cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
jstrp@mail.unnes.ac.id
Phone
-
Journal Mail Official
jstrp@mail.unnes.ac.id
Editorial Address
D8 Building 2nd Floor, Sekaran, Kec. Gunung Pati, Kota Semarang, Jawa Tengah 50229
Location
Kota semarang,
Jawa tengah
INDONESIA
Journal of Science and Technology Research for Pharmacy
Published by Universitas Negeri Semarang
ISSN : -     EISSN : 27760685     DOI : https://doi.org/10.15294/jstrp.v1i2
Core Subject : Science,
Chemistry
Journal of Science and Technology Research for Pharmacy is open access, peer-reviewed journal published by Pharmaceutical Science Study Program, Faculty of Mathematics and Natural Sciences, Universitas Negeri Semarang, Indonesia. The journal publishes only papers describing original findings and review articles of all aspects in developing the field of pharmaceutical science and technology.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 5 Documents
 1 
Search results for , issue "Vol 1 No 1 (2021)" : 5 Documents clear
Formulation and Physical Characterization of Essential Oil Bangle (Zingiber cassumunar Roxb.) Nanoemulsion Gel Purwanto, Ungsari Rizki Eka; Sholikhah, Mar’atus; Munisih, Siti
Journal of Science and Technology Research for Pharmacy Vol 1 No 1 (2021)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v1i1.43500

Abstract

Background: Bangle rhizome (Zingiber cassumunar Roxb) essential oil as long been used by Indonesian and often used by postpartum women, as a treatment for abdominal obesity. The formulation of bangle essential oil into topical preparations has not been widely reported. So far, bangle essential oil is not available in pharmaceutical dosage form. The users immediately apply essential oil to the abdominal area and previous study showed that the terpinene-4-ol only diffused 0,39% from 2 mg/cm2 of Bangle essential oil through skin membrane. The development of topical bangle essential oil is necessary to increase the effectiveness of the delivery of active substances through the skin and the comfort of the user. In order to increase the penetration of the terpinen-4-ol, the Bangle essential oil was formulated in the form of a nanoemulsion and then the nanoemulsion was dispersed into a gel base to increase user convenience. Aim: The aim of the present study was to investigate the potential of nanoemulsion formulations for Bangle essential oil and to know the optimum the composition of surfactants and cosurfactants in nanoemulsion system. This study also aims to determine the effect of base gel used in the nanoemulsion gel formulation on the appropriate physical properties. Method: The pre-emulsion was made beforehand with oil and a mixture of surfactant and cosurfactant. With the help of a Design Expert® ver. 10.0.1 software, component of sufactant and co-surfactant were optimized. The design formula was divided into seven nanoemulsion formulas with a ratio of Polysorbate 80: PEG 400, F1 (1: 8), F2 (8: 1), F3 (6,25: 2,75), F4 (8: 1), F5 (1: 8), F6 (1: 8), F7 (4,5: 4,5). The optimum consentration of Polysorbate 80 as surfactant and PEG 400 as co-surfactants in Bangle essential oil nanoemulsion was analyzed using simplex lattice design methode. The optimal formula was further evaluated for its distribution, droplet size, and zeta potential. Distilled water was used as the aqueous phase in nanoemulsion. The amount of aqueous phase: the amount of pre-emulsion is 9 : 1. The optimum nanoemulsion formula then dispersed in carbophol hydrogel to be nanoemulsion gel. Physical characterization of Bangle nanoemulsion gel like a pH, adhesion power, spreadability, viscosity before and after cycling test had been investigated. Result: The optimum composition of surfactant Tween 80 and co-surfactan PEG 400 was 7.659: 1.34. The results showed that the optimal formula with 2% Bangle Essential Oil Loaded in Nanoemulsion had the Z-average 95,2 nm with Index Polidispersity 0,176 and Zeta Potensial -0,1 mV. Bangle Nanoemulsion-Gel had a homogenous organoleptic, spreadability in 6,69 + 0.85 cm, adhesion power in 2.14 + 0.29 seconds, viscosity 5969 + 32.03 cps, and pH 6,58 + 0,29. Conclusion: Bangle Essential Oil Nanoemulsion-Gel formulation has the good physical characteristics and potentially be used as topical dosage forms. A further study is needed to determine the effectiveness of the treatment of abdominal obesity by topical administration of this preparation.
Analysis Tolerance of Monosodium Glutamate (MSG) In instant noodles With Uv-Vis Spectrophotometry Rachma, Firstca Aulia; Saptawati, Tunik
Journal of Science and Technology Research for Pharmacy Vol 1 No 1 (2021)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v1i1.43568

Abstract

Background: MSG has become one of the most widely used food flavorings in the world, the FDA (Food and Drug Administration) reported an average per capita intake of MSG in the United States of 550 mg / day in 1973. The use of MSG as a food additive has been regulated by its use. WHO. This rule stipulates that daily consumption of MSG per person should not exceed the safe threshold of 120 mg / kg / day. MSG is proven to be a risk factor for obesity. The increase in body weight in mice occurred after MSG was given as much as 15-30 mg / kg or the equivalent of 1-2 g / person. Based on the description above, it is known that there is a significant influence of MSG in the health sector if consumed in excess. Therefore, researchers are interested in conducting further research related to MSG levels in instant noodle samples in the Semarang city area. Aim: The purpose of this study was to test the MSG levels in instant noodles with a spectrophotometer. Method: The tools used are a UV-Vis spectrophotometer (Shimadzu), NaCl and MSG salts. MSG used in instant noodles, 0.5% Ninhydrin Reagent. Result: MSG levels from each of the 10 samples of instant noodles that are traded in Semarang City, the highest levels are found in sample J of 4.70% and the lowest MSG levels are in sample G of 2.90%. Conclusion: Instant noodles sold in the city of Semarang are positive for Monosodium glutamate (MSG) and The results of quantitative analysis, where the MSG levels contained in each sample of instant noodles in Semarang City show that it is still below the standard for adults.
Formulation and Evaluation of Antioxidant Peel-Off Mask Ethanol Extract Sarang Semut (Myrmecodia sp.) Using DPPH 2,2-Diphenyl-1-picrylhydrazyl Method Ayuningtyas, Nurista Dida; Febrianto, Yahya; Prasetyo, Alno
Journal of Science and Technology Research for Pharmacy Vol 1 No 1 (2021)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v1i1.44159

Abstract

Background: Myrmecodia sp extract is known to be effective as an antioxidant on a concentration of 5-50 ppm. Antioxidants are substances that can scavenge free radicals. Free radicals can cause skin damage. Peel off mask is a cosmetic product that function as a dead skin peel mechanically containing synthetic polymers that are quite safe and effective. Aim: The purpose of this study was to determine the antioxidant effectiveness of the Myrmecodia sp extract. Method: The research used variations in the Myrmecodia sp extract of 2 %, 3%, and 4 %. The evaluation was carried out on the physical properties of the peel off mask and the antioxidant activity test. The antioxidant activity test used the 2,2-Diphenyl-1-picrylhydrazyl method. Statistical tests were carried out on the physical properties of the preparation and IC50 peel off mask using the one-way ANOVA test with a 95% confidence level. Result: Based on this research, it was found that the gel peel-off mask preparation of Myrmecodia sp. extracts has organoleptic of a bit thick, brown and odourless. The value of adhesion is between 10.33-13.04 seconds, pH 6.27-6.75, viscosity 17.00-22.67 dPas, and drying time 17.33-24.33 minutes. The test for the antioxidant activity of IC50 peel off mask at F 2, F 3 and F 4 was 49.4 ppm, 39.41 ppm and 35.25 ppm respectively. Conclusion: The peel-off gel mask of Myrmecodia sp. extracts has the potential as an antioxidant with the strong ability category.
Effect of Variation Conditions of The Extraction Process of Morinda Citrifolia L Leaves Using Ultrasound-Assisted Extraction Method (Uae) Buanasari, Buanasari; Dhamayanti, Sonia Murniana Sri; Suryaningsih, Suryaningsih
Journal of Science and Technology Research for Pharmacy Vol 1 No 1 (2021)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v1i1.44348

Abstract

Background: Morinda citrifolia L. is widely used as traditional medicine for various diseases. The benefits of noni are studied from the seeds, fruit, leaves and root bark. This leaf active compound is rich in flavonoids, so an effective extraction process is needed to extract it. Conventional extraction generally takes a long time and involves a thermal process that can damage the compound, so it requires extraction with the latest methods, one of which is the use of ultrasonic waves. Aim: This study aims to examine the effect of variations in extraction process conditions on present yield, DPPH scavenging activity, flavonoid content and phenol content of Morinda citrifolia L leaves by varying the solids-solvent ratio (1:10, 1:20, 1:30, dan 1:40 g/mL), and extraction temperature (25, 35, 45, and 55ºC). Method: The process uses the ultrasonic assisted extraction method with 50 %V ethanol for 60 minutes. Result: The highest yield was obtained in the extraction with a solids-solvent ratio of 1:40 g/mL, at an extraction temperature of 55ºC, which was 32.29±0.066%. The highest flavonoid content (173.41±0.615 mg quercetin equivalent/g extract), phenol content (197.00±0.148 mg gallic acid equivalents/g extract) and DPPH scavenging activity (97.65±0.912%) was obtained in the extraction with a solids-solvent ratio of 1:30 g/mL, at an extraction temperature of 25ºC. The best extract measured antioxidant activity and IC50 values obtained with 23.21 µg/mL. Conclusion: The use of the ultrasonic assisted extraction method by selecting the optimal operating conditions greatly increases the amount of active compound uptake required.
Quality Test of Palm Cooking Oil Used Repeatedly Based on Free Fatty Acid Content, Moisture Content, Peroxide Number Dewi, Pevy Syntia; Ulfah, Maria
Journal of Science and Technology Research for Pharmacy Vol 1 No 1 (2021)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v1i1.44461

Abstract

Background: Cooking oil used repeatedly can increase levels of free fatty acids and the number of peroxides in the blood, so that the risk of heart disease and diabetes. Aim: The purpose of the study was to find out the quality of palm cooking oil used repeatedly in tempeh mendoan against organoleptic, moisture content, free fatty acid content and peroxide number content. Method: Samples of palm cooking oil are used to fry tempe mendoan at 105oC for 10 and 60 minutes as much as 1 frying pan per day for 3 days, then the oil is cooled at room temperature and filter the oil so that it does not mix from the rest of the fried tempeh mendoan. Filtered oils are tested for quality with test parameters including organolepty including shape, color, odor, moisture content, peroxide levels, and free fatty acid levels. The data results were compared with sni 01-3741-2002 cooking oil quality standard and each level was analyzed using nonparametric statistics (Kruskall-Wallis) with a confidence level of 95%. Result: Organoleptic test results obtained the form of cooking oil in light yellow to yellow gold at the 10th minute on the 2nd day after 2 frying pans and orange in the 60 minutes after 3 frying pans for 3 days. Moisture content obtained results 2,086± 2,142 (10th minute) and 0.369± 0.304 (60th minute), free fatty acid content obtained results 0.317± 0.044 (10th minute) and 0.337± 0.076 (60th minute), the rate of peroxide numbers obtained resulted in 0.281± 0.090 (10th minute) and 0.386±0.158 (60th minute). Based on statistics tests there are significant differences (<0.05) to the decrease in water content quality, free fatty acid content and peroxide levels in palm oil cooking oil used repeatedly in tempe mendoan.

Page 1 of 1 | Total Record : 5

 1 

Filter by Year

2021 2021


Reset
Filter By Issues
All Issue Vol 3 No 1 (2023) Vol 2 No 2 (2022) Vol 2 No 1 (2022) Vol 1 No 2 (2021) Vol 1 No 1 (2021)