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Hanif Amrulloh
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Journal of Multidisciplinary Applied Natural Science
Published by Pandawa Institute
ISSN : -     EISSN : 27743047     DOI : 10.47352/jmans
Core Subject : Science, Education, Agriculture, Social, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Immunology & microbiology Materials Science & Nanotechnology Mathematics Physics
Journal of Multidisciplinary Applied Natural Science (abbreviated as J. Multidiscip. Appl. Nat. Sci.) is a double-blind peer-reviewed journal for multidisciplinary research activity on natural sciences and their application on daily life. This journal aims to make significant contributions to applied research and knowledge across the globe through the publication of original, high-quality research articles in the following fields: 1) biology and environmental science 2) chemistry and material sciences 3) physical sciences and 4) mathematical sciences. The J. Multidiscip. Appl. Nat. Sci. is an open-access journal containing original research articles, review articles, and short communications in the areas related to applied natural science. The J. Multidiscip. Appl. Nat. Sci. publishes 2 issues in a year on January (first issue) and July (second issue). This journal has adopted a double-blind reviewing policy whereby both the referees and author(s) remain anonymous throughout the process.
Arjuna Subject : Umum - Umum
Articles 156 Documents
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Three Decades of Sunda Pangolin (Manis javanica) Conservation Research: Mapping Indonesia’s Role in the Global Engagement Trends Novriyanti, Novriyanti; Masy’ud, Burhanuddin; Soekmadi, Rinekso; Buchori, Damayanti
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.361

Abstract

Limited scientific attention to the Sunda pangolin (Manis javanica) persists despite being among the most trafficked mammals globally and a key species distributed across Indonesia. This study examines Indonesia’s contribution to global Sunda pangolin research and identifies priority directions to strengthen evidence-based conservation. A combined bibliometric–content analysis approach was applied to 4,474 publications recorded between 1993–2023, from which 130 articles met the topic-specific criteria, and 37 were directly related to Sunda pangolin conservation in Indonesia. Results show that Indonesia contributed only 37 documents (0.83%) to the global pangolin research landscape, with 12 thematic categories dominated by trade and crime studies, while ecological and policy-oriented research remained critically underrepresented. Research on Sunda pangolins was also largely driven by international authors from non-habitat countries, indicating a lack of local leadership and collaboration gaps. These findings highlight a strategic need to increase locally led and multidisciplinary research, expand Indonesia’s role as a key habitat country, and establish collaborative research agendas that align ecological knowledge, conservation policy, and wildlife crime mitigation.
Hoof Pathologies in Cattle Kulynych, Serhii; Klymas, Anastasiia; Shabalin, Oleksandr; Zvenihorodska, Tamila; Petrenko, Maksym; Kolomak, Ihor; Tul, Oleksandra; Slynko, Viktor; Avramenko, Nataliia; Panasova, Tetiana; Omelchenko, Hanna
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.363

Abstract

Hoof pathologies are among the most widespread orthopedic disorders in dairy cattle and are a major contributor to reduced animal welfare and productivity. The present study investigated the prevalence, clinical presentation, and treatment outcomes of the most common hoof lesions – digital dermatitis (Mortellaro’s disease), Rusterholz ulcers, purulent pododermatitis, and interdigital dermatitis – across multiple dairy farms in Ukraine. Clinical examinations and therapeutic procedures were performed on more than 9,800 cows from 7 farms during 2022–2023. Diagnosis was conducted during scheduled functional hoof trimming using an orthopedic crush and was confirmed based on lesion morphology, presence of exudate, odor, and pain response. A locally formulated topical powder composed of copper sulfate, zinc oxide, iodoform, and potassium permanganate was applied to purulent–necrotic lesions and compared with a control treatment using a commercial chemi-spray. Therapeutic efficacy was evaluated by lesion healing dynamics and locomotion scores (AHDB system) on days 3, 14, 21, and 45. Digital dermatitis was identified as the predominant lesion, accounting for 50–66% of all diagnosed hoof disorders. The locally formulated powder showed markedly superior therapeutic performance relative to the chemi-spray, accelerating tissue repair and improving locomotion, with full recovery achieved in 86.7–100% of treated cows, depending on farm and lesion type. These findings confirm the persistently high prevalence of hoof diseases in dairy herds and demonstrate the clinical advantage of an affordable, locally prepared treatment formulation. Routine functional trimming, early lesion detection, and evidence-based local therapy remain critical components of effective lameness management in modern dairy production systems.
Discovery of New Antibacterial Peptide from Trypsin Hydrolysate of Monocled Cobra (Naja kaouthia) Venom Protein using C18 SPE Column and LC-HRMS Erlista, Garnies Putri; Raharjo, Slamet; Raharjo, Tri Joko
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.364

Abstract

Antimicrobial peptides (AMPs), as new antibiotic candidates, have the potential to treat infectious diseases. Peptides from N. kaouthia venom proteins can be used to produce AMP. The aim of this study was to identify the antibacterial potential of peptides derived from N. kaouthia venom protein purified by a reverse-phase solid-phase extraction column (SPE C18). N. kaouthia venom protein was isolated using Amicon® Ultra-15 with a 3000 Da centrifugal filter and then hydrolyzed using trypsin. The hydrolyzate was fractionated using reverse-phase (SPE C18), and the resulting fraction was tested for its antibacterial activity against S. aureus (Gram-positive) and E. coli (Gram-negative) bacteria. The most active fraction as an antibacterial was analyzed by high-resolution mass spectrometry (HRMS). The results showed that the 50% methanol fraction was active against E. coli bacteria, and the 100% methanol fraction was active against S. aureus. There are seven peptides identified, namely TVPVKR, TTMMNMLK, WWSDHR, SSLLVK, NSLLVK, LIPIASK, and GALMLK, which are responsible for the activity of the 50% methanol fraction. Meanwhile, there are two peptides, namely SSLLVK and NSLLVK, responsible for the activity of the 100% methanol fraction. LIPIASK and GALMLK peptides are predicted to show better potential as antimicrobial peptides.
Furosemide Increases GABAA Receptor Activity via Antagonism to Sodium-Potassium-Chloride Cotransporter 1 In Silico and In Vivo Siregar, Marsintauli Hasudungan; Nurdiana, Nurdiana; Bal’afif, Farhad; Djajalaksana, Susanthy; Setiawansyah, Arif
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.365

Abstract

GABAA receptor dysfunction and altered chloride homeostasis significantly contribute to seizure pathophysiology, with the sodium-potassium-chloride cotransporter 1 (NKCC1) playing a crucial role in regulating neuronal excitability. This study investigated furosemide's capacity to enhance GABAA receptor activity through NKCC1 antagonism and evaluated its therapeutic profile in combination with diazepam for seizure management. Comprehensive molecular docking analyses were conducted to assess binding affinities of furosemide and diazepam to NKCC1, followed by in vivo experiments using pentylenetetrazol-induced seizure models to evaluate GABAA receptor expression, seizure duration, and multiple pathophysiological biomarkers. Molecular analysis revealed that furosemide demonstrated measurable NKCC1 binding capacity (binding energy: -7.09 kcal/mol; Ki: 6.34 µM), though significantly lower affinity compared to diazepam (binding energy: -7.83 kcal/mol; Ki: 1.81 µM). The furosemide-diazepam combination exhibited complex competitive binding interactions, with furosemide substantially reducing diazepam's NKCC1 binding affinity. NKCC1 antagonism by furosemide effectively enhanced GABAA receptor expression by 29.8 ± 1.60% when used alone and 37.60 ± 2.0% in combination with diazepam. However, combination therapies resulted in significantly longer seizure durations (80 ± 3.0 s) compared to diazepam monotherapy (42.5 ± 2.10 s), suggesting antagonistic interactions on acute seizure suppression that may reflect altered chloride gradients or competitive pharmacokinetic effects. Despite reduced efficacy in seizure termination, combination therapy demonstrated selective advantages in other pathophysiological domains, including superior blood-brain barrier protection (reduced albumin level to 90.90 ± 2.70 µg/mL) and reduced excitotoxic damage. These findings indicate that furosemide-diazepam combination therapy presents a complex therapeutic profile characterized by trade-offs between acute seizure control and neuroprotective mechanisms. The data suggest potential utility in maintenance therapy or prevention of seizure-related complications rather than acute seizure termination, warranting further investigation into temporal optimization strategies and dose modifications.
Subsurface Identification Using Horizontal to Vertical Spectral Ratio and Inverse Velocity Modelling in Suoh Pull-apart Basin, Indonesia Mulyasari, Rahmi; Sarkowi, Muh; Haerudin, Nandi; Utama, Hari Wiki; Widiatama, Angga Jati; Darmawan, I Gede Boy; Kurniawan, Andri; Husni, Yayan Mi’rojul; Hesti, Hesti; Fatmawati, Nofita; Marlina, Serli
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.366

Abstract

Suoh is a pull-apart basin located along the Semangko segment of the Sumatra Fault Zone and filled by thick fluvio-volcanic and alluvial deposits that strongly amplify seismic waves and increase surface damage during earthquakes. This study aims to perform seismic micro-zonation of Suoh using the horizontal-to-vertical spectral ratio (HVSR) method combined with shallow shear-wave velocity (Vs) inversion to support hazard assessment and land-use planning in the Suoh aspiring geopark. Single station microtremor measurements were acquired at 30 sites and processed with Geopsy to obtain dominant frequency (f0), amplification factor (A0), and seismic vulnerability index (Kg). The HVSR curves were further inverted using the Dinver module to retrieve 1D Vs profiles, with initial models constrained by the global CRUST1.0 model and local geology. The results indicate strong lateral variability in site conditions, with low f0 and high A0 values concentrated in the central–western basin, producing high Kg and reflecting thick-soft sediments overlying deep engineering bedrock (Vs ≥ 800 m/s) at depths exceeding 80–100 m. These high-vulnerability zones spatially coincide with shallow seismicity associated with the Semangko Fault. Based on Kg, the study delineates low, moderate, and high seismic vulnerability zones, highlighting areas where seismic amplification and resonance effects are most pronounced. The combination of HVSR parameters with 2D Vs imaging provides a practical framework for identifying high-risk zones and guiding risk-informed land-use planning in tectono-volcanic basins such as Suoh.
Antioxidant and Anticancer Effects of Red Okra (Abelmoschus esculentus L.) Ethanol Extract through In Vitro and In Vivo Colorectal Cancer Models Wahyuningsih, Sri Puji Astuti; Mamuaya, Brigita Klara Krisdina; Dewi, Firli Rahmah Primula; Hapsari, Lukiteswari Dyah Tri; Kusuma, Baskara Wiku Adi; Nurhayati, Awik Puji Dyah
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.367

Abstract

Colorectal cancer (CRC) remains the second leading cause of cancer-related mortality worldwide. Affordable herbal sources such as red okra (Abelmoschus esculentus L.) pods have gained attention as potential alternative therapies for CRC. This study aimed to evaluate the antioxidant and anticancer effects of red okra ethanol extract (ROE) using both in vitro and in vivo colorectal cancer models. The antioxidant activity of ROE was assessed using the DPPH assay, while cytotoxic activity was evaluated using the MTT assay on SW480 and HCT116 cell lines. An in vivo study was conducted using rats divided into six groups: normal control, negative control (MNU 10 mg/kg BW), positive control (MNU + methotrexate 0.08 mg/kg BW), and treatment groups receiving MNU combined with ROE at doses of 50, 100, and 200 mg/kg BW for 28 days. Serum levels of Bcl-2, COX-2, VEGF, and MMP-9 were analyzed, and histopathological evaluations of colon tissues were performed. Data were statistically analyzed using one-way ANOVA followed by Duncan’s post hoc test. Statistical significance was determined at p<0.05. ROE exhibited potent antioxidant activity (IC₅₀ = 59.66 ppm) and induced cytotoxic effects by reducing SW480 cell growth and inhibiting HCT116 cell proliferation. Moreover, ROE significantly decreased the expression of Bcl-2, COX-2, VEGF, and MMP-9. These biomarkers are associated with apoptosis inhibition, angiogenesis, inflammation, and metastasis, respectively. Histopathological analysis confirming reduced inflammatory infiltration and suppression of colon carcinogenesis. The optimal in vivo dose was 50 mg/kg BW. These findings support the development of ROE as a promising natural agent for colorectal cancer prevention and therapy.

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