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Jurnal Mahasiswa PSPD FK Universitas Tanjungpura
Published by Universitas Tanjungpura
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Core Subject : Education,
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Articles 585 Documents
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EFEK HEPATOPROTEKTOR EKSTRAK ETANOL LIDAH BUAYA (Aloe vera) TERHADAP AKTIVITAS ENZIM ALANIN AMINOTRANSFERASE (ALT) DALAM PLASMA Rattus norvegicus JANTAN GALUR WISTAR YANG DIINDUKSI PARASETAMOL ., Ryan Arifin
Jurnal Mahasiswa PSPD FK Universitas Tanjungpura Vol 1, No 1 (2014): Jurnal Mahasiswa PSPD FK UNTAN Tahun 2014
Publisher : Jurnal Mahasiswa PSPD FK Universitas Tanjungpura

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Latar Belakang : daun lidah buaya (Aloe vera) mengandung metabolit sekunder flavonoid yang berfungsi sebagai senyawa antioksidan danmenstimulasi pembentukan GSH (glutation) sehingga memberikan efekhepatoprotektor berupa penurunan aktivitas enzim alaninaminotransferase (ALT). Tujuan : penelitian ini bertujuan mengetahui efekhepatoprotektor dan dosis efektif ekstrak etanol lidah buaya (Aloe vera)pada tikus putih jantan galur Wistar dibandingkan kurkuma melaluiindikator enzim alanin aminotransferase (ALT). Metodologi: penelitian inimerupakan jenis penelitian eksperimental rancang acak lengkap (RAL)dengan desain pretest dan posttest. Sebanyak 30 ekor tikus putih jantangalur wistar dibagi secara acak ke dalam 5 kelompok perlakuan, yaitukontrol negatif (CMC 0,5%), kontrol positif (kurkuma), dosis I (1000mg/kgBB), dosis II (2000 mg/kgBB), dosis III (4000 mg/kgBB) yangdiinduksi parasetamol satu jam kemudian selama 7 hari. Data dianalisismenggunakan uji One-way anova yang dilanjutkan dengan uji Post-HocLSD. Hasil : Uji skrining fitokimia menunjukkan bahwa ekstrak etanol lidahbuaya (Aloe vera) mengandung flavonoid, alkaloid, tanin, saponin, dansteroid. Hasil analisa statistik menunjukkan perbedaan yang bermaknapada rata-rata aktivitas enzim ALT kelompok kontrol negatif dan positifdengan kelompok dosis I, II, dan III ekstrak etanol lidah buaya (Aloe vera)(p<0,05) pada pengukuran aktivitas enzim ALT setelah perlakuan(posttest). Dosis efektif yang didapatkan adalah 4000 mg/kgBB.Kesimpulan : Ekstrak etanol lidah buaya (Aloe vera) memiliki efekhepatoprotektor berupa penurunan aktivitas enzim ALT yang lebih baikdibandingkan kurkuma pada dosis 4000 mg/kgBB.Kata Kunci : Aloe vera, ekstrak etanol  lidah buaya, parasetamol, aktivitas enzim ALT, hepatoprotektor.1) Program Studi Pendidikan Dokter, Fakultas Kedokteran, Universitas 3 Tanjungpura Pontianak, Kalimantan Barat. Email:ryanarifin.expobioenergy@gmail.com 2) Departemen Farmakologi, Program Studi Pendidikan Dokter,Fakultas Kedokteran, Universitas Tanjungpura Pontianak,Kalimantan Barat 3) Departemen Biokimia, Program Studi Pendidikan Dokter, FakultasKedokteran, Universitas Tanjungpura Pontianak, Kalimantan Barat.
DESCRIPTIONS OF FLUID INTAKE AND HYDRATION STATUS IN PANTI SOSIAL TRESNA WERDHA MULIA DHARMA KUBU RAYA REGENCY ., Vini Cahyani
Jurnal Mahasiswa PSPD FK Universitas Tanjungpura Vol 1, No 1 (2014): Jurnal Mahasiswa PSPD FK UNTAN Tahun 2014
Publisher : Jurnal Mahasiswa PSPD FK Universitas Tanjungpura

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Background: Dehydration has been linked with high morbidity andmortality. During aging process, many physiological changes put theelderly at greater risk of dehydration. Decreasing sensation of thirsty cancaused low fluid consumption in elderly and they may be purposely restrictthe consumption in manner to lower frequency of urination. Maintaininghydration is essential for elderly health. Objective: The purpose of thisresearch was to determine distribution of fluid intake and hydration statusin elderly who lived in Panti Sosial Tresna Werdha Mulia Dharma KubuRaya Regency. Method: This research was descriptive study with crosssectional approach. Data were collected from 41 elderly people aged 6079years old. Data were recruited with consecutive sampling technique.This research was implemented in Panti Sosial Tresna Werdha MuliaDharma Kubu Raya on February 2014. Fluid intake was measured by foodfrequence quesioner (FFQ) and hydration status was detected by urinchart. Result: There were 65,4% elderly with inadequate fluid intake and61% elderly had dehydration, among them were 34,1% male and 26,8%female with dehydration, dehydration occurred in 4,9% elderly withmalnutrition, 29,3% in elderly with risk of malnutrion and 26,8% in elderlywith normal status nutrition. Conclusion: Inadequate fluids intake canevoke dehydration in elderly. It makes fluid consumption should beseriously noted, hydration status can be monitored by using urin chart.Keywords: fluid, dehydration, elderly1) Medical School, Faculty of Medicine, Tanjungpura University Pontianak, West Kalimantan2) Department of Community Medicine, Family and Public Health, Medical School, Faculty of Medicine, Tanjungpura UniversityPontianak, West Kalimantan 3) Department of Parasitology, Faculty of Medicine, TanjungpuraUniversity Pontianak, West Kalimantan
HUBUNGAN TROMBOSITOPENIA, HIPOALBUMINEMIA, DAN SPLENOMEGALI SEBAGAI PREDIKTOR VARISES ESOFAGUS PADA PASIEN SIROSIS HATI DI RSUD DR. SOEDARSO PONTIANAK ., Yenni Andriana
Jurnal Mahasiswa PSPD FK Universitas Tanjungpura Vol 2, No 1 (2013): Jurnal Mahasiswa PSPD FK Universitas Tanjungpura
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Liver cirrhocis is a disease that most found in the worldincluded Indonesia, with the major bleeding complication that esophagealvarices broken which has high mortality rate. Thus, it needs a predictor topredict the occurrence of esophageal varices, they are simply the numberof trombocyt, albumin levels, and splenomegaly, in Dr. Soedarso generalhospital Pontianak has never implemented.Methodology: This research is an obvervational analytic research andcross sectional's approach. The data was collected in the medical recordsof Dr. Soedarso general hospital Pontianak on the 1-8 January, 2011.Thedata was collected from 96 samples using medical record. The data wasanalyzed using Chi-square test.Result: There are 47 people (49%) the research's subject havetrombocytopenia, 67 people (69%) have hypoalbuminemia, and 29 people(31%) have splenomegaly. There is a significant relationship oftrombocytopenia (p = 0,000), hypoalbuminemia (p = 0,001), splenomegaly(p = 0,000), with esophageal varices. The strength measurementrelationship of varices esophagus from the biggest to the smallest arehypoalbuminemia (p = 0,241), trombocytopenia (p = 0,227), andsplenomegaly (p = 0,008). According to the ROC Curve, this comparisonhas value of 92%, is very strong.Conclusion: There is a relationship between trombocytopenia,hypoalbuminemia, splenomegaly, and varises esofagus to cirrhoticpatients in Dr. Soedarso general hospital Pontianak in the year 20092010.Trombocytopenia, hypoalbuminemia and splenomegaly can bepredicts varices esophageal.
UJI AKTIVITAS EKSTRAK ETANOL DAUN SINGKONG (Manihot utilissima Pohl) SEBAGAI LARVASIDA Aedes aegypti ., Novi Ervina
Jurnal Mahasiswa PSPD FK Universitas Tanjungpura Vol 1, No 1 (2014): Jurnal Mahasiswa PSPD FK UNTAN Tahun 2014
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Background. Dengue Haemorrhagic Fever is a very dangerous virusdisease because it can cause people die quickly (a few days). One of theefforts to overcome the disease is using larvacide. Cassava’s leaves(Manihot utilissima Pohl) contain saponins and flavonoids that havelarvacide activity. Objective. The purpose of this research is to know theactivity of cassava’s leaves ethanol extract as larvacide of Aedes aegypti,to know the compounds that contained in cassava’s leaves, to determineconcentration of cassava’s leaves ethanol extract which has larvacideactivity with LCand to analyze larvacide activity comparison betweencassava’s leaves ethanol extract and temephos. Methodology. 1125instar III/IV Aedes aegypti larvae were used for this experiment whichdivided into nine groups. The groups were one negative control group(aquades), one positif control group (temephos) and seven experimentalgroups with concentration of 0,5%, 1%, 1,5%, 2%, 2,5%, 3% and 3,5%.Each group consist of 25 larvae. Each experiment was replicated fivetimes. Mortality rate data was analyzed with One Way Anova Test andthen continued with Tukey Test. Probit Analysis was used to know thevalue of LC9090,. Results. Cassava’s leaves ethanol extract has larvacideactivity to Aedes aegypti with LCvalue at 2,613%. There is nosignificance difference of larvacide activity between cassava’s leavesethanol extract with concentration of 3% and 3,5% compared to temephos.Conclusion. Cassava’s leaves ethanol extract has larvacide activity toAedes aegypti.90Keywords: Ethanol extract, cassava’s leaves, larvacide, Aedes aegypti1)Medical School, Faculty of Medicine, University of Tanjungpura,Pontianak, West Borneo2)Pharmacy School, Faculty of Medicine, University of Tanjungpura,Pontianak, West Borneo3)Departement of Parasitology, Medical School, Faculty of Medicine,University of Tanjungpura, Pontianak, West Borneo
KARAKTERISTIK KERATITIS NUMMULARIS DI RSUD DR. SOEDARSO PONTIANAK JANUARI 2010-DESEMBER 2012 ., Vicky Victorine Persia Wardenaar
Jurnal Mahasiswa PSPD FK Universitas Tanjungpura Vol 3, No 1 (2013): Jurnal Publikasi Mahasiswa PSPD FK UNTAN
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Background. Nummular keratitis can cause serious impaired vision if there is notany prompt treatment and prevention. There was not any data aboutcharacteristic of nummular keratitis in dr. Soedarso General Hospital Pontianak.Objective. To know about characteristic of nummular keratitis in dr. SoedarsoGeneral Hospital Pontianak on 2010 2012.Metodology. This study was a descriptive observational study with crosssectionaldesign.The samplethat usedin this study are 70 patients. Data weretakenfromthepatient's medicalrecord.Result. The most common age group who have nummular keratitis was 28-35years old as many as 14 patients. The number of male patients with nummularkeratitis were 36 patients and woman were 34 patients. There were 56 patients ofnummular keratitis who experience impaired vision and 14 patients had a normalvision. There were 18 patients of nummular keratitis with corneal traumaexperience, and 52 patients who did not have any corneal trauma experience.Nummular keratitis were more often found on students, as many as 15 patients.Unilateral nummular keratitis was found in 58 patients.Conclusion. Patients with nummular keratitis who had given treatment in dr.Soedarso general hospital had characteristic that were most common age groupwas 28-35 years old (20,00%); more often found on male patients (51,40%);more experience impaired vision (80,00%); 74,30% patients never experiencecorneal trauma and unilateral nummular keratitis (82,90%) was more commonthan bilateral nummular keratitis (17,10%).Keywords : Nummular keratitis, incidence, corneal trauma
UJI AKTIVITAS ANTIBAKTERI FRAKSI n-HEKSANA KULIT BUAH MANGGIS (Garcinia mangostana L.) TERHADAP PERTUMBUHAN Shigella flexneri SECARA IN VITRO ., Umar Syarif Asifa
Jurnal Mahasiswa PSPD FK Universitas Tanjungpura Vol 1, No 1 (2014): Jurnal Mahasiswa PSPD FK UNTAN Tahun 2014
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Background: diarrhea is one of the health problems that still needs moreattention especially in developing countries such as Indonesia. Shigellaflexneri is a bacterial isolates were found in most cases of diarrhea. Basedon scientific information about Garcinia mangostana L., this plant has apotentcy  as an alternative treatment of antibacterial. Objective: the aimedof this study was to determined the antibacterial activity of n-hexane fractionof mangosteen peels (Garcinia mangostana L.) and the effectiveconcentration to inhibit growth of Shigella flexneri Method: mangosteenpeels were extracted by maceration method using 90% methanol then thisextracts was fractionated using n-hexane. The chemical compound of nheksanefraction was screened by phytochemical screening. Antibacterialactivity was conducted by using well diffusion with concentration of 5%,10%, 20%, and 40%. Ciprofloxacin 5μg/hole was used as positive controland DMSO 10% was used as negative control. Result: the phytochemicalscreening of n-heksana fraction of mangosteen peels is contains alkaloids,flavonoids, quinones and terpenoids. Concentration of 40% is the highestconcentration that has great antibacterial effect of all various concentrationtests but this concentration only moderate inhibition zone (p=0,000). Theinhibition zone of each concentration has decreased at 48 hours incubation.Conclusion: n-hexane fraction of mangosteen peels has antibacterialactivity against Shigella flexneri..  Keywords: Antibacterial, n-heksane fractions of mangosteen peels,Shigella flexneri1) Medical Education Study Program, Faculty of Medicine, Tanjungpura University, Pontianak, West Kalimantan2) Biology Study Program, Faculty of Mathematics and Natural Science, Tanjungpura University, Pontianak, West Kalimantan3) Department of Physiology, Medical Education Study Program, Faculty of Medicine, Tanjungpura University, Pontianak, West Kalimantan
HUBUNGAN ANTARA PENGETAHUAN, SIKAP, DAN PERILAKU IBU MENGENAI PROGRAM SANITASI TOTAL BERBASIS MASYARAKAT TERHADAP KEJADIAN DIARE PADA BALITA DI KELURAHAN SIANTAN TENGAH ., Arianti Miranti Lestari Fajrin
Jurnal Mahasiswa PSPD FK Universitas Tanjungpura Vol 3, No 1 (2013): Jurnal Publikasi Mahasiswa PSPD FK UNTAN
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Backround: Diarrhea is one of public health problem in Pontianak.Sanitation, early complementary feeding, and not-exclussive breastfeedingcan affect the incidence of diarrhea in toddlers. Community-Led TotalSanitation (CLTS) program is a program to decrease the incidence ofdiarrhea by change the sanitation behavior in community. Objective: Thisresearch aimed to investigate the correlation between mothersknowledge, attitude, and behavior on CLTS program toward the toddlerssdiarrhea in Siantan Tengah district and to know the description ofbreastfeeding and complementary feedings characteristics.Methodology: This research was an observational analytic study withcross sectional design which has done to 100 mothers in Siantan Tengah.Chi Square test was used to analyze data. Results: Chi Square testshowed a significant correlation between mothers knowledge (p = 0.003) ,attitude (p = 0.000) , and behavior (p = 0.000) on CLTS program towardthe incidence of diarrhea in toddlers. Results also showed 17,6% oftoddlers got exclusive breastfeeding and 85.3% got early complementaryfeeding. Conclusion: There is a significant correlation between mothersknowledge, attitude, and behavior on CLTS program toward the toddlerssdiarrhea in Siantan Tengah district and almost of responden gave an earlycomplementary feeding and not-exclussive breastfeeding to their toddlers.Keyword: Community-led total sanitation, diarrhea, motherbehavior1) Medical School, Faculty of Medicine, University of Tanjungpura,Pontianak, West Borneo2) Department of Public Health, Faculty of Medicine, University ofTanjungpura, Pontianak, West Borneo3) Department of Pediatric, Faculty of Medicine, University ofTanjungpura, Pontianak, West Borneo
HUBUNGAN ANTARA PERILAKU MEROKOK DAN PENYAKIT JANTUNG KORONER DI UNIT RAWAT INAP RUMAH SAKIT UMUM SANTO ANTONIUS PONTIANAK TAHUN 2012 ., Kevin
Jurnal Mahasiswa PSPD FK Universitas Tanjungpura Vol 3, No 1 (2015): Jurnal Pendidikan Dokter Kalbar
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Background: Coronary heart disease and it’s complication was one of themost cause of death worldwide. Smoking was one of the risk factors ofcoronary heart disease. The objective of ths study was to examine therelationship between cigarette and coronary heart disease in SaintAntonius Hospital. Methods: This research was analytic study with casecontrol approach. One hundred and thirty participants were recruited usinga non-probability sampling (consecutive sampling) technique.Measurement was taken include subject’s based on AHA (american heartassociation) diagnostic criteria for myocardial infarction and anginapectoris with a confirmation of an internist or a cardiologist, cigarettesmoking status based on NSDUH (National Survey on Drug use andHealth). Based on cigarette smoking status, all participants were dividedinto two groups that has been smoking and never smoke. Based ondiagnostic criteria, all participants were divided into two groups that wassubjects conary heart disease and subjects with coronary heart disease.Data were analyzed with Statistical Product and Service Solution Program(SPSS). Results: There was statistically significant relationship (P <0,002) betweeen cigarette smoking and coronary heart disease. Therelative risk (odds ratio [OR] and 95% confidence interval [CI]) ofdeveloping coronary heart disease among the cigarette smoking subjectswas (OR 3,23; CI 1,52 – 6,87). Conclusions: There is signicantrelationship between cigarette smoking and coronary heart disease.Cigarette smoking is the risk factor of coronary heart disease andincreased the risk of developing coronary heart disease among thecigarette smoking subjects is 3,23 fold compared with the normal weightsubjects.Key words: coronary heart disease, cigarette smoking, saint antoniusgeneral hospital pontianak
KARAKTERISTIK PASIEN TB PARU YANG PATUH DAN TIDAK PATUH BEROBAT DI PUSKESMAS PERUMNAS II KECAMATAN PONTIANAK BARAT PERIOD 1 JANUARI - 31 DESEMBER 2010 ., Heldiastri K. Randung
Jurnal Mahasiswa PSPD FK Universitas Tanjungpura Vol 3, No 1 (2013): Jurnal Publikasi Mahasiswa PSPD FK UNTAN
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Background: Pulmonary tuberculosis (TB) is a global infectious disease thatwas causing mortality in the world. Indonesia ranks fifth in the world that hasthe largest number of pulmonary TB cases. Pulmonary TB treatment needs along time to achieve healing and needs a combination of several kinds ofdrugs. The adherence is absolutely needed in pulmonary TB treatment toreach out the goal. It is important to know the characteristics of pulmonary TBpatients who adherent and non-adherent in pulmonary TB treatment.Methods: The study was a descriptive study with cross-sectional design.Object: To investigate the characteristics of pulmonary TB patients whoadherent to treatment and non-adherent to treatment in Perumnas II primaryhealth center, West Pontianak, on January 01 to December 31, 2010.Results: The patients who adherent to pulmonary TB treatment are 86.48%that have characteristics: in range of age 20-29 years, male, grade ofeducation in senior high school, have good knowledge about pulmonary TBdisease, and did not have drug side effects. The patients who non-adherentto pulmonary TB treatment are 13.51% that have characteristics: in range ofage 20-49 years, female, grade of education in elementary school, have poorknowledge about pulmonary TB disease, and have drug side effects.Key words: Characteristics, Adherence, Treatment, TuberculosisNotes:*Medical School, Faculty of Medical, Universitas Tanjungpura, Pontianak,West Kalimantan; **Departemen of Pulmonology, General Hospital of dr.Soedarso, Pontianak, West Kalimantan; ***Departemen of Biochemistry,Universitas Tanjungpura, Pontianak, West Kalimantan
PENGARUH BEBAN LATIHAN-RENANG TUNGGAL DAN BERULANG YANG BERLEBIHAN TERHADAP AKTIVITAS SPESIFIK ENZIM LDH JARINGAN OTOT RANGKA TIKUS (Rattus norvegicus) JANTAN GALUR WISTAR ., Budi Hartono
Jurnal Mahasiswa PSPD FK Universitas Tanjungpura Vol 4, No 1 (2018): Jurnal Pendidikan Dokter Kalbar
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Latar Belakang: Latihan fisik merupakan pergerakan tubuh yang terstruktur dan dilakukan berulang-ulang, bertujuan untuk meningkatkan atau mempertahankan kebugaran fisik. Tetapi latihan fisik yang berlebihan sangat bergantung kepada glikolisis anaerobik. Enzim laktat dehidrogenase (LDH) yang salah satunya terdapat di otot rangka dibutuhkan pada proses tersebut Tujuan: Mengetahui pengaruh beban latihan-renang tunggal dan berulang yang berlebihan terhadap aktivitas spesifik enzim LDH jaringan otot rangka tikus (Rattus norvegicus) jantan galur wistar. Metode: Penelitian ini merupakan eksperimental murni dengan rancangan acak lengkap posttest only control group design. Dua puluh tujuh tikus galur wistar dibagi menjadi tiga kelompok: kelompok kontrol, kelompok beban latihan-renang tunggal yang diberikan latihan selama satu hari dan kelompok beban latihan-renang berulang diberikan latihan selama tujuh hari dengan durasi 45 menit per hari.Pada akhir perlakuan, jaringan otot rangka diambil untuk diukur  dan dianalisis dengan One-way anova yang dilanjutkan dengan Post hoc LSD. Hasil: Diperlihatkan tidak terdapat perbedaan bermakna rerata aktivitas spesifik enzim LDH pada jaringan otot rangka tikus diantara ketiga kelompok tersebut. Kesimpulan:Perlakuan renang secara tunggal maunpun berulang dalam waktu 45 menit tidak menunjukkan perbedaan bermakna rerata aktivitas enzim spesifik LDH secara statistik.

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