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INDONESIA
Cermin Dunia Kedokteran
Published by PT. Kalbe Farma Tbk.
ISSN : 0125913X     EISSN : 25032720     DOI : 10.55175
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Cermin Dunia Kedokteran (e-ISSN: 2503-2720, p-ISSN: 0125-913X), merupakan jurnal kedokteran dengan akses terbuka dan review sejawat yang menerbitkan artikel penelitian maupun tinjauan pustaka dari bidang kedokteran dan kesehatan masyarakat baik ilmu dasar, klinis serta epidemiologis yang menyangkut pencegahan, pengobatan maupun rehabilitasi. Jurnal ini ditujukan untuk membantu mewadahi publikasi ilmiah, penyegaran, serta membantu meningkatan dan penyebaran pengetahuan terkait dengan perkembangan ilmu kedokteran dan kesehatan masyarakat. Terbit setiap bulan sekali dan disertai dengan artikel yang digunakan untuk CME - Continuing Medical Education yang bekerjasama dengan PB IDI (Pengurus Besar Ikatan Dokter Indonesia)
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 2,961 Documents
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Aplikasi Sistem Skor Stroke Dave dan Djoenaidi (SSSDD) untuk Membedakan Stroke Hemoragik dan Stroke Iskemik Umbas, David Gunawan
Cermin Dunia Kedokteran Vol 42, No 9 (2015): Pediatri
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (880.833 KB) | DOI: 10.55175/cdk.v42i9.966

Abstract

Pendahuluan: Tatalaksana stroke akut yang cepat dan tepat sangat bergantung kepada kecepatan diagnosis jenis stroke, agar dapat menurunkan mortalitas dan morbiditasnya. Diperlukan cara yang cepat membedakan stroke hemoragik (SH) dan stroke iskemik (SI), terutama jika fasilitas neuroimaging tidak tersedia pada saat fase akut stroke. Tujuan: Menilai ketepatan skor stroke berdasarkan 5 variabel: tekanan darah (TD), aktivitas, nyeri kepala, muntah dan tingkat kesadaran dalam membedakan SH dan SI. Metode: Penelitian cross-sectional terhadap 185 penderita stroke yang masuk rumah sakit pendidikan FK-UNHAS RSWS dan jejaringnya di Makassar periode Januari-Juni 2014. Total skor dari 5 komponen SSSDD diuji validitasnya terhadap hasil CT scan kepala, komponen tekanan darah dan aktivitas menggunakan tes chi square (X² test), komponen nyeri kepala, muntah, dan penurunan kesadaran menggunakan tes Kolmogorov-Smirnov; dilakukan uji nilai prediksi positif, nilai prediksi negatif, sensitivitas, spesifisitas, akurasi dan area under the curve (AUC). Total skor dinilai cut-offnya berdasarkan kurva receiver operating characteristic (ROC) untuk membedakan SH dan SI. Hasil: Cut-off point SSSDD ≥ 17 adalah SH dan <17 adalah SI, dengan nilai prediksi positif 89,4%, nilai prediksi negatif 90,1%, sensitivitas 90,3%, spesifisitas 89,1%, akurasi 89,7%, dan AUC 97,3%. Simpulan : SSSDD dapat membedakan SH dan SI dengan nilai diagnostik yang baik.Introduction: Management of acute stroke quickly and accurately depends on the accuracy of diagnosis to reduce mortality and morbidity. A rapid assessment to differentiate hemorrhagic stroke (SH) and ischemic stroke (SI) is needed, especially if neuroimaging facilities are not available. Objective: To assess the accuracy of stroke score based on five clinical variables: blood pressure, activity, headache, vomiting, and consciousness level to distinguish hemorrhagic and ischemic stroke. Method: A cross-sectional study was performed on 185 acute stroke patients admitted to Hasanuddin University Teaching Hospitals from January to June 2014. Total score of the 5 components of SSSDD are validated against head CT scan using chi square X2 test; the positive predictive value, negative predictive value, sensitivity, specificity, accuracy, AUC were determined. The cut-off point of total score to differentiate hemorrhagic stroke (SH) and ischemic stroke (SI) was analyzed using ROC curve. Result: SSSDD point ≥17 is SH and <17 is SI, with positive predictive value of 89.4%, negative predictive value of 90.1%, sensitivity of 90.3%, specificity of 89.1%, accuracy of 89.7% and AUC 97,3%. Conclusion: SSSDD can be used to distinguish SH and SI with good diagnostic value. 
Penggunaan Produk Biosimilar pada Transplantasi Ginjal Ardi, Laurencia
Cermin Dunia Kedokteran Vol 48, No 11 (2021): Kardio-SerebroVaskular
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (147.183 KB) | DOI: 10.55175/cdk.v48i11.1559

Abstract

Transplantasi ginjal sering menimbulkan rejeksi, oleh karenanya diperlukan obat-obatan imunosupresan sebelum, saat, dan setelah transplantasi ginjal. Terapi imunosupresan pada transplantasi ginjal terdiri dari terapi induksi, pemeliharaan awal, dan pemeliharaan jangka panjang. Beberapa produk biosimilar dapat digunakan untuk terapi rejeksi pada transplantasi ginjal. Kidney transplantation often results in rejection; it is necessary to give immunosuppressant drugs before, during, and after kidney transplantation. Immunosuppressant therapy in kidney transplantation consists of induction therapy, early maintenance, and long-term maintenance. Several biosimilar products can be used for immunosuppressant in kidney transplants.
Transeksi Komplit Trakhea dan Transeksi Parsial Esofagus akibat Trauma Tumpul Leher Y, Khosama; N., Lumintang; W, Sumanti
Cermin Dunia Kedokteran Vol 43, No 11 (2016): Kesehatan Ibu - Anak
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (416.357 KB) | DOI: 10.55175/cdk.v43i11.890

Abstract

Laporan kasus transeksi trakhea dan esofagus karena trauma tumpul leher (jeratan). Seorang laki-laki, 21 tahun dirujuk setelah kecelakaan sepeda motor tunggal karena lehernya tersangkut tali pengikat sapi. Pasien sadar penuh dan mengalami depresi napas. Kulit di area leher tampak lecet pada zona I-II dan pada bagian anterior tampak kulit kembang-kempis (fluktuasi) sesuai pernapasan. Pada eksplorasi leher darurat tampak laserasi trakhea, terjadi robekan pada cincin kedua hingga ke bagian posterior, bagian distal trakhea retraksi ke inferior, dan ruptur esofagus dengan diameter > 50% pada bagian anterior. Dilakukan trakheostomi dilanjutkan anastomosis esofagofaringeal dan repair trakheaA case report of trachea and esophageal transection caused by strangulation. A 21-year old male was referred because his neck was strangled on cow’s rope after single vehicle accident. Patient was alert but difficult to breath. The skin in zone I-II of neck was blistered and the anterior part was fluctuated in rhythm with breathing. On exploration, complete laceration of trachea at the second ring was found, the distal part of trachea was retracted to inferior, partial esophageal rupture with circumference more than 50% on anterior part. Tracheostomy, esophagopharyngeal anastomosis, and trachea repair were done.
Penatalaksanaan Medication-overuse Headache Artini, Ni Made Yuli; Adnyana, I Made Oka
Cermin Dunia Kedokteran Vol 41, No 9 (2014): Diabetes Mellitus
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (167.982 KB) | DOI: 10.55175/cdk.v41i9.1104

Abstract

Medication-overuse Headache (MOH) adalah nyeri kepala kronik akibat penggunaan berlebihan analgesik, triptan, atau kombinasi obat nyeri kepala lain. Patofisiologi MOH belum jelas, diduga ada peranan faktor genetik, fisiologi dan regulasi reseptor, serta faktor psikologis. Tujuan pengobatan MOH adalah mengurangi frekuensi dan atau keparahan nyeri kepala, mengurangi konsumsi obat akut, memperbaiki respon terhadap obat akut dan obat preventif, mencegah kecacatan dan memperbaiki kualitas hidup. Langkah-langkah pencegahan termasuk membatasi konsumsi obat, menghindari kafein dan obat-obatan mengandung kafein atau kodein. Profilaksis dini mungkin diperlukan. Penanganan MOH meliputi edukasi pasien serta withdrawal obat. Pasien diikuti secara teratur untuk mencegah kambuh, terutama di tahun pertama setelah withdrawal.Medication-overuse Headache (MOH) is a chronic headache caused by overuse of analgesics, triptans, or other drugs. Pathophysiology of MOH is unknown, presumably influenced by genetics, physiology and regulation of the receptor, as well as psychological factors. The goal of MOH treatment is to reduce the frequency and/or severity of headache, to reduce acute drug consumption, to improve response to acute and preventive treatment, to prevent disability and improve quality of life. Measures to prevent MOH include limiting drugs consumption, avoiding caffeine and medications containing caffeine or codeine. Early prophylaxis either with medication or behavioral therapy may be necessary. Management consists of patient education and drug withdrawal. Patients should be followed regularly, especially in the first year, to prevent relapse.
Wilson’s Disease: Current Therapies, Its Controversies, and Potential New Therapeutics Rima Sutiono, Dias; Syafitri Sudiro, Giardani
Cermin Dunia Kedokteran Vol 45, No 1 (2018): Suplemen
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (148.793 KB) | DOI: 10.55175/cdk.v45i1.164

Abstract

Wilson’s Disease is a rare genetic disorder with the prevalence of 1 in every 30,000 people, due to the mutation of the ATP7B gene responsible for copper metabolism. The mutation causes copper accumulation in the body, especially in the liver and brain, which leads to hepatic, neurological, psychological symptoms. These symptoms, if not treated properly, may lead to death after several years. Several treatments including low copper diet, zinc salts treatment, chelating agents (penicillamine, trientine, ammonium tetrahimiolybdate), and liver transplant are currently available. Severe neurological deterioration and other side effects need new, more efficient, and safer therapeutics. Several new therapeutic agents including 4-phenylbutyrate, curcumin, chelating polymeric beads, and long term metabolic correction have been tested in vitro and in vivo. These new therapeutics may be a potential new treatment with less side effect and greater efficacy for Wilson’s Disease patients.
Ekstraksi Benda Asing di Laringofaring Anak Menggunakan Kateter Foley Juwarna, Wijaya; -, Rusly; Prihastika, Esti
Cermin Dunia Kedokteran Vol 46, No 9 (2019): Neuropati
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (975.132 KB) | DOI: 10.55175/cdk.v46i9.439

Abstract

Aspirasi benda asing sering terjadi pada anak- anak. Kasus anak laki- laki berusia 3 tahun 4 bulan datang dengan keluhan sulit menelan dan suara serak. Pemeriksaan fisik dalam batas normal, foto toraks mendapatkan gambaran radiopak bulat dan pipih di leher. Ekstraksi benda asing dilakukan dengan menggunakan kateter Foley.Foreign body aspiration is common in peadiatrics. A 40-month old boy admitted with swallowing difficulties and voice change. Physical examination was normal, chest x-ray finding was radiopaque thin and spherical object in the neck. Removal of the foreign body was done using Foley catheter.
Potensi Suplemen dalam Tatalaksana COVID-19 Febriana, Lydia
Cermin Dunia Kedokteran Vol 48, No 2 (2021): Farmakologi - Vitamin D
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (140.892 KB) | DOI: 10.55175/cdk.v48i2.1303

Abstract

Coronavirus Disease 2019 (COVID-19) merupakan pandemi penyakit baru; berbagai studi dilakukan untuk menemukan terapi yang tepat. Beberapa suplemen juga diteliti potensinya dalam upaya pencegahan ataupun terapi adjuvan COVID-19, antara lain: vitamin C, vitamin D, vitamin E, vitamin B kompleks, zinc, selenium, n-asetilsistein, quercetin, dan melatonin.Coronavirus Disease 2019 (COVID-19) is a new disease pandemic. Several studies are being conducted to find effective therapeutic options. Several supplements are also recommended for their potential in preventing and as adjuvant therapy for COVID-19, including: vitamin C, vitamin D, vitamin E, vitamin B complex, zinc, selenium, n-acetylcysteine, quercetin, and melatonin. 
Intoleransi Makanan pada Neonatus Kurang Bulan Handayani Ardy, Nurul; Sianturi, Pertin
Cermin Dunia Kedokteran Vol 45, No 11 (2018): Neurologi
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (492.433 KB) | DOI: 10.55175/cdk.v45i11.570

Abstract

Intoleransi makanan adalah masalah pencernaan yang paling umum pada bayi prematur saat menyusui. Intoleransi makanan akan menyebabkan kurangnya nutrisi neonatus sehingga mempengaruhi proses pertumbuhan. Mekanisme intoleransi makanan tidak jelas tetapi dapat dipengaruhi oleh beberapa faktor fisiologis seperti pematangan motilitas saluran pencernaan, penundaan pengosongan lambung, saluran pencernaan dan penyerapan yang belum matang. Intoleransi makanan juga berhubungan dengan morbiditas seperti sepsis neonatal dan Necrotizing Enterocolitis (NEC).Food intolerance is the most common digestive problems in preterm infants during breastfeeding. Infant with food intolerance will get less nutrients thus affecting growth. The exact mechanism of food intolerance may be affected by several physiological factors such as maturation of the gastrointestinal tract motility, delayed gastric emptying, gastrointestinal tract and malabsorption. Food intolerance is also associated with morbidity such as neonatal sepsis and necrotizing enterocolitis (NEC)
Pitiriasis Rubra Pilaris yang Berhubungan dengan HIV Chandra, Rudi; Arif, Abdul; Antonius, Cayadi S
Cermin Dunia Kedokteran Vol 47, No 8 (2020): Kardiologi
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (377.452 KB) | DOI: 10.55175/cdk.v47i8.781

Abstract

Pitiriasis rubra pilaris (PRP) merupakan dermatosis papuloskuamosa idiopatik yang tidak diketahui penyebabnya, ditandai dengan papul-papul folikular hiperkeratotik berkoalesen menjadi plak bersisik jingga-kemerahan, islands of sparing, dan keratoderma palmoplantar. PRP awalnya diklasifikasikan oleh Griffiths ke dalam 5 kelompok berdasarkan gambaran klinis, onset usia, dan prognosis. Kemudian oleh Miralles et al diusulkan kelompok ke-6 yang berhubungan dengan human immunodeficiency virus (HIV). Insidensi PRP berkisar dari 1 dari 5.000 di Inggris sampai 1 dari 50.000 di India, puncaknya pada dekade pertama dan ke lima. Diagnosis PRP melalui manifestasi klinis dan pemeriksaan histopatologi. Pilihan pengobatan PRP tipe VI berbeda dengan tipe lainnya.Pityriasis rubra pilaris (PRP) is an idiopathic papulosquamous dermatosis with unknown etiology; characterized by hyperkeratotic follicular papules which coalesce into reddish-orange scaly plaques, islands of sparing, and palmoplantar keratoderma. PRP was initially classified by Griffiths into 5 groups based on clinical features, age of onset, and prognosis. Miralles et al. proposed the 6th group related to human immunodeficiency virus (HIV). The incidence of PRP ranges from 1 in 5.000 in the UK to 1 in 50.000 in India, with peaks in the first and fifth decades. Diagnosis can be established through clinical manifestations and histopathological examination. Treatment options for PRP type VI is different from other types. 
Efek Segera Jamu J terhadap Kadar Kolesterol Subjek Normo dan Hiperkolesterolemi Harmanto, Ning; -, Jumaroh; Nando, Aryaprana; Japaries, Willie
Cermin Dunia Kedokteran Vol 42, No 6 (2015): Malaria
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (302.121 KB) | DOI: 10.55175/cdk.v42i6.1000

Abstract

Tujuan: Analisis deskriptif terhadap data kadar kolesterol darah subjek sebelum dan sesudah diberi jamu J. Metodologi: Subjek terdiri atas pasien yang diberi jamu J. Sebelum dan satu jam sesudah diberi J peroral, pada subjek diperiksa kadar kolesterol total darah sewaktu. Dilakukan tes-t dua ekor untuk menguji perbedaan antara kadar kolesterol darah pasca pemberian dibandingkan pra pemberian J. Hasil: Subjek sejumlah 41 orang, 21 wanita dan 20 pria, usia rata-rata 45,66±14,03 tahun. Kadar kolesterol darah sewaktu rata-rata sebelum diberi jamu J adalah 232,98±37,02 mg/dl, dan sesudahnya adalah 194,12±34,85 mg/dl. (P<0,01). Perubahan kadar kolesterol darah pada subkelompok subjek dengan kadar kolesterol darah pra-pemberian J kurang dari 200mg/dl (N=8), tidak signifikan (P>0,05). Simpulan: Jamu J berefek menurunkan kolesterol darah sangat signifikan (P<0,01), khususnya subjek dengan kadar kolesterol total di atas 200mg/dl. Pada subjek dengan kadar kolesterol darah 200mg/dl atau kurang, J perubahan kadar kolesterol darah tidak signifikan (P>0,05).Aim: This study was to describe the immediate effect of Indonesian herbal liquid J on total blood cholesterol level among normo and hypercholesterolemic subjects. Materials and methods: Subjects were clients/patients of a traditional medicine clinic in Jakarta who had agreed to be tested. Their random blood cholesterol levels were measured before and one hour post ingestion of two spoonful of herbal liquid J. The pre and post ingestion data were analyzed with paired t test. Results: There were 41 subjects, 21 females and 20 males, with average 45,66±14,03 years old. Their average random blood total cholesterol level before treatment was 232,98±37,02 mg/dl, and after treatment was 194,12±34,85 mg/dl. The difference was highly significant (P<0.01). In subgroup with initial blood total cholesterol levels below 200mg/dl there was no significant change of blood total cholesterol (P>0,05) after ingestion of J. Conclusion: The herbal liquid J was significantly decrease random blood total cholesterol levels (P<0,01), especially among those with initial level of 200mg/dl and above. Among subjects with initial blood total cholesterol levels below 200mg/dl, the change was not significant (P>0.05).

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