cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Hanif Amrulloh
Contact Email
jmans@pandawainstitute.com
Phone
+6285664335022
Journal Mail Official
jmans@pandawainstitute.com
Editorial Address
Pratama Praja Street No. 17 Mulyojati West Metro, Metro City, Lampung. 34111
Location
Kota metro,
Lampung
INDONESIA
Journal of Multidisciplinary Applied Natural Science
Published by Pandawa Institute
ISSN : -     EISSN : 27743047     DOI : 10.47352/jmans
Core Subject : Science, Education, Agriculture, Social, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Immunology & microbiology Materials Science & Nanotechnology Mathematics Physics
Journal of Multidisciplinary Applied Natural Science (abbreviated as J. Multidiscip. Appl. Nat. Sci.) is a double-blind peer-reviewed journal for multidisciplinary research activity on natural sciences and their application on daily life. This journal aims to make significant contributions to applied research and knowledge across the globe through the publication of original, high-quality research articles in the following fields: 1) biology and environmental science 2) chemistry and material sciences 3) physical sciences and 4) mathematical sciences. The J. Multidiscip. Appl. Nat. Sci. is an open-access journal containing original research articles, review articles, and short communications in the areas related to applied natural science. The J. Multidiscip. Appl. Nat. Sci. publishes 2 issues in a year on January (first issue) and July (second issue). This journal has adopted a double-blind reviewing policy whereby both the referees and author(s) remain anonymous throughout the process.
Arjuna Subject : Umum - Umum
Articles 19 Documents
 1   2 
Search results for , issue "Vol. 4 No. 1 (2024): Journal of Multidisciplinary Applied Natural Science" : 19 Documents clear
Cytotoxic Activity of Green Seaweed Halimeda tuna Methanolic Extract Against Lung Cancer Cells Amir Husni; Mohamad Gazali; Nurjanah Nurjanah; Rina Syafitri; Abdul Matin; Zuriat Zuriat
Journal of Multidisciplinary Applied Natural Science Vol. 4 No. 1 (2024): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.172

Abstract

Lung cancer is a malignant tumor that attacks the lungs generated by carcinogenic free radicals such as cigarette smoke. Seaweed contains bioactive compounds that have the potential to reduce cancer-causing free radicals. This study aimed to determine the phytochemical content and cytotoxic activity of Halimeda tuna seaweed extract against lung cancer cells (A549). The H. tuna sample was macerated using methanol for 24 h. Cytotoxic test of H. tuna crude extract used the MTT test against A549. The crude extract was phytochemically tested and analyzed using gas chromatography–mass spectrometry (GC-MS). The results showed that the H. tuna crude extract had cytotoxic activity against A549 with an IC50 value of 2771 µg/mL. The phytochemical test showed that H. tuna crude extract contained flavonoids and steroids. showed the presence of fatty acid compounds including palmitic acid, oleic acid, myristic acid, palmitoleic acid and stearic acid. Based on the results can be concluded that H. tuna extract had cytotoxic activity against A549 with low cytotoxicity to be used as a chemo-preventive agent.
The Potential of Moringa Leaf Nanoparticles (Moringa oleifera) on the Expression of TNFα, IL10, and HSP 27 in Oral Cavity Cancer Theresia Indah Budhy; Deddy Adam; Zulikran Moh Rizki Azis; Vania Syahputri; M Gandul Atik Yuliani; Muhammad Febriano Sugiarso Suwarto; Fery Setiawan
Journal of Multidisciplinary Applied Natural Science Vol. 4 No. 1 (2024): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.198

Abstract

Oral cancer is currently the sixth leading malignancy in the world, with over 330,000 cases resulting in death. Several cytokines and proteins protect the survival of cancer cells, such as TNF-α, HSP27, and IL-10. Moringa oleifera is an herbal medicine with anti-cancer properties. Nanoparticles of M. oleifera have the property to be easily absorbed by water-soluble cells, so only small doses are needed to be used as anti-cancer ingredients. This research aims to prove the ability of M. oleifera nanoparticle extract against oral cancer through the expression of tumour necrosis factor α (TNF-α), heat shock protein (HSP27), and interleukin 10 (IL-10). Rat as non-human experimental subjects were divided into four groups: control group (K), treatment group 1 (P1), treatment group 2 (P2), and treatment group 3 (P3). Cancer induction was carried out by injecting with benzo[a]pyrene, and then M. oleifera nanoparticle extract was administered in three forms of treatment doses of 125 μg/mL (P1), 250 μg/mL (P2), and 500 μg/mL (P3). Immunohistochemical examination was analysed through TNF-α, HSP27, and IL-10’s expression. The expression of TNF-α and HSP27 between control and treatment groups was significantly different. P2 had the lowest expression of TNF-α and HSP27. The expression of IL-10 between control and treatment groups was also significantly different. P1 had the lowest expression of IL-10. M. oleifera nanoparticle extract can reduce oral cancer progression by decreasing the expression of TNF-α, HSP27, and IL-10.
Evaluation of The Integrated Protocol for The Management of Severe Malnutrition in Children at The National Hospital of Nouakchott-Mauritania Sima Boulebatt Mahfoud; Hamid El Oirdi; El Hafedh El Mouhab; Nasser Abdellahi; Feil Ahmed; Jaouad Mostafi; Manal Maaroufi; Saïd Lotfi; Khadija El Kharrim; Driss Belghyti
Journal of Multidisciplinary Applied Natural Science Vol. 4 No. 1 (2024): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.199

Abstract

Malnutrition is a worldwide concern with worrisome outcomes that affect substantially the lifestyle of infants. The main aim is to investigate the efficacy of the IMSAM protocol over malnourished Mauritanian children during hospitalization. A cohort of 230 participants, including 126 boys and 104 girls collected from rural and urban areas with an average age of 15.52 ± 7.727 months were enrolled. The study is carried out in the Pediatric Service of the National Hospital Center of Nouakchott, Mauritania on children who have undergone the national protocol for the Integrated Management of Severe Acute Malnutrition (IMSAM). In addition, the medical and nutritional treatment, and body measurements were appreciated as well as the anthropometric parameters. The findings exhibit during nutritional-based intervention significant differences between the mean of weight during the pre- and post-intervention (P < 0.001). Moreover, through a regression test, we found a negatively predicted weight gain (P < 0.05) by the variables Z-score of weight to height (P / T) Edema after Nutritional Support and final health status. Last, but by no means least, the IMSAM-based intervention with rational management might make inroads into mitigating adverse outcomes of malnutrition through maximizing social skills.
Antioxidant and Antibacterial Activities of Curd and Whey Kefir Produced from Etawa Goat Milk Siwi Meutia Sadewi; Nurhasanah Nurhasanah; Sudibyo Sudibyo; Neneng Windayani; Agung Abadi Kiswandono; Heri Satria
Journal of Multidisciplinary Applied Natural Science Vol. 4 No. 1 (2024): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.200

Abstract

Kefir is a fermented drink with many benefits. Kefir contains antioxidant compounds that can inhibit free radical activity.In addition, kefir contains lactic acid bacteria, which provide good antibacterial activity and improve the health of the digestive tract. This research aimed to determine the antioxidant and antibacterial activities of kefir made from Etawa goat milk. The methods used in this research included fermentation of Etawa goat milk with 10 % kefir seeds at 37 °C and a fermentation time of 2 days. Antioxidant activity was tested using 1,1-diphenyl-2-picrylhydrazyl (DPPH), and antibacterial activity was tested using agar diffusion. The peptide molecular weights in kefir were analyzed using SDS-PAGE. The results showed that the antibacterial and antioxidant activities in Etawa goat's milk curd kefir has a higher activity than whey kefir. The antioxidant activity of curd has an IC50 of 43.99 ppm, which is a powerful antioxidant. Curd's antibacterial activity forms a clear zone of 7 mm against Bacillus cereus and is included in the solid antibacterial category. In Escherichia coli, a clear zone of 6 mm was formed and included in the moderate antibacterial category. The results of SDS-PAGE gel visualization found three prominent bands measuring 10, 15, and 33 kDa, respectively.
Application of Response Surface Methodology (RSM) to Study Transesterification of Palm Oil in the Presence of Zeolite-A as Catalyst Kamisah Delilawati Pandiangan; Khoirin Nisa; Wasinton Simanjuntak; Diska Indah Alista; Erika Noviana; Selvia Anggraini Hasan
Journal of Multidisciplinary Applied Natural Science Vol. 4 No. 1 (2024): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.201

Abstract

In this research, the application of response surface methodology with central composite design (RSM-CCD) to optimizetransesterification of palm oil in the presence of zeolite-A as catalyst was investigated. Zeolite-A was synthesized from rice husk silica (RHS) and food-grade aluminium foil using hydrothermal method and then characterized using XRD and SEM. The synthesized zeolite was then applied to an optimized transesterification reaction using response RSM with three factorial levels, for three variables including methanol to oil ratio, catalyst load, and reaction time. The experimental results indicate that the yield of 99% was achieved at optimum conditions of methanol to oil volume ratio of 6, catalyst load of 9.6%, and reaction time of 4.3 hours. The results of experiments and predicted results based on the RSM model are in agreement as shown by the p-value less than 0.05 at a confidence level of 95%.
Comparative Analysis Between Two Reliability Models of a Three-Unit Complex Industrial System Syed Zegham Taj; Syed Mohammed Rizwan
Journal of Multidisciplinary Applied Natural Science Vol. 4 No. 1 (2024): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.202

Abstract

A comparative analysis between two reliability models of a three-unit complex industrial system has been presented in this paper. Previously, real failure-maintenance data of a three-unit complex industrial system were collected. The situations depicted in the data were used for developing two appropriate reliability models for the system. Important reliability indicators of the system were estimated by applying Semi-Markov and regenerative processes. Here, a comparison between the reliability indices and profits of the two models is performed, which helps in identifying the suitability of one model over the other. Cut-off points for profits based on costs, revenues, and failure rates have also been obtained for deciding which of the two models is more profitable. Graphical analysis is also presented to illustrate the outcomes.
Characterization of Extracellular Chitinase from Bacillus cereus SAHA 12.13 and Its Potency as a Biocontrol of Curvularia affinis Muhammad Asril; Didik Supriyadi
Journal of Multidisciplinary Applied Natural Science Vol. 4 No. 1 (2024): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.203

Abstract

Bacillus cereus SAHA 12.13 can produce chitinase, an enzyme that digests chitin in the main compounds of cell walls, mycelia, and spores in pathogenic fungi that cause leaf spots on oil palm plants such as Curvularia affinis. This study aims to determine the properties of the chitinase enzyme B. cereus SAHA 12.13 that can inhibit the growth of C. affinis. Chitinase enzyme production and characterization were measured using the Spindler method. Antagonism test against pathogenic fungi using dual culture method by testing cell culture and enzyme crude extract. This result showed that the isolate produced a high level of specific chitinase activity at 37 °C for 45 h of incubation with 8.45 U mg-1 proteins with a growth rate (k) of 0.25 generation/h, and the generation time was 3.96 h/generation. The optimum chitinase activity was achieved at pH 7.0 and 45 °C and was stable for 3 h with a half-life (t1/2) of 770 min. The crude enzyme and cell culture of strain can inhibit the growth of C. affinis by 36.27±0.043% and 34.25±0.041%, respectively. These characteristics indicate that B. cereus strain SAHA12.13 can be used to inhibit C. affinis, which causes leaf blight of oil palm, under varying pH and temperature conditions.
Green Synthesis of ZnO Nanoparticles using Abelmoschus esculenthus L. Fruit Extract: Antioxidant, Photoprotective, Anti-inflammatory, and Antibacterial Studies Christina Astutiningsih; Tias Eka Rahmawati; Nanik Astutik Rahman; Meri Meri
Journal of Multidisciplinary Applied Natural Science Vol. 4 No. 1 (2024): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.204

Abstract

Nanoparticles are extensively studied for their promising biological properties. In this study, the fruit extract of Abelmoschus esculenthus L. was used as a chelating agent for the synthesis of zinc oxide nanoparticles (ZnOPs-AE) using a zinc acetate solution. The prepared ZnOPs-AE were identified and characterized using UV-vis spectroscopy, Fourier-transformed infrared spectroscopy (FTIR), particle size analyzer (PSA), scanning electron microscopy (SEM), and energy dispersive spectrum (EDS). The green synthesized ZnOPs-AE were evaluated for their antioxidant, photoprotective, anti-inflammatory, and antibacterial activities. The synthesized nanoparticles showed an intensity peak at 370 nm in the UV-vis spectrum. The FTIR result shows the presence of O-H, C=O, C-O, C-OH, and C=C chelating functional groups on the surface of nanoparticles. The size of ZnOPs-AE was determined using a PSA with particle size distribution of 102.2 nm. The ZnOPs-AE were shown to be spherical by SEM analysis and composition was 82.11% and 14.79% for Zn and O, respectively. The antioxidant properties of ZnOPs-AE showed significant antioxidant potential in DPPH, ABTS, and FRAP assays compared to the quercetin standard. The photoprotection activity test showed a SPF value of 19.63, the percentage of erythema transmission was 5.98%, and the percentage of pigmentation transmission was 5.62%. The ZnOPs-AE showed good anti-inflammatory with the synthesized nanoparticle performing activity between positive control and the fruit extract of Abelmoschus esculenthus L. Also, the ZnOPs-AE exhibited good antibacterial activity against Staphylococcus aureus (20.78 mm) and Pseudomonas aeruginosae (11.13 mm). Overall, the results highlight the effectiveness and potential of ZnOPs-AE for biological application.
Chicken Eggshell Powder as Antibacterial Against Staphylococcus aureus and Escherichia coli Through In Vitro Studies Rodhiansyah Djayasinga; Rudy Tahan Mangapul Situmeang; Fuangfa Unob; Sutopo Hadi; Posman Manurung; Sumardi Sumardi
Journal of Multidisciplinary Applied Natural Science Vol. 4 No. 1 (2024): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.205

Abstract

Identifying the most effective material with antibacterial properties against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) is a challenging task considering the rising concerns about drug resistance. Various experiments through in vitro and in vivo studies to obtain antibacterial agents using abundant and easily available raw material sources have been conducted. Therefore, this study aimed to acquire semiconducting nanoparticle material derived from purebred chicken eggshell waste that could effectively function as an antibacterial agent. The waste treatment was carried out using a top-down method applying the thermal decomposition method with calcination temperatures of 700 and 800 ºC for 30 hours. XRD analysis results showed CaO as a major phase and this was further supported by Rietveld calculation. The size of the crystalline phases obtained ranged from 10–45 nm, while FTIR analysis showed the appearance of CaO bond at a wave number of 715.65 cm-1. Furthermore, SEM analysis showed a rough folded particle surface with a pore percentage of 48.20%. Based on the UV-Vis DRS analysis results, chicken eggshell powder had band gap energy characteristics of 2.07, 2.74, 3.71, and 5.96 eV for sample B, as well as 4.60 and 5.82 eV for sample C. Activation of purebred chicken eggshell powder as antibacterial was performed both qualitatively and quantitatively using photocatalytic and non-photocatalytic methods. Qualitatively, both samples showed antibacterial activity, with a minimal inhibitory concentration (MIC) of 1,000 µg/mL.

Page 2 of 2 | Total Record : 19

 1   2 

Filter by Year

2024 2024


Reset
Filter By Issues
All Issue Vol. 5 No. 3 (2025): Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 2 (2025): Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 1 (2025): Journal of Multidisciplinary Applied Natural Science Articles in Press Vol. 4 No. 2 (2024): Journal of Multidisciplinary Applied Natural Science Vol. 4 No. 1 (2024): Journal of Multidisciplinary Applied Natural Science Vol. 3 No. 2 (2023): Journal of Multidisciplinary Applied Natural Science Vol. 3 No. 1 (2023): Journal of Multidisciplinary Applied Natural Science Vol. 2 No. 2 (2022): Journal of Multidisciplinary Applied Natural Science Vol. 2 No. 1 (2022): Journal of Multidisciplinary Applied Natural Science Vol. 1 No. 2 (2021): Journal of Multidisciplinary Applied Natural Science Vol. 1 No. 1 (2021): Journal of Multidisciplinary Applied Natural Science More Issue