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Proceeding of Mulawarman Pharmaceuticals Conferences
Published by Universitas Mulawarman
ISSN : -     EISSN : 26144778     DOI : https://doi.org/0.30872/mpc
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
LINGKUP DAN TUJUAN Lingkup naskah mencakup bidang ilmu: Kimia Farmasi Biologi Farmasi Farmakologi Teknologi Farmasi dan Farmasetika Farmasi Klinik dan Komunitas Kedokteran dan Bidang ilmu lain yang terkait Tujuan penerbitan adalah memberikan informasi ilmiah tentang perkembangan ilmu pengetahuan dan teknologi bidang Farmasi dan yang terkait
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 34 Documents
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Search results for , issue "Vol. 18 (2023): Proc. Mul. Pharm. Conf." : 34 Documents clear
Level of Knowledge, Attitudes and Behavior towards Antibiotic Resistance and Use in The Community in Kota Bangun Seberang Village Riska Febriyanti; Nur Masyithah Zamruddin; Adam M. Ramadhan
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 18 (2023): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v18i1.693

Abstract

Antibiotics are highly used drugs in Indonesia to treat infections. However, low public knowledge about antibiotics leads to their inappropriate use. Inappropriate use of antibiotics will eventually increase health problems in the form of resistance. This study aims to determine the level of knowledge, attitudes and behavior towards resistance and the use of antibiotics in the community in Kota Bangun Seberang. The method used in this research is observational analysis with cross sectional study approach. Data collection was conducted by interviews using questionnaires consisting of questions about resistance and antibiotic use. Sample collection of 80 people using purposive sampling technique. Data were analyzed univariately and bivariately using the Spearman correlation test. The results showed that the majority of respondents' knowledge level was in the good category at 55%, the majority of respondents' attitudes were in the moderate category at 47.5%, and the majority of respondents' behavior was in the good category at 51.25%. Spearman correlation test showed that there was no correlation between the level of knowledge and attitude, as well as the relationship between attitude and behavior of respondents regarding antibiotic resistance and use (sig > 0.01), and there was a very strong positive correlation between the level of knowledge and antibiotic use behavior of respondents (sig < 0.01).
Profil Fitokimia dan Uji Aktivitas Antibakteri Ekstrak Kulit Buah Nanas (Ananas comosus (L.) Merr): Phytochemical Profile and Antibacterial Activity Test of Pineapple Peel Extract (Ananas comosus (L.) Merr) Aisyah Mursidah; Supriatno Salam; Risna Agustina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 18 (2023): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v18i1.695

Abstract

Pineapple (Ananas comosus (L.) Merr) is one of the plants that is widely consumed by the public. However, the use of pineapple fruit is mostly for the flesh of the fruit, while the skin of the fruit is thrown away and becomes waste. In fact, pineapple skin contains many chemical compounds that can be used because they have properties. The aim of this research was to determine the secondary metabolite compounds and antibacterial activity of pineapple peel. The results showed that pineapple peel extract was positive for containing flavonoids, alkaloids, tannins and phenolics, while the negative results contained saponins, steroids and triterpenoids. Pineapple peel extract has moderate to very strong antibacterial activity with the diameter of the inhibition zone at concentrations of 5%, 10%, 15% and 20% respectively being 11.69; 14.88; 17.51; 22.01 mm against Staphylococcus aureus bacteria and 9.79;13.09;16.48;18.46 mm against Propionibacterium acnes bacteria. Keywords: Pineapple peel, antibacterial, Staphylococcus aureus, Propionibacterium acnes Abstrak Buah Nanas (Ananas comosus (L.) Merr) adalah salah satu tanaman yang banyak dikonsumsi oleh masyarakat. Namun pemanfaatan buah nanas lebih banyak pada daging buahnya saja sedangkan kulit buahnya dibuang dan menjadi limbah. Padahal di dalam kulit buah nanas banyak terkandung senyawa kimia yang dapat dimanfaatkan karena memiliki khasiat. Tujuan penelitian ini adalah untuk mengetahui senyawa metabolit sekunder dan aktivitas antibakteri dari kulit buah nanas. Hasil penelitian menunjukkan ekstrak kulit buah nanas positif mengandung flavonoid, alkaloid, tanin dan fenolik, sedangkan hasil negatif mengandung saponin, steroid dan triterpenoid. Ekstrak kulit buah nanas memiliki aktivitas antibakteri dengan kategori sedang hingga sangat kuat dengan diameter zona hambat pada konsentrasi 5%, 10%, 15% dan 20% secara berturut-turut adalah 11,69;14,88;17,51;22,01 mm terhadap bakteri Staphylococcus aureus dan 9,79;13,09;16,48;18,46 mm terhadap bakteri Propionibacterium acnes. Kata Kunci: Kulit nanas, antibakteri, Staphylococcus aureus, Propionibacterium acnes
Analisis Karakteristik Dismenore pada Remaja Putri: Analysis of the Characteristics of Dysmenorrhea in Adolescent Girls Alfenia Rahmayanti; Fahriani Iatiqamah Jafar; Laode Rijai
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 18 (2023): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v18i1.696

Abstract

Menstrual pain or dysmenorrhea is pain felt during menstruation so that it can interfere with a woman's daily activities. Usually women experience discomfort during menstruation, such as cramps and are usually accompanied by nausea and dizziness. The aim of this research is to determine the characteristics of young women who experience dysmenorrhea at SMKN 1 Muara Bengkal. This research is descriptive in nature with an observation method. It was found that the incidence of dysmenorrhea occurred most frequently in respondents who were 16 years old at 36.67%, at menarche age 12-13 years at 63.33%, with a duration of menstrual pain of 1 day at 40.00%, respondents did not take care of the pain. amounted to 66.67%, respondents with symptoms of dizziness amounted to 60.00%, and it was found that 76.67% of respondents said that menstrual pain could affect activities. So it can be concluded that there is no relationship between age, age of menarche, duration of menstrual pain, treatment during menstrual pain, other symptoms during dysmenorrhea which can influence the occurrence of dysmenorrhea. Keywords: Menstruation, dysmenorrhea, menstrual pain, teenage girls Abstrak Nyeri haid atau dismenore adalah nyeri yang dirasakan pada saat menstruasi sehingga dapat mengganggu aktifitas sehari-hari wanita. Biasanya wanita mengalami rasa yang tidak nyaman pada saat menstruasi, seperti keram dan biasanya disertai mual dan pusing. Tujuan penelitian ini untuk mengetahui gambaran karakteristik remaja putri yang mengalami dismenore di SMKN 1 Muara Bengkal. Penelitian ini bersifat deskriptif dengan metode observasi. Diperoleh hasil kejadian dismenore paling banyak terjadi pada responden yang memiliki 16 tahun sebesar 36,67%, memiliki usia menarche 12-13 tahun sebesar 63,33%, dengan durasi nyeri haid 1 hari sebesar 40,00%, responden tidak melakukan penanganan saat nyeri sebesar 66,67%, responden dengan gejala pusing sebesar 60,00%, dan didapatkan responden sebesar 76,67% mengatakan bahwa nyeri haid dapat mempengaruhi aktivitas. Sehingga dapat disimpulkan bahwa tidak ada hubungan antara usia, usia menarche, durasi nyeri haid, penanganan saat nyeri haid, gejala lain saat dismenore yang dapat mempengaruhi terjadinya dismenore. Kata Kunci: Menstruasi, dismenore, nyeri haid, remaja putri
Pengaruh Kemoterapi terhadap Kadar Hematologi pada Pasien Kanker Payudara di RSUD dr. Kanujoso Djatiwibowo Balikpapan: The Effect of Chemoterapy on Hematological Levels in Breast Cancer Patients at RSUD dr. Kanujoso Djatiwibowo Balikpapan Annisa Nabilah; Wisnu Cahyo Prabowo; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 18 (2023): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v18i1.697

Abstract

Breast cancer is a malignant disease of breast tissue that can originate from the duct epithelium or lobules. Breast cancer therapy can be done with several types of therapy, one of which is chemotherapy. The most common side effect of chemotherapy is myelosuppression, a decrease in blood cell levels because chemotherapy agents are toxic to blood-forming organs. This research was conducted to understand the effect of chemotherapy in reducing blood cell levels in breast cancer patients who received chemotherapy at RSUD dr. Kanujoso Djatiwibowo Balikpapan for the period July 2022 to June 2023. This research is descriptive with a cross-sectional design. Of the 82 samples, 50 patients (60%) had erythrocyte levels below normal; hemoglobin in 79 patients (96%); hematocrit in 75 patients (91%); neutrophils in 20 patients (24%); leukocytes in 25 patients (30%); and thrombocytes in 7 patients (9%). The most common hematological levels below normal are hemoglobins and hematocrits. Keywords: ca mamae, hematology, mielosuppresion Abstrak Kanker payudara merupakan penyakit keganasan pada jaringan payudara yang dapat berasal dari epitel duktus maupun lobulusnya. Terapi kanker payudara dapat dilakukan dengan beberapa macam terapi, salah satunya adalah kemoterapi. Efek samping kemoterapi yang paling umum adalah mielosupresi yaitu penurunan kadar sel darah karena agen kemoterapi bersifat toksik terhadap organ pembentuk darah. Penelitian ini dilakukan untuk mengetahui gambaran pengaruh kemoterapi dalam menurunkan kadar sel darah pasien kanker payudara yang menerima kemoterapi di RSUD dr. Kanujoso Djatiwibowo Balikpapan periode Juli 2022 sampai Juni 2023. Penelitian ini bersifat deskriptif dengan desain cross-sectional. Dari 82 sampel, pasien dengan kadar eritrosit dibawah normal sebanyak 50 pasien (60%); hemoglobin 79 pasien (96%); hematokrit 75 pasien (91%); neutrofil 20 pasien (24%); leukosit 25 pasien (30%); dan trombosit 7 pasien (9%). Kadar hematologi di bawah normal paling banyak adalah hemoglobin dan hematokrit. Kata Kunci: kanker payudara, hematologi, mielosupresi
Skrining Fitokimia dan Optimasi Basis Spray Gel Ekstrak Etanol Kulit Bawang Putih (Allium sativum L.) sebagai Anti Jerawat: Phytochemical Screening and Optimization of Garlic Peel (Allium sativum L.) Ethanol Extract Gel Spray Base as Anti-Acne Brilian Dwisaputra Bandu; Maria Almeida; Laode Rijai
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 18 (2023): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v18i1.698

Abstract

Spray gel is topical pharmaceutical preparations that can last long when sprayed on the skin. Because without physical contact, this preparation can reduce waste and the risk of developing skin diseases. The purpose of this study are determine the secondary metabolite content of garlic skin extract and obtain the optimal spray gel base. This study begins with the extraction of samples using 70% ethanol. Then qualitative phytochemical screening was conducted. Spray gel base optimization was carried out by varying the concentration of carbopol where F1(0,1%), F2(0,2%) and F3(0,3%) were then evaluated. The results of this study are garlic skin extract contains alkaloids, flavanoids, saponins and tannins. While the results of the base evaluation are in the organoleptic test all bases form are slightly cloudy in color, odorless and liquid, not sticky and has no air bubbles. All base formulas have been homogeneous, attached and spread, the range of the pH are 8.67-9.80 and the results of the viscosity test is range of average viscosity are 33.33-780 dPa.s. In this study, it can be concluded that garlic skin extract contains alkaloid, flavanoid, saponin and tannin that have potential as anti acne and the optimum carbopol concentration for spray gel base is 0,2%. Keywords: Phytochemical Screening, Allium sativum L., Spray Gel, Anti Acne Abstrak Spray gel termasuk kedalam sediaan topikal farmasi yang dapat bertahan lama ketika disemprotkan pada kulit, karna tanpa adanya kontak fisik sediaan ini dapat mengurangi limbah dan risiko terkena penyakit kulit seperti jerawat. Tujuan dari penelitian ini adalah untuk mengetahui kandungan metabolit sekunder dari ekstrak etanol kulit bawang putih dan mendapatkan basis optimal spray gel. Penelitian ini diawali dengan ekstraksi sampel menggunakan pelarut etanol 70%. Kemudian dilakukan skrining fitokimia secara kualitatif. Optimasi basis spray gel dilakukan dengan memvariasikan konsentrasi bahan pembentuk gel (karbopol) dimana F1(0,1%), F2(0,2%) dan F3(0,3%) yang kemudian dievaluasi. Hasil dari penelitian ini adalah ekstrak kulit bawang putih mengandung alkaloid, flavanoid, saponin dan tanin. Sedangkan hasil dari evaluasi basis adalah pada uji organoleptik dari semua basis didapatkan sediaan berwarna agak keruh, tidak berbau dan berbentuk cairan, tidak lengket serta tidak memiliki gelembung udara. Semua formula basis telah homogen, melekat dan menyebar, memiliki pH dengan rentang 8,67-9,80 dan hasil dari uji viskositas didapatkan hasil berupa rata-rata kekentalan sediaan 33,33-780 dPa.s. Pada penelitian ini dapat disimpulkan bahwa ekstrak etanol kulit bawang putih mengandung senyawa alkaloid, flavanoid, saponin dan tanin yang berpotensi sebagai anti jerawat serta konsentrasi karbopol yang optimum untuk sediaan spray gel ekstrak etanol kulit bawang putih adalah 0,2%. Kata Kunci: Skrining Fitokimia, Allium sativum L., Spray Gel, Anti Jerawat
Formulasi Sediaan Lip cream Ekstrak Etanol Bunga Asoka (Ixora coccinea) sebagai Pewarna Alami: Formulation of Lip cream from Ethanol Extract of Asoka Flower (Ixora coccinea) as a Natural Dye Chintiya Vera Nanda; Dwi Elfira Kurniati; Niken Indriyanti
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 18 (2023): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v18i1.699

Abstract

Asoka flower (Ixora coccinea) possesses pigments that can be used as natural colorants in decorative cosmetics. The use of natural colorants in decorative cosmetics is still limited and the demand for decorative cosmetics especially lip cream is increasing. This research aims to determine whether ethanol extract of Asoka flowers can be used as an alternative natural colorant in lip cream formulations. This research began with extraction of Asoka flowers using maceration method with 96% ethanol solvent and citric acid. Base was optimized using a single thickener and combination of carnauba wax and candelilla wax. Base was evaluated and formulated with flower extract. The formulation quality was determined through organoleptic, homogeneity, spreadability, adhesion, viscosity, and pH tests. The extraction results yielded a yield of 27,1%. Best base was bases F3, F4, and F5. Formulations using Asoka flower extract with 2%, 4%, and 6% produced sequentially light brown, reddish-brown, and red colors. F3 produces the best color at pH 4.6. The evaluation results include the distinctive aroma of chocolate, semi-solid consistency, homogeneity, spreadability, adhesion, viscosity, and pH that meet the pharmaceutical requirements. In conclusion, ethanol extract from Asoka flowers can be utilized as a natural colorant in lip cream formulations. Keywords: Ixora coccinea, Natural Colorants, Lip cream, Carnauba wax, Candelilla wax Abstrak Bunga asoka (Ixora coccinea) memiliki pigmen warna yang dapat digunakan sebagai pewarna alami pada kosmetik dekoratif. Namun penggunaan pewarna alami pada kosmetik dekoratif masih kurang dan permintaan penggunaan kosmetik dekoratif terutama lip cream semakin meningkat. Penelitian ini bertujuan untuk mengetahui apakah ekstrak etanol bunga asoka dapat digunakan sebagai alternatif pewarna alami pada sediaan lip cream. Penelitian ini diawali dengan ekstraksi bunga asoka dengan metode maserasi dengan pelarut etanol 96% dan asam sitrat. Lalu dilakukan optimasi basis dengan pengental tunggal dan kombinasi berupa carnauba wax dan candelilla wax. Basis dievaluasi dan diformulasikan dengan ekstrak bunga asoka. Kualitas sediaan ditentukan melalui uji organoleptis, uji homogenitas, uji daya sebar, uji daya lekat, uji viskositas dan uji pH. Hasil ekstraksi didapatkan rendemen sebesar 27,1%. Formula basis terbaik yaitu F3, F4, dan F5. Sediaan dengan ekstrak bunga asoka konsentrasi 2%, 4%, dan 6% menghasilkan warna berturut-turut coklat muda, coklat kemerahan, dan merah. F3 menghasilkan warna terbaik dengan pH 4,6. Hasil evaluasi karakteristik fisik seluruh sediaan meliputi aroma khas coklat, konsistensi semipadat, homogen serta memiliki daya sebar, daya lekat, viskositas, dan pH yang memenuhi persyaratan evaluasi sediaan lip cream. Disimpulkan bahwa ekstrak etanol bunga asoka dapat digunakan sebagai pewarna alami pada sediaan lip cream. Kata Kunci: Ixora coccinea, Pewarna Alami, Lip cream, Carnauba wax, Candelilla wax
Analisis Kadar Flavonoid Total Ekstrak Etanol Daun Kelakai Merah (Stenochlaena palustris (Burm F.) Bedd) Berbantu Ultrasonik: Analysis of Total Flavonoid Content in Ethanol Extract of Kelakai Merah Leaves (Stenochlaena palustris (Burm F.) Bedd) Assisted by Ultrasonication Chisilia Brydhita Karangan; Wisnu Cahyo Prabowo; Risna Agustina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 18 (2023): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v18i1.700

Abstract

Kelakai merah is a typical plant of Kalimantan that is widely used for medicinal purposes. This plant is reported to contain numerous secondary metabolite compounds, including phenolic and flavonoid compounds. This research aims to determine the flavonoid content of the ethanol extract of red kelakai leaves (Stenochlaena palustris (Burm F.) Bedd) extracted using ultrasonic assistance. Ultrasonic-assisted extraction was carried out with variations in time (5, 10, 15, 20, and 25 minutes) and temperature (20, 30, 40, 50, and 60°C). The extract obtained during the ultrasonic-assisted extraction process was then measured for flavonoid content using the spectrophotometry method. The research results showed the highest yield of the extraction process at a temperature variation of 60°C with a time of 20 minutes (20%). The highest flavonoid content was obtained at a temperature variation of 50°C with a time of 25 minutes (51.86 ppm quercetin in 100 mg of extract). This study provides evidence that ultrasonication can be used as an effective method for extracting total flavonoids from red kelakai leaves, which have the potential for applications in the development of herbal and pharmaceutical products based on this plant material. Keywords: Kelakai merah, Extraction, Ultrasonic, Flavonoid Abstrak Kelakai merah merupakan tanaman khas kalimantan yang banyak digunakan sebagai obat. Tanaman ini dilaporkan memiliki banyak kandungan senyawa metabolit sekunder diantaranya senyawa golongan fenolik dan flavonoid. Penelitian ini bertujuan untuk mengetahui kadar flavonoid dari ekstrak etanol daun kelakai merah (Stenochlaena palustris (Burm F.) Bedd) yang diekstraksi dengan menggunakan bantuan gelombang ultrasonik. Ekstraksi berbantu ultrasonik dilakukan dengan variasi waktu (5, 10, 15, 20 dan 25 menit) dan suhu (20, 30, 40, 50 dan 60°C). Ekstrak yang diperoleh pada proses ekstraksi berbantu ultrasonik kemudian diukur kadar flavonoid menggunakan metode spektrofotometri. Hasil penelitian menunjukkan rendemen terbesar proses ekstraksi terdapat pada variasi suhu 60°C dengan waktu 20 menit (15%). Kadar flavonoid tertinggi diperoleh pada variasi suhu 50°C dengan waktu 25 menit (2,56%). Penelitian ini memberikan bukti bahwa ultrasonik dapat digunakan sebagai metode yang efektif untuk mengekstraksi flavonoid total dari daun kelakai merah, yang memiliki potensi aplikasi dalam pengembangan produk-produk herbal dan farmasi yang berbasis pada bahan tumbuhan ini. Kata Kunci: Kelakai merah, Ekstraksi, Ultrasonik, Flavonoid
Pola Pengobatan pada Pasien Malaria di Rumah Sakit Umum Daerah (RSUD) Timika, Kabupaten Mimika: Treatment Patterns in Malaria Patients in Timika General Hospital Christin Claritha Mote; Sabaniah Indjar Gama; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 18 (2023): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v18i1.701

Abstract

Malaria is a contagious disease caused by the parasite Plasmodium (class Sporozoa) which attacks red blood cells in the human body, malaria is very high in endemic areas, one of which is in Papua Province, especially in Mimika Regency. This study aims to determine the characteristics and treatment patterns in inpatient malaria patients at Timika Hospital, Mimika Regency in the January-December 2022 period. The method used in the study was a descriptive non-experimental study with retrospective data collection of 100 medical record data of hospitalized malaria patients who met the inclusion criteria. The results showed that the male sex was more dominant than women with a total of 53 people. At the most dominant age, namely the age of 12-25 years, malaria becomes dominant with 25 people. Then in the most dominant job, namely students, became the main target of malaria infection as many as 25 people. Falciparum (tropical) malaria became dominant because the most cases of falsiparum malaria in Papua were 52 people. DHP (Dihydroartemisinin-piperaquine) treatment as many as 94 people, and artesunate as many as 98 people. For drug administration, proper dosage, and time administration, all in accordance with the management of the Ministry of Health. Keywords: Treatment pattern, patient Characteristics Abstrak Malaria merupakan penyakit yang menular disebabkan oleh parasit Plasmodium (kelas Sporozoa) yang menyerang sel darah merah pada tubuh manusia, malaria sangat tinggi di daerah endemik salah satunya dipropinsi papua kususnya dikabupaten mimika. Penelitian ini bertujuan untuk mengetahui karakteristik dan pola pengobatan pada pasien malaria rawat inap RSUD Timika Kab.Mimika pada periode januari-desember 2022. Metode yang digunakan pada penelitian yaitu studi non eksperimental secara deskriptif dengan pengambilan data secara retrospektif terhadap 100 data rekam medik pasien malaria rawat inap yang memenuhi kriteria inklusi. Hasil penelitian menunjukan bahwa pada jenis kelamin laki-laki lebih dominan di banding perempuan dengan jumlah 53 orang. Pada usia yang paling dominan yaitu usia 12-25 tahun menjadi dominan terkena malaria degan jumlah 25 orang. Kemudin pada pekerjaan yang paling dominan yaitu Pelajar menjadi target utama terinfeksi malaria sebanyak 25 orang. Malaria falciparum (tropika) menjadi dominan karena kasus malaria falsiparum terbanyak dipapua sebanyak 52 orang. Pengobatan DHP (Dihydroartemisinin-piperaquine) sebanyak 94 orang, dan artesunat sebanyak 98 orang. Untuk pemberian obat, tepat dosis, dan pemberian waktu, semua sesuai dengan penatalaksaan depkes. Kata Kunci: Pola Pengobatan, Karakteristik Pasien
Hubungan Pelayanan Informasi Obat dengan Pengetahuan dan Tingkat Kepatuhan Pasien Hipertensi di Puskesmas Kerang Kecamatan Batu Engau: The Relationship between Drug Information Services and the Knowledge and Level of Compliance of Hypertension Patients at the Kerang Community Health Center, Batu Engau District Dayuh Anggun Mandalika; Herman Herman; Nisa Naspiah
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 18 (2023): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v18i1.702

Abstract

The World Health Organization (WHO) states that hypertension is an increase in systolic pressure greater than or equal to 160 mmHg and/or diastolic pressure equal to or greater than 95 mmHg. According to data obtained from the Kerang health center for the 2022-2023 period, the total prevalence at the health center was 5,393 with a total population of 12,902. One way to overcome hypertension is to increase patient knowledge and compliance with treatment by providing Drug Information Services. The aim of this research is to determine the characteristics, knowledge and level of compliance, determine drug information services and determine the relationship between drug information services and the knowledge and level of compliance of hypertensive patients. The method used is observational analysis with data collection using a prospective approach using medical record data and interview results. The results of the research on the characteristics of the majority of patients were in the late adult phase, 25.4%, 70.1% were female, 59.7% had elementary school education and 64% worked as housewives. The level of compliance of hypertensive patients is still low with a percentage of 59.80% and the level of knowledge of hypertensive patients is also in the low category with a percentage of 52.24%. Drug information services that are often provided only include the name of the drug, preparation, dosage, how to use, storage and side effects. and a significant value was obtained for the Knowledge Level with a correlation value of 0.344 and the Compliance Level with a correlation value of 0.649. Keywords: Hypertension; Drug Information Services; Compliance and Knowledge Abstrak Salah satu cara untuk menanggulangi hipertensi adalah meningkatkan pengetahuan dan kepatuhan pasien dalam pengobatan dengan cara pemberian Pelayanan Informasi Obat. Tujuan penelitian ini untuk mengetahui karakteristik, pengetahuan dan tingkat kepatuhan, mengetahui pelayanan informasi obat serta mengetahui hubungan pelayanan informasi obat dengan pengetahuan dan tingkat kepatuhan pasien hipertensi. Metode yang digunakan adalah observasional analisis dengan pengambilan data secara pendekatan prospektif menggunakan data rekam medik dan hasil wawancara. Hasil penelitian karakteristik pasien mayoritas masuk fase dewasa akhir sebesar 25,4%, berjenis kelamin perempuan sebesar 70,1%, berpendidikan SD sebesar 59,7% dan berprofesi sebagai IRT sebanyak 64%. Tingkat kepatuhan pasien hipertensi masih rendah dengan presentase 59,80% dan tingkat pengetahuan pasien hipertensi juga termasuk kategori rendah dengan presentase 52,24%, pelayanan informasi obat yang sering diberikan hanya nama obat, sediaan, dosis, cara pakai, penyimpanan, dan efek samping dan diperoleh nilai signifikan pada Tingkat Pengetahuan nilai korelasi sebesar 0,344 dan Tingkat Kepatuhan dengan nilai korelasi sebesar 0,649. Kata Kunci: Hipertensi; Pelayanan Informasi Obat;Kepatuhan dan Pengetahuan
Uji Aktivitas Mukolitik dari Ekstrak Etanol Daun Sirsak (Annona muricata Linn) Menggunakan Mukosa Usus Sapi Secara In Vitro: Mucolytic Activity Test of Ethanol Extract of Soursop Leaf (Annona muricata Linn) Using Bovine Intestinal Mucosa In Vitro Dea Sefiana Putri; Fika Aryati; Angga Cipta Narsa
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 18 (2023): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v18i1.703

Abstract

Soursop leaves (Annona muricata Linn) are one of the traditional medicinal plants that have not been extensively studied for their use in cough medicine. Cough is a symptom of respiratory tract disorders and often causes discomfort. One example of a cough is a productive cough. Mucolytics are drugs that work by breaking down mucoprotein strands. This research aims to explore the potential of soursop leaf extract as a mucolytic and identify its active compound groups. The extraction method used is maceration with 70% ethanol. The test uses bovine intestinal mucosa with negative control using phosphate buffer, positive control using herbal medicine X, and the test group using soursop leaf extract with concentrations of 0.5%, 0.75%, and 1%. The viscosity of the test solution is measured with a Rion viscometer. Mucolytic activity is observed through the decrease in mucin viscosity. The research results show that soursop leaf extract at a concentration of 1% has mucolytic effects comparable to herbal medicine X as the positive control. Soursop leaf extract contains compounds such as alkaloids, flavonoids, tannins, and saponins. Keywords: Mucolytic, Soursop Leaf, Bovine Bowels Mucose Abstrak Daun sirsak (Annona muricata Linn) merupakan salah satu tanaman obat tradisional yang belum banyak diteliti penggunaannya sebagai obat batuk. Batuk merupakan gejala adanya gangguan pada saluran pernafasan dan seringkali menyebabkan rasa tidak nyaman. Salah satu contoh batuk yaitu batuk berdahak. Mukolitik merupakan obat yang bekerja dengan cara memecah benang-benang mukoprotein. Penelitian ini bertujuan untuk melihat potensi dari ekstrak daun sirsak sebagai mukolitik dan mengidentifikasi golongan senyawa aktifnya. Metode ekstraksi yang digunakan yaitu maserasi menggunakan etanol 70%. Pengujian ini menggunakan mukosa usus sapi dengan kontrol negatif berupa dapar posfat, kontrol positif berupa obat herbal X dan kelompok uji menggunakan ekstrak daun sirsak dengan konsentrasi 0,5%; 0,75% dan 1%. Viskositas larutan uji diukur dengan Viskometer rion. Aktivitas mukolitik dilihat dari penurunan nilai viskositas mukus. Hasil penelitian menunjukkan ekstrak daun sirsak pada konsentrasi 1% memberikan efek mukolitik yang sebanding dengan obat herbal X sebagai kontrol positif. Ekstrak daun sirsak mengandung senyawa golongan alkaloid, flavonoid, tanin dan saponin. Kata Kunci: Mukolitik, Daun Sirsak, Mukosa Usus Sapi

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