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INDONESIA
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL
Published by Universitas 17 Agustus 1945 Jakarta
ISSN : -     EISSN : 25028413     DOI : https://doi.org/10.52447/scpij.v7i1
Core Subject : Health, Social,
Health Professions Medicine & Pharmacology Public Health Social Sciences
Social Clinical Pharmacy Indonesia Journal (SCPIJ) is a scientific journal managed by the Faculty of Pharmacy Universitas 17 Agustus 1945 Jakarta, which is published twice a year (April and October). SCPIJ is a scientific research journal in the field of community service with articles that have never been published online or in print before. SCPIJ aims to disseminate conceptual thoughts or ideas and research results that have been achieved in the fields of pharmacy and health, Regulatory Affairs and Pharmaceutical Marketing Research, Pharmaceutical Care,Pharmacotheraphy, Pharmacoepydemology, Pharmacogenetic, Rational Therapeutics, Evidence-Based Practice, Health Services Research, Medication Management, Drug Interactions, Drug Utilization, Drug Prescribing, Drug Information. The results of the service published in this journal are in the form of experimental and non-experimental service.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 114 Documents
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EVALUASI PEMANTAUAN TERAPI OBAT PADA PASIEN KOLESISTITIS, CORONARY ARTERY DISEASE (CAD), CHRONIC KIDNEY DISEASE (CKD), DIABETES MELLITUS (DM), HIPOKALEMIA, DAN HIPONATREMIA DI RUMAH SAKIT “X” melasari, wulan panduwi
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 1 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i1.8635

Abstract

Pemantauan terapi obat (PTO) berperan penting dalam memastikan keamanan dan efektivitas penggunaan obat pada pasien dengan penyakit kronis dan akut. Studi ini mengevaluasi terapi obat pada pasien perempuan usia 59 tahun dengan diagnosis kolesistitis, Coronary Artery Disease (CAD), Chronic Kidney Disease (CKD), Diabetes Mellitus (DM), hipokalemia, dan hiponatremia di Rumah Sakit “X”. Data dikaji melalui rekam medis, hasil laboratorium, serta analisis interaksi obat. Ditemukan satu interaksi mayor antara candesartan dan suplemen kalium yang berpotensi meningkatkan risiko hiperkalemia. Terapi secara umum sesuai indikasi tetapi ditemukan ada interaksi obat. Hasil ini menekankan pentingnya pemantauan terapi serta edukasi pasien, terutama pada terapi jangka panjang.
EVALUASI PEMANTAUAN TERAPI OBAT PADA PASIEN SKIZOFRENIA PARANOID DI RUMAH SAKIT “Y” Lee, linawaty; Yehezkiel, Marthius Putra
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 1 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i1.8682

Abstract

Skizofrenia paranoid adalah jenis skizofrenia yang paling sering dijumpai di negara manapun. Gambaran klinis didominasi oleh waham-waham yang secara relatif stabil, sering bersifat paranoid, biasanya disertai oleh halusinasi-halusinasi terutama halusinasi pendengaran dan gangguan persepsi (gejala positif). Jenis penelitian yang digunakan adalah dengan menggunakan analisa profil pengobatan pasien dengan metode Subject, Object, Assesment, and Plan (SOAP). Pasien Tn. P umur 41 tahun didiagnosa skizofrenia paranoid dengan gejala gelisah, sering mengganggu warga, sering berbicara sendiri. Pasien memiliki riwayat gangguan jiwa sejak 5 tahun lalu dan putus obat, dan didiagnosa DHF (demam berdarah). Dari hasil Analisa yang dilakukan Tn. P masih mendapatkan pengobatan yang tidak rasional.
EVALUATION OF DRUG INTERACTION RISK AND PATTERNS IN HYPERTENSIVE PATIENTS WITH COMORBIDITIES IN A HOSPITAL SETTING Putri Nurhidayah, Eka
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 2 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.9038

Abstract

Hypertension is a chronic condition with a high prevalence and is frequently accompanied by comorbidities that require polypharmacy, thereby increasing the risk of drug–drug interactions (DDIs). This study aimed to evaluate the risk and patterns of DDIs among hypertensive inpatients with comorbidities using a retrospective observational design based on medical record data from 2023–2024. Descriptive analysis was performed on patient characteristics, antihypertensive regimens, and potential DDIs using scientific literature and standardized interaction-checking tools (Medscape, DrugBank, Drugs.com). Validation was conducted independently by a clinical pharmacy practitioner and a clinical pharmacy researcher. Of the 182 medical records reviewed, 65 met the inclusion criteria. Most patients were aged ≥60 years (56.9%) and female (55.4%). A total of 56.9% of patients experienced potential DDIs. Moderate-risk interactions most frequently involved pharmacodynamic mechanisms, particularly aspirin–furosemide, nifedipine–alprazolam, valsartan–insulin glargine, and candesartan–meloxicam. Major interactions were identified in combinations such as valsartan–spironolactone and ramipril–spironolactone, which may increase the risk of hyperkalemia, as well as diltiazem–bisoprolol, which has an additive effect on SA/AV nodal conduction.These findings highlight that hypertensive patients with comorbidities are at high risk for DDIs. Regular clinical monitoring and systematic medication review by clinical pharmacists are essential to enhance therapeutic safety and effectiveness in hospital settings.
ROLE OF ANTIBIOTIC STEWARDSHIP PROGRAM IN IMPROVING RATIONAL THIRD-LINE ANTIBIOTIC USE IN TYPE-2 DM INPATIENTS AT FATMAWATI HOSPITAL Budiastuti, Rizky Farmasita
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 2 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.8397

Abstract

Type-2 diabetes mellitus (T2DM) is the most common metabolic disorders, caused by a combination of two factors: damaged insulin secretion by pancreatic β-cell and the inability of insulin-sensitive tissues to respond appropriately to insulin. Epidemiological data reveal alarming values that predict a concerning future for T2DM. According to the International Diabetes Federation (IDF), in 2019, diabetes caused 4.2 million deaths, and 463 million adults aged between 20-79 years old were living with diabetes, a number that is projected to increase up to 700 million by 2045. Based on data from RISKESDAS in 2018, the prevalence of DM in Indonesia has increased from 6.9% in 2013 to 8.5% in 2018. The Antimicrobial Resistance Control Program (PPRA) team is essential in the development and implementation of evidence-based guidelines and policies. The purpose of this study was to determine the profile of patients receiving antibiotic therapy and the use of third-line antibiotics in T2DM patients at Fatmawati Hospital during the July-December 2021 period. This research used a retrospective descriptive design with a non-experimental approach. The sample size consisted of 52 medical records that met the inclusion criteria. The results showed that patients receiving the most antibiotic treatment were between the ages of 55-64 years (38.5%), women (52%), and those with diabetic foot complications (51.8%). The single and most used combination antibiotics were ampicillin-sulbactam (34.7%) and ampicillin-sulbactam+metronidazole (29.2%). 28.8% of the patients were recommended to receive third-line antibiotics and received considerations from the PPRA team, of which 73.33% obtained approval.
PENGARUH KONDISI KELEMBABAN LEMBAB DAN KERING TERHADAP JUMLAH DAN VIABILITAS SEL PUNCA MESENKIMAL PADA PASASE 6-9 Rismawan, Galuh; Rahmawati, Dewi; Budiastuti, Rizky Farmasita
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 2 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.8960

Abstract

Penelitian ini bertujuan untuk mengevaluasi pengaruh kondisi kelembaban inkubator terhadap jumlah dan viabilitas sel punca mesenkimal (Mesenchymal Stem Cell, MSC) pada pasase 6 hingga 9. Dua kondisi fisiologis diuji, yaitu kultur dalam inkubator dengan kelembaban tinggi (RH ±95%) dan kelembaban rendah (RH <80%) pada kondisi normoksia (37°C, 5% CO₂). Sel yang digunakan merupakan MSC manusia yang diperoleh dari jaringan lemak donor dewasa dan telah dikarakterisasi positif terhadap penanda CD73, CD90, dan CD105. Proses kultur dilakukan secara aseptis dengan media a-MEM yang diperkaya Human Platelet Lysate (HPL) serta antibiotik 1% penicillin-streptomycin. Parameter yang diukur meliputi jumlah total sel, viabilitas sel menggunakan pewarnaan Trypan Blue, dan Population Doubling Time (PDT). Hasil menunjukkan bahwa kelembaban tinggi memberikan hasil yang signifikan terhadap peningkatan jumlah sel dan viabilitas (p<0,05). Rata-rata jumlah sel akhir pada kondisi lembab mencapai 23,36×10⁶ dengan viabilitas 90,23%, sedangkan pada kondisi kering hanya 5,56×10⁶ dengan viabilitas 81,13%. Perbedaan kelembaban juga memengaruhi PDT, di mana kondisi lembab menghasilkan pertumbuhan lebih cepat (0,33 hari⁻¹) dibandingkan kondisi kering (0,54 hari⁻¹). Dengan demikian, kelembaban tinggi berperan penting dalam menjaga stabilitas fisiologis dan mempercepat proliferasi MSC in vitro.
Hubungan Antara Rasionalitas dengan Efektivitas Antihipertensi pada Pasien Hipertensi Dewasa di RSUP Dr. R. Soetijono Blora PRESTICASARI, HARDIYANI
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 2 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.8987

Abstract

Hipertensi merupakan penyakit dengan prevalensi tinggi di Indonesia, termasuk di Kabupaten Blora. Penelitian ini bertujuan untuk mengevaluasi hubungan antara rasionalitas terapi antihipertensi dengan efektivitasnya pada pasien hipertensi dewasa di RSUD Dr. R. Soetijono Blora. Metode penelitian menggunakan desain cross-sectional dengan pengambilan data dilakukan secara retrospektif dari rekam medis pasien periode 1 Mei 2023–30 April 2024. Sampel terdiri dari 75 pasien yang memenuhi kriteria inklusi dan ekslusi. Rasionalitas terapi dinilai berdasarkan terpenuhinya kriteria tepat obat, dosis, dan pasien sedangkan efektivitas terapi dilihat dari penurunan tekanan darah setelah satu bulan pengobatan. Hasil penelitian menunjukkan bahwa 36% pasien termasuk dalam kategori rasional efektif. Analisis statistik dengan uji Chi-square menunjukkan tidak ada hubungan yang bermakna antara rasionalitas dengan efektivitas antihipertensi pada pasien hipertensi dewasa (p>0,05).
PROFIL DRUG UTILIZATION (DU) 90% DAN KESESUAIAN ANTIBIOTIK PADA PASIEN DEMAM TIFOID DI RS X KABUPATEN WONOGIRI Kusumaningrum, Yunita Dyah; Rachmawati, Ema; Firandi, Adelia; Norcahyanti, Ika
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 2 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.8821

Abstract

Demam Tifoid merupakan infeksi bakteri Salmonella thypi yang memerlukan terapi dengan antibiotik. Penggunaan antibiotik perlu dilakukan dengan bijak supaya efektif untuk penyembuhan infeksi dan mencegah terjadinya resistensi. World Health Organization (WHO) merekomendasikan penggunaan metode Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) untuk menilai kuantitas penggunaan antibiotik dan dapat dikombinasikan dengan metode Drug utilization (DU) 90% untuk menilai segmen obat dengan penggunaan tinggi. Penelitian ini bertujuan untuk menganalisis penggunaan antibiotik dengan metode DU 90% pada pasien demam tifoid pada tahun 2020-2022 di RS X Wonogiri dan menganalisis kesesuaian pemilihan antibiotik berdasarkan panduan klinik rumah sakit. Penelitian ini merupakan penelitian observasional menggunakan metode cross sectional dengan pengambilan data secara retrospektif. Data penggunaan antibiotik dianalisis dengan menghitung nilai DDD/100 patient-days dan dilanjutkan menghitung segmen DU 90%. Untuk analisis kesesuaian pemilihan antibiotik dihitung dalam persentase kesesuaian terhadap panduan praktik klinik RS X Wonogiri. Hasil penelitian menunjukkan penggunaan antibiotik untuk demam tifoid paling tinggi yaitu tiamfenikol dan seftriakson. Antibiotik dengan nilai DDD/100 patient-days tertinggi tahun 2020-2022 adalah tiamfenikol, berturut-turut sebesar 50,80; 56,63; dan 50,95 DDD/100 patient-days. Antibiotik yang masuk ke dalam segmen DU 90% pada tahun 2020-2022 yaitu tiamfenikol, sefriakson, kloramfenikol, sefoperazon, sefotaksim, levofloksasin, dan seftazidim. Kesesuaian penggunaan antibiotik berdasarkan panduan praktik klinik rumah sakit yaitu 76,39% pada tahun 2020, 58,73% pada tahun 2021, dan 71,28% pada tahun 2022
DRUG THERAPY IN PATIENTS WITH GRADE 4 DEXTRA HIP OSTEOARTHRITIS WITH COMORBID HYPERTENSION AND TYPE 2 DIABETES MELLITUS Astiani, Rangki; Piter, Piter; Anggraeni, Ria; Luthfiana, Farisa; Sari, Dini Permata; Ramatillah, Diana Laila; Khan, Khasif
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 2 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.8977

Abstract

Osteoarthritis (OA) is a chronic degenerative disease that affects the joints, especially heavy joints such as the knees and hips. OA often causes chronic pain and limited mobility, which is even more complex when accompanied by comorbid hypertension and type 2 diabetes mellitus. These comorbidities increase the risk of pharmacotherapy side effects and drug interactions, requiring a multidisciplinary approach and careful clinical pharmacy monitoring. The purpose of this report is to review the pharmacotherapy management of grade 4 OA Hip Dextra with comorbid HT and DMT2, assessing the safety, effectiveness, and role of clinical pharmacists in therapy optimization. A retrospective case study was conducted by analyzing the patient's medical records, including anamnesis, physical examination, laboratory, pharmacological therapy, and clinical response. The analysis was conducted based on the national guidelines of the Indonesian Ministry of Health, the 2021 National Formulary, PERKENI 2023, and PAPDI 2021. The patient was given combination therapy of NSAIDs, analgesics, prophylactic antibiotics, muscle relaxants, gastric protection, and supplementation for anemia. Therapeutic adjustments were made according to the patient's response and laboratory parameters. Clinical pharmacy monitoring ensures pain control, mobility, hemoglobin, and blood sugar. A multidisciplinary approach based on national guidelines has been shown to improve the safety and effectiveness of OA therapy with multiple comorbidities.
Resistensi Clopidogrel pada Pasien Penyakit Jantung Koroner di Asia Tenggara: Sebuah Narrative Review Luthfiana, Farisa
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 1 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i1.9135

Abstract

Clopidogrel is a commonly used antiplatelet agent for the prevention of thrombotic events in patients with coronary artery disease (CAD), particularly in acute coronary syndrome and after percutaneous coronary intervention. However, interindividual variability in clopidogrel response, known as clopidogrel resistance or high on-treatment platelet reactivity (HPR), is associated with increased risks of adverse cardiovascular outcomes. This issue is especially relevant in Southeast Asia, where genetic and clinical factors may influence drug response.Objective: This narrative review aims to summarize current evidence regarding the mechanisms, prevalence, and clinical implications of clopidogrel resistance in patients with coronary artery disease in Southeast Asia. Methods: A narrative review of peer-reviewed literature was conducted focusing on clopidogrel resistance, platelet reactivity, CYP2C19 genetic polymorphisms, and cardiovascular outcomes in Asian and Southeast Asian populations. Results:Evidence indicates that CYP2C19 loss-of-function alleles are highly prevalent in Southeast Asia, resulting in a substantial proportion of patients classified as intermediate or poor metabolizers. These genetic variants are associated with reduced clopidogrel activation, increased platelet reactivity, and a higher risk of major adverse cardiovascular events, including stent thrombosis and recurrent myocardial infarction. Non-genetic factors such as diabetes mellitus, drug–drug interactions, and medication non-adherence further contribute to clopidogrel resistance. Pharmacogenetic-guided antiplatelet therapy and the use of alternative P2Y12 inhibitors, such as ticagrelor or prasugrel, have shown potential to improve clinical outcomes. Conclusion:Clopidogrel resistance represents a significant clinical challenge among patients with coronary artery disease in Southeast Asia. Integration of pharmacogenetic-guided strategies may enhance the effectiveness of antiplatelet therapy in this region.
Identifikasi Potentially Inappropriate Medication (PIM) Pada Pasien Geriatri : Review Artikel Ilmiah Anggraeni, Ria; melasari, wulan panduwi
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 1 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i1.9136

Abstract

Pasien geriatri memiliki kerentanan tinggi terhadap kejadian Potentially Inappropriate Medication (PIM) akibat perubahan fisiologis terkait usia, tingginya prevalensi penyakit kronis, dan praktik polifarmasi. Kejadian PIM dapat meningkatkan risiko efek samping obat, interaksi obat, serta luaran klinis yang merugikan. Review artikel ilmiah ini bertujuan untuk mengidentifikasi kejadian PIM, pola obat yang paling sering terlibat, serta faktor risiko yang berkontribusi terhadap terjadinya PIM pada pasien geriatri berdasarkan berbagai penelitian yang menggunakan kriteria eksplisit, khususnya Beers Criteria dan STOPP Criteria. Metode yang digunakan adalah narrative review dengan menelaah artikel penelitian nasional terkait PIM pada pasien geriatri di berbagai pelayanan kesehatan. Hasil telaah menunjukkan bahwa prevalensi PIM pada pasien geriatri masih tergolong tinggi dengan variasi yang dipengaruhi oleh perbedaan karakteristik pasien dan metode identifikasi. Obat yang paling sering teridentifikasi sebagai PIM meliputi antihipertensi tertentu, diuretik, benzodiazepin, NSAID, metoclopramide, PPI dan kortikosteroid. Faktor yang konsisten berhubungan dengan kejadian PIM adalah polifarmasi, jumlah komorbiditas, serta lama perawatan. Kesimpulan dari review ini menegaskan bahwa PIM masih menjadi permasalahan klinis yang signifikan pada pasien geriatri. Oleh karena itu, diperlukan evaluasi peresepan dan skrining PIM secara rutin sebagai upaya meningkatkan keamanan dan rasionalitas terapi obat pada populasi geriatri.

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