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Jurnal Hasi Penelitian Dan Pengkajian Ilmiah Eksakta - JPPIE
Published by Universitas Dharma Andalas
ISSN : -     EISSN : 28099532     DOI : https://doi.org/10.47233/jppie
Core Subject : Health, Science, Education, Agriculture, Art, Engineering,
Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Electrical & Electronics Engineering Energy Engineering Health Professions Industrial & Manufacturing Engineering Library & Information Science Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary
Jurnal Penelitian & Pengkajian Ilmiah Eksakta (JPPIE) merupakan media jurnal elektronik yang diterbitkan oleh Universitas Dharma Andalas sebagai sarana untuk penyebaran dan publikasi hasil penelitian dan pengkajian pemikiran kritis mahasiswa yang orisinil dan up to date. JPPIM memuat artikel bidang Ilmu Eksakta, yang diterbitkan 2 (dua) kali dalam setahun yaitu bulan Januari dan juli. Redaksi menerima artikel hasil penelitian skripsi, tesis dan tugas-tugas perkuliahan mahasiswa.
Arjuna Subject : Umum - Umum
Articles 112 Documents
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Pengaruh Rasio Etanol-Air terhadap Rendemen dan Aktivitas Sitotoksik Ekstrak Daun Azadirachta Indica Sinaga, Samuel Billie Tua; Ramanda, Putri; Mawakhid, Oki Rokhim; Shari, Winda; Wiradimafan, Khafit; ., Avidlyandi; Adfa, Morina
Jurnal Penelitian Dan Pengkajian Ilmiah Eksakta Vol 5 No 1 (2026): Jurnal Hasi Penelitian Dan Pengkajian Ilmiah Eksakta - JPPIE
Publisher : LPPM Universitas Dharma Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47233/jppie.v5i1.2491

Abstract

Neem leaves (Azadirachta indica) are widely recognized as a rich source of diverse bioactive compounds that exhibit promising pharmacological activities, including anticancer potential. Nevertheless, studies investigating how variations in solvent composition influence extract yield and cytotoxic activity remain limited. Therefore, this research aimed to evaluate the effect of different ethanol–water solvent ratios (50%, 70%, and absolute ethanol) on both the extraction yield of neem leaves and their cytotoxic activity against Artemia salina Leach. The extraction procedure combined sonication and subsequent maceration using the three solvent systems to enhance compound recovery. Cytotoxic assessment was performed through the Brine Shrimp Lethality Test (BSLT) at concentrations of 1000, 500, 100, and 10 ppm, utilizing 48-hour-old larvae with three experimental replicates. Larval mortality was observed after 24 hours of exposure, and LC₅₀ values were determined using probit analysis and linear regression methods. The results demonstrated that extraction with 50% ethanol produced the highest yield (23.5%), followed by 70% ethanol (20.8%) and absolute ethanol (16.10%). In contrast, the strongest cytotoxic activity was observed in the 70% ethanol extract, which exhibited the lowest LC₅₀ value (62.87 ppm), followed by the 50% ethanol extract (64.23 ppm) and the absolute ethanol extract (99.15 ppm). These findings indicate that solvent ratio significantly influences both extraction efficiency and cytotoxic potency; however, extract yield was not directly correlated with cytotoxic activity. Importantly, all extracts demonstrated LC₅₀ values below 100 ppm, suggesting notable toxicity and highlighting their potential as candidates for developing anticancer raw materials.
Penerapan Metode Hazop dalam Identifikasi Bahaya dan Pengendalian Risiko K3 pada Proyek LRT Jakarta Fase 1B Indra, Najwa Putri; Arifin, Ari Syaiful Rahman; Rifwan, Fitra; Andayono, Totoh
Jurnal Penelitian Dan Pengkajian Ilmiah Eksakta Vol 5 No 1 (2026): Jurnal Hasi Penelitian Dan Pengkajian Ilmiah Eksakta - JPPIE
Publisher : LPPM Universitas Dharma Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47233/jppie.v5i1.2513

Abstract

LRT (Integrated Rail Transit) is a public transportation system developed by PT. Kereta Api Indonesia (KAI) to facilitate mobility for residents of Greater Jakarta (Jabodetabek). The objectives of this study are: 1) identifying high-risk construction projects, 2) applying the HAZOP method to identify hazards and deviations in work processes, 3) assessing risk levels based on likelihood and severity parameters, and 4) providing risk control recommendations based on the HAZOP analysis results. This research is a descriptive analytical study with a qualitative-quantitative approach, conducted on the Jakarta LRT Phase 1B Project, Velodrome–Manggarai Segment, implemented in January 2026. Data collection involved field observations, interviews, questionnaires, and documentation. The results indicate: 1) Identification of High-Risk Work: High-risk construction work in the LRT Phase 1B project includes the use of heavy equipment (jack hammers), concrete casting, girder lifting, electrical installation, and welding processes. 2) The application of the HAZOP method is effective in identifying potential hazards and deviations in various work processes. 3) Risk assessment based on likelihood and severity indicates the greatest risks are in girder lifting and concrete casting. 4) Risk control through technical measures (e.g., low-vibration work methods, strict supervision, use of PPE), administrative measures (SOPs, training), and physical protection (electrical protection, barricades) is essential to reduce occupational risks.

Page 12 of 12 | Total Record : 112

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