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Optimizing Role and Synergy of Indonesian National Police for Handling Prevention of Covid-19 Spread: A Case Study in Human Resource Development Perspective Dimas Agung Trisliatanto; Anis Byarwati; Sri Iswati; Arif Rahman Nurdianto; Fery Setiawan; Heribertus Agustinus Bilo Tena; Hendro Puspito
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15728

Abstract

Background: The rise in cases of violations and criminal acts handled by the Indonesian National Police during the COVID-19 pandemic recorded 18 cases of hoarding and increasing prices for personal protective equipment and other items. This study aims to describe and describe the optimization and synergy of the Indonesian National Police in handling the prevention of the spread of COVID-19. Method: This study used a qualitative approach with a case study method which is explored and analyzed based on the data and research information obtained. Result: This study showed that the role of Bhayangkara Fostering Public Security and Order of Indonesian National Police as the Development of Public Security and Order can be optimized to educate the public to prevent hoaxes or stigma regarding this corona virus. This synergy between the Indonesian National Police, the Indonesian Army and the Community Health Center is urgently needed to avoid data falsification and vaccine abuse in the community. Conclusion: This study concluded that the Indonesian National Police optimizes the role and synergy collaboratively with the community and the Government by relying on the Sector Police as the basis for early detection of potential security problems in the community, especially related to handling COVID-19.
Molecular Review Covid19 from the Pathogenesis and Transmission Aspect Fery Setiawan; Heni Puspitasari; Jenny Sunariani; Ahmad Yudianto
JURNAL KESEHATAN LINGKUNGAN Vol. 12 No. 1si (2020): SPECIAL ISSUE
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkl.v12i1si.2020.93-103

Abstract

Introduction: Corona disease-19 virus (COVID-19) spread and caused a pandemic that affected people all over the world. COVID-19 is also called Severe Acute Respiratory Syndrome-Coronavirus Disease (SARS-CoV). Discussion: COVID-19 is a β-coronavirus serotype which is a single strain of RNA virus and was an outbreak in 2002 (SARS-CoV) and 2012 (MERS-CoV). COVID-19 has Open Reading Frames (ORFs) consisting of Spikes (S), Envelopes (E), Membranes (M), and Nucleocapsids (N) with S parts being a glycoprotein that can attach to receptors owned by host cells, the receptors are CD 26, ACE-2, Ezrin, and Cyclophilins with the main receptor being ACE-2 in the lung organs. Process would evoke a host body's immune response consisting of natural and adaptive immune systems, involving the Antigen Presenting Cell (APC) system which consists of two, namely: Major Histocompatibility Complex (MHC) class I and II. APC could also generate adaptive immune system, consists of B and T cells. COVID-19 had the ability to survive in B and T cells, so that cytokine-chemokine secretion continues to be known as cytokine storm that trigger Acute Respiratory Distress Syndrome (ARDS) and death. Conclusion: The recovery prognosis of COVID-19 depended on the detection of COVID-19 patients because it was related to the severity of ARDS, so the earlier it was detected, the greater the chance of recovery.
Sibling Indices as Comparisons in Personal Identification Process through Short Tandem Repeats [STR] Loci CSF1PO, THOI, TPOX, vWA of Maduranese Ethnic in Surabaya Ahmad Yudianto; Fery Setiawan; Simon Martin Manyanza Nzilibili
Journal of Tropical Biodiversity and Biotechnology Vol 6, No 2 (2021): August
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jtbb.60318

Abstract

Sibling indices can be used as a comparison through alleles Short Tandem Repeats [STR] loci. This is an observational study among Maduranese with 4 STR loci (CSF1PO, THOI, TPOX, vWA) obtained from their blood samples. The percentage of alleles shared: 82.5% [33 times] with 2 allele sharing, 12.5% [5 times] with 1 allele sharing, and 5 % [2 times] with 0 sharing alleles. Sibling indices (SI) calculation results: 65% of sibling indices pairs have SI greater than 100 and 15% of them were between 10-100 (strong and very strong). Sibling indices interpretation is supported; therefore, the claimed sibling indices relationships were indeed true among Maduranese ethnic group in Surabaya.
Paternity Test Through Kinship Analysis as Forensic Identification Technique Ahmad Yudianto; Fery Setiawan; Reni Sumino
Majalah Kedokteran Bandung Vol 53, No 1 (2021)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v53n1.2154

Abstract

Paternity tests is often faced with the unavailability of information from the father, mother, or child as a comparison in forensic DNA examination process. Therefore, comparisons with information from close family lines are needed, for example from the victim's siblings or the perpetrator if there are no comparisons from parents or siblings. This study was conducted by the Human Genetic Study Group of Airlangga University in its campus from January to April 2020. The aim of the study was to analyze the use of kinship analysis in paternity test through STR CODIS examination on siblings. This was an observational laboratory study with a temporary design. DNA sample extraction level and purity results were measured with the mean DNA sample level of 675±5.35ng/µL, while the purity values ranged from 1.05 to 1.86. The paternity test principle is based on comparison process between the parents’ alleles with the child’s alleles. However, if the parents’ alleles are not available, the siblings’ alleles can be used as a comparison for identification purpose, which is known as kinship analysis. Statistically, full siblings have a 2 alleles accuracy probability of [0.25] 25%, which was the same as not having the same allele or 0 allele, while 1 allele accuracy reached 50%. All CODIS STR loci had the highest percentage of 2 allele sharing. Therefore, it is recommended to use sibling or kinship analysis if both parents are absent.
Nuclei DNA Damage Due to Extreme High-Temperature Exposure during Forensic Identification Examination Ahmad Yudianto; Masniari Novita; Ariyanto Wibowo; Fery Setiawan
Majalah Kedokteran Bandung Vol 52, No 4 (2020)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v52n4.2143

Abstract

Accurate personal identification is important in investigations because an error in the identification process may bring fatal consequences during trial. The most common identification process is the Deoxyribonucleic acid [DNA] analysis. Degraded DNA sample due to extremely high-temperature exposure may limit DNA analysis. This study aimed to analyze DNA damage patterns caused by an extremely high temperature using STR (short tandem repeat) CODIS marker. This study was conducted at the Forensic and Medicolegal Department, Laboratorium Balai Besar Kesehatan Surabaya, Ministry of Health of the Republic of Indonesia, Human Genetic Study Group of Universitas Airlangga, and Faculty of Science and Technology of Universitas Brawijaya Malang from July until October 2009. Results of PCR visualization using STR CODIS for costae demonstrated that the THO1 detection (+) in 1,2500C - 40’: 25% and the TPOX detection (+) in 1,0000C - 30’: 50% whereas the results from molar teeth showed that the THOI locus detection (+) in 1,2500C - 30’: 25% and TPOX in 1,0000C - 40’: 50%. Results for PCR visualization using mini-STR CODIS for the costae presented that the mini-THOI in 1,2500C - 20’: 50% (+) while for the molar tooth the mini-THOI in 1,2500C - 30’ : 25% (+) and mini-TPOX in 1,0000C - 40’ : 50% (+). All loci were detected on costae and second molar teeth samples of the control group. Thus, extreme high-temperature exposure significantly decreased the DNA level of second costae and second molar tooth. Sequence patterns of STR loci successfully detected were TPOX, THO1, and CSF1PO.Kerusakan DNA Inti Karena Paparan Suhu Tinggi Selama Proses Identifikasi ForensikIdentifikasi melalui DNA secara tepat penting dalam penyelidikan karena kesalahan akan berakibat fatal selama proses persidangan. Salah satu keterbatasan adalah DNA yang terdegradasi karena paparan suhu yang sangat tinggi. Penelitian ini bertujuan menganalisis pola kerusakan DNA akibat suhu sangat tinggi menggunakan penanda CODIS STR (short tandem repeat). Penelitian dilakukan di Instalasi Kedokteran Forensik, Laboratorium Kemenkes, Human Genetic Study Group, dan Universitas Brawijaya Malang pada periode Juli sampai Oktober 2009. Visualisasi PCR menggunakan STR CODIS untuk costae adalah sebagai berikut: deteksi THO1 (+) pada 12500C - 40’: 25%, deteksi TPOX (+) pada 10000C - 30’: 50%, sedangkan hasil dari gigi molar adalah sebagai berikut: THOI locus detection (+) di 12500C - 30’: 25% dan TPOX di 10000C - 40’: 50%. Hasil visualisasi PCR menggunakan mini-STR CODIS untuk costae adalah sebagai berikut: mini-THOI pada 12500C - 20’: 50% (+) dan untuk gigi molar: mini-THOI pada 12500C-30': 25% (+ ) dan mini-TPOX di 10000C - 40’ : 50%  (+). Semua lokus terdeteksi pada kelompok kontrol pada sampel costae dan gigi molar kedua. Kesimpulannya, paparan suhu tinggi yang ekstrim secara signifikan menurunkan tingkat DNA kosta dan gigi molar kedua. 
PERAN KAPSAISIN PADA PENGHAMBATAN TERJADINYA KANKER Fery Setiawan; Arif Rahman Nurdianto; Rizal Fauzi Nurdianto; Heribertus Agustinus B Tena; Jenny Sunariani
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 10 No 2 (2021): MEDFARM: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v10i2.62

Abstract

Kapsaisin (8-methyl-N-vanillyl-6-nonanenamide) adalah rasa pedas utama dalam batang cabai yang dikonsumsi secara umum. Fungsi utama kapsaisin adalah mengurangi rasa nyeri dan inflamasi neurogenik, selain itu juga memiliki efek anti-tumor. Reseptor kapsaisin dan substansi lain yang terkait dengan kapsaisin telah diidentifikasi dan dikloningkan. Reseptor ini adalah reseptor vaniloid subtipe 1 (VR-1), yang membentuk saluran kation non-selektif dalam membran plasma yang memediasi beberapa efek pleitropik. Kapsaisin dan substansi analog yang sejenis mempunyai efek anti-proliferatif dalam sel kanker manusia melalui induksi siklus sel fase G0/G1 sehingga proliferasi sel terhenti dan terjadi apoptosis pada beberapa sel yang mengalami transformasi. Kemampuan untuk menginduksi apoptosis merupakan aktivitas supresi plasma membran NADH-oksidoreduktase (PMOR), enzim yang mentransfer elektron dari sitoplasmik NADH melalui ko-enzim Q (ubikuinon) ke akseptor elektron eksternal, seperti oksigen. Selain menginduksi apoptosis melalui PMOR, kapsaisin juga menginduksi peningkatan p21, Bax, dan Poly ADP Ribose Polymerase (PARP). Mekanisme antitumor kapsaisin secara utama dengan melakukan stabilisasi dan aktivasi gen p53. Kapsaisin secara substansial memperpanjang siklus hidup p53 dan secara signifikan meningkatkan aktivitas transkripsional p53. PMOR diperkirakan terlibat dalam pengaturan pertumbuhan sel dan proliferasi dengan menjaga rasio NADH+/NADH yang sesuai dengan kebutuhan sel.
FAKTOR KONTEKSTUAL TERHADAP INTENSI KEWIRAUSAHAAN MAHASISWA PESERTA BUSINESS ORIENTATION AT SUPER SURO (BOSS) Fery Setiawan
ISOQUANT : Jurnal Ekonomi, Manajemen dan Akuntansi Vol 3, No 2 (2019): Oktober 2019
Publisher : Universitas Muhammadiyah Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (405.208 KB) | DOI: 10.24269/iso.v3i2.281

Abstract

Penelitian ini membahas tentang faktor kontekstual dalam pengaruhnya pada intensi kewirausahaan mahasiswa. Objek penelitian ini adalah mahasiswa program studi S1 Manajemen Universitas Muhammadiyah Ponorogo yang telah mengikuti kegiatan BOSS, Business Orientation at Super Suro, yakni kegiatan kompetisi berwirausaha yang diadakan untuk mengasah mental entrepreneurship mahasiswa. Penelitian ini dilakukan untuk mengetahui intensi berwirausaha mahasiswa peserta BOSS, sehingga diperoleh informasi yang berguna bagi evaluasi dan penentuan strategi pelaksanaan BOSS selanjutnya. Faktor kontekstual dipilih dalam penelitian ini, sebagai salah satu faktor yang dianggap penting dalam mempengaruhi intensi kewirausahaan mahasiswa. Penelitian ini menggunakan metode kuantitatif dengan populasi adalah mahasiswa peserta BOSS pada tahun 2019. Pengolahan data dalam penelitian ini menggunakan aplikasi program Structural Equation Model (SEM)  Partial Least Square (Smart PLS). Hasil penelitian diketahui bahwa faktor kontekstual berpengaruh positif terhadap intensi kewirausahaan mahasiswa BOSS.Kata kunci: kewirausahaan, faktor kontekstual, intensi  
Description of complaints/clinical symptoms and examination results of the SARS-CoV-2 rapid test in Brata Medika Laboratory Clinic Pare - Kediri in February 2021 Acivrida Mega Charisma; Arif Rahman Nurdianto; Rizal Fauzi Nurdianto; Fery Setiawan; Heribertus Agustinus Tena
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 6, No 2 (2022): Journal Qanun Medika Vol 6 No 02
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v6i2.9734

Abstract

 SARS-CoV-2 antigen rapid test is one of the examinations widely used for early detection of Covid-19 infection. Rapid test is considered to have more advantages, is faster, and is cheaper than molecular PCR testing, and more accurate than rapid antibody tests. Its weakness is especially in detecting samples with small quantities of the virus. The study was conducted using a retrospective method. The data was taken from the patient's medical record of the SARS -CoV-2 antigen rapid swab test at Brata Medika Pare Clinical Laboratory for the period of February 2021. Data inclusion criteria including the examination, complete identity, results of anamnesis examination and rapid test examinations. Data were analyzed in a tabular form containing frequency and percentage. There were 18 (22.5%) patients with positive SARS-CoV-2antigen rapid swab test results, 16 (89%) with complaints/symptoms, and 2 (11%) without complaints/symptoms. Meanwhile, 62 (77.5%) were found with negative SARS-CoV-2 antigen rapid swab test results where 18 (29.0%) were patients with complaints/symptoms and 44 (71.0%) were patients without complaints/symptoms. The high percentage of negative SARS-CoV-2 antigen rapid swab test results in patients with complaints/symptoms (29.0%), it is recommended that a confirmatory examination with the molecular PCR test be carried out. 
Entrepreneurial Curriculum Development through the Production of Eco Print Batik for Primary School Ranti Kurniasih; Slamet Santoso; Fery Setiawan; Nur Sayidatul Muntiah
Budapest International Research and Critics Institute-Journal (BIRCI-Journal) Vol 5, No 3 (2022): Budapest International Research and Critics Institute August
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birci.v5i3.6019

Abstract

This study is designed to cultivate a primary school curriculum that is particularly related to entrepreneurship. It is vital for primary school students to recognize and be taught Entrepreneurial education earlier as a paramount component in enhancing their independence and competence to seize the opportunities in the era of free marketplace today. Not only is this research driven by the fact that the introduction of entrepreneurial-related professions has been low compared to other professions, but also conducted to explore and stimulate the entrepreneurship values of primary school students, empowering the human resources competence. Entrepreneurial-based curriculum can direct the learning process of both students and teachers possessing indispensable roles to cultivate concepts concerning entrepreneurial activities. This curriculum development, ultimately, becomes a challenge to encounter an economic crisis, as well as, an opportunity to prepare young generations that are not limited to be ready to work but open field work. 
A Mixture of Ceramic Biomaterials (Hydroxyapatite and β-Tricalcium Phosphate) and Chitosan as a Scaffold For Critical Sized Defect Bone Dian Agustin Wahjuningrum; S. Setyabudi; Fery Setiawan; Dwikora Novembri Utomo; Ria Chusnita; Andi Syahrimayani; Arif Rahman Nurdianto
Conservative Dentistry Journal Vol. 11 No. 2 (2021): July - December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cdj.v11i2.2021.93-97

Abstract

Background: Bone is a living tissue that undergoes a continuous regeneration-remodeling process and the second largest organ implanted after the blood transfusion process. Bones can heal completely, but Critical Size Defects (CSD) require graft materials to support the healing process. There are several graft materials, namely: autologous, allogenous, xenograft, and alloplastic material with their respective advantages and disadvantages through the properties: osteogenesis, osteoconduction, osteoinduction, and others. One of the alloplastic materials is Hydroxypatite/HA and β-Tricalcium Phosphate/β-TCP widely used in the grafting process. HA has the disadvantage of having a low degree of solubility, while β-TCP has a high solubility level when exposed to body fluids. Purpose: To explain the mixture of ceramic biomaterials (Hydroxyapatite and β-Tricalcium Phosphate) and Chitosan as a Scaffold for Critical Sized Defect Bone. Methods: This study used article based review from some journals that contain of the review about HA and -TCP. Results: The CSDs are condition where the bone can not heal by itself. It needs bone graft to bridge the heal of CSDs. One of the transplant materials is ceramic biomaterials contains of HA and β-TCP. Each of material has its strengths and weaknesses so that mixture of these ingredients will increase the positive effects and reduce the negative effects of each ingredient. Conclusion: CSD healing requires a scaffold that mimics cancellous bone in the healing process of bone defects played by the mixture of BCP as a bioceramic material and chitosan as a natural biopolymer with low toxicity and high biocompatibility.
Co-Authors Achmad Basori, Achmad Achmad Nurdin Himawan Acivrida Mega Charisma Acivrida Mega Charisma Acrivida Mega Charisma Agung Sosiawan Ahmad Yudianto Ahmad Yudianto Amellya Octifani Andi Syahrimayani Anis Byarwati Anis Dwi Anita Rini Anita Devi Arif Rahman Nurdianto Arif Rahman Nurdianto Arif Rahman Nurdianto Arif Rahman Nurdianto Arif Rahman Nurdianto Arif Rahman Nurdianto Arif Rahman Nurdianto Ariyanto Wibowo Aurelia, Shalsa Fadela Azis Akbar Ramadhan Azizah Fatin Hasanah Deddy Adam Dian Agustin Wahjuningrum Dimas Agung Trisliatanto Dina Ismaya Dwikora Novembri Utomo Dyah Ayu Febiyanti Dyah Irnawati Elis Anita Farida ELOK PUTRI NIMASARI Farida Anwari Farida Anwari Gandul Atik Yuliani Hendro Puspito Heni Puspitasari Heribertus Agustinus B Tena Heribertus Agustinus B Tena Heribertus Agustinus Bilo Tena Heribertus Agustinus Tena Hisnindarsyah, Hisnindarsyah Jenny Sunariani Jenny Sunariani Juni Handajani Kurniasih, Ranti Latief Mooduto, Latief Lisdrianto Hanindriyo Lusiyanti Martina Kurnia Rohmah Martina Kurnia Rohmah Martina Kurnia Rohmah Masniari Novita Moh. Khafid Muhammad Febriano Sugiarso Suwarto Niken Hilvanda Putri Nur Sayidatul Muntiah Nurdianto, Arif Rahman Reni Sumino Ria Chusnita Riawan Riyanto Riyanto Rizal Fauzi Nurdianto Rizal Fauzi Nurdianto Rizal Fauzi Nurdianto Rizaldi Patria Setyabudi Setyabudi Simon Martin Manyanza Nzilibili Siregar, Siti Julianita Slamet Santoso Sri Hartono Sri Iswati Swadheena Patro Theresia Indah Budhy Umi Farida Vania Syahputri Vera Rimbawani Sushanty Yusma Amrulloh Tri Firmansyah Yuvi Safitri Zulikran Moh Rizki Azis