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Rahmawati
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INDONESIA
Jurnal Ilmiah Kesehatan (JIKA)
Published by Sarana Ilmu Indonesia
ISSN : 23379847     EISSN : 26862883     DOI : https://doi.org/10.36590/jika
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health
Jurnal Ilmiah Kesehatan (JIKA) aims to provide forum exchanges and interfaces between researchers and related practitioners in the field of health. The journal only accepts articles from original research results (top priorities), case study articles (not priorities), and scientific studies of recent articles (not preferences). JIKA is a scientific journal that contains research papers from the field of health sciences including: Medical and clinical research, food and nutrition research, public health research, obstetrics management research, nursing management research, and pharmacy research.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 341 Documents
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Packaging Methods and Storage Duration on the Organoleptic, Microbiological, and Chemical Qualityof Patin fish-Tempeh Nugget Hesti Atasasih; Irma Susan Paramita; Dewi Rahayu; Nurlisis Nurlisis; Ana Yuliah Rahmawati
Jurnal Ilmiah Kesehatan (JIKA) Vol. 8 No. 1 (2026): Volume 8 Nomor 1 April 2026
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v8i1.1432

Abstract

The modification of nuggets by incorporating tempeh can improve their nutritional value. NUPATE (Patin Fish–Tempeh Nugget) is a product made from catfish and tempeh with the best formulation consisting of 30% catfish and 70% tempeh. This study aimed to determine the effect of packaging methods and storage duration on the organoleptic, microbiological, and chemical quality of NUPATE. An experimental study was conducted using a factorial Completely Randomized Design (CRD) with packaging methods (vacuum and non-vacuum), storage duration (0, 10, 20, and 30 days), and storage temperatures (20–25°C, >2–10°C, -4–2°C, and -18 to -23°C) as factors. Organoleptic evaluation was carried out by 30 untrained panelists. The results showed that packaging methods and storage duration at different temperatures significantly affected NUPATE quality (p < 0.05). Total Plate Count (TPC) analysis indicated a significant difference between vacuum and non-vacuum packaging (p < 0.05), while protein and fat content decreased with increasing storage duration (p < 0.05). Vacuum packaging at freezer temperature (-18 to -23°C) was the most effective method for maintaining NUPATE quality for up to 30 days.
Development of Ulva lactuca Nori-like Products with Heritage Flavors from Traditional Fermented Products from Riau M. Haekal Tiftazani; Joko Santoso; Wahyu Ramadhan
Jurnal Ilmiah Kesehatan (JIKA) Vol. 8 No. 1 (2026): Volume 8 Nomor 1 April 2026
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v8i1.1435

Abstract

The demand for nori in Indonesia continues to rise; however, the limited availability of local raw materials, such as Porphyra sp., necessitates the development of alternative products based on other types of seaweed. This study aimed to evaluate the effects of adding terasi and rusip to the formulation of nori-like products made from Ulva lactuca on sensory, physical, and chemical characteristics. A Completely Randomized Design (CRD) was employed, consisting of one factor with four levels and three replications. The treatments involved varying formulations of terasi:rusip ratios (1:4, 2:3, 3:2, and 4:1). The best formula was determined based on hedonic sensory evaluation by trained panelists. The selected formula was then subjected to proximate analysis and color profiling. The results revealed that the best formulation was the 3:2 terasi:rusip ratio, which achieved the highest hedonic score for overall acceptability (4.5, categorized as "very liked"). Proximate analysis of the best formula showed a protein content of 18.14%, moisture content of 2.46%, ash content of 20.53%, fat content of 10.28%, and carbohydrate content of 48.59%. The dominant amino acids in the nori-like product were glutamic acid, aspartic acid, and alanine. Color profile analysis indicated an L* value of 41.46 (high brightness), a* value of -9.33 (green dominance), and b* value of 30.32 (yellowish tendency). These findings suggested that the combination of terasi and rusip enhances the sensory quality and physicochemical characteristics of nori-likeproducts while offering potential for the development of local nori products with distinctive Indonesian flavors.
Resistance Exercise and Diabetic Foot Exercises on ABI and Blood Glucose Levels in Patients Diabetes Mellitus Dewi Nur Puspita Sari; Imas Sartika
Jurnal Ilmiah Kesehatan (JIKA) Vol. 8 No. 1 (2026): Volume 8 Nomor 1 April 2026
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v8i1.1482

Abstract

Diabetes Mellitus causes microvascular and macrovascular complications that affect peripheral circulation and blood glucose levels. Resistance exercise and diabetic foot exercises, as non-pharmacological therapies, can improve the Ankle Brachial Index (ABI) and help control blood glucose levels. This study used a quasi-experimental design with a pretest-posttest control group design. The population consisted of all Diabetes Mellitus patients at Puskesmas Jati Uwung. A total of 60 subjects were selected using purposive sampling. Statistical tests included the Wilcoxon signed-rank test, Mann–Whitney test, and General Linear Model. The Mann–Whitney test results showed that resistance exercise and diabetic foot exercises had a significant effect on the Ankle Brachial Index (ABI) (p = 0.001). The mean blood glucose level in the intervention group decreased from 259 mg/dL to 183 mg/dL (76 mg/dL), while the control group decreased from 257 mg/dL to 182 mg/dL (75 mg/dL). These findings indicated that the intervention helped improve peripheral circulation and reduce blood glucose levels in patients with Diabetes Mellitus. In conclusion, resistance exercise was found to be an effective, safe, and comfortable physical exercise intervention to improve ABI and blood glucose levels independently in patients with Diabetes Mellitus.
Environmental Health Risk Assessment of Hydrogen Sulfide and Ammonia Exposure among Scavengers at Jatibarang Landfill Semarang City Lina Nur Qolifah; Suhartono Suhartono; Nurjazuli Nurjazuli
Jurnal Ilmiah Kesehatan (JIKA) Vol. 8 No. 1 (2026): Volume 8 Nomor 1 April 2026
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v8i1.1533

Abstract

The City of Semarang generated the largest volume of waste in Central Java Province, with 72.01% deposited at the Jatibarang Landfill. The waste was predominantly domestic and had the potential to produce H₂S and NH₃ gases, which might pose health risks. This study aimed to assess the health risks associated with exposure to H₂S and NH₃ among waste pickers at the Jatibarang Landfill. An EHRA approach was applied, involving 77 waste pickers selected through simple random sampling from a total population of 250. Ambient air samples were collected at five locations within the landfill based on areas with the highest scavenging activity. The measured concentrations showed that average H₂S levels were 0.001 ppm and NH₃ levels averaged 0.0168 ppm. Mean exposure duration, frequency, length of employment, and body weight were 24 hours/day, 325.71 days/year, 11 years, and 57.05 kg, respectively. The average H₂S exposure intakes for real-time and realtime exposurewere 1.40 × 10⁻⁴ and 3.23 × 10⁻⁴ mg/kg/day, while NH₃ exposure intakes were 1.66 × 10⁻³ and 3.81 × 10⁻³ mg/kg/day. The cumulative risk characterization for real-time exposure indicated that 100% of waste pickers had RQcum ≤ 1, suggesting no immediate health risk. In contrast, the lifetime projection showed that 100% had RQcum > 1, indicating potential long-term health risks. These findings underscore the need for effective risk management strategies to mitigate health hazards from NH₃ and H₂S exposure among waste pickers at the Jatibarang Landfill in Semarang.
Optimization of Annealing Temperature and Agarose Concentration in Detecting the mecA Gene of Methicillin-Resistant Staphylococcus aureus (MRSA) Muhammad Abdullah Alhakim; Kurnia Ritma Dhanti; Kurniawan Kurniawan; Arif Mulyanto
Jurnal Ilmiah Kesehatan (JIKA) Vol. 8 No. 1 (2026): Volume 8 Nomor 1 April 2026
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v8i1.1585

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is associated with the expression of the mecA gene. This study aimed to determine the optimal annealing temperature and agarose concentration to achieve the best PCR product quality based on the evaluation of DNA band integrity, thickness, and resolution. DNA was extracted from five S. aureus samples to detect isolates containing the mecA gene. The experimental variations included annealing temperatures of 53°C, 55°C, 57°C, and 59°C, as well as agarose concentrations of 1% and 1.5%. Through densitometry measurements, the optimal mecA gene band thickness was achieved at an annealing temperature of 59°C. Furthermore, the use of a 1.5% agarose concentration provided the best DNA separation resolution compared to the 1% concentration. In conclusion, optimization of annealing temperature and agarose concentration parameters was crucial to ensure the accuracy of MRSA diagnosis in the laboratory .
Downregulation of RGS2 Expression in Ovarian Cancer: A TCGA–GTEx Transcriptomic Analysis Annisa Abdi Ghifari; Marni Sianturi; Suyanto Suyanto; Zahtamal Zahtamal; Darmawi Darmawi
Jurnal Ilmiah Kesehatan (JIKA) Vol. 8 No. 2 (2026): Volume 8 Nomor 2 Agustus 2026
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v8i2.1604

Abstract

Regulator of G protein signaling 2 (RGS2), a negative regulator of G protein-coupled receptor signaling, is implicated in ovarian cancer. Given the disease's late-stage diagnosis and poor prognosis, identifying reliable molecular biomarkers is crucial. This study evaluated RGS2 gene expression in ovarian cancer and its clinicopathological and prognostic associations using public transcriptomic data. RNA-sequencing data from 419 The Cancer Genome Atlas (TCGA) tumor samples and 88 Genotype-Tissue Expression (GTEx) normal samples were compared using the Mann-Whitney U test. Additionally, 308 TCGA cases were analyzed for associations with tumor grade, clinical stage, and survival outcomes—including overall survival (OS), disease-specific survival (DSS), progression-free interval (PFI), and disease-free interval (DFI) using the Kaplan-Meier method and log-rank tests based on median RGS2 expression. Results demonstrated that RGS2 was significantly down-regulated in ovarian cancer tissues compared to normal tissues (p<0,001). However, RGS2 expression showed no significant correlation with tumor grade, clinical stage, or any evaluated survival metrics (all p>0,05). In conclusion, while RGS2 is consistently down-regulated at the transcript level in ovarian cancer, it is not significantly associated with patient survival. These findings suggest that although reduced RGS2 expression is a common molecular feature of ovarian cancer, its utility as a standalone prognostic biomarker is limited in unstratified transcriptomic analyses.
Drug Management in Increasing Immigrant Patient Satisfaction through Service Quality at Dr. Wahidin Sudirohusodo Hospital Makassar Abdelrazig Babiker Ahmed; Faradiba Abdul Rasyid; Ahmad Najib
Jurnal Ilmiah Kesehatan (JIKA) Vol. 8 No. 1 (2026): Volume 8 Nomor 1 April 2026
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v8i1.1628

Abstract

Patient satisfaction is a key indicator in assessing the quality of healthcare services, especially for immigrant patients who face language, cultural, and information access challenges. This study aimed to analyze the influence of medication management and service quality on immigrant patient satisfaction at Dr. Wahidin Sudirohusodo General Hospital in Makassar. The study employed a quantitative approach with a causal design, involving 60 immigrant subjects selected through purposive sampling. Data collection was conducted via questionnaires and direct interviews, then analyzed using the Partial Least Square (PLS) method. The results indicated that medication management has a positive and significant effect on immigrant patient satisfaction (β = 0.319; p < 0.05), while service quality demonstrates a stronger and more significant influence (β = 0.668; p < 0.001). The R² value of 0.953 indicates that both variables can explain 95.3% of the variation in patient satisfaction. Service quality dimensions including reliability, responsiveness, assurance, empathy, and tangibles played an important role in enhancing satisfaction. These findings emphasized the importance of culturally sensitive medication management and quality service in shaping positive experiences for immigrant patients and improving the overall effectiveness of healthcare services.
Education, Tenure, and Training on Nurse Knowledge in Handling Emergency Patients Rasi Rahagia; Zumrotul Ula; Suprapto Suprapto
Jurnal Ilmiah Kesehatan (JIKA) Vol. 8 No. 1 (2026): Volume 8 Nomor 1 April 2026
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v8i1.1642

Abstract

The knowledge and competencies of nurses critically influence the quality and safety of emergency patient care. This study aimed to analyze the relationship between education level, tenure, and participation in emergency training programs with nurses’ knowledge in handling emergency patients. An analytical observational study with a cross-sectional design was conducted among 30 nurses working in the Emergency Department of a Type C regional hospital in Indonesia. Data were collected using a structured and validated questionnaire. Bivariate analysis was performed using Fisher’s Exact Test with a significance level of α = 0.05. The findings showed that most respondents were aged 20–30 years (80%), had higher educational qualifications (53.3%), had worked for less than five years (60%), and had participated in formal emergency training (53.3%). Significant associations were identified between nurses’ knowledge and educational level (p = 0.011), tenure (p = 0.007), and emergency training participation (p = 0.014). Nurses with higher education and emergency training demonstrated better knowledge levels. Interestingly, nurses with shorter working experience showed higher knowledge, possibly due to greater exposure to updated curricula and recent emergency training. This study highlights the importance of continuous professional development, structured emergency training, and competency-based nursing education in improving emergency nursing preparedness and patient safety. Hospitals should strengthen regular certification and refresher training programs to maintain the quality of emergency healthcare services.
Antibacterial Effectiveness of Star Anise Extract (Illicium verum) Against the Growth of Klebsiella pneumoniae ESBL Andi Muhammad Alif; Marzelina Karim; Andy Visi Kartika; Yani Sodiqah; Rachmat Faisal Syamsu
Jurnal Ilmiah Kesehatan (JIKA) Vol. 8 No. 1 (2026): Volume 8 Nomor 1 April 2026
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v8i1.1656

Abstract

Klebsiella pneumoniae is an opportunistic pathogen with high antibiotic resistance, posing significant treatment challenges. Star anise (Illicium verum) contains bioactive compounds like shikimic acid and anethole, which exhibit antibacterial potential. However, its effectiveness against Klebsiella pneumoniae remains underexplored. This study aimed to evaluate the antibacterial efficacy of star anise extract against Klebsiella pneumoniae and compare it with meropenem as a positive control. This in vitro experimental study employed the Kirby–Bauer disc method with a post-test-only control group design. Star anise extract was prepared via maceration and tested at concentrations of 20%, 40%, 60%, 80%, and 100%. Phytochemical tests identified active compounds, while Klebsiella pneumoniae was confirmed through biochemical tests and Gram staining. Antibacterial effectiveness was assessed based on inhibition zone diameters on Mueller Hinton agar. Data were analyzed using one-way ANOVA at a 95% significance level. The extract contained saponins, alkaloids, flavonoids, tannins, and trans-anethole. While increasing extract concentration significantly enhanced the inhibition zone diameter (p < 0.05), all concentrations were categorized as weak against Klebsiella pneumoniae. Based on the diameter of the inhibition zones, the antibacterial activity of the star anise extract against Klebsiella pneumoniae can be classified as weak, particularly against resistant strains.
Exploring the Cardioprotective Mechanisms of the Ethyl Acetate Fraction of Vitex cofassus Through Network Pharmacology Puput Widarini; Ruslin Ruslin; Muhammad Arba
Jurnal Ilmiah Kesehatan (JIKA) Vol. 8 No. 2 (2026): Volume 8 Nomor 2 Agustus 2026
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v8i2.1755

Abstract

Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide, with an increasing prevalence each year. The complexity of CVD pathophysiology, which involves multiple biological pathways, required a multitarget therapeutic approach. This study aimed to investigate the potential anti-cardiovascular activity of the ethyl acetate fraction of Vitex cofassus leaves through integrated phytochemical analysis, network pharmacology and molecular docking approaches. The ethyl acetate fraction of Vitexcofassus leaves was analyzed using liquid chromatography-high-resolution mass spectrometry (LC-HRMS), identifying 232 compounds, of which 104 met drug-likeness criteria. Network pharmacology screening revealed 274 potential cardiovascular-related targets. Gene Ontology (GO) analysis highlighted enriched biological processes including responses to oxygen-containing compounds, while cellular component analysis localized target genes primarily to plasma membrane structures, neuron projections, and synapses. Molecular functions were significantly associated with signaling receptor activity and kinase activity, while KEGG pathway analysis further linked Vitex cofassus to key cardiovascular pathways including neuroactive ligand-receptor interactions.The results of Network pharmacology analysis identified SRC, HSP90AA1 and TNF-a proteins as potential targets associated with cardiovascular diseases. Molecular docking studies demonstrated strong binding affinities of selected compounds to HSP90AA1, particularly Compound 74 (-9.703 kcal/mol) and Compound 199 (-9.471 kcal/mol), surpassing the HSP90AA1 native ligand. Similarly, TNF-α binding analysis revealed potent interactions, with Compound 20 (-4.483) and Compound 74 (-4.444) exhibiting superior affinity compared to the native ligand. In conclusion, these findings suggest that Vitex cofassus ethyl acetate fraction contains bioactive compounds with multi-target cardiovascular protective effects, supporting its potential as a therapeutic candidate for cardiovascular diseases.

Page 31 of 35 | Total Record : 341

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