cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
I Nyoman Hariyasa Sanjaya
Contact Email
editor.perinasia@gmail.com
Phone
+6281337051550
Journal Mail Official
editor.perinasia@gmail.com
Editorial Address
Tebet Timur Dalam IIIM Street, No.09, South Jakarta
Location
Kota adm. jakarta selatan,
Dki jakarta
INDONESIA
Indonesian Journal of Perinatology
Published by The Indonesian Society of Perinatology
ISSN : 27750744     EISSN : 27750736     DOI : https://doi.org/10.51559/inajperinatol.
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing
peer-reviewed journal aiming to communicate high-quality research articles, reviews, and general articles in the field. InaJPerinatol publishes articles that encompass basic research/clinical studies related to the cardiovascular and thorax field. The Journal aims to bridge and integrate the intellectual, methodological, and substantive diversity of medical scholarship and encourage a vigorous dialogue between medical scholars and practitioners.
Arjuna Subject : Kedokteran - Obstetrics and Gynaecology
Articles 64 Documents
 3   4   5   6   7 
Cooling therapy in severe neonatal asphyxia: a case of hypoxic-ischemic encephalopathy with neonatal pneumonia and neurological recovery Aliya Sari; Syibra Sabrina; Neni Sumarni
Indonesian Journal of Perinatology Vol. 7 No. 1 (2026): Available online: 1 June 2026
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v7i1.80

Abstract

Background: Neonatal asphyxia, defined as failure to establish breathing at birth, remains a major contributor to early neonatal mortality, causing around 900.000 deaths globally each year. One of its most serious complications is hypoxic-ischemic encephalopathy (HIE), a brain injury due to oxygen deprivation leading to a long term neurological impairment. Up to 60% of infants with severe HIE die or develop profound disability. Early cooling therapy reduces mortality and improves neurodevelopmental outcomes. Comorbidities such as pneumonia may complicate management. This case describes a neonate with severe asphyxia and HIE with pneumonia, and its purpose is to elucidate a case of severe neonatal asphyxia with HIE and pneumonia successfully managed with early cooling therapy as evidence of effective neuroprotective. Case Presentation: A male neonate born at 38 weeks by cesarean section due to fetal distress had meconium-stained amniotic fluid. Apgar scores of 1-2-5. The patient underwent resuscitation with intubation, ventilation, and meconium suctioning.  Seizures developed at 20 minutes of life. Examination showed chest retraction and coarse crackles. Babygram showed pneumonia, while cranial ultrasonography indicated increased intracranial pressure. Labs revealed hypercalcemia and prolonged coagulation. Supportive therapy included oxygen, IV glucose, antibiotics, calcium gluconate, fluids, and anticonvulsants. Cooling therapy was initiated within 6 hours, maintained for 72 hours at 33.5–34.5°C, followed by gradual rewarming. Neurological reflexes improved, and the patient was successfully extubated. Conclusion: Cooling therapy remains a cornerstone for HIE after severe neonatal asphyxia. Early initiation within six hours, with careful monitoring and infection control, can significantly improve neurological outcomes even in complicated cases.
Abdominal Packing for Management of Refractory Postpartum Hemorrhage I Gde Sastra Winata Winata; Belinda Carlisa; Jessica Nathalia; Ni Nyoman Trijayanti
Indonesian Journal of Perinatology Vol. 7 No. 1 (2026): Available online: 1 June 2026
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v7i1.85

Abstract

Changes in the demographic and clinical characteristics of pregnant women increase the risk of postpartum hemorrhage, which remains one of the leading causes of maternal mortality in Indonesia. Management of severe postpartum hemorrhage may include abdominal packing. This procedure is performed using a balloon tamponade system combined with gauze-based packing. The fundamental principle of balloon tamponade involves the strategic placement of the tampon within the true pelvis (below the pelvic brim), rather than the false pelvis (above the pelvic brim), to achieve direct physical compression against the pelvic bony boundaries. Following the procedure, patients must be closely monitored, and abdominal tampon removal should be performed in a timely manner, typically within 24–48 hours. Complications associated with abdominal packing may occur if sustained intra-abdominal pressure exceeds 20 mmHg, which can lead to organ failure and necessitate abdominal decompression. However, with adequate monitoring and careful implementation, abdominal packing can serve as a safe and effective alternative for the management of refractory postpartum hemorrhage.
Systems perinatology of autoimmunity: placental immune endophenotypes linking SLE, RA, Sjögren’s, and APS to specific obstetric complications: a systematic review and translational framework Wisnu Prabowo; I Nyoman Hariyasa Sanjaya; Wiku Andonotopo; Muhammad Adrianes Bachnas; Mochammad Besari Adi Pramono; Julian Dewantiningrum; Efendi Lukas; Anak Agung Gede Putra Wiradnyana; Anak Agung Ngurah Jaya Kusuma; Khanisyah Erza Gumilar; Ernawati Darmawan; Dudy Aldiansyah; Aloysius Suryawan; Ridwan Abdullah Putra; Cut Meurah Yeni; Nuswil Bernolian; Laksmana Adi Krista Nugraha; Waskita Ekamaheswara Kasumba Andanaputra; Wibisana Andika Krista Dharma; Niranjani
Indonesian Journal of Perinatology Vol. 7 No. 1 (2026): Available online: 1 June 2026
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Autoimmune diseases—including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren’s syndrome, and antiphospholipid syndrome (APS)—confer disproportionate risk for adverse obstetric outcomes, yet the underlying placental immunopathology remains fragmented across disciplines. This systematic review integrates evidence from 2012–2025 to define reproducible placental immune endophenotypes linking maternal autoimmunity to obstetric complications. Following PRISMA 2020 guidelines, a comprehensive search of PubMed, Embase, and ClinicalTrials.gov identified 1,042 records, of which 54 studies met eligibility after duplicate removal, multi-reviewer screening, and bias appraisal (AMSTAR-2, ROBINS-I, NOS). No protocol was registered on PROSPERO. Evidence was synthesizednarratively and diagrammatically to capture mechanistic convergence across diseases. Findings delineate six immune endophenotype axes—type I interferon, complement/NETosis, B-cell/autoantibody, FcRn–IgG transport, microchimerism, and stromal–immune crosstalk—each associated with specific placental lesions (e.g., villitis, intervillositis, fibrinoid necrosis) and outcomes including preeclampsia, fetal growth restriction, preterm birth, and fetal loss. SLE and APS dominate complement-mediated patterns, whereas RA and Sjögren’s reflect IFN-driven trophoblast stress and stromal immune imbalance. Integrating histopathology, single-cell transcriptomics, and biomarker data, this framework proposes a Systems Perinatology model bridging discovery, mechanism, and clinical translation.This review reconceptualizes autoimmune pregnancy not as disease-specific, but as an endophenotype-mediated placental immune disorder amenable to precision stratification and targeted therapy. Future research should operationalize these axes for biomarker development, interventional trials, and predictive algorithms in precision obstetrics.
Microplastics in the human placenta: mechanisms, risks, and futures: a systematic review Muhammad Adrianes Bachnas; I Nyoman Hariyasa Sanjaya; Wiku Andonotopo; Wisnu Prabowo; Mochammad Besari Adi Pramono; Julian Dewantiningrum; Efendi Lukas; Anak Agung Gede Putra Wiradnyana; Anak Agung Ngurah Jaya Kusuma; Khanisyah Erza Gumilar; Ernawati Darmawan; Dudy Aldiansyah; Aloysius Suryawan; Ridwan Abdullah Putra; Cut Meurah Yeni; Nuswil Bernolian; Laksmana Adi Krista Nugraha; Waskita Ekamaheswara Kasumba Andanaputra; Wibisana Andika Krista Dharma; Niranjani
Indonesian Journal of Perinatology Vol. 7 No. 1 (2026): Available online: 1 June 2026
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v7i1.92

Abstract

Background: Micro- and nanoplastics have been detected in the human placenta, raising concerns regarding fetal development, immune programming, and long-term health. This systematic review synthesized evidence on their presence in placental and perinatal compartments, mechanisms of translocation across the maternal–fetal interface, and potential biological and perinatal health effects.Methods: PubMed, Embase, Web of Science, Scopus, the Cochrane Library, trial registries, and relevant reference lists were searched from inception to September 2025 without language or publication-date restrictions. Eligible studies included human observational studies, ex vivo placental models, in vitro trophoblast or placental cell experiments, and animal models investigating micro- or nanoplastics in placental or perinatal compartments. Reviews were included for contextual synthesis. Two reviewers independently screened studies, extracted data, and appraised quality using AMSTAR-2, ROBIS, or the Newcastle–Ottawa Scale, as appropriate. Findings were synthesized narratively because of methodological heterogeneity. Results: Of 1,226 records identified, 25 studies were included: eight human detection studies, two ex vivo placental models, two in vitro studies, two animal models, and eleven systematic, scoping, or narrative reviews. Microplastics were detected in placental tissue, cord blood, and meconium across multiple regions using μ-FTIR, Raman, LD-IR, and Py-GC/MS. Mechanistic studies demonstrated placental and trophoblast uptake and reported endoplasmic reticulum stress, apoptosis, oxidative stress, inflammatory responses, vascular impairment, and endocrine disruption. Human studies were limited by small sample sizes, inconsistent contamination-control procedures, heterogeneous analytical methods, and lack of standardized dosimetry. Overall certainty of evidence was low to moderate. Conclusion: Current evidence indicates that micro- and nanoplastics can reach the maternal–fetal interface and may adversely affect placental function. However, their clinical significance and long-term consequences remain uncertain. Standardized detection protocols, environmentally relevant dose–response studies, and prospective longitudinal investigations are urgently needed.

Page 7 of 7 | Total Record : 64

 3   4   5   6   7 

Filter by Year

2020 2026


Reset
Filter By Issues
All Issue Vol. 7 No. 1 (2026): Available online: 1 June 2026 Vol. 6 No. 2 (2025): Available online : 1 December 2025 Vol. 6 No. 1 (2025): (Available online: 1 June 2025) Vol. 5 No. 2 (2024): (Available online: 1 December 2024) Vol. 5 No. 1 (2024): Available online: 1 June 2024 Vol. 4 No. 2 (2023): Available online : 1 December 2023 Vol. 4 No. 1 (2023): (Available online: 1 June 2023) Vol. 3 No. 2 (2022): (Available online: 1 December 2022) Vol. 3 No. 1 (2022): Available online : 1 June 2022 Vol. 2 No. 2 (2021): Available online : 1 December 2021 Vol. 2 No. 1 (2021): Available Online: 1 June 2021 Vol. 1 No. 1 (2020): Available Online: 1 December 2020 More Issue