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Redaksi Indonesian Archives of Biomedical Research (InABR), Gedung Konsorsium Ilmu Biomedik Indonesia, Salemba Raya No. 4, Jakarta Pusat, 10430
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INDONESIA
Indonesian Archives of Biomedical Research (InABR)
Published by Konsorsium Ilmu Biomedis Indonesia
ISSN : -     EISSN : 27988236     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
InABR publishes three categories of papers: Original research papers, Case report articles, and Literature review articles on applied or scientific research relevant to biomedical sciences. The scope of this journal covers biomedicine, molecular biology, stem cell, herbal medicine, anti-aging, reproduction, and genetics.
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 16 Documents
 1   2 
Biosensor development as an alternative test for Leptospirosis diagnosis: a systematic review Susanti Susanti; Radiana Dhewayani Antarianto
Indonesian Archives and Biomedical Sciences Vol 1 No 2 (2021): Indonesian Archives of Biomedical Research (InABR). 1(2): 2021
Publisher : Konsorsium Ilmu Biomedik Indonesia (KIBI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (818.951 KB) | DOI: 10.55392/indarcbiores.v1i2.22

Abstract

Leptospirosis is a zoonotic disease caused by pathogenic bacteria from the genus Leptospira that can attack livestock, wild animals, and humans. The diagnosis of leptospirosis is currently carried out by Leptospira culture, Microscopic Agglutination Test (MAT), Enzyme Linkage Immunosorbent Assay (ELISA), and Polymerase Chain Reaction (PCR). This test requires a specific laboratory, long test time, experienced personnel, a lot of equipment and is expensive and difficult to apply in the field. Biosensor technology is a necessary method of disease diagnosis to detect biomolecules such as protein and bacteria biomarkers. The purpose of this article is to provide information on the development of biosensors as an alternative test for the diagnosis of leptospirosis. The method used is a systematic review using the PRISMA protocol. The results showed that the electrochemical biosensor with monoclonal anti-LipL32 and ssDNA probe specific to the LipL32 gene of Leptospira had advantages for leptospirosis diagnosis because it was cheap, accurate, portable, small test equipment, and capable of detecting leptospirosis. Optical biosensors (specifically lateral flow systems, magnetogenosensors and paper fluidic devices) can detect Leptospira bacteria with sensitive, specific, easy manipulation, and users can get fast visual test results within minutes. This biosensor technology can be used as a promising alternative diagnostic method for the diagnosis of leptospirosis with simplicity, high sensitivity, fast detection time, low cost, and portable so that it is easy to apply in the field.
Sulforaphane as a potential therapy for multiple sclerosis: a review article Gede Febby Pratama Kusuma, Pratama Kusuma; Kadek Dede Frisky Wiyanjana; Sri Maliawan
Indonesian Archives and Biomedical Sciences Vol 1 No 2 (2021): Indonesian Archives of Biomedical Research (InABR). 1(2): 2021
Publisher : Konsorsium Ilmu Biomedik Indonesia (KIBI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (370.969 KB) | DOI: 10.55392/indarcbiores.v1i2.24

Abstract

Multiple Sclerosis (MS) is a chronic immune-mediated Neuroinflammatory disease that attacks the Central Nervous System (CNS). It creates serious physical disabilities characterized by neuronal injury, demyelination, and axonal loss. Several mechanisms are responsible for the progression of MS, including the infiltration of T-cells from the peripheral to the CNS, the autoreactivity of B-cells that contribute to abnormal regulation of antibodies and antigen presentation, and the assault of Macrophage that lead to inflammation and neuron damage. Additionally, oxidative stress plays a more important role in chronic inflammation of MS. Sulforaphane (SFN) is an isothiocyanate derived from glucoraphanin (GRA) that is found mostly in broccoli. SFN can act as an anti-inflammatory and anti-oxidant agent by activating the Nuclear factor-erythroid 2-(NF-E2-) Related Factor 2 (Nrf2). Nrf2 is expressed in the central nervous system and upregulated in response to inflammation and cerebral insults. Nrf2 binds to the antioxidant response element (ARE) which is a DNA promoter region of genes codifying antioxidant enzymes, which in turn can reduce oxidative stress. Several in vitro and in vivo studies show that SFN can increase the anti-inflammatory and anti-oxidant genes. Thus, SFN is very promising as a potential therapy for MS.
The Comparison of COVID-19 Preventive Strategies in Indonesia, Turkey, and China Based on the Number of New COVID-19 Cases in 2020 Nur Rachmawati Maulida; Yasmin Karimah Ikhsan; Anastasya Annisa Karlina; Asmahan Farah Adiba; Alfian Nur Rosyid
Indonesian Archives and Biomedical Sciences Vol 2 No 1 (2022): Indonesian Archives of Biomedical Research (InABR) 2(1): 2022
Publisher : Konsorsium Ilmu Biomedik Indonesia (KIBI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55392/indarcbiores.v2i1.21

Abstract

Background; There is no specific drug for COVID-19 yet, therefore it is important to focus on preventing its spread in the community. COVID-19 prevention strategies in each country are certainly different. This review will compare strategies to prevent COVID-19 in Indonesia, Turkey, and China by the number of COVID-19 new cases. Reviews; The number of new cases in Turkey showed a decline after implementing social distancing policies, calling for activities from home, and implementing policies to limit the mobility of people, especially vulnerable groups. In China, the number of new cases shows a decline and tends to ramp up until there are no new cases for some time with additional preventive measures (different from others) shifting offline consultations and treatment to online. In Indonesia, the prevention strategy to stop the spread of COVID-19 which is almost the same as in other countries, but the number of new positive cases of COVID-19 continues to increase. Conclusion; China and Turkey can be said to have succeeded in preventing the spread of COVID-19 by restricting people's entry and exit policies in an area, working from home, and having a good health system, meanwhile Indonesia's COVID-19 new cases tend to continue to increase because of lack of hygiene awareness. Keywords: COVID-19, Prevention, Indonesia, Turkey, China
Does Cytoglobin Play a Role as Anti-Fibrosis? Maftuhatun Fista Amalia; Sri Widia A. Jusman
Indonesian Archives and Biomedical Sciences Vol 2 No 1 (2022): Indonesian Archives of Biomedical Research (InABR) 2(1): 2022
Publisher : Konsorsium Ilmu Biomedik Indonesia (KIBI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55392/indarcbiores.v2i1.25

Abstract

Cytoglobin (Cygb) is a vertebrate globin protein that is synthesized by fibroblasts and expressed in a variety of organs. Cygb’s function is not fully understood. In contrast, activated fibroblasts (myofibroblasts) are known to produce collagen, which is the major component of the extracellular matrix (ECM) and contributes to abnormal wound healing. There are three phases in wound healing: (1) injury; (2) inflammation; and (3) tissue regeneration. Myofibroblasts will apoptosis throughout the healing phase. If myofibroblasts fail to undergo apoptosis, this might end in fibrosis. This condition induces relative hypoxia in fibrosis. Several investigations have found that overexpression of Cygb serves as an antifibrosis agent by reducing collagen production. The potential involvement of Cygb in avoiding fibrosis in diverse tissues is discussed in this article.  Keywords: Cytoglobin (Cygb), wound healing, anti-fibrosis, collagen
Moringa oleifera Seeds Extract Effervescent Tablets as Water Purifier: to Overcome Clean Water Issues Rosda Rodhiyana; Siti Nur Fadillah
Indonesian Archives and Biomedical Sciences Vol 2 No 1 (2022): Indonesian Archives of Biomedical Research (InABR) 2(1): 2022
Publisher : Konsorsium Ilmu Biomedik Indonesia (KIBI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55392/indarcbiores.v2i1.28

Abstract

Background; Water quantity and quality are important determinants of health. However, this does not fit with the availability of clean water. Today, 771 million people in the world lack access to it. In Indonesia, only 84.91% of households have access to clean water. Moreover, with the COVID-19 pandemic, access to clean water becomes a vital part to eliminate the spread of the virus.  Reviews; People usually treat groundwater, river water, and wastewater by adding inorganic coagulants, such as aluminium sulphate to meet this need. But these coagulants aren't completely safe for health and the environment. Aluminium sulphate could cause neurological disease and carcinogens. In the environment, it’s causing pollution since it's undegradable. Hence, alternative coagulants to overcome these problems should be considered. Among the plants that have shown coagulant effect is Moringa oleifera. Many researchers have shown that Moringa seeds can reduce water effluent by up to 80-99%. The seeds are biodegradable and safe for humans. However, the use of Moringa seeds as a coagulant is only in the form of dry powder without further formulation. Therefore, to maximize its activity as a coagulant, Moringa seeds need to be processed further by forming effervescent tablets. Conclusion; Effervescent tablets were chosen because they can dissolve quickly and evenly so that all active compounds of Moringa can work perfectly. This formulation is expected to increase the ability as a coagulant so that public access to clean water can increase. So, contributing to the Sustainable Development Goals (SDGs) number six, Clean Water and Sanitation. Keywords: Moringa oleifera, clean water, coagulant, effervescent, SDGs
Detection of COVID-19 Cases in the Hospital of Universitas Brawijaya Malang Nuning Winaris; Andre William Tulle; Soeyati Poejiani; Sri Andarini; Wening Prastowo; Agustina Tri Endharti; Dwi Yuni Nur Hidayati
Indonesian Archives and Biomedical Sciences Vol 2 No 1 (2022): Indonesian Archives of Biomedical Research (InABR) 2(1): 2022
Publisher : Konsorsium Ilmu Biomedik Indonesia (KIBI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55392/indarcbiores.v2i1.29

Abstract

The global pandemic of COVID-19 was caused by a novel coronavirus identified as SARS-CoV-2. The outbreak started in Wuhan, China and spread rapidly all over the world. Escalation of daily test capacity can accelerate the new suspect of COVID-19 cases finding and rapidly trace the close contacts of confirmed cases. In this study, we reported the total number of confirmed cases based on the number of samples tested in the diagnostic laboratory of the Hospital of Universitas Brawijaya Malang. The data for this study were collected from the result of the RT-qPCR test, which was used as the gold standard to identify active cases of COVID-19. The data collection was started from May 2020 until April 2021. Based on our findings, it appeared that the peak of the first wave of COVID-19 happened between December 2020 and January 2021. Keywords: COVID-19; RT-qPCR; ‎‎‎‎‎‎‎‎‎‎‎‎SARS-CoV-2

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