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All Journal GHIDZA: Jurnal Gizi dan Kesehatan Jurnal Ilmu Kefarmasian Indonesia Medical Sains : Jurnal Ilmiah Kefarmasian Media Bina Ilmiah Medical Sains : Jurnal Ilmiah Kefarmasian
Ratna Djamil
Universitas Pancasila
Humanities Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Identifikasi Senyawa Flavonoid dalam Fraksi n-Butanol Taraxacum officinale, Asteraceae Wiwi Winarti; Ratna Djamil; Indah Yuniasari
JURNAL ILMU KEFARMASIAN INDONESIA Vol 5 No 2 (2007): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Herbs of Taraxacum officinale, a native of Europe, contain a flavonoid, steroid/triterpenoid, saponin, tanin, and a volatile oil. The purpose of this research was to determine the flavonoid substances, after partitioning of the methanolic extract by the Charaux-Paris method with n-butanol. Identification by uv-visible spectrophotometry confirmed that flavonoid from isolate la was a flavonol with an OH at 3, 7 position, oxygen at 6 or 8, while isolate III, also a flavonol, showed an OH at 3, 7 position, oxygen at 6 or 8, and besides that an additional o-diOH attached to ring B.
Karakterisasi Sediaan Granul Biji Sirsak (Annona muricata L.) dan Uji Efektivitas terhadap Larva Aedes aegypti L. sebagai Kandidat Biolarvasida SARAH ZAIDAN; RATNA DJAMIL; SUPRIYONO SUPRIYONO; SITI Nuraini
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 2 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

A. aegypti mosquito is a vector of virus caused dengue fever. The effort to control A. aegypti vector has been done so many times, including chemical, physical and biological method. A biological control against this vector can be performed by utilizing soursop seeds which are known to have larvicidal effect against the larva. Previously, it has been proven that the extract of soursop seed demonstrated larvicidal activity against A. aegypti. In this research, the extraction of soursop seed has been carried out by kinetic maceration with the solvent 70% of ethanol. Furthermore, the wet granulation of the obtained extract was used for the preparation of granules which were then tested its larvicidal activity against A. aegypti. Based on the activity test against the larva of Aedes aegypti, the granules showed LC50 values of 295.434 ppm smaller than temephos as a positive control that has larvicidal activity of 1 ppm cause 100% mortality A. aegypti.
Isolasi dan Identifikasi Senyawa Flavonoid dalam Fraksi n-Butanol Daun Dewa (Gynura pseudochina (L.) DC) secara Spektrofotometri UV-Cahaya Tampak RATNA DJAMIL; CATHARINA YENNI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 1 (2014): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Plant of dewa leaves (Gynura pseudochina ( L. ) DC) from family Asteraceae is a plant that has been widely used for some treatments including blood circulation , trauma, bleeding and blood clot. In this research, the isolation and identification of flavonoid compounds in n-butanol fraction of the methanol extract of dewa leaves (Gynura pseudochina ( L. ) DC) has been carried out. The compound in Dewa leaves was isolated using maceration with methanol which was then partitioned by n-hexane solvent, ethyl acetate and n-butanol. The n-butanol phase was then isolated by paper chromatography with BAW (4:1:5) as a mobile phase which resulted in seven bands. Each of the bands was further identified using spectrophotometry UV-vis to show wavelength of maximum absorption that was given from only three bands for flavonoids namely NB-III, NB-V and NB-VI. Moreover, the bands were further eluated with 15% acetic acid as second mobile phase and the spot appeared in the presence of ammonia. The final isolates were identified by UV-vis spectrophotometer with addition of a shift reagent. The resulting spectrum from the isolates NB-III was considered as the one of flavonol compounds with the OH group at theposition of 3.7 and oxygenation at 6 or 8 and o– at OH group in ring B; NB-V isolates, OH groups at positions 3, 5, 7 and o– at OH group in ring B and NB-VI isolates, the OH group at position 5,7 and 8.
Aktivitas Ekstrak dan Tablet Nanopartikel Buah Okra (Abelmoschus esculentus (L) Moench.) Sebagai Anti- Dislipidemia Pada Tikus Yang Diberi High Fat Diet Sarah Zaidan; Deni Rahmat; Ratna Djamil; Nadya Vresya Saputri
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.1097

Abstract

Dyslipidemia is a condition caused by disruption of lipid metabolism due to the interaction of genetic factors and environmental factors. There is strong evidence of an association between LDL cholesterol and cardiovascular events based on clinical outcome studies, so LDL cholesterol is the main target in the management of dyslipidemia. In addition to using synthetic drugs, dyslipidemia can be treated by consuming natural ingredients, one of which is okra (Abelmoschus esculentus (L) Moench). The form of nanoparticles and nanoparticle tablets of okra fruit extract is an effort to increase antidyslipidemic activity and to make it easier to use. This study aims to obtain nanoparticle extracts and nanoparticle tablets of okra fruit extract which have antidyslipidemic activity in vivo against mice given the High Fat Diet (HFD). The research used 24 rats divided into 6 treatment groups, namely group I as normal control, group II as positive control using simvastatin as the control control, group III as a negative control, group IV as a control treatment of ethanol extract 70% okra fruit, group V as a control treatment of okra fruit extract nanoparticles, and group VI as a treatment of okra fruit extract nanoparticles tablets. All test substances are given for 14 days. Blood sampling was carried out on days 0, 14, and 28, with the parameters measured were lipid profiles including total cholesterol (KT), LDL, Triglycerides (TG) and HDL. 70% ethanol extract, extract nanoparticles, and okra fruit extract nanoparticle tablets can decrease KT levels by 33.14%, 46.31%, 45.42%, decrease TG levels by 39.46%, 43.56%, 41, 62%, decrease LDL levels by 45.22%, 68.76%, 59.94%, and can increase HDL levels by 103.80%, 119.20%, 114.39%. Based on the lipid profile of mice given HFD, 70% ethanol extract, nanoparticles, and okra fruit extract nanoparticle tablets had antidyslipidemic activity.
Isolasi Senyawa Flavonoid dari Ekstrak Metanol Daun Katuk (Sauropus androgynus (L.) Merr), Euphorbiaceae RATNA DJAMIL; SARAH ZAIDAN
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Katuk (Sauropus androgyrus (L.) Merr) is one of the plants used for medicinal purposes. It has been carried out the research to isolate and to identify flavonoid compounds in the methanol extract of katuk leaves using paper chromatography and spectrophotometry ultraviolet-visible. The results demonstrated that light spectrum of uv-visible in the presence of a reagent gave an isolate NB-3 which was a compound suspected of flavonol with OH group in positions 5,7,4 ‘and o-di OH groups in the position of the A-ring (6,7 or 7,8) whrereas NB-4 isolate was suspected as flavonoids with OH groups at 5.7 and the prenil groups in position 6, methylation or glycosylation at OH group in a position 3 and o-di OH groupsin position of the a-ring (6,7 or 7,8).
Identifikasi Golongan Senyawa Flavonoid dalam Fraksi n-butanol dari Ekstrak Metanol Buah Muda Phaleria macrocarpa Ratna Djamil; Tri Astuti
JURNAL ILMU KEFARMASIAN INDONESIA Vol 3 No 2 (2005): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Unripe fruits of Mahkota Dewa (Phaleria macrocarpa [Scheff.](Boerl) containing alkaloid, flavonoid, saponin, terpenoid, volatile oil and tannin, were extracted with methanol and partitioned by the Charaux-Paris method, with. n-butanol Identification by UV-Visible spectrophotometry showed that the flavonoid from that isolate NB-1 was chalcone with OH on 3, 4, 4' position and o-diOH on ring B, and isolate NB-II was also a chalcone with OH on 4, 2', 4' position, oxygenation on 3' and o- diOH one ring B, while isolate NB-III was a flavonol with OH on 3,5,4' position with prenil on 6, and o-diOH on ring A (6,7 or 7,8).
Isolation and Identification of Flavonoid Compounds in n-Butanol Phase Mulberry Leaves (Morus alba L.) using Spectrophotometry RATNA DJAMIL; FATIMAH BAKRIYYAH
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 2 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Murbei (Morus alba L.), suku Moraceae adalah salah satu tanaman yang tumbuh di Indonesia dan banyak digunakan dalam pengobatan secara tradisional. Daun murbei banyak mengandung senyawa kimia seperti flavonoid yang menunjukkan berbagai khasiat farmakologi dan aktivitas biologi. Tujuan penelitian ini untuk mengetahui senyawa flavonoid yang terdapat pada daun murbei. Berdasarkan hasil pemeriksaan penapisan fitokimia dari fase n-butanol daun murbei menunjukkan adanya senyawa flavonoid, saponin, tanin dan kumarin. Telah dilakukan isolasi dan identifikasi senyawa flavonoid dalam fase n-butanol dari ekstrak metanol daun murbei dengan cara kromatografi kertas menggunakan eluen n-butanol-asam asetat-air (4:5:1). Hasil identifikasi dengan spektrofotometer ultraviolet-cahaya tampak diduga mengandung senyawa flavonoid, yaitu isolat NB III merupakan senyawa flavonol dengan gugus OH pada posisi 5, 4’, dan o-diOH pada cincin A serta gugus prenil pada posisi 6. Isolat NB IV merupakan senyawa flavonol dengan gugus OH pada posisi 5, 4’, dan o-diOH pada cincin A serta gugus prenil pada posisi 6. Isolat NB V merupakan senyawa flavonol dengan gugus o-diOH pada cincin A (6,7 atau 7,8). Isolat NB VI merupakan senyawa dihidroflavonol dengan adanya gugus o-diOH pada cincin A (6,7 atau 7,8) dan gugus OH pada posisi 4’.
Identifikasi Senyawa Penghambat Enzim α-Glukosidase dari Ekstrak Etanol 96% Daun Yakon (Smallanthus sonchifolius [Poepp.& Endl.]H. Robinson) Zuhelmi Aziz; Farhana Hanida Al Qisthi; Ratna Djamil; Nancy Dewi Yuliana; Partomuan Simanjuntak; Syamsudin Abdillah
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (709.339 KB) | DOI: 10.35814/jifi.v17i1.652

Abstract

The leaves of yacon (Smallanthussonchi folius [Poepp. &Endl.] H. Robinson) or in Indonesia known as “Daun insulin” (Insulin leaf), scientifically has various medicinal properties and one of them as antidiabetic. The aim of this research is to know α-glucosidase enzyme inhibitor compound in the ethanol 96% extract of yacon leaves. Fractionation of ethanol extract subjected to column chromatography (SiO2; dichloromethane-methanol-water = 5 : 5 : 1) gave 5 fractions (Fr -1 ~Fr – 5). The results of the -glucosidase enzyme inhibition activity test in vitro against the five fractions obtained the 3rd fraction as the most active of 87.84 %. Purification of the 3rd fraction with preparative thin layer chromatography (SiO2; n-BuOH-ethanol-water = 4 : 1 : 2.2) gave pure isolate as Fr 3-1. Identification of pure isolates Fr 3-1 was carried out by interpreted spectra of Ultraviolet, Fourier Transform-Infra Red, Mass Spectra (from LC-MS) and compared data on the chemical shift of the Nuclear Magnetic Resonance (proton and carbon) and determined as Nystose (GF3) compound. The results of the -glucosidase enzyme inhibition activity showed that Fr 3-1 has IC50 of 21.36 ppm
Penapisan Fitokimia dan Uji Hayati secara BSLT dari Daun, Buah dan Biji Phaleria macrocarpa Suci Eka Lestari; Ratna Djamil
JURNAL ILMU KEFARMASIAN INDONESIA Vol 3 No 2 (2005): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Mahkota Dewa (Phaleria macrocarpa [Scheff] Boerl), is Indonesian herb that famous for its medicinal activity. The chemical constituens of the leaves, fruits and seeds have been examined, and BSLT (brine shrimp lethality test) have been carried out. On phytochemical screening, the leaves showed the existence of: volatile oil, sterol, triterpene, higher fatty acid, alkaloid, flavon aglycon, coumarine, tannin, steroid glycoside, flavonoid, polyuronide and triterpene, the fruits contain: volatile oil, sterol, triterpene, higher fatty acid, alkaloid, flavon aglycon, coumarine, tannin, reducing compound, steroid glycoside, flavonoside, polyuronide and saponine; while the seeds contain: steroid, triterpene, higher fatty acid, alkaloid, flavon aglycon, coumarine, tannin, reducing compound, steroid glycoside and flavonoid. Brine shrimp lethality test showed that the LCs of the n-hexane fraction of the leaves, fruits and seeds are 2.34 ppm, 32.62 ppm and 4.33 10-28 ppm respectively; the aethyl acetate fraction of the leaves, fruits and seeds are 10.55 ppm, 29,12 ppm and 4.71 ppm respectively; while the methanol fraction of the leaves, fruits and seeds are 1.46.10-5ppm, 39.32 ppm, and 53.31 ppm respectively. From this study it may be concluded that the n-hexane and aethyl acetate fraction of the seeds have the most active compounds, while the leaves have the most active compounds in the ethyl acetate fraction.
Isolasi dan Identifikasi Senyawa Hasil Fermentasi Kapang Endofit Pasak Bumi (Eurycoma longifolia Jack) Ratna Djamil; Titi Parwati; Nani Khomeni
JURNAL ILMU KEFARMASIAN INDONESIA Vol 2 No 2 (2004): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Endophytic fungi of Pasak bumi (Eurycoma longifolia Jack). were inoculated to synthetic medium and incubated for 28 days. The fumated medium then were extracted with chloroform. The antioxidant activities by 1,1-diphenyl 2-picrylhidrazyl (DPPH) methods showed that isolated compound has scavenging effect at IC285.7 ppm. Identification by interpretation of infra red spectra showed that the isolated compound was a terpenoid.
Co-Authors CATHARINA YENNI Deni Rahmat Dian Karina Farhana Hanida Al Qisthi FATIMAH BAKRIYYAH Indah Yuniasari Linawaty Lee Nadya Vresya Saputri Nancy Dewi Yuliana Nani Khomeni Partomuan Simanjuntak Rina Hijayanti SARAH ZAIDAN SITI Nuraini Stella Giovanny Suci Eka Lestari Supriyono, Supri Syamsudin Abdillah Syamsul Arifin Titi Parwati TRIA ANELIA Wiwi Winarti Zuhelmi Aziz