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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Indonesian Journal of Chemistry Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) JCRS (Journal of Community Research and Service) Jurnal Mandala Pharmacon Indonesia Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Sainstech Farma: Jurnal Ilmu Kefarmasian Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal Ilmiah Berkala: Sains dan Terapan Kimia Jurnal Pengabdian dan Pengembangan Masyarakat Indonesia Abdimas Indonesian Journal Journal of Pharmaceuticals and Natural Sciences al Kimiya : Jurnal Ilmu Kimia dan Terapan Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Jurnal Abdita Naturafarm Jurnal Riseta Naturafarm

Herman Herman

Fakultas Farmasi Universitas Mulawarman

Author-ID : 4140107

Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Identifikasi Golongan Metabolit Sekunder dan Aktivitas Antioksidan Eksstrak Daun Brotowali (Tinospora tuberculata Beumee) Lia Puspitasari; Laode Rijai; Herman Herman
SAINSTECH FARMA Vol 11 No 1 (2018): Sainstech Farma Jurnal Ilmu Kefarmasian
Publisher : FAKULTAS FARMASI, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Penelitian ini bertujuan untuk mengetahui golongan metabolit sekunder, aktivitas antioksidan, nilai IC50, ekstrak yang memiliki aktivitas terbaik sebagai antioksidan, serta mengetahui potensi antioksidan daun brotowali (Tinospora tuberculata Beumee) yang dibandingkan dengan kontrol positif (vitamin C). Penelitian ini menggunakan metode peredaman radikal bebas 1,1-diphenyl-2-picrylhidrazyl (DPPH), yang diujikan pada ekstrak kasar metanol (konsentrasi 50, 150, dan 250 ppm), ekstrak fraksi n-heksana (konsentrasi 300, 500, dan 700 ppm), dan ekstrak fraksi etil asetat (konsentrasi 100, 200, dan 300 ppm) daun brotowali (Tinospora tuberculata Beumee), serta kontrol negatif (pelarut metanol), dan kontrol positif (vitamin C). Hasil identifikasi golongan metabolit sekunder pada ekstrak kasar metanol dan ekstrak fraksi etil asetat yaitu alkaloid, karotenoid, fenol, tanin, steroid dan triterpenoid. Sementara pada ekstrak fraksi n-heksana yaitu alkaloid, karotenoid, steroid dan triterpenoid. Nilai IC50 masing-masing sampel antara lain: ekstrak kasar metanol 184,76 ppm; ekstrak fraksi n-heksana 1173,40 ppm; ekstrak fraksi etil asetat 910,60 ppm. Hasil pengujian aktivitas antioksidan diketahui bahwa ekstrak yang memiliki aktivitas antioksidan terbaik adalah ekstrak kasar metanol pada konsentrasi 250 ppm. Pada pengujian potensi diperoleh kesimpulan bahwa potensi antioksidan ekstrak kasar metanol daun brotowali tidak berbeda nyata dengan vitamin C.

Optimizing Natural Deep Eutectic Solvent Citric Acid-Glucose Based Microwave-Assisted Extraction of Total Polyphenols Content from Eleutherine bulbosa (Mill.) Bulb Bohari Yusuf; Selvi Jumiatul Astati; Mirhansyah Ardana; Herman Herman; Arsyik Ibrahim; Laode Rijai; Firzan Nainu; Islamudin Ahmad
Indonesian Journal of Chemistry Vol 21, No 4 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.58467

Application of natural deep eutectic solvent (NADES) citric acid-glucose-based microwave-assisted extraction (MAE) method for total polyphenol content (TPC) enriches the use of Eleutherine bulbosa (Mill.) bulb more widely and commercially. Therefore, this study aims to optimize NADES citric acid-glucose-based MAE on the TPC from E. bulbosa bulbs using response surface methodology (RSM). In the present study, the dried sample of E. bulbosa bulb was extracted using the NADES based MAE. Determination of TPC was conducted using Folin-Ciocalteau reagent and standard gallic acid, then measured using a UV-Vis spectrophotometer at 761 nm. Extraction condition optimization of the NADES based MAE method was performed using RSM with Box Behnken Design (four-factors-three-levels and 29 runs) on Design Expert v12. Based on the results study, the optimum condition extraction on the TPC enrichment was obtained at the NADES ratio (citric acid: glucose) 1:1 g/g; solid-liquid ratio 1:8 g/mL; extraction time of 15 min; and 270 Watt microwave power. The confirmation test and scale-up (50 g samples) were obtained with a 61.63 ± 2.23 mg GA/g sample.

OPTIMASI METODE EKSTRAKSI BERBANTU MIKROWAVE DENGAN PELARUT HIJAU (ASAM SITRAT-GLUKOSA) TERHADAP KADAR POLIFENOL TOTAL DARI DAUN KADAMBA (Mitragyna speciosa Korth. Havil) MENGGUNAKAN RESPONSE SURFACE METHODOLOGY Islamudin Ahmad; Wisnu Cahyo Prabowo
Majalah Farmasi dan Farmakologi Vol. 24 No. 1 (2020): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Kadamba (Mitragyna speciosa Korth Havil) merupakan salah satu tumbuhan endemik di Asia Tenggara, di Indonesia, tumbuhan ini banyak di jumpai di pulau Kalimantan. Tumbuhan ini dipercaya oleh masyarakat dapat mengobati berbagai macam penyakit. Namun, karena kandungan alkaloidnya, tumbuhan ini dilarang digunakan sebagai bahan baku obat herbal oleh Badan Pengawas Obat dan Makanan. Oleh karena itu, perlu dilakukan pengembangan metode ekstraksi untuk menarik senyawa metabolit sekunder target dan meminimalkan senyawa yang tidak diinginkan yaitu dengan menggunakan metode ekstraksi berbantu mikrowave dengan pelarut hijau (Natural Deep Eutectic Solvent) yang dioptimasi menggunakan response surface methodology (RSM). Simplisia kering daun Kadamba diekstraksi menggunakan metode ekstraksi berbantu mikrowave dengan pelarut hijau (asam sitrat-glukosa) dengan berbagai kondisi ekstraksi dengan empat faktor dan tiga level (Box Behnken Design) yang dioptimasi menggunakan RSM dengan aplikasi perangkat lunak Design Expert versi 12 berlisensi. Penetapan kadar polifenol total dilakukan menggunakan reagen Folin-Ciocalteau dan diukur absorbansinya pada spektrofotometer UV-Vis pada panjang gelombang 770 nm, serta asam gallat sebagai standar. Berdasarkan hasil penelitian, diperoleh kondisi optimum pada perbandingan rasio pelarut NADES (asam sitrat : glukosa) 5:1 g/g, rasio pelarut-sampel sebesar 1:20 g/mL, waktu ekstraksi selama 20 menit dan kekuatan gelombang mikro sebesar 30% dengan kadar polifenol total prediksi sebesar 314,924 ±35,95 mg GAE/g sampel, sedangkan dari hasil proses verifikasi (scale-up confirmation) yaitu dengan meningkatkan jumlah sampel yang digunakan sebanyak sepuluh kali lipat dengan Kadar polifenol total diperoleh sebesar 427,12 ±35,95 mg GAE/g. Penelitian ini merupakan langkah awal dalam pengembangan metode ekstraksi untuk memperoleh senyawa target secara cepat, mudah, efisien, dan ramah lingkungan.

Standarisasi Ekstrak Umbi Bawang Tiwai (Eleutherine americana (Aubl.) Merr.) Asal Kalimantan Timur Aditya Fridayanti; Yurika Sastyarina; Herman Herman; Agung Rahmadani; Ganjar Firmansyah; Tri Woro Widyanti; Yuspian Nur; Hadi Kuncoro; Enggar Wijayanti
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 6 (2017): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Telah dilakukan standarisasi pada ekstrak etanol umbi bawang tiwai (Eleutherine americana (Aubl.). Merr). Hasil pengujian parameter spesifik menunjukkan organoleptik ekstrak kental, berwarna merah, tidak berbau dan memiliki rasa sedikit pahit, dengan kandungan senyawa larut air 25,36 ± 1,61 (%) dan senyawa larut etanol 11,52±1,87 (%) serta hasil kandungan senyawa marker ekstrak 0,002/g. Hasil pengujian parameter non spesifik ekstrak etanol 96% umbi bawang tiwai menunjukkan kadar abu total 0,90±0,35 (%), kadar abu tidak larut asam 0,78±0,25 (%), bobot jenis 0,9437±0,0012, kadar air 5,28±0,14%, sisa pelarut 1,019345±0,0001626% dan kadar fenol total 163,43 ppm. Pada ekstrak terdapat cemaran bakteri 3,5 x 104 koloni/gram dan cemaran kapang khamir sejumlah 3,0 x 103 koloni/gram. Pengujian cemaran logam berat diperoleh kadar timbal 0,0105 mg/mL, kadmium 0,0318 mg/L dan arsen 0,0412 mg/L. Pengujian residu pestisida negatif pada golongan klorin, organo fosfat dan karbamat. Hasil penelitian menunjukkan bahwa ekstrak memenuhi persyaratan umum obat yang dibuat oleh bahan alam

Uji Aktivitas Antibakteri Ekstrak Daun Gelinggang (Cassia alata L): Antibacterial Activity Test of Gelinggang Leaf Extracts (Cassia alata L) Khofifah Nur Oktavia; Fika Aryati; Herman Herman
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Traditionally, gelinggang leaves are widely used for treatment of various skin diseases. The potential of gelinggang leaves as a medicinal plant is expected due to the presence of secondary metabolite compounds that have activities, one of which can inhibit the growth of fungi and bacteria. This study aims to determine the antibacterial activity of gelinggang leaf extract against Staphylococcus aureus and Escherichia coli bacteria. The study began with extraction process of gelinggang leaves, phytochemical screening tests and testing of antibacterial activity from gelinggang leaf extracts carried out by the agar diffusion method using a well. Gelinggang leaf samples were macerated with 96% ethanol solvent and then tested for antibacterial activity in concentrations of 5%, 10%, and 15%. The results of the phytochemical screening test indicated that the gelinggang leaf extract was positive for flavonoids, saponins, phenolics, and terpenoids. On antibacterial activity test of the ethanolic extract of gelinggang leaves, it revealed that there was an inhibition activity for both Staphylococcus aureus and Escherichia coli bacteria with the best activity at a concentration of 15%.

Isolasi Fungi Endofit Daun Kopi Robusta (Coffea canephora): Isolation of Endophytic Fungus Robusta Coffee Leaf (Coffea canephora) Nilam Ratna Rizkyanti; Herman Herman; Fika Aryati
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Endophytic fungi are organisms that live in plant tissues that have the potential to produce the same secondary metabolites as their host. This study attempted to isolate and also characterize endophytic fungi from Robusta coffee leaves (Coffea canephora). Data collection was carried out in several stages, namely isolation of endophytic fungi by surface sterilization method, and conventional characterization of endophytic fungi by observing the morphology of endophytic fungi. The results showed that as many as 4 isolates of endophytic fungi were isolated from Robusta coffee leaves (Coffea canephora) with macroscopic characteristics of white color with orange circle edges, cotton-like shape, and green and orange spots on the underside of the fungus.

PERBANDINGAN METODE SINTESIS DAN KARAKTERISASI ETILENDIAMIN-FOLAT SEBAGAI PREKURSOR PEMBUATAN SENYAWA PENGONTRAS MRI GADOLINIUM DIETILENTRIAMINPENTAASETAT-FOLAT Retna Putri Fauzia; Abdul Mutalib; R Ukun M S Soedjanaatmadja; Anni Anggraeni; Zuhrotun Nafisah; Muhammad Yusuf; Husein H Bahti
Jurnal Sains dan Terapan Kimia Vol 11, No 1 (2017)
Publisher : Program Studi Kimia, Universitas Lambung Mangkurat

Uji Aktivitas Penghambatan Radikal Bebas DPPH dari Ekstrak Etil Asetat Batang Penara (Myristica Iners Blume.): DPPH Free Radical Scavenging Activity Test Of Ethyl acetate Extract of Stem Penara (Myristica iners Blume.) Faizah Hanan Lestari; Hifdzur Rashif Rija’i; Herman Herman
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 15 (2022): Proceeding of Mulawarman Pharmaceuticals Conferences (Proc. Mul. Pharm. Conf.)
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v15i1.619

Optimasi Basis Carbopol dan Uji Fisik Basis Gel Anti Jerawat: Optimization of the Carbopol and Physical Testing of the Anti-acne Gel Base Helga Lisu Sarira; Juniza Firdha Suparningtyas; Herman Herman
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 15 (2022): Proceeding of Mulawarman Pharmaceuticals Conferences (Proc. Mul. Pharm. Conf.)
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v15i1.623

Optimasi Konsentrasi Basis HPMC Sediaan Sampo Antiketombe Ekstrak Daun Belimbing Wuluh (Averrhoa bilimbi L.) Kombinasi Ekstrak Daun Pandan Wangi (Pandanus amaryllifolius Roxb): Optimization of HPMC Base Concentration for Anti-dandruff Shampoo Preparations Starfruit Leaf Extract (Averrhoa bilimbi L.) Combination of Pandan Fragrant Leaf Extract (Pandanus amaryllifolius Roxb) Herlita Gasella Salsabila; Nur Masyithah Zamruddin; Herman Herman
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 15 (2022): Proceeding of Mulawarman Pharmaceuticals Conferences (Proc. Mul. Pharm. Conf.)
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v15i1.624

Co-Authors Abdul Mutalib Abdul Mutalib Abdul Mutalib Aditya Fridayanti Agung Endro Nugroho Agus Setiawaty Almeida, Maria Andi Tenri Kawareng Anggreini, Putri Anni Anggraeni Anni Anggraeni Anni Anggraeni Arie Hardian Arifian, Hanggara Arifuddin, M Arifuddin, Muhammad Arsyik Ibrahim Badawi, Satriani Baso Didik Hikmawan Bohari Yusuf Bone, Mahfuzun Dayuh Anggun Mandalika Devara, Rachel Dewi Mayasari Difta, Rismania Shita Enggar Wijayanti Fahriani Istiqamah Jafar Fahrul Rozi Faizah Hanan Lestari Farah Erika Farah, Harra Ismi Febrianto Ubang Febrina, Lizma Fika Aryati Firzan Nainu Ganjar Firmansyah Hadi Kuncoro Haeruddin Haeruddin Haeruddin Haeruddin Haeruddin Haeruddin Hanggara Arifian Helga Lisu Sarira Helmi Helmi Henny Hidayah Herlita Gasella Salsabila Hifdzur Rashif Rija’i Hikmawan, Baso Didik Husein Hernadi Bahti Ibrahim, Arsyik Ilimu, Edi Indriana Tasya Islamudin Ahmad Islamudin Ahmad Iswahyudi Iswahyudi Iswahyudi Ivan Satria K.P. Junaidin Junaidin Junaidin, Junaidin Khofifah Nur Oktavia Laode Rijai Laode Rijai Laode Rijai Laode Rijai Lia Puspitasari Lisda Virdasari M. Arifuddin, M. Maharani, Dhea Nur Fadillah Maryam Jamila Arief Maryam Jamila Arief Mirhansyah Ardana Mitha Saputri Mohd Azlan Nafiah, Mohd Azlan MUHAMMAD AMIR MASRUHIM Muhammad Faisal Muhammad Faisal Muhammad Yusuf Muljadji Agma Mus, Nurul Muhlisa Nia Audina Nilam Ratna Rizkyanti Nisa Naspiah Noviyanty Indjar Gama Nur Masyithah Zamruddin Nur Masyithah, Z Nur Zakiyah Darajat Nur, Yuspian Nurdeni, Nurdeni Nurdewi Halik Nurdianah Abdul Kadir Nurfitri Nurfitri Nurul Fitriani Nurul Fitriani Olivia Siregar, Vita Otsuka Khaera Nurmala Prabowo, Wisnu Cahyo R. Ukun M.S. Soedjanaatmadja Rahmadani, Agung Rashif Rijai, Hifdzur Retna Putri Fauzia Rezky Khairun Nisaa, Nur Ridhotulloh, Yusuf Isro Rija'i, Hifdzur Rashif Rijai, Hifdzur Rashif Rija’i, Hifdzur Rashif Riki RIKI RIKI, RIKI Rimba Hamid Rimba Hamid Rolan Rusli Rusli, Rolan Rusman, Arman Salam, Supriatno Samsul, Erwin Selvi Jumiatul Astati Selvi Megawati Senadi Budiman Sukemi Sukemi Suparningtyas, Juniza Firdha Supriatno Supriatno Salam Suwijiyo Pramono Tri Woro Widyanti Usman Usman Vina Maulidya Vita Olivia Siregar Wahyu Yunita Lestari Yurika Sastyarina Yusniah, Andi Yuspian Nur Zahra Praselya Zamruddin, Nur Masyithah Zuhrotun Nafisah Zuliayu Arizka Pratiwi

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