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Medical Sains : Jurnal Ilmiah Kefarmasian
Published by Sekolah Tinggi Farmasi Muhammadiyah Cirebon
ISSN : 25412027     EISSN : 25482114     DOI : 10.37874/ms
Core Subject : Health,
Medicine & Pharmacology
The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy covering the fields of formulation, pharmacology, communication pharmacy, A natural chemical chemistry, pharmacognomy and other health sciences which is a means for lecturers and researchers in the health sector to share knowledge and establish cooperation in implementing the Tri Dharma of Higher Education. Purpose and Scope The objective of the publication of the Medical Science journal is to publish articles in the field of pharmacy and other health as well as application of pharmaceutical . Based on this, the editorial board of Medical Sains invites lecturers and researchers to contribute to submit research articles related to the following themes: 1. Pharmaceutical formulation technology 2. Pharmacology 3. Community pharmacy 4. Clinical Pharmacy 5. Natural material chemistry 6. Pharmacognosy 7. Pharmaceutical Analysis and Medicinal Chemistry
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 42 Documents
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Search results for , issue "Vol 8 No 3 (2023)" : 42 Documents clear
ANALYSIS OF ADVERSE DRUG REACTIONS TO ANTIRETROVIRALS USE IN A SECONDARY HOSPITAL Vitarani Dwi Ananda Ningrum; Nadia Hanrisari; Tiara Amalia; Sufiyah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.812

Abstract

Although antiretrovirals (ARV) evidently extend the life expectancy of people living with HIV/AIDS (PLWH), their associated Adverse Drug Reactions (ADRs) are unavoidable, particularly in long-duration regimens. Several studies have reported a correlation between ADRs and adherence to ARV therapy. Meanwhile, ARV is the main determinant of achieving an immunological and virologic response. Pharmacists play the role of counselors in improving therapeutic outcomes including ADR management. This study aimed to analyze ADRs induced by ARV based on pharmacy documentation and to describe the frequency of PLWH follow-up visits over a two-year period. The study was conducted at Sleman Regional Hospital, an HIV/AIDS referral hospital in Yogyakarta. A cross-sectional design was used with saturated sampling, including all ARV use for HIV/AIDS. Data were collected from the pharmacy unit and patients’ spontaneous reports. Prescribed ARV came from the electronic system, whereas ADR reports were from patients during voluntary consultation with the pharmacist or in PITC services. A total of 110 ARV were administered mostly to male patients aged 25-40 years. The most regimen was tenofovir+lamivudine+efavirenz (91%) with the highest frequency of follow-up visits ? 12 times (53%). The top three ADRs were dizziness (30%), nausea (11%), and headache (8%). Three of the four pediatric patients experienced ADRs, each with AZT-induced fatigue, bloating, and diarrhea in LPV/r monotherapy. Most of the patients did not maintain appointments for hospital visits. Further studies are recommended to analyze the causative factors of non-adherence, including the loss to follow-up group.  Keywords: Adverse Drug Reaction, Antiretroviral, Hospital, Indonesia
THE LEVEL OF CONSUMER SATISFACTION WITH THE NON-PRESCRIPTION DRUG INFORMATION SERVICE AT THE PHARMACY WEDOMARTANI YOGYAKARTA AREA Nova Aprilia; Yosef Wijoyo
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.817

Abstract

An essential pharmacy service is the pharmacists' information service on medications. This service will have an effect on improving customer satisfaction and raising awareness of the use of medications. Many clients are still unhappy with this service. This study aims to assess consumer satisfaction levels with the non-prescription drug information service provided at pharmacies in the Wedomartani area and identify gaps between consumer expectations and the actual service. This investigation is a cross-sectional, analytical, and observational study. A total of 142 customers, who bought over-the-counter medications at four pharmacies in the Wedomartani region between March and April 2022, served as respondents. The research instrument used is a service quality questionnaire with the servqual method. The questionnaires used have undergone validity tests, language comprehension tests, and reliability tests. There are two ways to complete surveys: offline (on paper) and online (using a Google form). Three methods are used to assess the data: gap analysis, customer satisfaction index computation, and importance-performance analysis (IPA). The findings revealed that (1) the results of the gap analysis were < 0 (negative value f), (2) the CSI analysis yielded a minimum value of 80%, and (3) there is a need to strengthen medication information services. The conclusions of this study are: there is still a gap between reality and expectations felt by consumers; Theoretically, drug information should be based on scientific information, but the delivery of drug information needs to be simplified so that it is easily understood by the recipient of the information...
EFFECTIVENESS ANTI-INFLAMMATORY OF SUNGKAI LEAF (Peronema canescens Jack.) ETHANOL EXTRACT ON MALE RABBIT (Oryctolagus cuniculus) Riana Versita; Aknes Dewi Setiani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.822

Abstract

Sungkai leaves are medicinal plants used empirically by the people of Bengkulu, often found in the tropical rainforests of Bengkulu province. Sungkai leaf secondary metabolites include flavonoids, alkaloids, saponins, and steroids/triterpenoids. Flavonoid compounds have hundreds of bioactivities including antipyretic, analgesic, antidiabetic, anticholesterol and anti-inflammatory. The aim of this study was to obtain a new drug that has effectiveness as an anti-inflammatory from ethanol extract of Sungkai leaves (Peronema canescens Jack) n male rabbits (Oryctolagus cuniculus) The study used an experimental method using male rabbits as experimental animals. The samples were divided into 5, namely negative control, positive control, and 2%, 4%, and 6% bioplacenton and sungkai leaf extract. Each group was subjected to 2nd degree burns.”Measurements were taken every day for 8 days after injury. The results of the study proved that there was a decrease in wound diameter from Sungkai leaf extract, on average at a concentration of 2% it decreased by 64% and at a concentration of 66% it decreased by an average of 13.3% and at a concentration of 6% it decreased by an average of 78,67%. Based on the statistical results of the analisis of variance test, there is a significant difference. Keywords: Sungkai leaf extract, anti-inflammatory, Bioplacentone
PHYTOCHEMICALS SCREENING AND ANTIOXIDANT ACTIVITY TEST OF ETHYL ACETATE FRACTION OF CHINESE BETLE LEAVES (Peperomia pellucida L.) Naida Rahma Almira; Didin Ahidin; Iin Indawati
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.823

Abstract

Peperomia pellucida (Chinese betel) is considered as a plant with antioxidant activity for  inhibiting oxidation reactions. This study aims to determine the yield of secondary metabolites, total flavonoid levels, and antioxidant activity. Dried leaves of Chinese betel were macerated using 70% ethanol as solvent. The extract was partitioned until the n-hexane and ethyl acetate fractions were obtained. A phytochemical screening test was followed by determining total flavonoid levels and antioxidant activity using UV-Vis spectrophotometry. Phytochemical screening results containing an ethanolic extract of Chinese betel leaves (ECBL) showed positive results on alkaloid, flavonoid, saponin, and tannin. Meanwhile, the ethyl acetate (EAF) and n-hexane (HF) fractions showed positive results only for flavonoid presence. The total flavonoid contents of ECBL, EAF, and HF were 3.30%, 2.54%, and 2.03%, respectively. The IC50 values of  ECBL, EAF, and HF were 7.51 ppm, 8.02 ppm, and 8.04 ppm, respectively. The highest flavonoid content was found in ECBL. Antioxidant activity test of Peperomia pellucida ethanolic extract, ethyl acetate fraction, and n-hexane fraction showed potent antioxidant activity.  Keywords: Antioxidant, Peperomia pellucida , DPPH
FORMULATION AND CHARACTERIZATION OF 50% ETHANOL EXTRACT OF ARECA NUT (Areca catechu) NANOPARTICLES USING THE IONIC GELATION METHOD Humaryanto; Fathnur Sani Sani K; Yuliawati; Ave Olivia Rahman; Muhaimin; Alfi Khatib
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.826

Abstract

The extract of areca nuts (Areca catechu) contains secondary metabolites, such as flavonoids, alkaloids, saponins, tannins, and steroids. These compounds possess pharmacological effects and can be developed into herbal medicine products. The objective of this study is to determine the optimal nanoparticle formulation by varying the concentrations of chitosan and sodium tripolyphosphate. The 50% ethanol extract of areca nuts was obtained through the maceration method. The extract obtained calculation the yield value. Then tested for phytochemical screening. Subsequently, the extract was formulated into nanoparticle colloids with different ratios of extract concentration: chitosan: sodium tripolyphosphate: Tween 80. The resulting nanoparticles were characterized by their particle size, zeta potential, and polydispersity index. The research findings demonstrated that Formula 3 exhibited the best results, with a particle size of 254.2 ± 0,00, zeta potential of 12.7 ± 0,71, and polydispersity index of 0.436 ± 0,03. Keywords: Formulation, Nanoparticles, 50% Ethanol, Areca Nuts, Ionic Gelation.
FORMULATION OF EYESHADOW CREAM COMBINATION OF EXTRACT SPISSUM BUTTERFLY PEA FLOWER (Clitoria ternatea L.) WITH SECANG WOOD (Caesalpinia sappan L.) AS A NATURAL COLOR Dini Agustina Yuniaty; Deni Rahmat; Rahmaniar Rachmat
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.827

Abstract

Eye shadow is one of the decorative cosmetic that contains color that is applied to the eyelids. Eye shadows were generally blue, pink, dark red, silver, green, and brown. Natural dyes are derived from plants, animals, and microorganisms. Butterfly pea flower (Clitoria ternatea L.) and secang wood (Caesalpinia sappan L.) are plants that contain natural dyes that can be used as dyes. The two plants were removed by maceration in 70% ethanol. Eye shadow preparation using a combination of extract spissum of  butterfly pea flower and secang wood produces eye shadow with a purple color in 3 formulations, namely F3 extract spissum butterfly pea flower and secang wood (3:2), F4 extract spissum butterfly pea flower and secang wood (2:3), F5 extract spissum butterfly pea flower and secang wood (1:4). In the hedonic test, there was no significant difference >0.05% among F3, F4, and F5. Thus, the results of the irritation test showed that the eye shadow cream preparation produced an irritation index of 1.00, namely, mild irritation. Keywords: Eye shadow, butterfly pea flower, Secang wood.
SOLID EYELINER FORMULATION CONTAIN CLITORIA TERNATE L. EXTRACT IN PH ACID AND ALKALI AND IN VIVO IRRITATION TEST Linawaty Lee; Ratna Djamil; Deni Rahmat
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.828

Abstract

Clitoria ternatea flowers contain blue anthocyanin that has potential as natural coloring. The purpose of this study was to obtain an eyeliner product containing natural coloring that is safe, stable, and can replace hazardous chemicals. Clitoria ternatea flowers were extracted by kinetic maceration with 70% ethanol. The obtained extract was subjected to standard quality tests, phytochemical screening, and determination of total anthocyanin content and antioxidant activity (DPPH assay). Eyeliner-containing extracts were prepared in three pH variations (acidic, neutral, and alkaline). These three types of eyeliner preparations were subjected to an irritation test on shaved male albino white rabbit skin. stability test using the cycle test method, hardness, break point, and melting point were also performed. The results showed that Clitoria ternatea extract contains 0.2187% anthocyanin, has an antioxidant activity IC50 of104.7 µg/mL, and is free of heavy metals. The eyeliner contained Clitoria ternatea extract was dark blue when applied to the skin. Eyeliner preparations were stable in three stability cycle tests. The irritation test on the male albino rabbit skin showed no irritation. Clitorial ternatea extract can be used as natural coloring in eyeliner preparation. Keywords: Butterfly pea, Clitoria ternatea L., Anthocyanin, Antioxidant, Eyeliner.
ARTICLE REVIEW: EFFECT OF COUNSELING ON QUALITY OF LIFE IN TYPE-2 DIABETES MELLITUS PATIENTS Della Puspatari; Siti Saidah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.831

Abstract

Quality of life is a general term for health status, although the term also has a special meaning that ranks the population according to objective and subjective aspects of health status. A disease that reflects a lot of quality of life related to a person's disease is diabetes. Many countries have explained that diabetes is a disease that is serious enough to cause high mortality. PubMed, Science Direct, and Google Scholar are several sources of articles used in searching for information regarding the effect of counseling on the quality of life of Type 2 Diabetes Mellitus patients. The majority of the articles used are the most recent articles written within the last 10 years, namely from 2013 to 2023. The keywords used in the search for these journals were “pharmacy interventions”, “patient counseling”, “quality of life”, “type 2 diabetes mellitus”. Intervention by pharmacists significantly improves the quality of life of type 2 diabetes mellitus patients. Similar studies have been conducted by researchers in several countries. It has been proven that the quality of life of patients with type 2 diabetes mellitus is significantly improved by clinically mediated pharmacist interventions on medication, illness, nutrition, exercise, lifestyle change, and self-care practices in the management of diabetes,. Through counseling that promotes patient trust and compliance, pharmacists play a crucial role in educating patients. It has an effect on patient satisfaction with DM therapy as well as on improving quality of life. Patients have high expectations for pharmacist education...
A MINI REVIEW ON ZINGIBERACEAE FAMILY AS ANTIDIABETIC PLANTS: ACTIVE INGREDIENTS AND MECHANISMS OF ACTIONS Fatiya Zata Ishmah; Agus Sulaeman
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.833

Abstract

Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia that occurs due to abnormalities in insulin secretion. Therapy using conventional anti-diabetic drugs is associated with serious side effects, and herbs to maintain chronic disease if conventional drugs not adequate. The purpose of this article review is to find out information about plants of the Zingiberaceae family that have anti-diabetic activity with the mechanism of action of ? -glucosidase enzyme inhibition, ? -amylase enzyme inhibition, and increased GLP-1 levels. The sources used consisted of 27 journals and reviewed 9 research journals originating from Google Scholar, Pubmed, NCBI, Elsevier, Science Direct with a span of under 10 years. The articles were then analyzed using the systematic literature review method, by collecting, evaluating, and developing research on a particular topic. From several studies conducted, the results showed that plants from the family that have antidiabetic activity include Zingiber officinale (ginger), Curcuma longa (turmeric rhizome), Curcuma aeruginosa (temu hitam), Curcuma zanthorrhiza (curcuma), Zingiber cassumunar (bangle), Kaempferia galanga (kencur), Alpinia galanga (lengkuas), Etlingera elatior (kecombrang, honje), and Elettaria cardamomum (kapulaga). Keywords: Antidiabetic; Diabetes Mellitus;  Zingiberaceae
ANTIBACTERIAL POTENTIAL OF EGGPLANT FRUIT (Solanum melongena L) ETHANOL EXTRACT AGAINST Propionibacterium acnes BACTERIAL GROWTH Irfan Zamzani; Islan Nor; Muhammad Raihan
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.840

Abstract

Acne is one of the skin problems that, without our realizing it, can reduce self-confidence, despair, and even depression among teenagers and young adults. The incidence of bacterial infections is increasing with the increasing cases of resistance of bacteria, such as Propionibacterium acnes, to the side effects of anti-acne drugs. Indonesia has many plants that are beneficial to humans and have properties for treating and improving health, one of which is the eggplant. The purpose of this study is to test whether eggplant has antibacterial activity against P. acnes. The eggplant was extracted using a maceration extraction method. For antibacterial activity, well diffusion agar was used with extract concentrations of 60%, 70%, 80%, and 90%. The inhibition zones of the ethanol extract of S. melongena at 60%, 70%, and 80% concentrations were 13,76 mm, 18,63 mm, and 20,79 mm, respectively, with the highest inhibition zone at 90% concentration at 20,64 mm. The ethanolic extract of S. melongena has a strong inhibitory effect on P. acnes.  Keywords: antibacterial activity, Solanum melongena L, maceration, Propionibacterium acnes.

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