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Rahmawati
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Jurnal Ilmiah Kesehatan (JIKA)
Published by Sarana Ilmu Indonesia
ISSN : 23379847     EISSN : 26862883     DOI : https://doi.org/10.36590/jika
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health
Jurnal Ilmiah Kesehatan (JIKA) aims to provide forum exchanges and interfaces between researchers and related practitioners in the field of health. The journal only accepts articles from original research results (top priorities), case study articles (not priorities), and scientific studies of recent articles (not preferences). JIKA is a scientific journal that contains research papers from the field of health sciences including: Medical and clinical research, food and nutrition research, public health research, obstetrics management research, nursing management research, and pharmacy research.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 288 Documents
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AstraZeneca Vaccine Administration and Treatment Outcomes in Cardiovascular Patients Chastity, Phoebe Clarissa; Ramatillah, Diana Laila
Jurnal Ilmiah Kesehatan (JIKA) Vol. 7 No. 2 (2025): Volume 7 Nomor 2 Agustus 2025
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v7i2.1068

Abstract

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. With the global rollout of COVID-19 vaccines, including the AstraZeneca vaccine, there is increasing interest in understanding their impact on individuals with pre-existing cardiovascular conditions. While effective in preventing COVID-19, concerns have been raised about potential cardiovascular side effects. This study aimed to determine the correlation between the AstraZeneca vaccine and treatment outcomes in CVD patients, focusing on differences in patients' CVD-related conditions before and after vaccination. Data were collected using validated questionnaires conducted in Jakarta, employing an analytical survey with a cohort approach. Reliability was assessed using Cronbach's alpha, and validity was tested with a modified Delphi method involving clinical pharmacy experts. Data were analyzed using crosstab analysis via Chi-square test. The study included 200 subjects, with 115 females (57,5%) and 85 males (42,5%), with a majority of participants being over 45 years old (45,0%). A significant correlation (p-value < 0,05) was observed across various factors, including comorbidities and sociodemographic variables, patients' drug intake before and after vaccination, and the relationship between vaccination and comorbid diseases. The findings indicate a strong association between vaccination and patients history of cardiovascular disease. This correlation highlights the vaccine's possible impact on CVD-related symptoms post-vaccination. Consequently, the research provides evidence that the AstraZeneca vaccination significantly affects the risk of cardiovascular disease.
Optimization of Cream Base and Hedonic Evaluation of Telon Cream with Variations in Essential Oil Composition Marissa, Zahra; Mita, Soraya Ratnawulan; Kusumawulan, Cahya Khairani
Jurnal Ilmiah Kesehatan (JIKA) Vol. 7 No. 2 (2025): Volume 7 Nomor 2 Agustus 2025
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v7i2.1370

Abstract

Telon cream was developed as an alternative to traditional telon oil for infants to lower the risk of skin irritation from high essential-oil content while retaining its characteristic warming effect. This study optimized the cream base using the Simplex Lattice Design (SLD) and evaluated the effect of different essential-oil compositions on physical stability and sensory acceptance, focusing on the warming sensation. The base was optimized by varying the ratio of Olivem® 1000 and Flocare™ SK 425 to achieve suitable viscosity, spreadability, and adhesiveness. The optimized base was used to prepare four telon-cream formulas containing cajuput, fennel, ginger, and lavender oils. Stability was assessed by organoleptic observation, pH, viscosity, and spreadability under three storage conditions for four weeks. A hedonic test with 30 caregivers evaluated color, texture, aroma, and warming sensation using a 5-point liking scale. The optimal base ratio (Olivem® 1000:Flocare™ SK 425 = 4:1) yielded a desirability value of 1,0. All formulas met pH (5,9–6,1), viscosity (38,000–46,000 mPa·s), and spreadability (5,0–5,4 cm) requirements and remained stable. Hedonic testing showed no significant differences in color (p-value = 0,939) or texture (p-value = 0,665); aroma showed a borderline difference (p-value = 0,060), whereas the warming sensation differed significantly (p-value = 0,010). Formula F4 (cajuput 0,4%, fennel 0,4%, ginger 0,1%, lavender 0,1%) achieved the highest warming-sensation score with a favorable aroma. The optimized telon cream demonstrated good stability and was well accepted by users. The warming sensation emerged as a key attribute influencing consumer preference for telon creams.
Vitamin D3 on Oxidative Stress Markers and Blood Pressure in a UUO Rat Model of Chronic Kidney Disease Wibowo, Yogo Pardi; Susanto, Agung; Wijaya, Bayu Basuki; Pamungkasari, Eti Poncorini; Pramana, Triyanta Yuli
Jurnal Ilmiah Kesehatan (JIKA) Vol. 7 No. 3 (2025): Volume 7 Nomor 3 Desember 2025
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v7i3.1431

Abstract

Chronic kidney disease (CKD) is a major global health burden, with oxidative stress and hypertension contributing significantly to its progression. Although vitamin D3 is known for its pleiotropic effects, its influence on oxidative stress markers in obstructive nephropathy remains unclear. This study evaluated the effect of vitamin D3 supplementation on blood pressure, malondialdehyde (MDA) levels, and superoxide dismutase (SOD) activity in a rat model of CKD induced by Unilateral Ureteral Obstruction (UUO). In this experimental post-test-only control group study, 30 male white rats (Rattus norvegicus) were randomly assigned to five groups (n = 6 per group) following UUO induction: one control group (placebo) and four treatment groups receiving graded oral doses of vitamin D3 (36, 72, and 108 IU/rat) daily for 14 days. Blood pressure was measured using the tail-cuff method, and serum MDA levels and SOD activity were analyzed at the end of the treatment period. Vitamin D3 supplementation produced significant, dose-dependent improvements in all parameters (p-value < 0,01). Compared with controls, treated groups showed lower blood pressure, reduced MDA levels, and increased SOD activity. The highest dose (108 IU/rat) demonstrated the greatest reduction in oxidative stress and blood pressure. This study aimed to evaluate whether vitamin D3 supplementation ameliorates hypertension and oxidative stress in UUO-induced CKD in rats, supporting its potential as an adjunctive strategy to slow CKD progression. Further studies are required to confirm clinical applicability.
Antibacterial Extract of Red Dragon Fruit (Hylocereus polyrhizus) Peel Extract against ESBL-Producing Klebsiella pneumoniae Rivaldy, Naufal; Kartika, Andy Visi; Karim, Marzelina; Sodiqah, Yani; Anggita, Dwi
Jurnal Ilmiah Kesehatan (JIKA) Vol. 7 No. 3 (2025): Volume 7 Nomor 3 Desember 2025
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v7i3.1560

Abstract

The rising prevalence of infections caused by Extended-Spectrum Beta-Lactamase (ESBL)-producing Klebsiella pneumoniae necessitates the search for alternative antibacterial agents. Red dragon fruit (Hylocereus polyrhizus) peel is a potential source of bioactive compounds. This study aimed to evaluate the in vitro antibacterial activity of red dragon fruit peel extract against ESBL-producing K. pneumoniae. The bacteria were isolated and identified via culture on MacConkey agar, Gram staining, and biochemical tests. The peel was extracted using 96% ethanol via maceration. Antibacterial activity was assessed using the disk diffusion method on Mueller-Hinton agar with extract concentrations of 20%, 40%, 60%, 80%, and 100% (v/v), with three replicates per concentration. Meropenem (10 µg) and DMSO served as positive and negative controls. The extract exhibited concentration-dependent antibacterial activity, with mean inhibition zone diameters increasing from 5,6 ± 0,3 mm at 20% to 6,1 ± 0,2 mm at 100%. The positive control produced a 30,2 ± 0,5 mm zone, while the negative control showed no inhibition. One-way ANOVA confirmed significant differences between groups (p-value < 0,05). Red dragon fruit peel extract demonstrated promising in vitro antibacterial activity against ESBL-producing K. pneumoniae, although its potency was considerably lower than meropenem.
Evaluation of Mangosteen Peel Extract as a Substitute for Eosin 2% in Ascaris lumbricoides Egg Staining Nastiti, Hilari Rio Rosa; Widiyanto, SY Didik; Rosidah, Umi; Rokhani, Latifah Intan; Wahyuni, Sri; Handayani, Sih Rini
Jurnal Ilmiah Kesehatan (JIKA) Vol. 7 No. 3 (2025): Volume 7 Nomor 3 Desember 2025
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v7i3.1690

Abstract

Parasitic helminth infections remain a major public health problem in Indonesia, particularly among school-aged children. Tropical climatic conditions contribute to the high prevalence of Ascaris lumbricoides infection in endemic areas. Microscopic examination of helminth eggs commonly uses synthetic dyes such as eosin 2%; however, synthetic stains may pose potential health and environmental risks. This study aimed to evaluate the potential of mangosteen peel extract from Purbalingga (Garcinia mangostana L.) as a natural alternative stain for A. lumbricoides eggs. Mangosteen peel extract was tested at concentrations of 50%, 65%, and 80%, with eosin 2% used as a control. Staining quality was evaluated comparatively based on background contrast and clarity of egg morphology. The results showed that extract concentrations of 50% and 65% produced suboptimal visualization of A. lumbricoides eggs, whereas the 80% concentration provided better staining quality and clearer egg morphology, comparable to eosin 2%. Post hoc analysis demonstrated a significant difference between the eosin 2% control and the 50% extract concentration (p-value <0,001), while no significant differences were observed between eosin 2% and the 65% (p-value = 0,571) or 80% (p-value = 1,000) extract concentrations. These findings indicate that mangosteen peel extract at an 80% concentration has potential as a natural alternative stain to assist microscopic visualization of A. lumbricoides eggs. However, further studies are required to evaluate the reproducibility and chemical stability of the extract before its broader application in diagnostic parasitology laboratories.
Bioinformatics Analysis of Potential Targets of Betulinic Acid Against Virulence Factors of Chlamydia trachomatis Nurani, Erla; Roza, Putri Diana; Darmawi, Darmawi; Irham, Lalu Muhammad; Adikusuma, Wirawan; Anggraini, Dewi
Jurnal Ilmiah Kesehatan (JIKA) Vol. 7 No. 3 (2025): Volume 7 Nomor 3 Desember 2025
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v7i3.1465

Abstract

Chlamydia trachomatis is an obligate intracellular pathogen responsible for trachoma and sexually transmitted infections, with rising antibiotic resistance posing a major therapeutic challenge. Natural compounds such as betulinic acid, a pentacyclic triterpenoid with broad-spectrum antimicrobial and anti-inflammatory properties, offer potential as alternative therapeutic agents. This study aimed to analyze the potential targets of betulinic acid against C. trachomatis virulence factors using bioinformatics approaches. Protein–compound interaction prediction was performed using STITCH v5.0, while virulence classification was analyzed through VICMpred and VirulentPred. BepiPred v2.0 was employed to identify B-cell epitopes, and PSORTb v3.0 was used to predict subcellular localization. The results identified five proteins targeted by betulinic acid, including DNA topoisomerase IV subunit B (parE), DNA topoisomerase IV subunit A (parC), DNA gyrase subunits (gyrA and gyrB), and sulfite reductase (cysJ). Among these, three were classified as virulence factors: parE (0,2959), parC (0,1754), and cysJ (0,4018). Subcellular localization analysis showed that parE and parC are cytoplasmic proteins essential for DNA replication, while cysJ is associated with the cytoplasmic membrane and metabolic processes. Betulinic acid showed strong potential as an antimicrobial compound targeting key virulence proteins of C. trachomatis. These findings provide foundational insight for further experimental studies to develop betulinic acid–based therapeutic strategies against chlamydial infections.
Analysis of Determinants of Hearing Health Based on Audiometric Examination in Boat Miners irawati, Ice; Sari, Chinta Yolanda; Maulina, Diina
Jurnal Ilmiah Kesehatan (JIKA) Vol. 7 No. 3 (2025): Volume 7 Nomor 3 Desember 2025
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v7i3.1536

Abstract

Boat miners at Sagulung Port, Batam City face the risk of high noise exposure from boat engines that can affect hearing health. This study analyzed the determinants of hearing loss among 30 boat miners at Sagulung Port, Batam City, using a quantitative analytic cross-sectional design. Through audiometric examinations and noise measurements, the research found significant relationships between hearing loss and age (p-value = 0,015; PR = 4,24), exposure duration (p-value <0,001; PR = 5,34), and noise intensity (p-value <0,001; PR = 8,5). Multivariate and Poisson regression analyses identified noise intensity as the dominant determinant (p-value <0,001; PR = 0,926), revealing that subjects exposed to noise within safe Threshold Limit Values (NAB) had a 7,4% lower prevalence of hearing loss than those exposed to unsafe levels. Conversely, the length of service did not show a significant individual relationship (p-value = 0,216; PR = 1,50). The study concludes that high occupational noise significantly impacts hearing health, leading to recommendations for mandatory ear protection, regulated working hours, and targeted safety education to mitigate permanent auditory damage among boat miners.
Multidrug Resistance and Invasive Medical Device Use with Staphylococcus aureus Biofilm Formation in Riau Mansyar, Putri Purnama Sari; Nuryastuti, Titik; Anggraini, Dewi
Jurnal Ilmiah Kesehatan (JIKA) Vol. 7 No. 3 (2025): Volume 7 Nomor 3 Desember 2025
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v7i3.1608

Abstract

Staphylococcus aureus (S. aureus) infection is a major cause of healthcare-associated infections, particularly among patients using invasive medical devices. These devices provide surfaces for bacterial adhesion and biofilm formation, a key mechanism that enhances antibiotic resistance, especially in multidrug-resistant (MDR) strains. This study aimed to analyze the association between MDR status and invasive medical device use with biofilm formation in clinical isolates of S. aureus at Arifin Achmad General Hospital, Riau Province. This was an analytic-observational study with a cross-sectional design involving 44 clinical isolates of S. aureus collected from patients between January and April 2025. Biofilm formation was assessed using the Microtiter Plate Assay (MtPA), and antibiotic susceptibility testing was conducted using the Vitek 2 System. Demographic and clinical data of the subjects, such as gender, age, and use of invasive medical devices, were obtained from medical records. The relationship was analyzed using the Chi-square test. The results showed that out of 44 clinical isolates of S. aureus, 29 isolates (65,91%) were capable of forming biofilm. There was a significant association between MDR status (p-value = 0,026) and the use of invasive medical devices (p-value = 0,019) with biofilm formation (p-value < 0,05). These findings indicate that MDR status and the use of invasive medical devices may contribute to the increased ability of S. aureus clinical isolates to form biofilms. Therefore, strengthening infection control measures and rationalizing the use of invasive medical devices are essential to prevent persistent infections that are difficult to treat due to biofilm formation.

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