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All Journal Karya Ilmiah S.1 Ilmu Keperawatan Jurnal Ilmu Keperawatan dan Kebidanan BAKTI BANUA : JURNAL PENGABDIAN KEPADA MASYARAKAT Jurnal Farmasi dan Sains Indonesia (JFSI) Journal of Science and Technology Research for Pharmacy Science and Community Pharmacy Journal
Tunik Saptawati, Tunik
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Pengaruh Eksrak Etanol Daun Salam terhadap Ekspresi Kolagen Mesangial Tikus Sprague dawley Diabetik Saptawati, Tunik; -, Winarto; Kristina, Tri Nur
Karya Ilmiah S.1 Ilmu Keperawatan Tahun 2015
Publisher : STIKES Telogorejo Semarang

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Abstract

Ekstrak etanol daun salam (EEDS)  dibuat dari maserasi daun salam (Syzygium polyanthum (Wight) Walp) mengandung flavonoid yang bersifat anti oksidan dan dapat menurunkan glukosa darah . Diperkirakan bahwa EEDS dapat menekan akumulasi kolagen mesangial sebagai komponen matriks ekstra seluler pada DM sehingga  dapat menghambat terjadinya komplikasi DM. Sebanyak 20 ekor tikus Sprague dawley jantan yang diinduksi DM dengan Streptozotocin dosis 40 mg/kgBB, dibagi menjadi 1 kelompok kontrol dan 3 kelompok perlakuan yang diberi EEDS  dosis 150:300;dan 450 mg/200grBB selama 15 hari. Pada hari ke 16 diperiksa kadar gula darah sewaktu (GDS), HBA1c , dan ekspresi kolagen mesangial (Allred Score). Hasil uji Kruskal Wallis menunjukkan bahwa terdapat perbedaan ekspresi kolagen yang bermakna pada 4 kelompok penelitian dengan nilai p=0,027 (p<0,05). Hasil uji Mann Whitney menunjukkan ekspresi kolagen pada kelompok P2  lebih rendah dibanding kelompok kontrol dengan nilai p=0,032 (p<0,05).Pemberian EEDS dosis 300 mg/200grBB dapat menurunkan ekspresi kolagen mesangial tikus DM. Kata kunci: EEDS, ekspresi kolagen mesangial, DM
PERBEDAAN EFEKTIFITAS KOMPRES ICE GEL DENGAN TERAPI DISTRAKSI MENGGENGGAM ES BATU TERHADAP SKALA NYERI ANAK YANG DILAKUKAN PEMASANGAN INFUS DI RSUD UNGARAN Nuraeni, Asti; Saptawati, Tunik
Jurnal Ilmu Keperawatan dan Kebidanan Vol 7, No 2 (2015): Juni 2015
Publisher : Jurnal Ilmu Keperawatan dan Kebidanan

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Abstract

Terapi kompres ice gel dan terapi distraksi menggenggam es batu merupakan suatu tindakan yang bertujuan untuk meminimalkan rasa nyeri dengan menimbulkan beberapa efek fisiologis. Penelitian ini bertujuan untuk mengetahui perbedaan efektifitas terapi kompres ice gel dengan terapi distraksi menggenggam es batu terhadap skala nyeri anak yang dilakukan pemasangan infus di RSUD Ungaran. Rancagan penelitian ini menggunakan quasi eksperimental dengan menggunakan two group design. Jumlah sampel pada penelitian ini sebanyak 44 responden, yang dibagi menjadi 22 responden kelompok terapi kompres ice gel dan 22 responden kelompok terapi distraksi menggenggam es batu dengan teknik pengambilan sampel menggunakan purposive sampling. Uji statistik untuk mengetahui perbedaan rata-rata skala nyeri menggunakan uji beda mean dua kelompok yaitu uji Mann Whitney didapatkan hasil p value 0,000 yang berarti terdapat perbedaan rata-rata skala nyeri terapi kompres ice gel dengan terapi distraksi menggenggam es batu. Sehingga dapat disimpulkan bahwa ada perbedaan efektifitas terapi kompres ice gel dengan terapi distraksi menggenggam es batu terhadap skala nyeri anak yang dilakukan pemasangan infus di RSUD Ungaran. Rekomendasi hasil penelitian ini adalah agar perawat mampu menerapkan terapi tersebut untuk mengurangi skala nyeri anak pada saat dilakukan pemasangan infus.
EVALUASI RASIONALITAS PENGGUNAAN ANTIBIOTIK PADA PASIEN ISPA DI PUSKESMAS KARANGAYU SEMARANG Ovikariani, Ovikariani; Saptawati, Tunik; Rahma, Firstca Aulia
Jurnal Ilmu Keperawatan dan Kebidanan Vol 11, No 2 (2019): Jurnal Ilmu Keperawatan dan Kebidanan
Publisher : Jurnal Ilmu Keperawatan dan Kebidanan

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Abstract

Prevalensi kematian yang disebabkan Infeksi Saluran Pernafasan Atas (ISPA) di Indonesia  mencapai 17% setiap tahunnya dan sebagian besar terjadi pada anak dengan usia di bawah 5 tahun. Sementara itu, prevalensi terjadinya Infeksi Saluran Pernafasan Atas di Propinsi Jawa Tengah pada tahun 2013 menduduki peringkat ketujuh di Indonesia dengan angka kejadian sebesar 26,6%. Terjadinya  peningkatan resistensi antibiotik di seluruh dunia, sebagian besar terkait dengan penggunaan antibiotik yang tidak tepat untuk saluran pernapasan bagian atas infeksi. Penelitian ini bertujuan untuk mengevaluasi ketepatan penggunaan antibiotik pada pasien yang di diagnosis ISPA di Puskesmas Karangayu Semarang. Penelitian ini merupakan penelitian non eksperimental deskriptif, dengan pengumpulan data secara retrospektif terhadap pasien infeksi saluran pernafasan atas di Puskesmas Karangayu Semarang. Antibiotik pada ISPA yaitu 92% diberikan antibiotik amoxicillin dengan evaluasi ketepatan obat yaitu tepat indikasi 23 %, tepat pasien, tepat obat dan tepat dosis dengan lama pemakaian antibiotik selama 5 hari 70,9 %. Penggunaan antibiotik pada pasien ISPA periode januari 2019- maret 2019 dengan persentase 42,3%. Hal ini menunjukkan bahwa penggunaan antibiotik pada pasien ISPA masih cukup tinggi dan melebihi batas standar indikator kesalahan penggunaan antibiotik yaitu kurang dari 20% berdasarkan instrumen indikator puskesmas yang dikeluarkan oleh Departemen kesehatan. Antibiotik pada ISPA yaitu 92% diberikan antibiotik amoxicillin dengan evaluasi ketepatan obat yaitu tepat indikasi 23 %, tepat pasien, tepat obat dan tepat dosis dengan lama pemakaian antibiotik selama 5 hari 70,9 %.
Analysis Tolerance of Monosodium Glutamate (MSG) In instant noodles With Uv-Vis Spectrophotometry Rachma, Firstca Aulia; Saptawati, Tunik
Journal of Science and Technology Research for Pharmacy Vol 1 No 1 (2021)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v1i1.43568

Abstract

Background: MSG has become one of the most widely used food flavorings in the world, the FDA (Food and Drug Administration) reported an average per capita intake of MSG in the United States of 550 mg / day in 1973. The use of MSG as a food additive has been regulated by its use. WHO. This rule stipulates that daily consumption of MSG per person should not exceed the safe threshold of 120 mg / kg / day. MSG is proven to be a risk factor for obesity. The increase in body weight in mice occurred after MSG was given as much as 15-30 mg / kg or the equivalent of 1-2 g / person. Based on the description above, it is known that there is a significant influence of MSG in the health sector if consumed in excess. Therefore, researchers are interested in conducting further research related to MSG levels in instant noodle samples in the Semarang city area. Aim: The purpose of this study was to test the MSG levels in instant noodles with a spectrophotometer. Method: The tools used are a UV-Vis spectrophotometer (Shimadzu), NaCl and MSG salts. MSG used in instant noodles, 0.5% Ninhydrin Reagent. Result: MSG levels from each of the 10 samples of instant noodles that are traded in Semarang City, the highest levels are found in sample J of 4.70% and the lowest MSG levels are in sample G of 2.90%. Conclusion: Instant noodles sold in the city of Semarang are positive for Monosodium glutamate (MSG) and The results of quantitative analysis, where the MSG levels contained in each sample of instant noodles in Semarang City show that it is still below the standard for adults.
Formulasi Krim Fraksi Ekstrak Daun Kemangi (Ocimum sanctum L) Sebagai Antibakteri Terhadap Staphylococcus aureus dan Escherichia coli Saptawati, Tunik; Nurwidianingsih, Silvia; Girsang, Valentina; Aldila, Silvy
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p112-120

Abstract

Dermatosis vesiculobullosa is a public health issue that frequently affects Indonesian society and even the world. Current treatment often involves topical application of a cream to the infected area, utilizing chemical substances and traditional medicine. One of the plants that has antibacterial properties is basil. This study determined the excellence of hexane fraction cream made from basil leaves to kill Staphylococcus aureus and Escherichia coli bacteria. This experimental study used the maceration method with 96% ethanol is used for extraction, while the liquid-liquid extraction method for fractionation. The well diffusion method examined the antibacterial activity. The concentration of the n-hexane fractions is 15%, 30%, and 45%. The physical characteristic tests of the cream include organoleptic, homogeneity, pH, spreadability, adhesion, and viscosity. The researcher conducted a one-way Anova statistical analysis using the post hoc Duncan test. Basil leaf cream with n-hexane fractions at 15%, 30%, and 45% concentrations has an antibacterial activity of 20.09 mm (very strong), 21.47 mm (very strong), and 22.43 mm (very strong) against Staphylococcus aureus. It has an antibacterial activity of 20.10 mm (very strong), 22.83 mm (very strong), and 23.76 mm. The cream formulations with 30% and 45% n-hexane fraction effective at stopping the growth of Staphylococcus aureus and Escherichia coli, with a significance value of 0.000 (p<0.05).
Potensi Anti Bakteri Hard Candy Ekstrak Asam Jawa (Tamarindus indica L.) dengan Minyak Sereh Wangi (Oleum Citronellae) Saptawati, Tunik; Handayani, Dwi Nurul; Gloria, Fransisca; Suwarni, Sri
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p98-103

Abstract

Tamarind and Sereh wangi (Citronellae winterianus Jowitt) are widely planted in Indonesia. Citronella oil is widely used as an anti-bacterial because of its secondary metabolite content. This study aims to determine the anti-bacterial potential of hard candy with active ingredients of tamarind extract and citronella oil. Tamarind fruit extract was prepared by maceration method using 96% ethanol solvent. Hard candy is made in 3 formulas with tamarind extract and citronella oil 0,1% (F1), citronella oil 0,2% (F2), and citronella oil 0,2% (F3). Antibacterial activity of hard candy examined using the disc diffusion method by measuring the diameter of the inhibition zone for the growth of Staphylococcus aureus and Escherichia coli bacteria. The result of the diameter of the inhibition zones F1, F2, and F3 for Escherichia coli were 4.25, 4.38, and 5.35 mm, respectively. The the diameter of the inhibition zones F1, F2, and F3 for Staphylococcus aureus were 2.30, 2.67 and 2.90 mm, respectively . It was showed that hard candy with active ingredients of tamarind extract and citronella oil was able to inhibit the growth of bacteria. The difference in the diameter of the inhibition zone between the formulas was analyzed using One Way Anova. The significance value is <0.05, so there is a significant difference in anti-bacterial activity between formulas. The concentration of citronella oil influence on antibacterial activity where the greater the concentration of citronella oil, the antibacterial activity to Staphylococcus aureus and Escherichia coli will increase. Keywords: Citronella oil, Tamarind, Hard Candy, Antibacterial.
The Potential Effect Of Ethanolic Extract Rambusa Leaf (Passiflora foetida L.) As Anti-inflamation To Male Mice (Mus musculus) Wijaya, Duma Aji; Ovikariani; Saptawati, Tunik
Science and Community Pharmacy Journal Vol. 1 No. 1 (2022): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v1i1.250

Abstract

One of the plants known as herbal medicine in Central Java is Brambutan or Rambusa. This research conducted on experimental animal using ethanol extract of rambusa leaf (Passiflora foetida L.) which has an anti-inflammation effect on reducing edema. The carrageenan used-induced feet edema was 1 % and animal subjects were grouped into 5 categories for different treatments, namely the administration of 1 % colloidal Na-CMC solution, diclofenac sodium solution, ethanol extract with various doses of 250 mg/kg body weight, 500 mg/kg body weight, and 750 mg/kg body weight given orally. By the time after 1 hour, the edema volume on mice feet measured until 6 hours. The data showed that the 1 % Na-CMC colloidal solution given did not affect the percentage of edema reduction (0 %), the subject group was given 250 mg/kg body weight and 500 mg/kg body weight showed a decrease level of edema (0.01 %), the group was given 750 mg/kg body weight decreased edema (0.02 %), and diclofenac sodium solution group showed decrease level of edema (0.04 %). In this study, it can be concluded that the ethanol extract of rambusa leaf (Passiflora foetida L.) has the highest anti-inflammation and anti-inflammation effect at a dose variation of 750 mg/kg body weight with a 0.02 % reduction in edema
PHYTOCHEMICAL SCREENING OF ETHANOL EXTRACT OF TREMBESI FRUIT SEEDS (Samanea saman) Saptawati, Tunik; Dayanti, Ema; Rachma, Firstca Aulia; Ovikariani
Science and Community Pharmacy Journal Vol. 1 No. 2 (2022): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v1i2.325

Abstract

Trembesi (Samanea saman) is a fast-growing plant from Central America and Northern South America. the Trembesi Tree is an easily recognize tree because it has an umbrella-shaped canopy with a canopy diameter greater than its height, the trembesi fruit is blackish-brown when ripe, with seeds embedded in the flesh of the fruit. This study aims to determine the class of compounds contained in the ethanol extract of trembesi fruit seeds extraction by maceration method using 70% ethanol solvent. The analysis uses univariates that present data with calculation results. The extract results were obtained by weight of 91% with an amendment value of 18.20%. The phytochemical screening were carried out with color tests and emphasized by the TLC test. The trembesi fruit seed ethanol extract containing alkaloid, flavonoids, saponins, and tannins compounds.
UPAYA PROMOTIF PREVENTIF KURATIF PADA ANAK DAN REMAJA BERSAMA ORGANISASI PROFESI DI PURWODADI KABUPATEN GROBOGAN Suwarni, Sri; Saptawati, Tunik; Rini, Tri Diana Puspita; Kristiani, Monica; Azani, Elia; Fajaryanti, Nita
Bakti Banua : Jurnal Pengabdian Kepada Masyarakat Vol. 6 No. 1 (2025): BAKTI BANUA: JURNAL PENGABDIAN KEPADA MASYARAKAT
Publisher : Sekolah Tinggi Ilmu Manajemen Indonesia (STIMI) Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35130/6qs5vh42

Abstract

Health efforts in the form of promotive, preventive, curative, rehabilitative, and/or palliative measures can be carried out by the government and community self-help groups. Children and adolescents are important assets for shaping a healthy future generation. This service aims to improve the health quality of children and adolescents through promotive, preventive, and curative activities in collaboration with professional organizations in Purwodadi, Grobogan Regency. The methods used were designed as part of the celebration of National Children's Day at Purwodadi City's Green Park on July 27, 2025. The activities included promotive services such as health education on clean and healthy living, balanced nutrition education, and oral health education. Preventive services included free health check-ups, vaccination administration, and health screenings. Meanwhile, curative services include free treatment and vitamin distribution, which provide tangible benefits for children and adolescents in the Purwodadi area. This synergy expands the scope of services and improves the quality of health interventions provided. With 327 participants, this activity successfully increased public knowledge, awareness, and concern about the importance of maintaining health from an early age. The success of this activity is expected to serve as the basis for similar programs in the future, with a focus on sustainability, expansion of the target area, and increased service coverage. This activity is not merely a celebration of National Children's Day but also a collective commitment to building a healthy, intelligent, and competitive younger generation.
Co-Authors Aldila, Silvy Asti Nuraeni Dayanti, Ema Elia Azani Girsang, Valentina Gloria, Fransisca Handayani, Dwi Nurul Kristiani, Monica Nita Fajaryanti, Nita Nurwidianingsih, Silvia Ovikariani Ovikariani, Ovikariani Rachma, Firstca Aulia Rahma, Firstca Aulia Sri Suwarni Tri Diana Puspita Rini Tri Nur Kristina Wijaya, Duma Aji Winarto -