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INDONESIA
Cermin Dunia Kedokteran
Published by PT. Kalbe Farma Tbk.
ISSN : 0125913X     EISSN : 25032720     DOI : 10.55175
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Cermin Dunia Kedokteran (e-ISSN: 2503-2720, p-ISSN: 0125-913X), merupakan jurnal kedokteran dengan akses terbuka dan review sejawat yang menerbitkan artikel penelitian maupun tinjauan pustaka dari bidang kedokteran dan kesehatan masyarakat baik ilmu dasar, klinis serta epidemiologis yang menyangkut pencegahan, pengobatan maupun rehabilitasi. Jurnal ini ditujukan untuk membantu mewadahi publikasi ilmiah, penyegaran, serta membantu meningkatan dan penyebaran pengetahuan terkait dengan perkembangan ilmu kedokteran dan kesehatan masyarakat. Terbit setiap bulan sekali dan disertai dengan artikel yang digunakan untuk CME - Continuing Medical Education yang bekerjasama dengan PB IDI (Pengurus Besar Ikatan Dokter Indonesia)
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 2,961 Documents
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Clindamycin 0.025% and Tretinoin 0.005% Cream for Infantile Acne Vulgaris Gabriela Reginata; Sukmawati Tansil Tan; Listyani Gunawan
Cermin Dunia Kedokteran Vol 46, No 4 (2019): Dermatologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i4.494

Abstract

Acne vulgaris is an inflammatory disease of pilosebaceous unit marked by the presence of comedones, papules, pustules, nodules, and cysts. A boy aged 4 years old was reported of having red spots on his cheeks since the age of 1 month old. Erythematous papules and pustules with white heads were found in the facial area. Infantile acne diagnosis was considered. Combination of clindamycin 0.025% and tretinoin 0.005% cream was given to accelerate healing process and to prevent complications such as post-inflammatory hyperpigmentation. The patient’s condition was considerably better after 1 month.Acne vulgaris merupakan inflamasi kelenjar pilosebaceous yang ditandai dengan komedon, papula, pustula, nodula, and kista. Kasus anak laki-laki usia 4 tahun mempunyai bintik kemerahan di pipi sejak usia 1 bulan. Dijumpai papula dan pustula eritematous dengan white heads di wajah, didiagnosis sebagai infantile acne. Diberikan krim kombinasi clindamycin 0.025% and tretinoin 0.005% untuk terapi dan mencegah komplikasi hiperpigmentasi. Keadaan pasien lebih baik setelah terapi 1 bulan.
Korelasi Kadar Asam Urat dengan Derajat Keganasan Kanker Kolorektal Subandrate -; Ella Amalia; Dwi Indira Setyorini; Safyudin -
Cermin Dunia Kedokteran Vol 45, No 7 (2018): Onkologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i7.637

Abstract

Pendahuluan: Hiperurisemia pada pasien kanker meningkatkan angka kematian terutama pada stadium lanjut. Metode: Studi observasional analitik korelatif dengan rancangan cross sectional, untuk mengetahui korelasi kadar asam urat dan derajat keganasan kanker kolorektal. Subjek penelitian 35 orang penderita kanker kolorektal yang dirawat di RSUP Mohammad Hoesin (RSMH), terdiri atas 15 laki-laki dan 20 perempuan. Stadium kanker kolorektal berdasarkan pemeriksaan histopatologi di Laboratorium Patologi Anatomi RSMH/FK Unsri Palembang. Pemeriksaan kadar asam urat serum di Laboratorium Biokimia FK Unsri. Hasil: Stadium klinis penderita terdiri dari stadium II (17,1%), stadium III (48,6%) dan stadium IV (34,3%). Rata-rata kadar asam urat penderita adalah 11,8±3,5 mg/dL, 88,6% mengalami hiperurisemia. Kadar asam urat pada pasien kanker kolorektal stadium awal adalah 10,6 mg/dL, pada pasien kanker kolorektal stadium akhir adalah 12,3 mg/dL. Korelasi antara kadar asam urat dan stadium kanker kolorektal sangat lemah (r=0,072) dan tidak bermakna (p=0,647). Simpulan: Hiperurisemia terjadi pada hampir semua penderita kanker kolorektal. Kadar asam urat tidak berkorelasi dengan stadium kanker kolorektal.Introduction: Hyperuricemia in cancer patients increases mortality, especially in advanced phase. Methods: An observational analytic correlative study with cross sectional design on correlation between uric acid level and cancer stage in colorectal cancer patients. Subjects were 15 male and 20 female colorectal cancer patients treated at RSUP Mohammad Hoesin (RSMH). Stage of colorectal cancer based on histopathology examination in Anatomy Pathology Laboratory of RSMH/Medical Faculty of Sriwijaya University, Palembang. Serum uric acid level was measured in Biochemistry Laboratory of Medical Faculty of Sriwijaya University. Results: The cancer stage of the patients were stage II (17.1%), stage III (48.6%) and stage IV(34.3%). The mean uric acid levels were 11.8±3.5 mg/dL. Approximately 88.6% of colorectal cancer patients have hyperuricemia. The mean level of uric acid in patients with early stage colorectal cancer was 10.6 mg/dL, in patients with end-stage colorectal cancer was 12.3 mg/dL. The correlation between uric acid levels and colorectal cancer stage was very weak (r=0.072) and was not significant (p=0.647). Conclusion: Hyperuricemia occurs in almost all colorectal cancer patients. Uric acid level did not correlate with colorectal cancer stage. 
Terapi Makanan dan Akupunktur Berbasis Traditional Chinese Medicine untuk Kasus Obstipasi Kronis Refrakter Aryaprana Nando; Cinderella Sisilia Indradjaja; Wijono Agussalim Sukaputra; Willie Japaries
Cermin Dunia Kedokteran Vol 48, No 7 (2021): Infeksi - [Covid - 19]
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v48i7.1456

Abstract

Latar belakang: Sembelit merupakan gangguan buang air besar yang cukup banyak diderita masyarakat. Tujuan: Analisis kasus obstipasi kronis refrakter yang diterapi dengan metode pengobatan tradisional Tiongkok (TCM). Kasus. Wanita 26 tahun, menderita obstipasi selama 8 tahun, telah makan banyak pepaya, berobat ke beberapa dokter, diberi terapi pelunak feses dan laksatif, namun kurang berhasil. Dengan metode TCM didiagnosis sebagai sindrom Qi jantung lemah.Terapi akupunktur dan mengonsumsi daun singkong. Setelah diterapi 7 kali dalam sekitar satu bulan, obstipasi teratasi. Simpulan: Kasus obstipasi kronis refrakter yang kurang berhasil diterapi dengan pelunak feses dan laksatif serta konsumsi buah, berhasil diatasi dengan terapi akupunktur dan konsumsi daun singkong berdasarkan diagnosis TCM.Background: Obstipation or difficulty in defecation is frequently found in practice. Aim: Analysis on a case of chronic refractory obstipation treated by traditional chinese medicine (TCM) approaches. Case: A woman aged 26 years suffering from eight years of refractory obstipation. Consumption of papaya and prescribed fecal softener and laxative were unsatisfactory. TCM diagnosis is cardiac Qi weakness. After treated with acupuncture and consuming cassava leaves seven times in more than a month, her obstipation was relieved. Conclusion: A case of chronic refractory obstipation unsuccesfully treated conventionally with papaya, fecal softener and laxative, relieved by TCM approach using acupuncture and cassava leaves. 
A case of juvenile dermatomyositis responding to methotrexate and steroid Prastiya Indra Gunawan; Darto Saharso
Cermin Dunia Kedokteran Vol 44, No 6 (2017): Dermatologi
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v44i6.793

Abstract

A 4-year-old patient presented with skin rash and weakness. She was diagnosed with juvenile dermatomyositis based on Bohan and Peter criteria and laboratory result. The treatment consist of steroid combined with methotrexate. The response is good.Pasien anak perempuan berusia 4 tahun dengan keluhan bercak kemerahan di kulit dengan kelumpuhan. Pasien didiagnosis juvenile dermatomyositis berdasarkan kriteria Bohar dan Peter dan hasil laboratorium. Pasien mendapat terapi steroid dikombinasi dengan methotrexate, menunjukkan hasil baik.
Manajemen Varisela Neonatal Rohmatul Hajiriah Nurhayati
Cermin Dunia Kedokteran Vol 46, No 11 (2019): Kesehatan Anak
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i11.408

Abstract

Infeksi primer varicella-zoster virus (VZV) neonatal sangat menular dan berisiko tinggi kematian. Diagnosis klinis varisela neonatal melalui temuan lesi patognomonik dalam berbagai stadia di saat bersamaan. Infeksi ini dapat diatasi dengan asiklovir; penelitian terbaru lebih merekomendasikan rute intravena dibandingkan rute oral, terutama untuk infeksi yang telah menyebar. Selain pengobatan, dilakukan pencegahan untuk meminimalkan penularan virus.Primary infections of varicella-zoster virus (VZV) in neonatus are highly contagious and have a high risk of death. Neonatal varicella can be diagnosed clinically through simultanous pathognomonic lesions at various stages. Recent research shows that intravenous route is recommended, especially in systemic infections. Preventive measures should be taken to minimize virus transmission.
Teknik –teknik Biopsi Kulit Erlina Pricilla Sitorus; Indah Julianto
Cermin Dunia Kedokteran Vol 45, No 6 (2018): Penyakit Dalam
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i6.663

Abstract

Prosedur biopsi merupakan tahap penting diagnosis di bidang dermatologi, karena informasi histopatologis dapat dengan mudah diperoleh dari sampel kulit. Teknik biopsi kulit terdiri dari biopsi snip atau gunting, kuretase, shave, plong, eksisi dan biopsi insisi. Biopsi kulit perlu penjelasan dan mendapat persetujuan pasien. Dokumentasi lesi bertujuan untuk mencegah kekeliruan lokasi biopsi, meningkatkan kepercayaan pasien dan dapat memantau ketepatan pengobatan. Seorang dermatologis hendaknya dapat mengaplikasikan tindakan ini secara aman dan tepat dalam praktik sehari-hari.Biopsy is an important step in dermatology diagnosis, because histopathology information is easy to obtain from skin samples. Six type of skin biopsy are snip, curettage, shave, punch, exsicion, and incision biopsy. Explanation and informed consent is necessary. Documentation of lesion should prevent misplaced biopsy, enhance patient’s confidence, and monitoring the accuracy of treatment. A dermatologist should apply these procedures safely and appropriately in daily practice.
Kolestasis Neonatal di Rumah Sakit Umum Daerah Wangaya, Bali Virly Isella; Made Ratna Dewi
Cermin Dunia Kedokteran Vol 48, No 9 (2021): Nyeri Neuropatik
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v48i9.1492

Abstract

Kolestasis neonatal terjadi akibat kelainan sistem hepatobiliar, sering terlambat didiagnosis karena dianggap fisiologis. Identifikasi dini, menentukan etiologi hingga merujuk ke bagian gastroenterologi-hepatologi anak pada saat yang tepat adalah penting untuk keberhasilan terapi dan prognosis yang optimal. Kasus seorang bayi laki-laki usia 3 minggu dengan keluhan muntah, diare, tubuh kuning, dan tinja kuning pucat. Pada pemeriksaan laboratorium didapatkan hiperbilirubinemia disertai peningkatan kadar bilirubin direk, gama glutamil transferase (GGT), peningkatan hitung leukosit dan trombosit; pemeriksaan tinja menunjukkan infeksi bakteri. Diagnosis kolestasis berdasarkan peningkatan bilirubin direk >20% kadar bilirubin total, mengarah pada tipe intrahepatal berdasarkan peningkatan GGT <10 kali lipat batas atas normal. Pasien mendapat terapi antibiotik, disertai terapi suportif stimulasi aliran empedu dan vitamin larut lemak.Neonatal cholestasis is caused by the abnormality of the hepatobiliary system, often unrecognized and late-diagnosed because of misinterpretation as physiological jaundice. Early identification of the underlying etiology and timely referral to pediatric gastroenterology and epatology are important for successful treatment and optimal prognosis. We reported a male infant age 3 weeks with vomiting, diarrhea, icterus, and pale stool. Laboratory findings were hyperbilirubinemia with high direct bilirubin, gamma-glutamyl-transferase (GGT), elevated leukocyte and thrombocytes, and stool test indicated bacterial infection. Diagnosis of cholestasis is based on high direct bilirubin >20% total bilirubin, with intrahepatic type based on elevated GGT <10 times from the upper limit. The patient was treated with antibiotics and supportive treatment of bile flow stimulant and fat-soluble vitamin 
Pengelolaan Gangren Kaki Diabetik Ronald W. Kartika
Cermin Dunia Kedokteran Vol 44, No 1 (2017): Nutrisi
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v44i1.810

Abstract

Diabetes Mellitus adalah kondisi seumur hidup yang merupakan salah satu penyebab utama kematian di dunia. Hingga 15 % pasien diabetes mellitus akan menderita ulkus kaki diabetik. Pasien ulkus di kaki berisiko tinggi untuk amputasi dan kematian. Pengenalan dini melalui skrining penting untuk mengurangi morbiditas dan mortalitas. Pendekatan interprofessional (dokter, perawat, dan spesialis perawatan kaki) sering diperlukan untuk mendukung kebutuhan pasien.Diabetes Mellitus is a serious, life-long condition which is one of the leading cause of death in the world. Up to 15% diabetes mellitus patients will develop diabetic foot ulcers with increased risk of amputation and mortality. The risk of diabetic foot can be identified with a simplified screening, and subsequent foot ulcers can be prevented. Early recognition of the high-risk foot and timely treatment will save legs and improve patients’ quality of life. An interprofessional approach (physicians, nurses, and foot care specialists) is needed to support patients’ needs.
Cancer Immunotherapy and CAR T Cells Khing S. Ong; Zack ST. Lim; Boenjamin Setiawan
Cermin Dunia Kedokteran Vol 45, No 12 (2018): Farmakologi
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i12.551

Abstract

Within the past decade, radical changes of idea emerged from the works of research scientists, medical experts and oncologists. Instead of treating cancers with man-made chemicals or chemotherapy and radiotherapy, or surgically remove the tumor, we should unleash the power of our own body immune system. Indeed, such approach has borne fruits and benefited at least for some cancer patients. This review described various types of immunotherapy known to date, with its beneficial effects, albeit some with serious harmful effects. To understand how immunotherapies worked, we also review some biologic characteristic of cancer cell that let them evade attacks from our immune system; cancer microenvironment that works in favor or protecting the growth of cancer against our immune system will also be discussed.Hanya dalam jangka 10 tahun terakhir, telah terjadi perubahan radikal hasil penelitian penyakit kanker. Di samping cara klasik penyembuhan kanker seperti obat-obat kimia sintetik, kemoterapi dan radiologi atau pembedahan, kini para ahli telah menggunakan sistim imunitas tubuh penderita sendiri. Cara ini telah terbukti dalam pengobatan beberapa pasien kanker. Dalam ulasan ini kami akan memaparkan beberapa immunoterapi saat ini dengan hasil baik meskipun masih terdapat beberapa kesalahan dan efek samping. Akan diulas dan dijelaskan sifat-sifat biologi sel kanker, dan bagaimana kanker sel bisa menghindari serangan sistim imun; dan lingkungan mikrokanker (cancer microenviroment) yang melindungi kanker dari sistim imun. 
Tinjauan atas Angiotensin Receptor Blocker Generasi Baru Jane Cherub
Cermin Dunia Kedokteran Vol 47, No 10 (2020): Optalmologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i10.1088

Abstract

Angiotensin receptor blockers (ARB) yang bekerja menghambat reseptor AngII-AT1 secara selektif direkomendasikan sebagai agen antihipertensi lini pertama. Saat ini terdapat 8 varian ARB di pasaran. Selain efek antagonisasinya terhadap AT1, ARB generasi baru memiliki mekanisme tambahan yang dapat menarget hipertensi, penyakit kardiovaskular, dan diabetes. ARB generasi baru juga memblokir reseptor endotelin, berfungsi sebagai donor oksida nitrat, menghambat aktivitas neprilysin dan meningkatkan kadar peptida natriuretik, atau merangsang peroxisome proliferatoractivated receptor gamma (PPARγ). ARB generasi baru dapat memiliki nilai klinis dan manfaat terapeutik lebih besar daripada hanya melalui penghambatan reseptor AT1.Angiotensin receptor blockers (ARBs) works by selectively blocking AngII-AT1 receptors; it is recommended as a first-line antihypertensive agent. Currently there are 8 variants of ARB in the market. In addition to its AT1 antagonist effect, new generation of ARB can have additional mechanisms on hypertension, cardiovascular disease and diabetes. New generation ARBs also block endothelial receptors, as nitric oxide donors, inhibit neprilysin activity and increase levels of natriuretic peptides, or stimulate peroxisome proliferator-activated gamma receptors (PPARγ). New generation of ARBs can have considerable clinical value and provide greater therapeutic benefits.

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