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Medical Sains : Jurnal Ilmiah Kefarmasian
Published by Sekolah Tinggi Farmasi Muhammadiyah Cirebon
ISSN : 25412027     EISSN : 25482114     DOI : 10.37874/ms
Core Subject : Health,
Medicine & Pharmacology
The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy covering the fields of formulation, pharmacology, communication pharmacy, A natural chemical chemistry, pharmacognomy and other health sciences which is a means for lecturers and researchers in the health sector to share knowledge and establish cooperation in implementing the Tri Dharma of Higher Education. Purpose and Scope The objective of the publication of the Medical Science journal is to publish articles in the field of pharmacy and other health as well as application of pharmaceutical . Based on this, the editorial board of Medical Sains invites lecturers and researchers to contribute to submit research articles related to the following themes: 1. Pharmaceutical formulation technology 2. Pharmacology 3. Community pharmacy 4. Clinical Pharmacy 5. Natural material chemistry 6. Pharmacognosy 7. Pharmaceutical Analysis and Medicinal Chemistry
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 5 Documents
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Search results for , issue "Vol 8 No 4 (2023): Forthcoming Issue" : 5 Documents clear
BIOAVAILABILITY AND MOLECULAR DOCKING PREDICTION OF SECONDARY METABOLITE OF Curcuma zedoaria AS POTENTIAL MPRO SARS COV-2 INHIBITOR Amaliyah Dina Anggraeni; Nia Yuniar Fitriana Putri; Septia Devi Amalia; M. Artabah Muchlisin
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023): Forthcoming Issue
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.805

Abstract

Almost all countries worldwide have been exposed to the COVID-19 pandemic, which can cause respiratory diseases. Therefore, it is necessary to identify and develop drugs for the treatment of COVID-19. White turmeric (Curcuma zedoaria) is very popular because it is effective as an anticancer and antiviral agent. This study used the in silico method to predict the secondary metabolite compounds contained in C. zedoaria as inhibitors of Mpro (main protease) SARS-CoV-2. Of the 30 secondary metabolite compounds identified, 26 compounds had good bioavailability prediction, and three compounds (curcumadiol, curcumin, and desmethoxycurcumin) were predicted to have potential as SARS-COV-2 Mpro inhibitors because they have low inhibition constants and numerous ligand-protein interactions. Curcumadiol have binding energy: -8.34 kcal/mol; pKi: 0.77 µM; hydrogen bond: Glu166, Thr190, and Gln192; and hydrophobic bond: Met165 and Gln189. Curcumin have binding energy: -8.28 kcal/mol; pKi: 0.85 µM; hydrogen bond: Leu141, Gly143, Ser144, and Thr190; and hydrophobic bond: Cys145, Met165, and Gln189. Desmethoxycurcumin have binding energy: -7.83 kcal/mol; pKi: 1.84 µM; hydrogen bond: Asp187, Thr190, and Gln192; and hydrophobic bond: Met165. Keywords: Curcuma zedoaria, SARS-CoV-2, bioavailability, molecular docking
UJI AKTIVITAS INHIBISI ENZIM a-Glukosidase TERHADAP EKSTRAK ASETON, ETANOL, DAN METHANOL DAUN MANGROVE (Rhizopora Mucronata) SEBAGAI ANTIDIABETES: INHIBITION ACTIVITY OF a-Glucosidase ENZYME OF EXTRACTS ACETONE, ETHANOL, AND METANOL MANGROVE (Rhizopora mucronata) LEAF AS ANTIDIABETIC Like Efriani; Ismanurrahman Hadi; Ade Irawan; Mariam Ulfah; Teguh Adiyas Putra
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023): Forthcoming Issue
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.651

Abstract

Diabetes mellitus tipe II merupakan kelainan metabolik yang disebabkan karena ketidakmampuan pankreas untuk memproduksi insulin sehingga menyebabkan hiperglikemia. Akarbose menjadi salah satu obat dalam pengobatan dari diabetes mellitus dengan cara menghambat inhibisi enzim a-glukosidase. Tanaman mangrove (Rhizopora mucronata) diketahui mempunyai senyawa fitokimia dengan berbagai aktivitas farmakologis. Tujuan dari peneltian ini adalah untuk mendapatkan informasi aktivitas penghambatan enzim a-glukosidase dari ekstrak metanol, etanol, dan aseton daun mangrove. Penelitian ini dilakukan dengan memaserasi simplisia daun mangrove pada pelarut metanol, etanol, dan aseton. Maserat yang didapatkan, diujikan secara kualitatif untuk mengidentifikasi kandungan golongan senyawa alkaloid, flavonoid, saponin, dan terpenoid, lalu dilanjutkan dengan mengujikan inhibisi aktivitas dari enzim a-glukosidase dengan konsentrasi ekstrak 0,5; 1; 1,5; 2; dan 3 mg/mL menggunakan Microplate Elisa Reader dan dilanjutkan pengukuran absorbansi dengan spektrofotometer UV-Vis dengan panjang gelombang 405 nm. Hasil yang didapatkan menunjukkan maserat dari ketiga jenis pelarut tersebut terbukti memiliki kandungan senyawa golongan alkaloid, flavonoid, saponin, dan terpenoid. Uji aktivitas inhibisi menunjukkan aktivitas inhibisi dari ekstrak metanol (3,5 mg/mL), etanol (2,6 mg/mL), dan aseton (2,1 mg/mL). Ekstrak aseton memiliki aktivitas inhibisi paling baik karena semakin kecil nilai IC50 maka semakin baik aktivitas inhibisi pada enzim a-glukosidase. Berdasarkan hal tersebut, dapat disimpulkan bahwa ekstrak aseton mangrove memiliki aktivitas inhibisi paling baik dibandingkan kedua ekstrak lainnya.
OPTIMIZATION OF AFRICAN LEAF EXTRACT CREAM FORMULA (Vernonia amygdalina Del.) AS AN ANTIBACTERIAL Staphylococcus aureus Iklila Zahra; Ana Indrayati; Ilham Kuncahyo
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023): Forthcoming Issue
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.884

Abstract

The use of natural ingredients as active medicinal substances has been developed again, one of which is African leaf extract (Vernonia amygdalina Del.), which is used as an antimicrobial bacterium against Staphylococcus aureus, which causes skin disease. The aim of this study was to compare the antibacterial activity of African leaf extracts and fractions, as well as to optimize the cream preparation formula using a factorial design with a combination of stearic acid, triethanolamine (TEA), and Adeps lanae with the critical parameters of pH, viscosity, spreadability, Franz diffusion, and KBM value. This study used experimental methods to determine the highest antibacterial activity by disc diffusion from extracts and active fractions of African leaves using solvents of different polarities. The extract or fraction with the highest antibacterial activity was formulated using a combination cream of stearic acid, triethanolamine, and adeps lanae. After obtaining the cream formula, physical testing of the cream, penetration test, and antibacterial test using macrodilution were performed, and the most optimal formula was determined using a factorial design. The extract standardization test results met both specific and non-specific parameters. In the disc diffusion antibacterial test, the highest activity was found in the African leaf extract (13.23 ± 0.757 mm) against Staphylococcus aureus bacteria. Variations in cream composition affect pH, viscosity, spreadability, and Franz diffusion...
COST-EFFECTIVENESS ANALYSIS OF ANTICOAGULANT USAGE IN COVID-19 PATIENTS AT 45 KUNINGAN HOSPITAL Juju Jumiati; Yusi Anggriani; Yati Sumiati; Umar Santosa
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023): Forthcoming Issue
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.892

Abstract

Cost-effectiveness analysis (CEA) is a pharmacoeconomic method that compares prices from all sources consumed (cost) with the outcome value of a program or intervention to obtain objective answers to the selection of drugs that are effective in terms of benefits and costs. COVID-19, or Coronavirus Disease 2019, is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV-2) and causes acute respiratory distress, including fever, coughing, and shortness of breath. Fondaparinux, aside from heparin and enoxaparin, can be given as an anticoagulant therapeutic option in hospitalized COVID-19 patients, according to the third edition of the COVID-19 care recommendations. This study aimed to find the most cost-effective therapy among heparin, enoxaparin, and fondaparinux in COVID-19 patients at the RSUD’45 Kuningan. It also applied descriptive non-experimental research methods with retrospectively collected data. The intervention that had been studied was the administration of anticoagulant medication, where the effectiveness of the drug was observed in the reduction of D-dimer levels to normal levels. Meanwhile, the costs were observed from the perspective of a healthcare provider, specifically the RSUD’45 Kuningan. The study sample included 107 patients, with 13 receiving heparin, 41 receiving enoxaparin, and 53 receiving fondaparinux. Bivariate analysis using the chi-square test revealed no significant difference between the drug groups in the proportion of patients who improved and did not improve (sig. value = 0.610)...
QUALITY ANALYSIS AND IDENTIFICATION OF FUNCTIONAL GROUPS OF SWEET ORANGE (Citrus sinensis) PEEL ESSENTIAL OIL USING FTIR Citra Dhea Cantika; Laela Hayu Nurani; Nina Salamah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023): Forthcoming Issue
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.898

Abstract

Organic waste in the form of citrus fruit peels has not been handled seriously, causing environmental pollution, such as the emergence of unpleasant odors.  Therefore, waste management becomes a more valuable product or item.  Citrus peel oil counterfeiting often occurs because there is no Indonesian National Standard (SNI) for citrus peel oil as a quality standard, making it difficult to identify the falsity of finished citrus peel oil products in the market. Research was conducted to test the quality of sweet orange peel oil so that it could be used as a standard to identify the content of sweet orange peel oil using the FTIR method. Oil quality testing included an organoleptic test, specific gravity, refractive index, and acid number. The oil quality test results showed clear yellow oil with a distinctive sweet orange peel aroma, specific gravity of 0.845, refractive index of 9.263, and acid number of 1.1. FTIR analysis revealed spectra that appeared in the region of 1490 with strong intensity (C-H aromatic), 1645 with medium intensity (C=C), and 2860 with medium intensity (C-H aliphatic). FTIR spectra of sweet orange peel oil showed similarity with limonene with a hit quality value of 958, the content of sweet orange peel oil is dominated by limonene compounds. Keywords: sweet orange peel, Essential oil, FTIR, Limonene, Oil quality

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