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I Nyoman Hariyasa Sanjaya
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INDONESIA
Indonesian Journal of Perinatology
Published by The Indonesian Society of Perinatology
ISSN : 27750744     EISSN : 27750736     DOI : https://doi.org/10.51559/inajperinatol.
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing
peer-reviewed journal aiming to communicate high-quality research articles, reviews, and general articles in the field. InaJPerinatol publishes articles that encompass basic research/clinical studies related to the cardiovascular and thorax field. The Journal aims to bridge and integrate the intellectual, methodological, and substantive diversity of medical scholarship and encourage a vigorous dialogue between medical scholars and practitioners.
Arjuna Subject : Kedokteran - Obstetrics and Gynaecology
Articles 59 Documents
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Loop electrosurgical excision procedure: A Review I Nyoman Bayu Mahendra; William Alexander Setiawan
Indonesian Journal of Perinatology Vol. 4 No. 1 (2023): (Available online: 1 June 2023)
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v4i1.34

Abstract

LEEP is a one-of-a-kind outpatient procedure for diagnosing and treating dysplastic cervical lesions. Loop diathermy treatment, loop excision of the transformation zone (LETZ), and large loop excision of the transformation zone (LLETZ) are other names. This approach yields high-quality cytologic specimens and has no negative effects on reproductive function. It also can be used to treat cervical cancer by replacing cryotherapy or laser. LEEP can be used to bypass the entire transformation zone. This is done with the help of a high-frequency, low-current electric generator and a stainless-steel loop. The LEEP procedure has a similar complication rate to cryotherapy. Bleeding is the most common complication. In addition, there may be inadequate lesion removal and cervical stenosis. LEEP has several advantages over other treatments, including removing aberrant tissue that allows cytologic examination, cheap cost, simplicity of acquiring important skills, and the potential to treat lesions with fewer visits. Patients are pleased with the surgery. LEEP is anticipated to be widely used by family physicians.
Risk factors and characteristics of cervical cancer patients under 40 years old at Prof Dr I.G.N.G. Ngoerah Hospital Denpasar, Bali from January until December 2022 I Nyoman Gede Budiana; I Nyoman Bayu Mahendra; I Gde Sastra Winata; Kade Yudi Saspriyana; Kevin Agastya Duarsa; Pande Made Suwanpramana; Rayvany Uil; Dewi, Putu Pradnya Paramitha; Made Yudha Ganesa Wikantyas Widia; Eric Gradiyanto Ongko; I Gede Indra Kumara; Charles Richard Thene; Johan Qalaba; Made Ayu Prabawaty Indraswari; Ida Bagus Arjuna; Putu Harrista Indra Pramana; Ernest T. B. Sianturi
Indonesian Journal of Perinatology Vol. 4 No. 2 (2023): Available online : 1 December 2023
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v4i2.33

Abstract

Background: Cervical cancer is the main cause of death for women worldwide. 500.000 new cases and 250.000 deaths are reported each year. In Indonesia, women as young as 25 are being diagnosed with this disease. The study will be conducted at Prof.Dr.I.G.N.G Ngoerah Hospital from January to December 2022 to analyze cervical cancer patients under 40. This study aimed to see the profile and the distribution of 40 year-old women with cervical cancer at our hospital. Methods: This descriptive study was conducted using medical records that were centered around female patients who were below 40 years of age and had been diagnosed with cervical cancer in Prof.Dr.I.G.N.G Ngoerah hospital in January - December 2022. Purposive sampling was done, and the samples were selected according to the inclusion criteria. The resulting data was presented in a table format. Results: Fifty-one cervical cancer patients aged under 40 years were included, with most of the age group being 30 – 39 years (88.2%). Twenty-eight patients (54.9%) were in the two-to-three parity group. The most dominant stage of cervical cancer is stage IIIB, with a total of 20 people (39.2%). Non-keratinizing squamous cell carcinoma (NKSCC) was the most common histopathological appearance (64.7%).  Conclusions: The study found that cervical cancer commonly affects those between 30-39 years old, particularly in the form of NKSCC. Many patients are diagnosed in advanced stages of the disease. Early screening, education, and vaccination programs are crucial in preventing cervical cancer.
Simultaneous Myomectomy and Cesarean Section: A Dual Surgical Approach Pregnancy with enormous fibroid Baktiar, Muhammad Priza; Abd Rauf, Khairunnisa binti; Gumilar, Khanisyah Erza
Indonesian Journal of Perinatology Vol. 4 No. 2 (2023): Available online : 1 December 2023
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v4i2.35

Abstract

Introduction: Myomectomy during cesarean section (CS) is a complex but increasingly common surgical approach used in cases of large uterine fibroids in pregnant patients. This report aims to evaluate the efficacy and safety of myomectomy in conjunction with CS for large uterine myoma. Case description: A retrospective study was conducted on two pregnant patients with large uterine myomas who underwent myomectomy during CS at a Hospital of Universitas Airlangga. Clinical data, myoma characteristics, and maternal and neonatal outcomes were evaluated. Myoma sizes were 15x15cm and 15x20cm, and both were intramural. No significant intraoperative complications occurred. Bleeding during surgery was well controlled, and all patients recovered without adverse events. The duration of surgery was 60 and 70 minutes. Patients were discharged home within 3 days after surgery, and all neonates were born healthy with no congenital abnormalities. Conclusion: Simultaneous myomectomy with CS is a successful and safe method of managing big uterine myomas in pregnant women. This surgery has two advantages: it treats maternal fibroid problems while also ensuring maternal and newborn safety during CS. The installation of a Foley catheter for uterine artery clamping aids in preventing excessive bleeding during surgery. This method can be used to handle pregnant individuals with big uterine myomas who require CS.
Pulmonary hypertension in pregnancy Bernolian, Nuswil; Kesty, Cindy; Mirani, Putri; Lestari, Peby Maulina; Martadiansyah, Abarham; Agustria, Rizky
Indonesian Journal of Perinatology Vol. 5 No. 1 (2024): Available online: 1 June 2024
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v5i1.36

Abstract

Pulmonary hypertension (PH) is a persistent increase in mean pulmonary arterial pressure (mPAP) of at least 20–25 mm Hg during right cardiac catheterization. For every million patients, there were 97 PH cases. Women are more likely than men (1.7:1) to receive a diagnosis, with a mean age of 37 years. The classification, pathophysiology, mechanism, and management of postpartum hemorrhage (PH) are the main aims of this review study. Pulmonary artery hypertension (PAH), pulmonary hypertension (PH) associated with left heart disease, pulmonary hypoxia and/or lung illnesses, chronic thromboembolic PH, and PH with unknown multifactorial processes are the five categories into which PH is divided. Women, particularly those of reproductive age, make up about 80% of individuals with idiopathic PAH. Pregnancy-related PH is one of the long-standing heart conditions with a significant morbidity and mortality rate. Its estimated death rate ranges from 30.56%. Pregnancy is therefore not advised in PH patients. Treating people with PH requires early diagnosis and effective treatment. These patients have optimism because of the impending PH medications (phosphodiesterase type 5 inhibitors, nitric oxide, endothelin receptor antagonists, and calcium channel blockers) as well as the advancements in hemodynamic monitoring and intensive care in PH specialty facilities. Pregnant women with PH should be treated with a multidisciplinary approach, such as obstetricians, cardiologists, intensivists, and neonatologists.
Relationship between total 25(OH)D and interleukin-2 contents in preterm conversion patients Sanjaya, I Nyoman Hariyasa; Mulyana, Ryan Saktika; Kamajaya, I Gusti Ngurah Agung Trisnu
Indonesian Journal of Perinatology Vol. 5 No. 1 (2024): Available online: 1 June 2024
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v5i1.37

Abstract

The most essential nutrient for pregnant women is vitamin D. A lack of vitamin D can cause preterm labor and other issues like low birth weight, preeclampsia, and issues with the baby's bones. According to some research, there is no safe top level and a 75–80 nmol/L range. According to additional studies, an ideal range is between 75 and 110 nmol/L and a daily dosage of 1800 to 4000 IU of vitamin D3. In both early and late pregnancies, women with sufficient vitamin D levels (at least 30 ng/mL) exhibited a significant decrease in the incidence of preeclampsia. It is also known that vitamin D modulates the immune system in several ways. T-cell proliferation can be suppressed, and pro-inflammatory cytokines, including IL-2, IFN-, and IL-17, can be produced less frequently when vitamin D is present. A lack of vitamin D may lead to a rise in cytokines that promote inflammation, such as IL-2. This paper will, therefore, examine the relationship between vitamin D, IL-2 levels, and the risk of premature labor.
Step-by-step bleeding management in cesarean section Winata, I Gede Sastra; Wibawa, I Gusti Ngurah Agung Satria
Indonesian Journal of Perinatology Vol. 4 No. 2 (2023): Available online : 1 December 2023
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v4i2.38

Abstract

Cesarean sections have recently increased dramatically worldwide in the last 50 years. Unfortunately, the post-cesarean section maternal morbidity rate is reported to be relatively high, which is as high as 36%. Some of the most common complications of cesarean section are fever (25%), bleeding (4%), hematoma (4%), and urinary tract infection (3%). Among these complications, obstetric hemorrhage is one of the most common causes of maternal death worldwide. Excessive hemorrhage associated with a cesarean section is defined as blood loss above 1000 ml is frequently underestimated, but is documented as occurring in more than 5–10% of cesarean sections. In most cases, this can be treated with conservative treatment such as vaginal packing and administration of uterotonic drugs. However, some persistent bleeding cases require specific treatment and techniques during the operation. Therefore it is essential to understand the steps and procedures for handling bleeding during cesarean section to reduce maternal mortality. This article review aims to summarize some techniques that can be used to control bleeding during cesarean section.
Comparison of punch biopsy and Loop Electrosurgical Excision Procedure (LEEP) on abnormal colposcopy findings in daily use which is preferable Sastra Wianta, I Gde; Marvy Khrisna Pranamartha, Anak Agung Gde; Alexander Setiawan, William
Indonesian Journal of Perinatology Vol. 4 No. 2 (2023): Available online : 1 December 2023
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v4i2.39

Abstract

Cervical cancer has become a global problem with high mortality and morbidity and contributed to around 311,000 deaths in 2018 which tends to rise every year. Detection of cervical cancer is very necessary to provide appropriate management to patients. Various detection and diagnosis approaches to cervical cancer continue to be developed along with advances in technology. However, comparisons of the types of methods used have not been widely reported. A biopsy is a tool used to detect a suspected malignancy that has been used for many years. One of them is a punch biopsy, a method often used to detect cervical cancer. Currently, technology is developed with the discovery of various other diagnostic tools such as Loop Electrosurgical Excision Procedure (LEEP). LEEP is an excisional procedure in high-resource settings to provide tissue for histopathology. However, the role of punch biopsy can’t be ruled out. This article discusses the differences between a punch biopsy and a LEEP procedure and the advantages and disadvantages of both.
Dilemmatic treatment of recurrent right breast mucinous carcinoma in a 34-year-old pregnant woman: a case report Widhusadi, Ni Luh Wita Astari; Setiawan, William Alexander
Indonesian Journal of Perinatology Vol. 4 No. 2 (2023): Available online : 1 December 2023
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v4i2.40

Abstract

Introduction: In females under 35, the incidence of mucinous carcinoma (MC), a rare form of breast carcinoma, is 1%. When pregnancy-associated breast cancer is diagnosed, it presents a challenge to strike a balance between a potentially fatal therapy for the fetus and a life-saving therapy for the mother's breast cancer. This study aimed to present an MC case in a 34-year-old female with seven weeks-old gestations. Case presentation: The 34-year-old woman presented with a lump on her right breast in 2012 and was diagnosed with giant fibroadenoma. Then, an excisional biopsy was performed, and the pathological finding showed a grade II MC. After one year of tumor regression, another mass was found on the same side of the breast. A repeated ultrasound was carried out, and then the patient was scheduled to have a radical mastectomy followed by radiotherapy. During the schedule of radiotherapy, she found out that she was 6-7 weeks pregnant. This condition brought a new problem since there was a chance that the radiotherapy may have affected the fetus. Therefore, the radiotherapy treatment was postponed until the 6-month gestational age or after the delivery of the baby. Conclusion: Our case report shows the complexity of judgments to achieve the holistic treatment of our patient's condition. Furthermore, the determination of 'wait-and-observe' could be contemplated for the characteristics of the tumor and the patient's decision.
Newer technique in surfactant administration Wandita, Setya
Indonesian Journal of Perinatology Vol. 4 No. 2 (2023): Available online : 1 December 2023
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v4i2.41

Abstract

Respiratory distress syndrome (RDS) is a morbidity often found in premature infants. The incidence of RDS is inversely proportional to gestational age and decreases with the presence of antenatal steroids. Surfactant is a phospholipid produced by type 2 pneumatocytes. Surfactant coats the alveoli and bronchioles so that their surface tension is reduced. Thus, the alveoli and bronchioli remain open, allowing gas exchange. After surfactants are known to benefit RDS, the next question is when is the right time to give them. There are 2 alternative times for surfactant therapy, namely before symptoms appear or a diagnosis is made (prophylaxis) and after RDS symptoms appear (rescue). Several Newer techniques in surfactant administration will be discussed in this article.
The effect of maternal diabetes on the formation of fetal surfactant Sanjaya, I Nyoman Hariyasa; Sutandi, Chatrine
Indonesian Journal of Perinatology Vol. 5 No. 1 (2024): Available online: 1 June 2024
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v5i1.42

Abstract

Elevated maternal blood glucose levels in pregnancy correlate with increased risk of pregnancy complications, labor, and pregnancy outcomes. Type II alveolus cells produce a combination of fat and protein called pulmonary surfactant. To assist in preserving lung stability, pulmonary surfactant plays a crucial function in lowering the propensity of the alveolus to recoil and preventing alveolus collapse. The hallmark of maternal diabetes is the malfunctioning of pancreatic β-cells, which results in insufficient insulin production to sustain proper blood glucose levels. Respiratory distress syndrome (RDS) in newborns is caused by surfactant lack of sufficiency, which is caused by fetal hyperglycemia and hyperinsulinism brought on by maternal diabetes. Appropriate treatments are required to improve glycemic management since maternal diabetes raises the risk of RDS in term newborns. These therapies include a deeper comprehension of the molecular mechanisms behind gestational diabetes mellitus that impact the surfactant system. Phosphatidylglycerol levels are either nonexistent or extremely low in infants with RDS. Phosphatidylglycerol synthesis during pregnancy in diabetics is known to be delayed in comparison to the non-diabetic control group. For this reason, proper care is essential to enhancing long-term health and neonatal outcomes. These findings underscore the need for early detection and management of maternal diabetes to mitigate the risk of RDS and improve neonatal health.

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