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Indonesian Journal of Perinatology

InaJPerinatol
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Published by The Indonesian Society of Perinatology

ISSN : 27750744 EISSN : 27750736 DOI : https://doi.org/10.51559/inajperinatol.

Core Subject : Health,

Health Professions Medicine & Pharmacology Nursing

peer-reviewed journal aiming to communicate high-quality research articles, reviews, and general articles in the field. InaJPerinatol publishes articles that encompass basic research/clinical studies related to the cardiovascular and thorax field. The Journal aims to bridge and integrate the intellectual, methodological, and substantive diversity of medical scholarship and encourage a vigorous dialogue between medical scholars and practitioners.

Arjuna Subject : Kedokteran - Obstetrics and Gynaecology

Articles 59 Documents

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Rhesus incompatibility in pregnancy: a case report Ali Sungkar; Raymond Surya
Indonesian Journal of Perinatology Vol. 1 No. 1 (2020): Available Online: 1 December 2020
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Introduction: Hemolytic disease of the fetus and newborn (HDFN) occurs due to the destruction of red blood cells, which the most common cause is rhesus incompatibility. This study aims to present a case of Rhesus incompatibility in pregnancy without a clinically significant effect on the baby. Case: A-38-years-old Indonesian woman with gravida 4 para 3 (G4P3A0), 32 weeks of gestational age came to the emergency department due to vaginal bleeding. On blood typing, she had an A-negative (A-) blood type. Her husband and all three of their children had O-positive (O+) blood type. The patient underwent a cesarean section due to recurrent antepartum hemorrhage following the total placenta previa. She gave birth to a baby girl, weighed 2,220 grams with an A-positive blood type. The hemoglobin level was 14.6 g/dL without any sign of neonatal jaundice during the first 24 hours of life. Conclusion: Our case illustrates a woman who did not show any sign of clinically Rhesus antigen alloimmunization. Low immunogenicity and dose-dependent response to a low fetal blood volume exposure might explain this phenomenon.

Congenital vulvar teratoma: a case report I Nyoman Hariyasa Sanjaya; Ryan Saktika Mulyana; Evert Solomon Pangkahila; Hartanto Hartanto
Indonesian Journal of Perinatology Vol. 1 No. 1 (2020): Available Online: 1 December 2020
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Introduction: Teratoma is an embryonal neoplasm consisted of 3 germinal layers. Teratoma usually arises along the line of embryonic cleft and sinus closure formed by the fusion of skin during the embryonic development. In this case report, we present a case of fetal Teratoma on the vulval region, a very rare variant of the disease. Case: A 28-year-old woman came for a routine check-up for her first pregnancy at her 26th weeks of gestational age. On ultrasound examination, a mass was found around the fetal vulva. There was no mass or malformations on other body parts. Placenta and the amount of amniotic fluid were normal. History of congenital anomaly in the family was denied. The patient then gave birth to a female baby at 38 weeks of gestational age without any complication. The baby was healthy, 2650 gram in weight, 50 cm in length, with good APGAR Score (8-10). On the baby left labia, there was a mass measured 5 cm x 4 cm x 3 cm, with slight discoloration. We recommend an early tumor excision to prevent unnecessary complication such as malignant transformation. Although at the time of writing, the patient still waiting for the schedule to remove the tumor due to a non-medical factor. Conclusion: Congenital Teratoma in the vulvar region was a very rare event. First-line therapy is early tumor excision and usually carries an excellent prognosis.

Management of polyhydramnios pregnancy without risk factors: a case report I Nyoman Hariyasa Sanjaya; Ryan Saktika Mulyana; Evert Solomon Pangkahila; Denni Prasetyo
Indonesian Journal of Perinatology Vol. 1 No. 1 (2020): Available Online: 1 December 2020
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Introduction: Polyhydramnios is a condition in which the amount of amniotic fluid increases more than 2 litres. The causes of polyhydramnios are multifactorial, and most are idiopathic. Here we report challenging management of polyhydramnios case without apparent risk factors. Case: A 30-year-old woman G2P1001, 27-28 weeks of gestational age referred due to our tertiary health care center due to polyhydramnios. The patient chief complaint was progressively enlarged abdomen since a month ago. Her previous pregnancy, medical history and family history were unremarkable. The obstetric examination reflects the size of uterus equivalent to 36 weeks of gestational age. The fetomaternal ultrasound reveals a life, single fetus with normal heart rate and fetal movement, estimated fetal weight about 1057 grams, placenta corpus posterior grade I, Maximum Vertical Pocket 22.83 cm, no major congenital abnormalities were visible and bladder appears filled. Laboratory tests revealed blood glucose levels 90 mg/dl, Hb-A1c 5.2%, Ureum 27.30 mg/dl, Creatinine 3.39 mg/dl, and numerous leukocytes on urine sediment. Amnioreduction and fetal pulmonary maturation were conducted by Dexamethason protocol. Amnioreduction yield 1500 ml of clear, yellowish amniotic fluid. Regarding abnormality in renal function, diagnosis of Acute on Chronic Kidney Disease (ACKD were established by Internal medicine department, and the patients were given a series of ceftriaxone injection. The patient was planned for indomethacin therapy; however, Indomethacin was not available in Bali. Conclusion: Careful search for causes both from the maternal factor and fetal abnormalities can help to determine the prognosis of pregnancy. Ideally, amnioreduction, coupled with indomethacin therapy, are needed to reduce amniotic fluid, and serial monitoring of the amniotic fluid volume is required to prevent preterm labor.

The role of circular Ribonucleic Acid in preeclampsia: a literature review William Alexander Setiawan; A.A. Gde Marvy Khrisna Pranamartha
Indonesian Journal of Perinatology Vol. 1 No. 1 (2020): Available Online: 1 December 2020
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Circular RNAs (circRNAs) are non-coding RNAs with a covalently closed circular structure that present in a variety of organisms. The circRNAs are more stable and durable than linear RNAs due to incompatibility with the RNases. Recent studies have shown that circRNAs are expressed differently at the mother-fetal interface of women with preeclampsia compared to women with normal pregnancy. Although the evidence showed that circRNAs mediate various pathological processes in pregnancy, the mechanism of action is still unclear. In this paper, we provide a highlight of the current state of knowledge about circRNAs, its relation to preeclampsia, and the potential applications as preeclampsia biomarkers.

The effect of antibiotic therapy on Salivary Catalase kinetic parameters in neonatal at risk of Sepsis Ari Yunanto; Pricilia Gunawan Halim; Iskandar Iskandar; Eko Suhartono
Indonesian Journal of Perinatology Vol. 1 No. 1 (2020): Available Online: 1 December 2020
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Introduction: This study describes the effect of antibiotic therapy on salivary catalase kinetic parameters (CAT) at neonatal at risk of sepsis. Methods: Study is conducted from February – June 2015. Salivary samples are obtained from 20 neonates (5 normal-healthy neonates and 15 neonates at risk of sepsis) at Ulin General Hospital, Banjarmasin, Indonesia. The samples were placed in four different groups: P0 as control group (saliva + hydrogen peroxide/H2O2), P1 (saliva + 2 mg Ampicillin + H2O2), P2 (saliva + 0.2 mg Gentamicin + H2O2), P3 (saliva + 2 mg Ampicillin + 0.2 mg Gentamicin + H2O2). The solution is incubated at 37oC and 40oC before catalase (CAT) activity is measured. Catalase activity is measured by using a spectrophotometer at 240 nm. Kinetic parameters are measured at different concentrations of H2O2 and temperature. Kinetic parameters are represented by the Michaelis-Menten constant (Km) and the maximum reaction speed (Vmax) obtained through the Lineweaver-Burk curve plot. Results: The Km of Catalase on the saliva of neonates at risk of sepsis treated with antibiotics (4.37, 1.84, 0.12, and 0.23, 3.74, 1.5, for P1, P2, P3 respectively) was lower than the control group (17.61 and 12.54), both at 37ºC and 40ºC. Similarly, Vmax of the neonates at risk of sepsis treated with antibiotics (0.46, 0.34, 0.04 and 0.07, 0.20, 0.24) was lower than the control group (1.47 and 0.53) at 37ºC and 40ºC. Conclusion: The study shows that the Catalase activity at the saliva of newborns at risk of sepsis treated with antibiotic was lower than the control group.

Methylglyoxals, Thiocyanate, and Hydrogen Peroxide in saliva of newborns at risk of sepsis: Methylglyoxals as a promising biomarker of early-onset neonatal sepsis Ari Yunanto; Pricilia Gunawan H; Eko Suhartono
Indonesian Journal of Perinatology Vol. 2 No. 1 (2021): Available Online: 1 June 2021
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Introduction. Sepsis represents a severe problem for newborns. The relatively high incidence rate of 1 to 10 cases per 1000 live births, with even higher rates in low-birth-weight neonates. Given its high incidence, identifying markers to optimize the early diagnosis and therapeutic interventions is highly desirable. This study investigates three oxidative markers taken from saliva, methylglyoxal (MG), Thiocyanate (SCN-) and hydrogen peroxide (H2O2), as early-onset neonatal sepsis markers. Methods. This study was conducted from June to August 2014, and saliva specimens were taken from 30 newborns of mothers with one major risk factor or two minor risk factors (case group) and 30 healthy newborns for the control group. Saliva levels of MG were determined by calculating the percentage of MG absorbance compared with the carbonyl compounds. Data were analyzed by using Kolmogorov-Smirnov and Student's t test. Results. We found a significant increase of SCN-, and MG level case group (28.91 mmol and 0.01%, respectively) compared to the control group (19.49 mmol and 0.005%, respectively) p-value = 0.03. In contrast, the H2O2 in the case group (32.56 mmol) was lower than the control group (37.47 mmol), with a p-value = 0.04. Conclusion. We found the increased levels of SCN–, MG and the decreased levels of H2O2 in neonates' saliva with the risk of sepsis. MG measurements as a routine diagnostic for suspected sepsis should be taken into consideration.

Early detection of Fetal Acrania on first-trimester sonography: a case report I Nyoman Hariyasa Sanjaya; Cokorda Istri Mirayani Pemayun; Ni Komang Anik Pirgantari; Made Diah Vendita Sakuntari; Ni Wayan Dewi Purwanti; NI Putu Nining Gianni; Ni Luh Made Diah Mas Cahyani Putri; Ni Luh Md Dwi Laxmi Satriani; Firsta Sesarina Mintariani; Ni Luh Putu Yulia Padmawati; Anak Agung Wahyu Putri Agustini
Indonesian Journal of Perinatology Vol. 2 No. 1 (2021): Available Online: 1 June 2021
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Introduction. Fetal Acrania is a rare fetal malformation characterized by the complete or partial absence of a skull covering the fetal brain. In the absence of a hard covering of the soft brain tissue, Acrania is known as a universally lethal malformation. Here we present a Fetal Acrania case detected by sonographic examination at our Center. Case Description. A 36 years old female was referred to the obstetric department to undergo an in-depth sonographic evaluation as a previous examination reveals a potential congenital fetal anomaly. Our sonographic evaluation revealed a singleton, live fetus, 12 weeks gestational age in cephalic presentation and longitudinal lie. One obvious malformation was a well-formed fetal brain without the surrounding cranium (Acrania). The absence of cranium was the main and only malformation. The absence of cranium was evident as the fetal brain was easily compressed on probe pressure, and the brain appeared like floating in the amniotic fluid over the base of the skull. Therapeutic abortion was carried out. The termination was conducted by administering four tablets of 200 mcg misoprostol sublingually and repeated 24 hours later. No adverse reaction or complication on termination. The aborted fetal examination confirmed the lack of fetal cranium. Conclusion. Although seemingly obvious, the first-trimester diagnosis of fetal Acrania must be made with caution as the fetal cranium is not fully calcified before 10- 11 weeks. As Acrania is a universally lethal malformation, therapeutic abortion is indicated.

The impact of the COVID-19 pandemic on the frequency of routine visits and breastfeeding plans on Kasih Medika Clinic I Nyoman Hariyasa Sanjaya; Cokorda Istri Mirayani Pemayun; Firsta Sesarina Mintariani; Made Diah Vendita Sakuntari; Ni Wayan Dewi Purwanti; NI Putu Nining Gianni; Ni Luh Made Diah Mas Cahyani Putri; Ni Luh Md Dwi Laxmi Satriani; Ni Komang Anik Pirgantari; Ni Luh Putu Yulia Padmawati; Anak Agung Wahyu Putri Agustini
Indonesian Journal of Perinatology Vol. 2 No. 1 (2021): Available Online: 1 June 2021
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Introduction. The SARS-CoV-2 pandemic has affected every part of the population, including pregnant mothers, breastfeeding mothers, and infants. There is an inadequate comprehension of SARS-CoV-2 transmission potential as of now. As expected, it will result in anxiety among the public, including a specific issue such as breastfeeding practice for the suspected or confirmed novel coronavirus infection. This study aimed to assess whether such anxiety was present in a population of patients that routinely visit Kasih Medika clinic. Methods. This is a simple study conducted on August 5-10, 2020. This study used a questionnaire instrument with samples of pregnant and postpartum mothers. The questionnaire includes a question regarding the anxiety surrounding breastfeeding, visiting the clinic and their everyday activity. Results. We reported that COVID-19 has an impact on the breastfeeding plans from the respondent's questionnaire. All respondents felt anxious about COVID-19, although only 18% of patients reduce their routine visits to Kasih Medika, while the rest keep visiting as scheduled. Eighty-six percent of respondents restricted their outdoor activities during the COVID-19 pandemic. The COVID-19 pandemic causes 27% of the respondents to feel afraid of their breastfeeding plans. However, in the primigravida population, 45.45% of respondents were afraid of their breastfeeding plans. Meanwhile, in the multigravida and postpartum respondents, 90.90% were not afraid about their breastfeeding plans during the COVID-19 period. Conclusion. COVID-19 pandemic brings a certain degree of anxiety to the mothers, including anxiety of safety during breastfeeding practice. Despite the risk of transmission, breastfeeding has more benefits than disadvantages. Breastfeeding makes the infant have a good immune system, which prevents any disease, including COVID-19. Breastfeeding during the COVID-19 is still recommended under health protocol.

Characteristics of pregnancy with Systemic Lupus Erythematosus (SLE) in Dr. Mohammad Hoesin Hospital, Palembang Nyimas Aliyah Faizatun Muthmainnah; Nuswil Bernolian; Eddy Roflin; Cindy Kesty
Indonesian Journal of Perinatology Vol. 2 No. 1 (2021): Available Online: 1 June 2021
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease with complex pathogenesis with broad clinical manifestations, more common in women of reproductive age between 15-44 years, so there is an increased incidence in pregnancies. Methods: This study was a descriptive observational study with a cross-sectional design using medical records of patients in Dr. Mohammad Hoesin Hospital Palembang from January 2018-June 2020. Sampling was carried out by total sampling with the presentation of data in tables and narratives. Data processing was performed using SPSS 25. Results: There were 1,039 pregnancies in January 2018-June 2020 with 26 pregnancies with SLE and 8 patients (30.8%) of moderate degree SLE. The demographic characteristics were 26-30 age range (30.8%), high school education status (53.8%), the number of pregnancies 2-3 times (53.8%), the number of primiparous births (46.2%), and the number of miscarriages was never experienced (65.4%). Based on clinical signs and symptoms, malaise (15.4%), malar rash, photosensitivity spots and alopecia (15.4%), inflammatory arthritis (46.2%), lupus nephritis (11.5%), abdominal pain ( 34.6%), lymphadenopathy (3.8%), anemia or lymphopenia (15.4%), and cephalgia (7.7%). Meanwhile, the parameter of diagnosis was lymphopenia (15.4%), eGFR stage 1 (34.6%), proteinuria or proteinuria and cylindruria (11.5%), ANA test (+) (19.2%), anti-dsDNA test (+) (19.2%), and the complement test decreased (7.7%). Pregnancy outcomes were found to have intrauterine growth restriction (IUGR) (19.2%) and preeclampsia and IUGR (11.5%). Conclusion: From the 26 pregnant patients with SLE, most were found with a moderate degree. Most demographic characteristics were age range 26-30 years old, high school education status, number of pregnancies 2-3 times, primipara, and never miscarriage. Characteristics of clinical signs and symptoms most commonly found in patients were malaise, malar rash, photosensitivity spots and alopecia, inflammatory arthritis, and abdominal pain. The diagnosis parameters were lymphopenia, stage 1 eGFR, proteinuria or proteinuria and cylindruria, ANA test (+), and anti-dsDNA test (+). Most pregnancy outcome is intrauterine growth restriction (IUGR).

Demographic bonus in Bali: hopes and challenges in reproductive health I Made Darmayasa; IGN Harry Wijaya Surya; Made Bagus Dwi Aryana
Indonesian Journal of Perinatology Vol. 2 No. 1 (2021): Available Online: 1 June 2021
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Background: Bali experienced an earlier demographic bonus and a longer duration than the national one. The demographic bonus provides both hope and challenges from a reproductive health perspective, especially in the current Covid-19 pandemic. Methods: Extracted from various sources, analyzed and presented in the form of a description. Result: In the period 1960-2000, the population growth rate in Bali continued to decline, but from 2000 to 2010, it increased again to 2.14. The age group below 50 years reaches 80%, the distribution is 30% under the age of 18 years, then 24% at the age 19-35 years, and 24% for the age group 35-50 years. In 2020 Bali entered the demographic bonus with the lowest dependency ratio between 42.2% - 43.3%. Bali's life expectancy rate reached 70.61 years in 2010 and is predicted to be 71.68 years in 2018. Based on the Regency/City of Bali Province's projected population in 2010-2020, the number of seniors in Bali in 2020 is 11.51%. The challenges faced include: 1. Knowledge of adolescents about reproductive health, 2. High number of the population in productive age accompanied by an understanding of reproductive health is still low. 3. Disease awareness of various pathological conditions in pregnancy is still low, coverage of contraceptive use is still low, causing pregnancy without planning, unwanted and high risk, 4. Low quality of antenatal care, 5. There are still many pregnant people, and giving birth without financing pattern, 6. Population mobility, many pregnant women who come to Bali, are not equipped with population data/identities, including family cards, 7. The increasing number of people over 60 years of age are unproductive, unhealthy, and not independent. These challenges will burden the family and or the government, especially if they do not have a good financing pattern. Conclusion: The demographic bonus in Bali occurs earlier than in some other regions in Indonesia due to success in managing population programs. This bonus does not guarantee the success of development in the overall sense of the Covid-19 pandemic era. Bali still has to strive hard to realize its development hopes and solve existing and real challenges.

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Home Page

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Contact Name I Nyoman Hariyasa Sanjaya

Contact Email editor.perinasia@gmail.com

Phone +6281337051550

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Editorial Address Tebet Timur Dalam IIIM Street, No.09, South Jakarta

Location Kota adm. jakarta selatan, Dki jakarta INDONESIA

Abstract

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Abstract

Contact Name
I Nyoman Hariyasa Sanjaya

Contact Email
editor.perinasia@gmail.com

Phone
+6281337051550

Journal Mail Official
editor.perinasia@gmail.com

Editorial Address
Tebet Timur Dalam IIIM Street, No.09, South Jakarta

Location
Kota adm. jakarta selatan,

Dki jakarta

INDONESIA