cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Marcellino Rudyanto
Contact Email
marcellino-r@ff.unair.ac.id
Phone
+628165434137
Journal Mail Official
bikfar@ff.unair.ac.id
Editorial Address
Department Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Airlangga Surabaya, Kampus C, Mulyorejo, Surabaya-60115, East Java, Indonesia
Location
Kota surabaya,
Jawa timur
INDONESIA
Berkala Ilmiah Kimia Farmasi
Published by Universitas Airlangga
ISSN : 23028270     EISSN : 28081048     DOI : http://dx.doi.org/10.20473/bikfar.v8i2.31763
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology
to facilitate interaction, discussion, and updating of research ideas in the fields of pharmacy, Pharmaceutical Chemistry, Medicinal Chemistry, Drug Development, Organic synthesis, Analytical chemistry, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Nutraceutical / functional foods.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Farmakologi
Articles 64 Documents
 3   4   5   6   7 
Reducing the Formaldehyde Levels in Meatballs using Fruit of Averrhoa bilimbi (Belimbing Wuluh) Gilang Robi Sadino; Fath Dwisari; Puspa Amalia; Abdurraafi’ Maududi Dermawan
Berkala Ilmiah Kimia Farmasi Vol. 13 No. 1 (2026): Vol. 13 No. 1 (2026): Jurnal Berkala Ilmiah Kimia Farmasi
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v13i1.73415

Abstract

Meatballs (Bakso) are processed meat products that are widely consumed in Indonesia. Owing to their high moisture and protein content, meatballs are highly susceptible to microbial spoilage, leading some vendors to illegally use formaldehyde as a preservative to extend shelf life. Prolonged consumption of formaldehyde-contaminated foods may pose serious health risks. Therefore, this study aimed to evaluate the effectiveness of Averrhoa bilimbi (belimbing wuluh) juice in reducing formaldehyde levels in meatballs and to determine the most effective juice concentration. A randomized pretest–posttest experimental design was employed using 12 commercial beef meatball samples collected from a local market in Pontianak and spiked with formaldehyde under laboratory conditions. The samples were treated with 30, 40, and 50% A. bilimbi juice for 60 min. Formaldehyde concentrations were quantified and validated using UV-Vis spectrophotometry. The results demonstrated a significant reduction in formaldehyde levels after juice application. The reductions achieved with 30%, 40%, and 50% juice were 27.07%, 28.78%, and 65.80%, respectively. In conclusion, formaldehyde reduction increased with increasing juice concentration, with the 50% treatment producing the greatest reduction (65.80%). Further studies using naturally contaminated food samples are required to verify the effectiveness and practical applicability of this approach.   Keywords: Averrhoa bilimbi, Belimbing Wuluh, formaldehyde, meatball, Spectrofotometry UV-Vis
Aktivitas Antibakteri Kombinasi Ekstrak Etanol Cinnamomum burmannii dan Physalis angulata L. terhadap Methicillin-Resistant Staphylococcus aureus secara In-Vitro Anni Humayroh Syawalia; Rachma Dessidianti; Isnaeni Isnaeni
Berkala Ilmiah Kimia Farmasi Vol. 13 No. 1 (2026): Vol. 13 No. 1 (2026): Jurnal Berkala Ilmiah Kimia Farmasi
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v13i1.76285

Abstract

This study aims to evaluate the antibacterial effectiveness of a combination of cinnamon bark ethanol extract and physalis, which is expected to have high potential as a natural antibacterial agent against Methicillin Resistant Staphylococcus aureus (MRSA). The antibacterial activity test was carried out using the agar well diffusion method. Ethanol extract preparation was carried out by maceration. The combination formula of physalis extract: cinnamon bark, which is divided into 5 ratios, namely 1:1, 1:2, 2:1, 3:1, and 4:3 with a concentration variation of 20%, 10%, 5%, 2.5%, and 1.25%, using 70% ethanol and kanamycin as negative and positive controls, respectively. The combination of extracts with the lowest MIC value was obtained in a ratio of 4:3 with a concentration of 1.25%. The diameter of the inhibition zone against MRSA was 8.17 mm ± 1.14, which is included to the moderate antibacterial effectivity. The combination obtained from diluting ¼ x MIC of each extract in a ratio of 1:1 produces an inhibition zone of 8.15 mm. A Fractional Inhibitory Concentration Index (FICI) value of 0.498 was obtained, indicating that the combination of ethanol extract of cinnamon bark and physalis is a synergistic combination as an alternative antibiotic from natural ingredients.   Keywords:  Antibacteria, Cinnamon bark, Physalis, MRSA, MIC
Perbandingan Aktivitas Antioksidan Ekstrak Etil Asetat, N-Heksana dan Metanil dari Daun Hantap (Sterculia oblongata R.Br) Rais Syifa Aristianto; Nitya Nurul Fadilah; Susanti
Berkala Ilmiah Kimia Farmasi Vol. 13 No. 1 (2026): Vol. 13 No. 1 (2026): Jurnal Berkala Ilmiah Kimia Farmasi
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v13i1.76293

Abstract

Degenerative diseases are chronic health conditions characterized by a gradual decline in organ function, often triggered by high levels of environmental pollutants and the accumulation of free radicals. Free radical activity can cause cellular and tissue damage, contributing to the development of various degenerative diseases such as diabetes, cancer, inflammation, immune disorders, premature aging, and cardiovascular diseases. This study aims to evaluate the antioxidant activity of Sterculia oblongata R.Br leaf extracts based on the polarity of the extraction solvents used. The extraction process was carried out through graded maceration using ethyl acetate, n-hexane, and ethanol. Antioxidant activity was assessed using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method with UV-Vis spectrophotometry to determine the IC₅₀ values of each extract. The results showed that the ethyl acetate extract exhibited the strongest antioxidant activity, with an IC₅₀ value of 17.33 µg/mL, followed by the ethanol extract (19.10 µg/mL) and the n-hexane extract (23.97 µg/mL). Based on the antioxidant activity classification, all three Sterculia oblongata leaf extracts demonstrated very strong antioxidant activity. These findings also indicate that higher solvent polarity corresponds to increased antioxidant activity.   Keywords: Antioxydant, Sterculia oblongata Leaves, Polarity, Solvent
The Effect of Zoledronic Acid Injection on the Effectiveness of Chitosan-Coated Ursolic Acid Niosomes for Treating Liver Damage in NDEA-Induced Mice Andang Miatmoko; Dwi Nur’aini Hidayati Hidayati; Dinda Chaerani; Berlian Sarasitha Hariawan; Devy Maulidya Cahyani; Liew Kai Bin; Esti Hendradi; Retno Sari
Berkala Ilmiah Kimia Farmasi Vol. 13 No. 1 (2026): Vol. 13 No. 1 (2026): Jurnal Berkala Ilmiah Kimia Farmasi
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v13i1.94899

Abstract

Background: Ursolic Acid (UA) is well known as a BCS class IV terpenoid with anticancer, anti-inflammatory, and antioxidant properties. Niosomes have been reported to improve the bioavailability of poorly water-soluble drugs, and chitosan coating may further increase the bioavailability and liver accumulation. However, macrophage-mediated nanoparticle uptake may affect it. This study aimed to determine the effect of macrophage depletion on the therapeutic and preventive efficacy of chitosan-coated Nio-UA against the hepatotoxic effects of N-nitrosodiethylamine (NDEA) in mice. Methods: Nio-UA was prepared by thin-layer hydration and coated with chitosan via vortexing. In the curative therapy model, mice received NDEA (25 mg/kgBW, intraperitoneally) weekly for 6 weeks, followed by Nio-UA (11 mg/kgBW, orally) every 2 days for 8 doses. In the preventive model, mice were given Nio-UA at the same dose 7 and 3 days before NDEA induction, then weekly with NDEA for 4 weeks. Macrophage depletion was induced with zoledronic acid (ZOL) at a dose of 40 μg/mouse intravenously for 3 days. Results: Chitosan coating increased the niosomal particle size and polydispersity index (PDI) while modifying the ζ-potential. In vivo bilirubin levels differed significantly between the healthy and negative control groups, whereas albumin levels showed no significant difference. ZOL treatment did not significantly alter bilirubin or albumin levels compared to non-ZOL groups in either model. Discussions: The UA niosomes therapy did not significantly improve serum albumin or total bilirubin levels after ZOL injection, suggesting that the ZOL dose injection may have not substantially affect niosome uptake. The effectiveness of macrophage depletion needs further validation. ZOL injection slightly reduced bilirubin levels in the preventive therapy model, may indicate partial depletion of hepatic macrophages and decreased hepatic clearance of Nio-UA and Nio-UA-Cs. These preliminary findings provide a basis for further investigation whether ZOL injection can increase the UA's therapeutic effectiveness. Conclusions: In this exploratory study, ZOL injection did not markedly improve the therapeutic effectiveness of chitosan-coated Nio-UA in preventing or treating the hepatotoxic effects of N-nitrosodiethylamine (NDEA) in mice. Further studies for validating macrophage depletions are required to clariy the mechanism.   Keywords: Cancer, Macrophage Depletion, Ursolic Acid, Niosomes, Hepatotoxic Effects, N-nitrosodiethylamine

Page 7 of 7 | Total Record : 64

 3   4   5   6   7 

Filter by Year

2020 2026


Reset
Filter By Issues
All Issue Vol. 13 No. 1 (2026): Vol. 13 No. 1 (2026): Jurnal Berkala Ilmiah Kimia Farmasi Vol. 12 No. 2 (2025): December Vol. 12 No. 1 (2025): June Vol. 11 No. 2 (2024): December Vol. 11 No. 1 (2024): June Vol. 10 No. 2 (2023): December Vol. 10 No. 1 (2023): June Vol. 9 No. 2 (2022): December Vol. 9 No. 1 (2022): June Vol. 8 No. 2 (2021): December Vol. 8 No. 1 (2021): June Vol. 7 No. 2 (2020): DESEMBER Vol. 7 No. 1 (2020): JUNI More Issue