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Indonesian Journal of Cancer

ijoc
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Published by National Cancer Center-Dharmais Cancer Hospital

ISSN : 19783744 EISSN : 23556811 DOI : https://www.doi.org/ 10.33371

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

Indonesian Journal of Cancer is a peer-reviewed and open-access journal. This journal is published quarterly (in March, June, September, and December) by Dharmais Cancer Hospital - National Cancer Center. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted acceptance for publication. The journal publishes original research articles, case reports, and review articles under the following categories: cancer management, cancer prevention, cancer etiology, epidemiology, molecular oncology, cancer diagnosis and therapy, tumor pathology, surgical oncology, medical oncology, radiation oncology, interventional radiology, as well as early detection.

Arjuna Subject : Kedokteran - Onkologi

Articles 562 Documents

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Spiritual Well-Being and Optimism as Contributing Factors that Influence the Subjective Well-Being of Cancer Patients Yesiana Dwi Wahyu Werdani
Indonesian Journal of Cancer Vol 16, No 1 (2022): March
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: Cancer is a serious stressor that induces spiritual distress, loss of optimism, and dissatisfaction with subjective well-being. This study aims to determine that spiritual well-being (SWB) and optimism as factors that contribute to influencing the subjective well-being of cancer patients. Methods: This study had a cross-sectional design. A total of 88 cancer patients from public health centers in Surabaya and the Indonesian Cancer Foundation of East Java were selected to be sampled by consecutive sampling in 4 months. The Instruments used were valid and reliable throughout the test, comprising of the spiritual well-being scale, the 9-item version of the personal optimism scale, self-efficacy optimism scale, and satisfaction with life scale. The ethical feasibility was declared ethical. Data were analyzed using Pearson Product Moment Correlation Test and Linear Regression Test with p < 0.05. Results: The demographic data show that the mean age of 52.5 years, female gender (84%), being married (78.4%), having cervical cancer (52.3%), having stage-III cancer (55.7%), having cancer therapy (surgery, chemotherapy, and radiotherapy) (37.5%), and patients newly diagnosed from 6 months to 1 year (33%). The mean score of SWB was 99.67 (high SWB), optimism 20.03 (high optimism), and subjective well-being 24.18 (good subjective well-being). Pearson Product Moment Correlation Test between SWB and optimism showed p < 0.001, indicating that SWB had a significant relationship with optimism; patients with high SWB will have high optimism. From the Linear Regression Test, there was a significant effect of SWB on subjective well-being (r2 = 0.982 and p < 0.001) and optimism on subjective well-being as well (r2 = 0.988 and p < 0.001), meaning that patients with high SWB and high optimism tended to have good subjective well-being. Conclusions: Cancer patients who have high scores of SWB become more optimistic, which has a positive effect on the high score of subjective well-being as well.

Internal Genital Organ-preserving Radical Cystectomy: A Case Report FINA WIDIA; GERHARD R SITUMORANG; AGUS RIZAL A.H HAMID; CHAIDIR A MOCHTAR
Indonesian Journal of Cancer Vol 10, No 2 (2016): April - June 2016
Publisher : National Cancer Center - Dharmais Cancer Hospital

ABSTRACTAdenocarcinoma of the bladder is usually managed by radical cystectomy. However, recent literature shows that internal genital organ-preserving radical cystectomy is feasible in selected cases in order to get a better impact on patient’s psychology, sexuality and potential fertility. Here, we report a 32-year-old woman with adenocarcinoma of the bladder who was managed with internal genital organ-preserving radical cystectomy. The patient was never had any child and the radiologic examination (MRI) showed no involvement of internal genitalia organ. This procedure aims to maintain fertility potential of the patient. Intraoperatively, no adhesion was found between the tumor and internal genitalia organ. The internal genitalia organ was successfully preserved during the radical cystectomy. ABSTRAKTata laksana adenokarsinoma kandung kemih umumnya berupa sistektomi radikal. Akan tetapi, penelitian terbaru menunjukkan bahwa preservasi organ internal genitalia dapat diterapkan pada kasus-kasus tertentu dengan tujuan untuk mempertahankan potensi seksual dan fertilitas pasien. Saat ini kami melaporkan seorang perempuan berusia 32 tahun dengan adenokarsinoma kandung kemih yang menjalani sistektomi radikal dengan tetap mempertahankan organ genitalia interna. Pasien merupakan nulipara dan pada pemeriksaan radiologi MRI tidak didapatkan infiltrasi tumor pada organ genitalia interna. Prosedur operasi dilakukan dengan tujuan mempertahankan potensi fertilitas. Intraoperatif, tidak didapatkan perlengketan antara tumor dan organ genitalia interna. Organ genitalia interna berhasil dipreservasi selama prosedur sistektomi radikal.

Auricular Acupuncture Effect to Hot Flush Score Decrease and Quality of Life Increase Associate with Luteinizing Hormone-Releasing Hormon (LHRH) Agonist Treatment for Prostate Cancer Patient PITA WULANSARI
Indonesian Journal of Cancer Vol 6, No 4 (2012): Oct - Dec 2012
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v6i4.234

Hot flush merupakan efek samping yang paling banyak dialami oleh penderita kanker prostat yang diterapi dengan agonis LHRH. Ternyata terdapat hubungan yang erat antara hot flush dengan penurunan kualitas hidup para penderita kanker. Ada banyak terapi untuk hot flush, di antaranya dengan akupunktur telinga. Akupunktur telinga meringankan gejala hot flush karena adanya ?-endorfin yang mempertahankan mekanisme negatife feedbeeck pada produksi noradrenalin hipotalamus. ?-endorfin juga menghambat efek CGRP sehingga terjadi penurunan gejala hot flush. Gejala hot flush yang menurun setelah diakupunktur akan dapat mengembalikan kembali kualitas hidup dari penderita prostat. Penelitian ini bertujuan untuk mengetahui efek akupunktur telinga terhadap penurunan skor Hot Flush Diary, skor Hot Flush Related Daily Interference Scale (HFRDIS), dan peningkatan kualitas hidup pasien kanker prostat yang diterapi dengan agonis LHRH setelah 12 kali tindakan akupunktur.Kata kunci: biopsi, diagnosis, kanker prostat, spesialis urologi, TRUS

Strategi Pemakaian Epoetin Alfa dalam Mempertahankan Kadar Hemoglobin pada Kemoterapi Ajuvan Berbasis Antrasiklin Karsinoma Payudara Operabel Dimyati Achmad; Yusuf Hariady; Benny Isakh; Maman Abdurahman
Indonesian Journal of Cancer Vol 7, No 1 (2013): Jan - Mar 2013
Publisher : National Cancer Center - Dharmais Cancer Hospital

Pada kanker payudara operabel dengan metastasis regional, pemberian kemoterapi ajuvan berbasis antrasiklin dapat menyebabkan terjadinya anemia ringan sampai berat pada sekitar 4% - 63% kasus. Telah dilakukan berbagai penelitian tentang peran epoetin alfa sebagai alternatif pengganti transfusi, tetapi hasilnya masih belum memuaskan. Dilakukan penelitian uji klinik desain paralel dengan randomisasi blok terhadap 64 sampel penelitian yang dibagi atas 2 kelompok, yaitu kelompok perlakuan yang mendapatkan epoetin alfa dan kelompok kontrol. Kadar Hb pasca-operasi yang termasuk dalam kriteria inklusi adalah > 10 gr/dL - 12 gr/dL. Epoetin alfa diberikan 1 minggu pasca-mastektomi diteruskan sampai 6 kali pemberian dengan dosis 40.000 IU/ minggu dan kadar Hb dinilai mulai dari pemberian kemoterapi siklus pertama sampai 3 minggu setelah kemoterapi siklus keenam. Hasil penelitian menunjukkan pemberian epoetin alfa dengan strategi di atas mampu mempertahankan kadar hemoglobin di atas 10 gr/dL dan tidak dibutuhkan transfusi selama kemoterapi. Sedangkan pada kelompok kontrol membutuhkan transfusi sebanyak 28,1% kasus dan kebutuhan transfusi paling banyak terjadi pada kemoterapi siklus keempat. Kesimpulan: strategi pemakaian epoetin alfa yang dapat dipilih adalah mulai 1 minggu pasca-mastektomi yang diteruskan sampai kemoterapi siklus kedua atau 6 kali pemberian dengan dosis 40.000 IU/minggu dan kadar Hb pasca-mastektomi harus > 10 gr/dL - 12 gr/dL.Kata kunci: kanker payudara, anemia, epoetin alfa.

Evaluasi Dosis Glandular dalam Pemeriksaan Mammografi Yulfiatry Yubhar; Rachmat Adi; Supriyanto Prawiro; Kardinah Kardinah
Indonesian Journal of Cancer Vol 1, No 3 (2007): Jul - Sep 2007
Publisher : National Cancer Center - Dharmais Cancer Hospital

Telah dilakukan pengukuran dosis rata-rata Glandular (mean glandular dose) pada pemeriksaan mammografi dengan menggunakan Thermoluminiscence Dosimeter (TLD) terhadap 49 pasien. Dosis yang terbaca pada TLD adalah Entrance Surface Dose (ESD) dengan nilai rata-rata yang didapat 7.6(±’b1 3.9) mGy. Untuk konversi ke nilai mean glandular dose, nilai ESD dikalikan dengan nilai Dgn (ESD dengan factor konversi average glandular dose per unit exposure) yang terkonversi dengan memperhitungkan prosentase glandular terhadap adipose. Data Dgn diperoleh dari perhitungan Jhon M Boone yang menggunakan metode Monte Carlo yang masih tergantung dari nilai HVL dan ketebalan payudara. Prosentase glandular terhadap adipose dihitung dengan menggunakan metoda analisa film Nooriah Djamal. Kemudian nilai Dgn 0% glandular untuk kontribusi adipose maupun Dgn 100% glandular untuk kontribusi glandular diperoleh dari table Dgn Boone. Nilai MGD yang diperoleh adalah 1.818 (±’b1 0.615) mGy. Nilai masih dibawah limit yang direkomendasikan FDA (Foor and Drug Administration) yaitu <3mGy.

Gambaran Pengharapan pada Ibu Pasien Kanker Pediatrik FRANSISCA SIDABUTAR; NGRID KARLI; YUSNITA KATAGORI; NINAWATI -
Indonesian Journal of Cancer Vol 6, No 1 (2012): Jan - Mar 2012
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v6i1.141

Ibu pasien kanker pediatrik menghadapi berbagai tantangan ketika mendampingi anaknya menjalani proses pengobatan. Selain beresiko mengalami simtom stres, ibu juga harus menghadapi perubahan peran dari mengasuh anak yang sehat ke mengasuh anak yang sakit. Pengharapan adalah salah satu faktor yang dapat mendukung ibu menghadapi tantangan dalam pengobatan anaknya. Pengharapan adalah kombinasi antara keyakinan dan strategi dalam proses berpikir individu agar ia berhasil mencapai suatu tujuan. Penelitian ini menggunakan pendekatan kualitatif dengan melakukan wawancara dan observasi terhadap tiga orang ibu pasien kanker pediatrik usia sekolah (6-11 tahun). Hasil penelitian menunjukkan bahwa ibu memiliki tujuan agar anaknya sembuh, keyakinan yang besar bahwa anaknya akan sembuh, serta strategi dengan menghindarkan anak dari makanan tertentu. Saran bagi relawan dan staf medis untuk memberikan edukasi perawatan anak dengan kanker yang kontinu dan sesuai dengan tingkat pemahaman ibu serta penyediaan support group bagi ayah yang mendampingi ibu dalam mengasuh anak.Kata kunci: pengharapan, ibu, anak usia sekolah, kanker

Paclitaxel, Iphospamide, and Cisplatin (TIP) as Bleomycin, Etoposide, and Cisplatin (BEP) Alternative for First-Line Therapy of Metastatic Germ Cell Tumor (GCT): A Case Series Syamsu Hudaya; Adianti Khadijah
Indonesian Journal of Cancer Vol 13, No 3 (2019): September
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: Bleomycin, etoposide, and cisplatin (BEP) is a standard first-line therapy for metastatic germ cell tumor (GCT), while paclitaxel, ifosfamide, and cisplatin (TIP) are commonly used as salvage therapy after failed BEP treatment. The unavailability of first-line drugs can be the reason for the use of second-line therapy. In this paper, we reviewed two initial cases of patients with metastatic GCT treated with TIP as first-line chemotherapy in our center.Case Presentation: We reviewed the medical record and followed up two patients who had been treated with TIP as first-line chemotherapy for metastatic GCT due to lack of BEP regiment. We evaluated efficacy and toxicity of this treatment. These two patients were diagnosed with seminoma, with intermediate-risk according to International Germ Cell Cancer Collaborative Group (IGCCCG) classification. Both achieved complete response after four courses of TIP chemotherapy with toxicities mainly consisted of myelosuppression.Conclusions: TIP demonstrated efficacy serves as the first-line therapy for germ cell tumors with an acceptable safety profile. Further studies with larger subjects are still needed for evaluation. However, TIP is more expensive compared to BEP, making BEP is still superior to TIP in public hospital setting where cost-effectiveness of treatment is important.

Kadar Nukleosom Serum sebagai Prediktor Respons Terapi Radiasi pada Kanker Leher Rahim Novana -; Djuita -; Kresno -
Indonesian Journal of Cancer Vol 5, No 1 (2011): Jan - Mar 2011
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v5i1.91

Nukleosom dilepaskan oleh sel- sel kanker saat apoptosis sebagai respons terhadap terapi antikanker, dan jumlahnya dalam serum berhubungan dengan tingkat apoptosis. Penelitian ini bertujuan menilai kadar nukleosom dalam serum sebagai respons pasien terhadap terapi dan menganalisis apakah kadar nukleosom ini dapat dipakai sebagai prediktor respons terapi pada pasien kanker leher rahim.Kami meneliti kadar nukleosom 40 pasien kanker leher rahim yang diterapi sesuai dengan protokol terapi di Rumah Sakit Kanker Dharmais sejak Juni 2008 sampai dengan September 2008. Kadar nukleosom serum diperiksa secara serial menggunakan ELISA kit sebagai pendeteksi sel- sel yang mati, di mana dapat diukur secara kuantitatif fragmen DNA yang mengandung histone dalam bentuk oligo dan mononukleosom, sebelum radiasi (baseline), setelah 10 kali radiasi, 11 kali radiasi, dan brakhiterapi selesai. Kadar nukleosom dibandingkan dengan hasil pap smear 1,5 bulan kemudian. Pasien- pasien dipantau selama 2 tahun.Hasilnya, kadar nukleosom meningkat pada pemeriksaan ke-2 dan menurun secara bermakna pada pemeriksaan ke-3, mencapai normal pada pemeriksaan ke-4 pada pasien yang responsnya baik (NED, negatif Paps smear). Sementara, pada pasien yang responsnya buruk atau ada metastasis maka kadar nukleosomnya tidak turun ke tingkat normal atau malahan meningkat lagi pada pemeriksaan ke-4. Terdapat perbedaan yang bermakna antara sebelum terapi dan 10 kali terapi (p=0,01) serta antara 11 kali terapi dan setelah selesai brakhiterapi (p=0,01). Perbedaan kadar nukleosom dalam multiple comparison antara kelompok radiasi saja dan kelompok kemoradiasi juga berbeda bermakna, berturut-turut p<0,05 dan p<0,01.Kesimpulannya, pemeriksaan kadar nukleosom serum selama terapi radiasi saja maupun kemoradiasi dapat dipakai sebagai prediktor respons terapi pada kanker leher rahim.Kata kunci: nukleosom, apoptosis, kanker leher rahim.

Tata Laksana Ekstravasasi Karena Pemakaian Kemoterapi Nelly Rosdiana
Indonesian Journal of Cancer Vol 3, No 2 (2009): Apr - Jun 2009
Publisher : National Cancer Center - Dharmais Cancer Hospital

Ekstravasasi merupakan suatu keadaan yang bisa muncul pada pasien kanker yang mendapat kemoterapi, yang menimbulkan rasa sakit dan eritema, ulkus, serta kerusakan jaringan. Beberapa obat sitostatika dapat bersifat vesicant, iritan, dan nonvesicant. Tata laksana ditentukan dari stadium ekstravasasi, banyaknya cairan yang terpapar, dan ketersediaan antidotum yang spesifik.Kata kunci: ekstravasasi, kemoterapi, tata laksana.

Jejunal MALT (Mucosa Associated Lymphoid Tissue) Lymphoma: A Case Report Alexandria Stephanie Suparman; Daniel Ardian Soeselo; Dyonesia Arie Harjanti
Indonesian Journal of Cancer Vol 12, No 4 (2018): October-December
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: MALT (Mucosa Associated Lymphoid Tissue) Lymphoma is an uncommon condition. It is an involvement of extranodal site in hematologic malignancy, Non-Hodgkin Lymphoma.Case Presentation: Pondok Indah, Puri Indah Hospital Jakarta treated a 38-year-old female with acute abdomen due to jejunal MALT Lymphoma perforation, one meter from treitz ligament. Emergency laparotomy was performed, the patient had a resection and end to end anastomose. She was hospitalized in intensive care unit for 4 days after the surgery and died because of prolonged septic shock.Conclusions: MALT lymphoma is an uncommon condition which is often encountered in emergency conditions due to acute abdominal pain caused by intra-abdominal perforation of the hollow viscus. Late diagnosis and treatment may cause severe outcome such as perforation and hypovolemic shock. This case report is expected to provide insight and to increase the awareness of the incidence of jejunal MALT lymphoma in Indonesia.

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Bayu Brahma

Contact Email journal.cancer@gmail.com

Phone +628176389956

Journal Mail Official admin@indonesianjournalofcancer.or.id

Editorial Address National Cancer Center - Dharmais Cancer Hospital Research and Development Building, 3rd-floor Jl. Letjen S. Parman Kav. 84-86, Slipi West Jakarta

Location Kota adm. jakarta barat, Dki jakarta INDONESIA

Abstract

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Abstract

Abstract

Abstract

Abstract

Contact Name
Bayu Brahma

Contact Email
journal.cancer@gmail.com

Phone
+628176389956

Journal Mail Official
admin@indonesianjournalofcancer.or.id

Editorial Address
National Cancer Center - Dharmais Cancer Hospital Research and Development Building, 3rd-floor Jl. Letjen S. Parman Kav. 84-86, Slipi West Jakarta

Location
Kota adm. jakarta barat,

Dki jakarta

INDONESIA