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I Nyoman Hariyasa Sanjaya
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INDONESIA
Indonesian Journal of Perinatology
Published by The Indonesian Society of Perinatology
ISSN : 27750744     EISSN : 27750736     DOI : https://doi.org/10.51559/inajperinatol.
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing
peer-reviewed journal aiming to communicate high-quality research articles, reviews, and general articles in the field. InaJPerinatol publishes articles that encompass basic research/clinical studies related to the cardiovascular and thorax field. The Journal aims to bridge and integrate the intellectual, methodological, and substantive diversity of medical scholarship and encourage a vigorous dialogue between medical scholars and practitioners.
Arjuna Subject : Kedokteran - Obstetrics and Gynaecology
Articles 59 Documents
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Differences in enteral nutrition on weight gain and length of stay of premature LBW at Kraton Hospital, Pekalongan Regency Ayu, Gista; Chabibah, Nur
Indonesian Journal of Perinatology Vol. 5 No. 1 (2024): Available online: 1 June 2024
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v5i1.43

Abstract

Introduction: Premature birth and low birth weight are major risk factors for infant mortality. The lower the birth weight, the higher the risk of mortality. Providing nutritional intake is very important for the survival of premature babies. Types of enteral nutrition that can be given are breast milk, HMF breast milk, and formula milk. This study aims to determine the difference in enteral nutrition on weight gain and length of stay of premature LBW. Method: This is a cross-sectional study with a simple random sampling technique—data from medical records of premature LBW babies from 2019 to 2023. Results: There was no significant difference between the type of enteral nutrition given on weight gain, both in the type of enteral breast milk (p-value: 0.081; mean: 134.19; SD: 103.31), breast milk HMF (p-value: 0.081; mean: 119.36; SD: 157.94), formula milk (p-value: 0.081; mean: 163.32; SD: 120.51). There was no significant difference between the type of enteral nutrition provided and the length of stay in both types of enteral breast milk (p-value: 0.256; mean 12.26; SD: 9.61), breast milk HMF (p-value: 0.256; mean: 20.91; SD: 17.277), formula milk (p-value: 0.256; mean: 13.46; SD: 11.877). Conclusion: The highest average weight gain of premature LBW infants was in HMF breast milk nutrition. The average length of the fastest period of care for premature LBW babies is on breast milk nutrition. Suggestions to provide education to pregnant women in optimizing breastfeeding through expressed breast milk for premature LBW babies who are being treated in the hospital. So that it can increase body weight and shorten the period of hospitalization.
The Role of Cytokines, Hormones, and Cellular Regulation in Improving Maternal and Fetal Well-Being Hariyasa Sanjaya, I Nyoman; Sutandi, Chatrine; Syauta, Fetrisya
Indonesian Journal of Perinatology Vol. 5 No. 1 (2024): Available online: 1 June 2024
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v5i1.51

Abstract

Maternal and fetal well-being is a complex interplay of various factors. A key factor is that women receiving early and adequate pregnancy care are more likely to achieve positive pregnancy outcomes. Several studies have identified internal maternal factors as significant contributors to the well-being of both mother and fetus. However, scientific research and discussions on the role of cytokines, hormones, and cellular regulation in maternal and fetal well-being outcomes still need to be completed. Progesterone, a vital hormone for pregnancy and humans, influences immune function directly and through mediators by promoting the synthesis of T helper cell-type cytokines. The favorable benefits of dydrogesterone on repeated spontaneous miscarriages and impending miscarriages may be attributed to the regulating effects of these cytokines and the hormone's capacities. T helper cell-produced cytokines are linked to allograft rejection. Lastly, our finding of cellular regulatory mechanisms, including apoptosis, autophagy, and cellular senescence, highlights the multifaceted nature of maintaining maternal and fetal health during pregnancy. This review aims to delve deeper into the role of cytokines, hormones, and cellular regulation in enhancing maternal and fetal well-being.
Various birth techniques: home birth, water birth, lotus birth, hypno birth, and birth position Winata, I Gde Sastra; Harrista, Daniel Victor; Setiawan, William Alexander
Indonesian Journal of Perinatology Vol. 5 No. 1 (2024): Available online: 1 June 2024
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v5i1.52

Abstract

Background: The birth process varies greatly; health workers should be able to provide education about each technique and help patients plan their labor process. Each delivery technique is assessed from the mother's side and the baby's side, not only for patient satisfaction but also for patient safety. This article will provide a review of various birth technique known which are home birth, water birth, lotus birth, hypno birth, and including various birth position. Methods: This article is a systematic review of qualitative and quantitative studies from studies published in PubMed, Cochrane, the British Medical Journal, BioMed Central, and Elsevier, published in 2015 to 2023. The study sample included healthy maternal nulliparous or multiparous women with a low risk of complications. The focus of the research is on childbirth using home birth techniques, water birth, lotus birth, hypno birth, and birth positions. This article includes research conducted in hospitals, maternity homes, and patients' homes. Results: There are 6 studies included in this review. Each of which provide the perspectives and experiences of patients and healthworkers regarding various birth technique used. Conclusions: Each birthing technique has its own advantages and disadvantages. Each birthing technique also has its own recommendation criteria so that a birthing technique cannot be used for every birthing patient. The birthing technique and birthing position must be adjusted to the patient's condition and the medical facilities available at that time.
Characteristic of Cervical Cancer in Reproductive Woman (Under 40 years old) at Prof. I.G.N.G. Ngoerah Denpasar Bali from January - December 2023 Suwiyoga, Ketut Suwiyoga; Budiana, i Nyoman Gede Budiana; Mahendra, I Nyoman Bayu; Winata, I Gde Sastra Winata; Saspriyana, Kade Yudi Saspriyana; Prayudi, Pande Kadek Aditya Prayudi; Ongko, Eric Gradiyanto Ongko; Hitasari, I Gusti Ayu Made Putri; Septiani, Winty Septiani; Mardana, I Wayan Rivandi Pradiyadnya Mardana; Ronaldo, Fransiscus Ronaldo; Yoga, I Putu Bagus Mulyana Yoga
Indonesian Journal of Perinatology Vol. 5 No. 2 (2024): (Available online: 1 December 2024)
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v5i2.53

Abstract

Background: Cervical cancer caused 275,000 deaths globally, with the mortality rate up to 52%. In the past 30 years, the percentage of young women affected by cervical cancer has increased, ranging from 10% to 40%. This study aims to describe the case of cervical cancer in reproductive women in Prof Dr. I.G.N.G Ngoerah General Hospital. Method: This is a cross-sectional retrospective descriptive study involving all cases of cervical cancer diagnosed from January to December 2023 in Prof Dr. I.G.N.G Ngoerah General Hospital. Prof Dr. I.G.N.G Ngoerah General Hospital. We included all cases of cervical cancer proven by histopathology or ultrasound reports. Data were tabulated in the table and analyzed using SPSS version 24.0. Result: We involved 61 patients in this study, with the mean age of participants was 33.91± 4.98. Most patients had two children (45.16%). Patients predominantly came with stage IIB (33.87%). Tumor size was varied, with ≤4 cm being more dominant (67.74%). Chemoradiotherapy was preferred for the management of cervical cancer (37.10%) Conclusion: The characteristics of patients with cervical cancer were varied compared to the literature. Multifactorial risk factors of this disease could explain these. The management should be tailored to the clinical condition of the patient's guidance under the available consensus.
Correlation between low level of vitamin D [25(OH)D] and high level of interleukin-2 (IL-2) in preterm birth: a systematic review Sanjaya, I Nyoman Hariyasa Sanjaya; Mulayana, Ryan Saktika Mulyana; I Gusti Ngurah Agung Trisnu Kamajaya
Indonesian Journal of Perinatology Vol. 5 No. 2 (2024): (Available online: 1 December 2024)
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v5i2.55

Abstract

Preterm birth, characterized by uterine contractions and cervical changes before 37 weeks of gestation, is a leading cause of neonatal morbidity and mortality worldwide. Its multifactorial pathophysiological mechanisms include inflammatory responses. Emerging evidence suggests that vitamin D and interleukin-2 (IL-2), a pro-inflammatory cytokine, play significant roles in preterm birth by modulating immune responses. A systematic literature review was conducted using Google Scholar and PUBMED databases (2010–2023). Keywords included "vitamin D," "interleukin-2," and "preterm birth." Inclusion criteria covered observational, cohort, and case-control studies investigating the relationship between vitamin D, IL-2, and preterm labor. A total of eight studies met the eligibility criteria and were synthesized narratively. The review revealed that vitamin D deficiency is linked to increased IL-2 levels and heightened inflammatory cytokine activity, contributing to uterine smooth muscle contractions and preterm labor. Conversely, sufficient vitamin D levels suppress IL-2 transcription and reduce pro-inflammatory cytokines, potentially mitigating the risk of preterm birth. However, inconsistencies across studies were observed, attributed to population heterogeneity and varying definitions of preterm birth. Vitamin D may protect against preterm birth by modulating immune responses and reducing inflammation. Incorporating vitamin D supplementation into antenatal care, particularly for at-risk populations, could reduce preterm birth rates. Further randomized controlled trials are necessary to validate these findings and determine optimal supplementation strategies.
The Outcome of Ethanol Directed Sclerotherapy for the Management of Endometrioma: A Systematic Review Kamajaya, I Gusti Ngurah Agung Trisnu; Suardika, Anom; Mahayasa, Putu Doster; Budiana, Nyoman Gede; Abhimantra, Gede Bagus Kantwa
Indonesian Journal of Perinatology Vol. 5 No. 2 (2024): (Available online: 1 December 2024)
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v5i2.56

Abstract

Background and Objectives: Ovarian endometriomas, commonly known as chocolate cysts, are prevalent gynecological conditions associated with chronic pelvic pain and infertility. Current standard treatment, laparoscopic cystectomy, poses risks such as reduced ovarian reserve. Ethanol-directed sclerotherapy has emerged as a minimally invasive alternative aiming to preserve ovarian tissue while treating endometriomas. This systematic review evaluates the outcome of ethanol directed sclerotherapy for the management of endometrioma. Methods: Following PRISMA guidelines, databases including PubMed, EMBASE, and Cochrane were searched in January 2024 using “endometrioma and sclerotherapy.” Inclusion criteria encompassed studies reporting success rate (SR), RR, and pregnancy rate (PR) post-treatment. Nine studies involving 499 patients were analyzed. Results: Ethanol sclerotherapy demonstrated >80% SR in six studies and <30% RR in seven studies, indicating efficacy in reducing recurrence. However, its impact on ovarian reserve remains inconclusive. Pregnancy outcomes were inconsistently reported, with one study achieving 100% PR, while others ranged from 0% to >30%. Variability in techniques, such as ethanol concentration and retention time, likely influenced outcomes. Conclusions: Ethanol sclerotherapy offers a promising alternative to surgery, showing lower RR and potential preservation of ovarian function. Despite these benefits, inconsistencies in procedural protocols and limited data on long-term fertility outcomes necessitate further research. Standardized guidelines and larger cohort studies are essential to establish sclerotherapy's role in endometrioma management, especially for fertility preservation.
A challenging strategy toward severe maternal outcome adversed from systemic lupus erythematosus and nephrotic syndrome in pregnancy: a case report Manuaba, Ida Bagus Gde Fajar Manuaba; Mahayasa, Putu Doster Mahayasa; Nyoman Gede Budiana; Kamajaya, I Gusti Ngurah Agung Trisnu Kamajaya; Andrian, Samuel Albert Andrian
Indonesian Journal of Perinatology Vol. 5 No. 2 (2024): (Available online: 1 December 2024)
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v5i2.57

Abstract

Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that affects multiple organ systems, characterized by the production of autoantibodies and a wide range of symptoms resulting from damage to vital organs. Renal involvement is observed in approximately 40% of SLE patients and can present as various forms of glomerulonephritis, including membranous lupus nephritis, diffuse proliferative glomerulonephritis, and minimal-change nephropathy (MCN), particularly in cases associated with nephrotic syndrome. This case report highlights the therapeutic challenges in managing women with severe SLE and nephrotic syndrome during pregnancy and the postpartum period. Case presentation: A 21-year-old woman at 37 weeks of gestation presented with a history of nephrotic syndrome secondary to severe SLE. She was diagnosed with nephrotic syndrome at 30 weeks of pregnancy, with differential considerations including pregnancy complications and severe SLE activity (ACR/EULAR score 10). Additional diagnoses included lupus nephritis, stage II hypertension, mild anemia (hemoglobin 8.9 g/dL), hypoalbuminemia (1.5 g/dL), hypercholesterolemia, anasarca edema, oligohydramnios, and a non-reactive non-stress test (NST). An emergency cesarean section was performed successfully, after which the patient was admitted to the high-care unit for close postoperative monitoring. Post-surgery, she received multidisciplinary management involving an intensivist and a nephrologist. Conclusion: This study explores the interplay between SLE and nephrotic syndrome, focusing on their impact on maternal and fetal health during pregnancy. It highlights the importance of a multidisciplinary approach in managing these conditions to mitigate the risk of severe maternal and fetal complications.
Operative treatment for adenomyosis: update on literature review Winata, Gde Sastra; Suardika, Anom; Mahayasa, Putu Doster; Budiana, Nyoman Gede; Kamajaya, I Gusti Ngurah Agung Trisnu
Indonesian Journal of Perinatology Vol. 5 No. 2 (2024): (Available online: 1 December 2024)
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v5i2.58

Abstract

Adenomyosis, a condition characterized by the presence of endometrial tissue within the myometrium, poses significant challenges in diagnosis and management due to its widespread and infiltrative nature. Operative treatment remains the primary treatment of choice for patients with symptomatic adenomyosis, especially those seeking fertility preservation or uterine conservation. This review explores the latest surgical techniques, emphasizing the balance between effective lesion removal and preservation of uterine function. Techniques such as asymmetric dissection, wedge resection, and various flap methods are discussed, highlighting their role in minimizing the loss of healthy myometrium while preserving uterine integrity. The evolution of laparoscopic and robotic approaches has improved accuracy and recovery, while innovative procedures such as the PUSH operation offer improved structural healing after excision. The choice of technique is guided by preoperative imaging and intraoperative findings, tailored to the extent and location of adenomyosis involvement. This review underscores the importance of individualized surgical strategy in achieving optimal outcomes in the surgical management of adenomyosis.
Role of hypogastric artery ligation in obstetric and gynecological hemorrhage: narrative review Winata, Gde Sastra Winata; Suardika, Anom; Mahayasa, Putu Doster; Budiana, Nyoman Gede; Kamajaya, I Gusti Ngurah Agung Trisnu
Indonesian Journal of Perinatology Vol. 5 No. 2 (2024): (Available online: 1 December 2024)
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v5i2.59

Abstract

Hypogastric artery ligation (HAL) is a vital surgical intervention for controlling severe pelvic hemorrhage in obstetric and gynecological cases. This narrative review examines the efficacy, safety, and implications of HAL in managing life-threatening hemorrhages, including postpartum hemorrhage (PPH) and gynecological emergencies. HAL is particularly effective in addressing hemorrhage associated with uterine atony, placenta accreta spectrum disorders, and secondary bleeding following hysterectomy or gynecological surgeries. Success rates vary widely, ranging from 33.3% to 89.2%, depending on the indication and clinical scenario. HAL offers significant advantages in fertility preservation, especially in cases where uterine conservation is desired. The procedure has been shown to reduce arterial pulse pressure by 85% and overall blood flow by nearly 50%, enabling effective hemostasis. Despite these benefits, the success of HAL heavily depends on the surgeon's expertise and the timely identification of hemorrhage. While complications such as organ ischemia and collateral vessel injury are rare, their potential underscores the need for meticulous surgical technique and postoperative monitoring. The search strategy for this review included PubMed databases, focusing on articles published up to 2019 with keywords such as "Hypogastric Ligation," "hypogastric ligation gynecology," and "hypogastric ligation obstetric." A total of 262 studies were initially identified, with 8 meeting the inclusion criteria for detailed analysis. These studies highlight HAL's role as a fertility-sparing, cost-effective option for managing severe pelvic hemorrhage, making it an indispensable tool in obstetric and gynecological practice.
Antioxidant administration on the incidence of preterm premature rupture of membranes: a literature review Winata, I Gde Sastra; Mahendrata, Prayascita; Wiraputri, Anak Agung Ratih Kusumadewi; Anwar, Meirisa Afifah Nurmalia; Jessica Nathalia
Indonesian Journal of Perinatology Vol. 6 No. 1 (2025): (Available online: 1 June 2025)
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v6i1.75

Abstract

One of the obstetric issues that can lead to consequences for both the mother and the unborn child is premature rupture of membranes (PROM).  In Indonesia, 35% of pregnancies ended in preterm rupture of the membranes in 2013.  The incidence of preterm pregnancy is 2% of all pregnancies, while the incidence of term pregnancy ranges from 6 to 19%.  At 37 weeks gestation, the phrase "premature rupture of membranes" is used.  Preterm premature rupture of membranes (PPROM) is the term used to describe when the membranes burst before birth in women whose gestational age is less than 37 weeks.  It is believed that the pathophysiology of premature membrane rupture involves reactive oxygen species (ROS).  The result of premature membrane rupture is anticipated to be impacted by antioxidant supplementation.

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