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Hanif Amrulloh
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Journal of Multidisciplinary Applied Natural Science
Published by Pandawa Institute
ISSN : -     EISSN : 27743047     DOI : 10.47352/jmans
Core Subject : Science, Education, Agriculture, Social, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Immunology & microbiology Materials Science & Nanotechnology Mathematics Physics
Journal of Multidisciplinary Applied Natural Science (abbreviated as J. Multidiscip. Appl. Nat. Sci.) is a double-blind peer-reviewed journal for multidisciplinary research activity on natural sciences and their application on daily life. This journal aims to make significant contributions to applied research and knowledge across the globe through the publication of original, high-quality research articles in the following fields: 1) biology and environmental science 2) chemistry and material sciences 3) physical sciences and 4) mathematical sciences. The J. Multidiscip. Appl. Nat. Sci. is an open-access journal containing original research articles, review articles, and short communications in the areas related to applied natural science. The J. Multidiscip. Appl. Nat. Sci. publishes 2 issues in a year on January (first issue) and July (second issue). This journal has adopted a double-blind reviewing policy whereby both the referees and author(s) remain anonymous throughout the process.
Arjuna Subject : Umum - Umum
Articles 198 Documents
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The Impact of Land Artificialization on Vegetation Cover and Land Surface Temperature (LST) in The Greater Constantine Kahoul Meriem; Mazouz Toufik; Kallab Debih Naouel
Journal of Multidisciplinary Applied Natural Science Vol. 6 No. 3 (2026): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.464

Abstract

Since the mid-1990s, Greater Constantine has undergone rapid and fragmented urbanization driven by population growth and resettlement policies, causing land artificialization, vegetation loss, and microclimatic changes. This study investigates the relationships between urban growth, vegetation cover, and land surface temperature (LST) from 1995 to 2024 using multi-temporal Landsat imagery processed in Google Earth Engine. The methodology combines supervised land-cover classification using the CART algorithm and the Dynamic World dataset, extraction of vegetation and thermal indices (NDVI and LST.), Normality test was evaluated using the Kolmogorov–Smirnov test with Lilliefors correction, revealing non-normal distributions for all variables (p ≤ 0.001). Therefore, Spearman’s rank correlation was used as the primary measure, while Pearson’s correlation was included for comparison. The results show a +68.21% increase in built-up areas and a −30.05% decrease in vegetated surfaces over the study period. Land surface temperature increased from 21.4 °C in 1995 to 32.6 °C in 2024, with a peak in 2015 (35.51 °C), partly attributable to El Niño event of that year. Statistical analysis indicates a weak inverse relationship between NDVI and LST (Spearman R² = 0.102–0.215) and a positive relationship between NDBI and LST (Spearman R² = 0.269–0.349). confirming that surface artificialization exerts a stronger influence on urban warming than vegetation loss alone. Nevertheless, the moderate explanatory power of both indices indicates that additional factors, including urban morphology, topography, and regional climatic forcing, contribute to spatial temperature variability. A key methodological limitation is the use of two distinct classification approaches (CART for 1995–2005; Dynamic World for 2015–2024), which introduces inter-temporal comparability uncertainty that should be considered when interpreting changes. These findings emphasize the need for nature-based urban planning, including green corridors, tree canopy targets, and permeable surface regulations, to reduce surface warming and strengthen climate resilience in rapidly urbanizing Mediterranean cities.
LC–HRMS-Guided Network Pharmacology Reveals PARP1-Targeting Phytochemicals from Zanthoxylum acanthopodium with Anti-Melanoma Activity Linda Chiuman; Dewi Purnama; Chrismis Novalinda Ginting; Ermi Girsang; Hariyadi Dharmawan Syahputra; Iksen Iksen
Journal of Multidisciplinary Applied Natural Science Vol. 6 No. 3 (2026): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.465

Abstract

Melanoma is an aggressive skin cancer with frequent therapeutic resistance, highlighting the need for multi-target discovery strategies. In this study, an integrative workflow combining LC–HRMS metabolite profiling, network pharmacology, structure-based modeling, and phenotypic evaluation was applied to explore the anti-melanoma potential of Zanthoxylum acanthopodium ethanol extract (ZAE). LC–HRMS analysis followed by ADMET-guided screening prioritized 12 candidate metabolites representing diverse structural classes. Integration of transcriptomic datasets, GeneCards targets, and compound-based predictions identified eight consensus genes, with poly(ADP-ribose) polymerase 1 (PARP1) emerging as the top hub within the protein–protein interaction network. Functional enrichment analysis highlighted pathways associated with DNA damage response and apoptosis-related signaling. Molecular docking against the PARP1 catalytic domain suggested favorable binding profiles for several prioritized metabolites, and molecular dynamics simulation supported stable interaction behavior under dynamic conditions. In vitro anticancer evaluation in A375 melanoma cells demonstrated concentration-dependent reduction in viability (IC₅₀ = 128.03 ± 10.17 μg/mL, 24 h) accompanied by apoptosis-associated nuclear alterations. Overall, this study provides a chemically informed, systems-level framework indicating that ZAE-derived metabolites may influence melanoma cell survival through PARP1-centered stress and apoptosis signaling, offering a foundation for future target validation and structure-guided optimization.
Lotus Bioactive-Loaded Carboxymethyl Cellulose Films for Shrimp Preservation J K Pallavi; P Hema Harshitha; N V Kanimozhi; M Sukumar
Journal of Multidisciplinary Applied Natural Science Vol. 6 No. 3 (2026): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.466

Abstract

Shrimp is highly susceptible to microbial spoilage, creating a need for sustainable antimicrobial packaging systems. In the present study, a biodegradable carboxymethyl cellulose (CMC)-based composite film incorporating lotus-derived flavonoids, essential oil, and carbon nanoparticles (CNPs) was developed for shrimp preservation. A Box–Behnken design was employed to optimize film composition, resulting in a minimum film formation time of 28.2 ± 0.2 h at 0.4% essential oil, 1.65% flavonoids, and 1.2% CNPs. The films were prepared by solution casting and characterized for physicochemical, mechanical, antioxidant, antimicrobial, and biodegradability properties. The optimized film exhibited good structural integrity, a maximum tensile force of 10.5 N, moderate water vapor barrier properties, strong antioxidant activity, and rapid biodegradability under soil conditions. Shelf-life evaluation of Litopenaeus vannamei stored at 16–18 °C demonstrated maintenance of acceptable pH, total phenolic content, and total volatile base nitrogen levels over 15 days. A modified Kaplan–Meier approach further indicated delayed microbial spoilage in shrimp packaged with the composite film compared to conventional plastic packaging, although the differences were not statistically significant at the 95% confidence level. The results suggest that lotus bioactive-loaded CMC films have potential as sustainable active packaging materials for seafood preservation.
Evolution of Population Genetics Research: Insights into Hardy-Weinberg Equilibrium and Mathematical Modeling Priyambodo Priyambodo; Agung Putra Wijaya; Nindy Permatasari; Hidayatulloh Hidayatulloh; Siti Hamidatul Aliyah; Elly Lestari Rustiati
Journal of Multidisciplinary Applied Natural Science Vol. 6 No. 3 (2026): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.469

Abstract

Population genetics has long relied on mathematical frameworks to interpret patterns of genetic variation and evolutionary processes within populations. Among these frameworks, the Hardy-Weinberg equilibrium is one of the most fundamental models for evaluating allele and genotype frequency distributions under theoretical population conditions. Despite its central role in population genetics, the development and research trends related to the Hardy-Weinberg equilibrium and mathematical modeling have not been systematically examined at the bibliometric level. This study aimed to analyze the evolution of scientific research on Hardy-Weinberg equilibrium and mathematical modeling within population genetics using bibliometric approaches. Bibliographic data were retrieved from the Scopus database, resulting in a final dataset of 1,899 research articles. Publication trends, leading journals, productive authors, citation impact, international collaboration networks, thematic structures, and historiographic evolution were analyzed using bibliometric techniques, VOSviewer, and Bibliometrix in R Studio. The results indicate a sustained growth in publications, particularly since the early 2000s, reflecting the increasing role of quantitative and computational approaches in population genetics. Citation and thematic analyses reveal a substantial intellectual transition from classical equilibrium-based population genetics toward molecular, computational, and genomics-oriented research. Historiographic periodization further demonstrates that Hardy-Weinberg-based mathematical frameworks have continuously evolved alongside advances in high-throughput sequencing, statistical genetics, and large-scale genomic analysis. An important insight from this study is that modern genomics research has not replaced the classical Hardy-Weinberg principles, but has instead expanded their application through the integration of computational biology, bioinformatics, and genomics technologies. These findings highlight the continuing relevance of mathematical population genetic frameworks in contemporary genetic science and provide a clearer understanding of the state of the art and future direction of population genetics research.
Viability and Sustainability Assessment of the Mangrove Ecosystem: A Case Study of Sausu Tambu, Indonesia Achmad Rizal; Muh. Saleh Nurdin; Sri Ningsih Mallombasang
Journal of Multidisciplinary Applied Natural Science Vol. 6 No. 3 (2026): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.470

Abstract

The management of mangrove areas is often hindered by the lack of integrated information regarding the ecological conditions and the social aspects of the surrounding communities, as previous studies tend to evaluate both aspects separately. Viability assessment addresses ecological conditions and sources of threats, while sustainability emphasizes multidimensional management strategies. The integration of both is important to bridge ecological diagnosis with long-term management. The research was conducted on the Sausu Tambu mangrove ecosystem by integrating Conservation Action Planning (CAP) and Rapid Appraisal for Fisheries Sustainability (Rapfish). The methodological novelty lies in the two-step matrix that sequentially crosses the viability and threat scores of CAP with the sustainability index of Rapfish, resulting in a final status that reflects the ecological condition and institutional social capacity in an integrated manner. The findings show that this area has nine types of mangroves. The viability is rated as fair, and the threats are rated as medium, which assigns it a vulnerable CAP status. The ecological and social domains of Rapfish are at a moderate level (57.85% and 53.90%), while the institutional domain is slightly lower (49.64%). The intersection of the CAP status with the Rapfish index still results in a final vulnerable status. Actionable conservation strategies include the establishment of management bodies for village mangroves, formulation of village regulations, periodic planting and monitoring, environmental awareness and pride campaigns, inter-party cooperation, and community economic empowerment. These results have consequences for long-term coastal governance and support the Sustainable Development Goals, especially for ocean ecosystems through the protection of coastal habitats and for land ecosystems through the management of mangrove vegetation and biodiversity. The findings can also be used as a model for evaluating other small mangrove areas in Indonesia and tropical coastlines.
New Limonoid from Chisocheton macrophyllus: Isolation, Synthesis, Molecular Docking Studies, and Cytotoxicity against Cancer Cells Muhammad Badrul Huda; Nurlelasari Nurlelasari; Faris Hermawan; Wahyu Safriansyah; Unang Supratman; Yudha Prawira Budiman
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.471

Abstract

Dysobinin is a naturally occurring limonoid and a type of triterpenoid, which shows certain efficacy, although its prospects in the field of pharmacology are still limited. Therefore, this study aimed to improve the pharmacological properties of dysobinin through structural rearrangement. A 56% yield was obtained using Selectfluor to convert dysobinin into a novel molecule, specifically 22α-carboxyacid-dysobinin (5). Compared to the other compounds, 22α-carboxyacid-dysobinin (5) exhibited significantly higher cytotoxicity against human epithelial tumor (HeLa) and B16-F10 cancer cells. However, this compound 5 exhibited the lowest cytotoxicity against MCF-7 cancer cells. Subsequently, a docking study showed that compound 5 had binding energies of -9.61, -7.81, and -6.08 kcal/mol for EGFR, Bcl-2, and Tyrosinase, respectively. In the prediction of pharmacokinetic parameters, compound 5 fulfilled the minimum standard parameters for the ADMET properties. Therefore, compound 5 may be considered a promising lead compound for anticancer development, warranting further optimization and validation.
Wound Grade–Associated Microbiome Diversity in Diabetic Ulcers: A Metagenomic Analysis Andi Ernawati; Iman Rusmana; Aris Tri Wahyudi; Sri Murtini; Sri Budiarti
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.472

Abstract

The wound's microbiome in patients with diabetes plays a vital role for developing of diabetic ulcers. Molecular sequencing technologies have enhanced our understanding of microbial diversity in diabetic wounds, making microbiome profiling analysis essential for supporting effective clinical management. A metagenomic approach enables the more accurate identification of pathogenic bacteria to support rational antibiotic use and the development of more targeted therapies. This study aimed to identify the bacterial diversity in diabetic ulcers before and after antibiotic therapy using a metagenomic approach to analyze changes in the microbiome profile and detect potentially antibiotic-resistant pathogenic bacteria. Wound swabs from each patient were genomically extracted for metagenomic analysis using nanopore sequencing. The samples from individuals administered antibiotics were coded 4, 7AB, and 8, whereas the samples from patients not administered antibiotics were coded 11. Limitations of this study include its relatively small sample size (n = 4). This study shows that the species with the highest abundance in sample 11 was Acinetobacter junii, in sample 4 was Proteus mirabilis, in sample 7AB were Alcaligenes faecalis and Pseudomonas aeruginosa, and in sample 8 was Acinetobacter baumannii. Both groups who did not receive antibiotic treatment and those who received antibiotic therapy showed the presence of diverse microorganisms, including potentially pathogenic bacteria. Future treatment regimens should be based on the type of bacterial infection in wounds of diabetic patients.
A Review of Design Strategies and Material Challenges for Magnesium-Based Rechargeable Seawater Batteries: Insights from Sodium-RSB Systems Rezza Ruzuqi; Agus Sigit Pramono; Lukman Noerochim
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.473

Abstract

Rechargeable seawater batteries (RSBs) are a new class of seawater-based energy storage technology. In this system, the two electrolytes—the non-aqueous anolyte and seawater as the catholyte—have distinct compositions. As an eco-friendly option, the technology is promising, with the potential to replace traditional rechargeable batteries and reduce harmful environmental impacts. It can also be used in locales without access to power. There are different classes of RSBs, including sodium-based (Na-RSBs). At present, Na-RSBs systems have attracted much more attention due to the availability of solvents derived from abundant sodium sources in seawater and because of their superior material costs and safety compared to lithium (Li)-based batteries. Nonetheless, Na-RSBs are inherently restricted by the relatively low theoretical capacity and electrochemical potential of sodium. As a result, magnesium-based rechargeable seawater batteries (Mg-RSBs) have emerged as a promising alternative. Magnesium is attractive because it offers a higher theoretical volumetric capacity (~3833 mAh cm⁻³) and a better cost-performance ratio than Li-ion batteries and Na-RSB systems. Given these merits, we summarize the potential of magnesium as a candidate alternative to sodium in RSB applications. To develop their potential, some strategies (alloying, surface modification, bifunctional catalyst design, and solid–liquid hybrid electrolyte construction) are proposed. The perspective concludes with an outlook that emphasizes the importance of accounting for integrated electrolyte–separator design, interface manipulation, and corrosion-mitigation strategies to realize the potential of Mg-RSBs as a high-durability, long-life, and economical battery system, especially in off-grid applications.

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