar TNF-α pada Larva Zebrafish yang Diinduksi Glukosa Tinggi Prastiwi, Fajar Dwi
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 11, No 1 (2026)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v11i1.9378

Abstract

Diabetes gestasional adalah jenis diabetes yang terjadi selama masa kehamilan. GDM ditegakkan dengan kondisi hiperglikemi dalam darah. Hiperglikemi memicu respon inflamasi yang ditandai dengan ekskresi sitokin pro inflamasi, salah satunya adalah TNF-α. Centella asiatica dan Rosmarinus officinalis dikenal sebagai anti-diabetes dan anti-inflamasi. Penelitian ini bertujuan untuk mempelajari efek kombinasi nanoemulsi Centella asiatica dan Rosmarinus officinalis terhadap ekspresi TNF-α di larva Zebrafish yang diinduksi glukosa 3%. Hiperglikemi ditandai dengan terjadinya peningkatan kadar Phosphoenolpyruvate carboxykinase di larva Zebrafish. Phosphoenolpyruvate carboxykinase dan TNF-α akan diukur menggunakan metode PCR konvensional. Kombinasi nanoemulsi Rosmarinus officinalis dan Centella asiatica diberikan dengan tiga dosis yang berbeda yaitu dengan konsentrasi 2.5, 5 dan 10 πg/mL. Analisis statistic yang digunakan adalah One Way ANOVA untuk mengukur kadar ekspresi TNF-α. Hasil dari penelitian ini menunjukkan bahwa kombinasi nanoemulsi Rosmarinus officinalis dan Centella asiatica tidak signifikan mempengaruhi kadar ekspresi TNF-α. Dosis yang menurunkan kadar ekspresi TNF-α adalah kelompok dengan konsentrasi 2,5 πg/mL, meskipun hasil akhir memiliki nilai tidak signifikansi . Kesimpulan dari penelitian ini adalah mengkombinasikan nanoemulsi Rosmarinus officinalis dan Centella asiatica dengan dosis 2,5 πg/mL; 5 πg/mL; dan 10 πg/mL tidak signifikan mempengaruhi kadar TNF-α di larva Zebrafish yang diinduksi glukosa tinggi (3%).
EVALUATION OF PHARMACEUTICAL STORAGE MANAGEMENT IN PRIMARY CLINICS BASED ON PHARMACEUTICAL SERVICE QUALITY INDICATORS Astuti, Briandini Dwi
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 11, No 1 (2026)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v11i1.9434

Abstract

Drug storage is a critical stage in pharmaceutical logistics management to ensure the quality of pharmaceutical preparations and budget efficiency. Inappropriate storage can trigger drug damage, expiration, and medication errors. Objective: This study aims to evaluate drug storage indicators in the pharmacy installation warehouse of a primary clinic. Methods: This research is a descriptive observational study with retrospective and prospective data collection. Indicators measured include the compatibility of physical stock with stock cards, the percentage of dead stock, the percentage of expired/damaged drugs, and the suitability of storage systems (alphabetical, FIFO, FEFO, and LASA). Results: The results showed that the percentage of match between the number of drugs and stock cards was 98.5%. The dead stock percentage was 7.29%, and expired drugs accounted for 0.72%. The placement of Look-Alike Sound-Alike (LASA) drugs and the implementation of alphabetical, FIFO, and FEFO systems both achieved 100% compliance. Conclusion:Overall, the drug storage system has met the efficiency indicator standards, although mitigation steps are still needed to minimize dead stock and optimize pharmaceutical supply management, thereby preventing financial loss.
EVALUASI FUNGSI GINJAL BERDASARKAN FARMAKOKINETIK EKSKRESI PADA PASIEN HIPERTENSI DI INSTALASI RAWAT INAP RSUD CILINCING JAKARTA UTARA Octaviani, Egy; Amirulah, Fajar; Sari, Dini Permata; Astiani, Rangki
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 11, No 1 (2026)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v11i1.8932

Abstract

Hypertension is a major risk factor for impaired renal function, which may progress to chronic kidney disease (CKD). This study aimed to evaluate renal function based on excretory pharmacokinetic parameters (urea, creatinine, and creatinine clearance) in hypertensive inpatients, and to assess the impact of patient characteristics and types of antihypertensive drugs on renal function decline. This observational analytic study with a cross-sectional design utilized secondary data from 100 medical records of hypertensive inpatients at RSUD Cilincing, North Jakarta, collected during March–April 2025. Most patients were classified in CKD stages 2–3a. The most frequently prescribed therapies were calcium channel blockers (CCBs) and angiotensin receptor blockers (ARBs). Chi-Square analysis revealed significant associations between renal function and gender, age, and CCB use (p < 0.05), while diuretic use was not significantly associated (p = 0.134). These findings highlight the importance of appropriate antihypertensive drug selection and regular renal monitoring to prevent CKD progression in hypertensive patients.
EVALUASI PEMANTAUAN TERAPI OBAT PADA PASIEN CKD ON HD + ANEMIA DI RS “X” BENGKULU Ningtyas, Maria Sheila Setya
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 11, No 1 (2026)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v11i1.9407

Abstract

Chronic kidney disease (CKD) merupakan masalah kesehatan global dengan insidensi, prevalensi dan angka mortalitas yang terus meningkat. Penyebabnya tidak hanya dikarenakan satu hal dan kerusakan umumnya ireversibel dan mengarah ke perburukan. Tujuan laporan ini dilakukan untuk mengetahui drug related problems (DRP’s) pada penatalaksanaan pengobatan pasien CKD (Chronic Kidney Disease) dengan hemodialisis, anemia di Rumah Sakit X Bengkulu. Selain itu, untuk memastikan penggunaan obat yang rasional, agar tidak terjadi peristiwa yang tidak diinginkan sehingga tercapai efek terapi yang optimal. Metode laporan kasus ini meggunakan rancangan case study dengan teknik pengambilan sampel purposive sampling. Data  yang digunakan yaitu data sekunder dari status rekam medik pasien. Hasil yang diperoleh dari laporan kasus ini yaitu terapi pengobatan yang diterima pasien telah sesuai dengan literatur/ rasional. Meskipun terdapat DRP yakni interaksi obat, tetapi dapat diatasi dengan lebih sering dilakukan pemantauan tekanan darah pasien. Dapat disimpulkan bahwa pasien telah mencapai efek terapi yang optimal dan tidak ada efek samping yang tidak diinginkan.
STUDI DRUG UTILIZATION REVIEW (DUR) TERHADAP PENGGUNAAN ANTIBIOTIK PADA INFEKSI SALURAN PERNAPASAN ATAS Amirulah, Fajar
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 11, No 1 (2026)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.9411

Abstract

Upper respiratory tract infection (URTI) is a condition characterized by irritation and swelling of the upper respiratory tract without pneumonia, usually accompanied by a cough. According to the Indonesian Ministry of Health, the use of medication can be categorized as rational when the medication given meets the patient's needs. Treatment can only be considered rational if it meets several criteria, namely: the right patient, the right indication, the right drug, the right dose, the right interval of administration, the right duration of administration, and others. The objective of this study is to examine the use of antibiotics for ARI in pediatric patients at Jawilan Health Center. The research method employed is a descriptive method with a cross-sectional design to determine the pattern of antibiotic use for ARI in pediatric patients. Data collection was conducted retrospectively using secondary data obtained from medical records and prescriptions of patients with ARI during the period of May 2024–April 2025 at Puskesmas Jawilan, Serang Regency, Banten. The number of patients was 261 patients aged 1-17 years, diagnosed with ARI and given antibiotics. The most commonly used class of antibiotics was amoxicillin, with 253 administrations (96.9%), followed by cotrimoxazole with 8 administrations (3.1%). The results of the treatment rationality are as follows: correct patient 100%, correct indication 77%, correct drug 100%, correct dosage 86.6%, correct interval of antibiotic administration 100%, and correct duration of antibiotic administration 97.7%. From this research data, it can be concluded that there are still irrational drug administrations below 100% that have long-term effects on the patient's body.

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