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Contact Name
Bayu Brahma
Contact Email
journal.cancer@gmail.com
Phone
+628176389956
Journal Mail Official
admin@indonesianjournalofcancer.or.id
Editorial Address
National Cancer Center - Dharmais Cancer Hospital Research and Development Building, 3rd-floor Jl. Letjen S. Parman Kav. 84-86, Slipi West Jakarta
Location
Kota adm. jakarta barat,
Dki jakarta
INDONESIA
Indonesian Journal of Cancer
ISSN : 19783744     EISSN : 23556811     DOI : https://www.doi.org/ 10.33371
Core Subject : Health, Science,
Indonesian Journal of Cancer is a peer-reviewed and open-access journal. This journal is published quarterly (in March, June, September, and December) by Dharmais Cancer Hospital - National Cancer Center. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted acceptance for publication. The journal publishes original research articles, case reports, and review articles under the following categories: cancer management, cancer prevention, cancer etiology, epidemiology, molecular oncology, cancer diagnosis and therapy, tumor pathology, surgical oncology, medical oncology, radiation oncology, interventional radiology, as well as early detection.
Arjuna Subject : Kedokteran - Onkologi
Articles 562 Documents
Metastasis of Epidermoid Cervical Carcinoma Cell to The Orbit Widiastuti Widiastuti; Rachmi Fauziah Rahayu; Djoko Susianto; Rita Budianti; Heru Priyanto; Ambar Moedigdo; Soegiartiningsih Soegiartiningsih
Indonesian Journal of Cancer Vol 12, No 1 (2018): Jan - Mar
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (903.26 KB) | DOI: 10.33371/ijoc.v12i1.552

Abstract

Orbital metastases of cervical cancer cell are very rare. There is only one case reported in Dr. Moewardi Public Hospital Surakarta between 1999 and 2017. A 45-year-old woman was admitted with the upper right orbital lesion. She had not received a routine gynecologic examination for more than 10 years. She had normal chest X-ray. Abdominal ultrasonography revealed a heteroechoic lesion poor defined edge in cervix utery expands to corpus utery and rectum. Bilateral uropathy obstruction occured. Bone survey demonstrated osteolytic bone metastasis in the right supra orbital bone and a compression fracture of the twelfth thoracal spine. Head and orbital Computed Tomography (CT) scan, which revealed multiple metastatic lesions in the right orbital expanding to extra cranial, was performed. Our diagnosis was cervical cancer FIGO IV-B stage with distant metastasis thus chemoradiation was given. The aim of this report is to give more references regarding this complicated clinical condition.  ABSTRAKKanker serviks metastasis ke orbita sangat jarang terjadi. Hanya satu kasus yang dilaporkan di Rumah Sakit Umum Daerah Dr. Moewardi Surakarta antara tahun 1999 - 2017. Seorang wanita usia 45 tahun dirawat oleh karena lesi di orbita kanan atas sejak 2 bulan yang lalu. Pasien tersebut belum pernah mendapatkan pemeriksaan kandungan rutin selama lebih dari 10 tahun. Foto Chest X Ray normal. Ultrasonografi abdomen tampak lesi heteroekoik batas tak tegas pada serviks uterus meluas ke korpus uterus dan rektum. Terjadi obstruksi uropati kanan dan kiri. Bone survei memperlihatkan gambaran metastasis tipe litik pada tulang supra orbita kanan dan fraktur kompresi pada tulang belakang toraks ke dua belas. Computed Tomography (CT) Kepala dan Orbita memperlihatkan beberapa lesi metastasis pada supra orbita kanan yang meluas ke tulang tengkorak. Diagnosis kami adalah kanker serviks tahap FIGO IV-B dengan metastasis jauh dan diberikan therapi kemoradiasi. Tujuan penulisan ini adalah untuk memberikan lebih banyak referensi data tentang kondisi klinis yang rumit ini.
The Effect of Dietary Modification and Nutritional Education on Nutrition Care Process (NCP) for Increasing Dietary Intake, Body Weight, and Nutritional Status of Cancer Patients at Risk of Malnutrition and Malnourished in the Inpatient of Dharmais Cancer Fauzatun Hadiyati; Ratna Supriastuti; Arifah Mujiharti
Indonesian Journal of Cancer Vol 15, No 2 (2021): June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (776.609 KB) | DOI: 10.33371/ijoc.v15i2.768

Abstract

Background: Cancer patients that are hospitalized often have problems with their nutrient intake. Low nutrient intake can be affected by malnutrition. In cancer patients, the intake of nutrients needs to be considered specifically in relation to the occurrence of metabolic changes that lead to decreased nutritional status. The objective of this study is to analyze the effect of dietary modification and nutritional education on nutrition care process (NCP) for increasing dietary intake, body weight, and nutritional status of malnourished cancer patients and cancer patients at risk of malnutrition.Methods: The study was a quasi-experiment with one-group pretest-posttest design. The population consisted of all new adult hospitalized cancer patients. The data were collected from July to September 2019. The statistical analysis used paired sample t-test. Dietary modification and nutritional education were given individually based on each nutrition problem of the patient and their nutritional needs.Results: There were 83 patients involved for the study. Most of the patients were female (61.4%), aged over 45 years (62.7%), graduated from high school (47%), were housewives (49.4%), and had clinical histories of no comorbidities (90.4%). Most of them had improvement in general condition (74.7%). The study showed significantly increasing dietary intake of energy (889.7 calorie), protein (36.4 gr), fat (49.3 gr), and carbohydrate (131.4 gr) (p = 0.000). The increasing percentage of nutrient intake to nutritional needs before and after intervention of NCP was 39.8 to 88.6% for energy, 44.4 to 104% for protein, 51 to 120% for fat, and 41.5 to 90.1% for carbohydrate. The average increase (but not significant related correlation) in body weight was 0.16 kg (p = 0.141) and body mass index 0.05 kg/m2 (p = 1.94). Conclusions: Dietary modification and nutritional education on NCP improve dietary intakes (energy, protein, fat, and carbohydrate) of cancer patients at risk of malnutrition and being malnourished.
Iatrogenic Damage of the Pedicle of Radial Forearm Free Flap Repaired with Super-Microsurgery Techniques: A Case Report Jonathan Velazquez- Mujica; Hung Chi Chen; Juan Carlos Reyes Cerda
Indonesian Journal of Cancer Vol 14, No 1 (2020): March
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (977.507 KB) | DOI: 10.33371/ijoc.v14i1.696

Abstract

Introduction: Accidental Iatrogenic damage of the pedicle or perforators has been frequently reported as a cause of failure of free flaps. Free radial forearm flap helps to cover defects that are not possible to cover with local flaps or skin graft.Case Presentation: A 91 years old patient with Bowen Disease had multiple actinic keratosis and a history of squamous cell carcinoma over the forehead, which was removed 4 years before. The recurrent tumor was detected and wide excision of the tumor was done. It resulted in a large defect of 8 x 5.5 cm2 in diameter at the forehead with exposure of bone, therefore, a free radial forearm flap was performed for reconstruction with right superficial temporal artery and vein as recipient’s vessel. We observed leakage of blood through the radial artery near to the anastomosis due to iatrogenic damage during flap harvesting.Conclusions: Nowadays, repairing iatrogenic damage through the main pedicle or perforators of the pedicle is possible with super-microsurgery technique due to the improvement of the skills and smaller sutures avoiding the obstruction of the lumen of the pedicle or perforator. This is considered a salvage procedure instead of harvesting new free flaps and can be useful for all kinds of free flaps.
The Profile of BCR-ABL1 Fusion Gene in Childhood Leukemia at “Dharmais” Cancer Hospital Mururul Aisyi; Puji Lestari; Siti Nadliroh; Anita Meisita; Didin Solachudin; Dewi Kristanti; Adhitya Bayu Perdana; Bambang Karsono
Indonesian Journal of Cancer Vol 14, No 3 (2020): September
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (247.201 KB) | DOI: 10.33371/ijoc.v14i3.729

Abstract

Background: BCR-ABL1 fusion gene, which originated from t (9;22), is an important biomarker for diagnosis, therapeutic approach, and prognosis in childhood leukemia. However, there are no data in Indonesia about the profile of BCR-ABL1 fusion gene for this disease. This study intends to demonstrate the profile of the BCR-ABL1 fusion gene in childhood leukemia at “Dharmais” Cancer Hospital.Methods: This descriptive retrospective study included 79 patients with childhood leukemia who performed the BCR-ABL1 examination in “Dharmais” Cancer Hospital during 2008–2018. Demographic data, leukemia types, BCR-ABL1 examination results, and protein isoforms developed by BCR-ABL1 fusion were obtained from Cancer Registry Data.Results: Among 79 patients’ data recorded in this study, 65.8% (52/79) were male and 34.2% (27/79) were female. A total of 74.7% (59/79) patients were diagnosed with Chronic Myelogenous Leukemia (CML), 21.5% (17/79) with Acute Lymphoblastic Leukemia (ALL), and 3.8% (3/79) with Acute Myelogenous Leukemia (AML). The profile of positive BCR-ABL1 in CML patients was 72.8% (43/59). About 97.7% (42/43) of CML patients with positive BCR-ABL1 fusion gene expressed 210-kDa protein, while only 2.3% (1/43) expressed 190-kDa protein.Conclusions: This study found that, from a total of 79 respondents, 45 of them showed a positive BCR-ABL result, with details of 43 in CML and 2 in ALL. Among the total of 43 CML patients with positive BCR-ABL1, 42 (97.7%) of them expressed 210-kDa protein isoform. Further research to investigate the relationship between protein isoforms and their clinical effects may also be important to discuss. The valuable recommendation suggests that BCR-ABL1 examination should be performed for all childhood leukemia patients in Indonesia, especially for CML and ALL.
Penanganan nipple discharge di RS Onkologi Surabaya ARIO DJATMIKO; WIWIEN RISTANTO; ISKANDAR ALI
Indonesian Journal of Cancer Vol 4, No 4 (2010): Oct - Dec 2010
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v4i4.115

Abstract

Nipple secretion in nonlactating period often creates anxiety. Frequently this was the reason women came to hospital to be examined. Not all nipple secretion can be defined as nipple discharge. The terminology of nipple discharge is spontaneous fluid secretion from single duct in the nipple in nonlactating women. Generally, nipple discharge is related to non cancerous cause. Yet, many researchers stated that nipple discharge is a sign of breast malignancy. Therefore, accurate diagnostic is vital to differentiate the normal and abnormal nipple discharge. In final analysis, there must be a correct procedure to decide whether nipple discharge is to be operated or not. From January 2007 to December 2009, 10,033 new patients came to Surabaya Oncology Hospital with breast complaints. It turned out 950 cases (9,47%) were malignant. Out of 10,033 patients, 510 (5.08%) complained of nipple secretion. From 510 nipple secretions, 62 were nipple discharge (0.62%). Following the indication, 15 out of 62 cases were operated duct exploration with result 10 were malignant and 5 were benign. From the 15 cases which were operated and preceded by ultrasonography (USG), duct dilatation can be seen. From 10 nipple discharge with malignancy, 7 cases (70%) did not display any Ca suspicion in their mammography examination. Malignancy cases were found more in older age: 7 cases (70%) were above 50 years old. From these 10 cases with malignancy, only 1 case clinically had palpable mass. Pathology anatomy report revealed 10 cancer cases, 1,1% from 950 all cases who came to RSOS from Januari 2007 until December 2010. 4 cases are insitu carcinoma, 1 nipple discharge with palpable mass, tumor was found 6x6x4 cm. There were 5 cases non cancer, 4 cases intraductal papilloma and 1 periductitis.
Factors Which Influenced on Two Years Recurrence of Epithelial Ovarian Cancer Patients After Surgery and Platinum Based Chemotherapy RESTI MULYA SARI
Indonesian Journal of Cancer Vol 8, No 4 (2014): Oct - Dec 2014
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (657.214 KB) | DOI: 10.33371/ijoc.v8i4.359

Abstract

Ovarian cancer was the leading cause of death in gynecologic cancer which had the two years recurrence rate of 50%. We used retrospective cohort design with survival analysis technique to examine the role of post-surgery residual tumor size, cancer cell histological subtype and cancer cell grading on epithelial ovarian cancer recurrence. We also want to know the prevalence of HER-2 (Human Epidermal Receptor-2) overexpression in epithelial ovarian cancer patients. Sixty-five epithelial ovarian cancer patient (1998-2012) who had achieved remission were observed for 24 months. We reported median age of 50 years with recurrence rate of 36.9% and mean time of first recurrence was 19.15 months. Size of post-surgery residual tumor more than 1 cm increase Hazard Ratio (HR) of two years recurrence of epithelial ovarian cancer with p value 0.02 and HR of 3.31 (95% CI 1.46-7.49) but papillary serous histology subtype and poor differentiated cancer cell grading did not influence the recurrence. One of 38 patients showed cytoplasmic staining in HER-2 overexpression examination by immunohistochemistry methods. Conclusion: Size of post-surgery residual tumor more than 1 cm increase Hazard Ratio of two years recurrence of epithelial ovarian cancer while papillary serous histology subtype and poor differentiated cancer cell grading did not influence the recurrence. One sample showed cytoplasmic staining on HER-2 overexpression examination.
Faktor Prognostik dan Kesintasan Pasien Leukemia Limfoblastik Akut Anak di RSUP Dr. Sardjito, Yogyakarta, 2010–2015 LUSIA PUTRI WIJAYANTI; EDDY SUPRIYADI
Indonesian Journal of Cancer Vol 11, No 4 (2017): October- December 2017
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (500.643 KB) | DOI: 10.33371/ijoc.v11i4.532

Abstract

Acute lymphoblastic leukemia (ALL) is the most common hematologic malignancy in children. Improvements in ALL management in developed countries have shown that the survival rate can be up to 90%. This achievement may be attributed to the stratification of therapy based on prognostic factors. This study aims to evaluate the survival rate of childhood ALL at Sardjito Hospital and prognostic factors for survival. Newly diagnosed patients with ALL aged less than 18 years from January 2010 - December 2015 were enrolled. Patients who have previously received chemotherapy, those with ALL type L3, and those with mixed leukemia were excluded. The survival rate was analyzed by Kaplan-Meier method using log-rank test. Cox regression analysis was used to identify prognostic factors. A total of 309 patients were analyzed. The survival rate of childhood LLA in 2010-2015 in Sardjito Hospital was 56.1 ± 3.9%. Risk grouping based on National Cancer Institute is a prognostic factor that influences the survival of childhood LLA. ABSTRAKLeukemia limfoblastik akut (LLA) merupakan keganasan hematologi yang paling sering ditemui pada anak. Perkembangan LLA anak di negara maju menunjukkan kesintasan pasien mencapai 90%. Keberhasilan terapi pada LLA salah satunya adalah karena adanya stratifikasi terapi berdasarkan faktor prognostik yang ada. Penelitian ini bertujuan untuk mengetahui kesintasan pasien LLA anak di RSUP Dr. Sardjito. Pasien berusia di bawah 18 tahun yang terdiagnosis LLA pada Januari 2010–Desember 2015 diikutsertakan dalam penelitian. Pasien yang pernah mendapatkan kemoterapi, LLA tipe L3, dan mixed leukemia dieksklusi. Kesintasan dianalisis dengan metode Kaplan-Meier menggunakan logrank . Analisis Cox regression digunakan untuk mengidentifikasi faktor prognostik. Sejumlah 309 pasien diikutkan dalam analisis. Kesintasan LLA anak tahun 2010–2015 di RSUP Dr. Sardjito sebesar 56,1±3,9%. Pengelompokan risiko berdasar National Cancer Institute (NCI) merupakan faktor prognostik yang berpengaruh pada kesintasan pasien LLA anak.
Potential Use of Biomarker γ-H2AX on Peripheral Blood Patient Who Underwent Radioiodine Ablation Treatment in Indonesia IIN KURNIA HASAN BASRI
Indonesian Journal of Cancer Vol 15, No 2 (2021): June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (364.929 KB) | DOI: 10.33371/ijoc.v15i2.764

Abstract

Thyroid cancer is one of the most common endocrine malignancies. Although the 10-year survival rate of differentiated thyroid cancer (DTC) is about 90% after conventional treatments, a small proportion of patients still suffer from tumor recurrence or drug resistance. DNA doublestrand breaks (DSBs) are important cellular lesions that can result from ionizing radiation exposure. The biomarker for DSB formation is the phosphorylated form of the histone H2 variant H2AX (γ-H2AX). We propose the use of γ-H2AX as a DNA DSB biomarker in thyroid cancer patients receiving radioiodine treatment as a possibility to detect the potential of instability genome after receiving the treatment. Evaluating DNA DSB damage with γ-H2AX biomarker might be important in managing thyroid cancer.
Peran Ekstrak Etanol Kulit Manggis (Garcinia mangostana L.) Dalam Menginduksi Apoptosis Sel Kanker Lidah Manusia Sp-C1 In Vitro SUPRIATNO -; HENDRI SUSANTO; SRI BUDIARTI
Indonesian Journal of Cancer Vol 7, No 4 (2013): Oct - Dec 2013
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v7i4.309

Abstract

Sel kanker lidah mempunyai karakteristik pertumbuhan sel yang cepat, invasi, dan metastasis yang tinggi. Penatalaksanaan untuk kanker primer, metastasis, dan residif masih menunjukkan hasil yang belum memuaskan sehingga dipikirkan untuk mengombinasi dengan terapi pengobatan alternatif menggunakan bahan alam kulit manggis (Garcinia mangostana L.). Tujuan penelitian menguji induksi apoptosis sel kanker lidah Sp-C1 menggunakan ekstrak etanol kulit manggis in vitro. Induksi apoptosis sel pasca-perlakuan ekstrak etanol kulit manggis konsentrasi 0, 2,5, 5, 7,5, 10, dan 12,5 ?g/ml dilakukan menggunakan uji kolorimetrik caspase-3 dan -9 (DVED-pNA dan LEHD-pNA). Data dianalisis menggunakan Anova satu jalur, dilanjutkan dengan uji Post-hoc LSD dengan derajat kemaknaan 95%. Hasil penelitian menunjukkan ekstrak etanol kulit manggis konsentrasi 12,5 ?g/ml menginduksi apoptosis sel kanker lidah manusia Sp-C1 melalui aktivitas proteolitik caspase-3 dan caspase-9 (P=0,001). Peningkatan kelipatan aktivitas proteolitik caspase-3 dan -9 diketahui sebesar 1,39 dan 2,15 kali lipat. Kesimpulannya, ekstrak etanol kulit manggis dapat menginduksi apoptosis sel kanker lidah manusia Sp-C1.Kata Kunci: sel kanker lidah Sp-C1, kulit manggis, apoptosis, caspase-3 dan -9.
Integrasi Perawatan Paliatif kedalam Penatalaksanaan Kanker Terpadu: Tantangan dan Kesempatan Maria -; Witjaksono -
Indonesian Journal of Cancer Vol 2, No 3 (2008): Jul - Sep 2008
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v2i3.50

Abstract

"Mengurangi penderitaan adalah menjadi hal yang sangat penting dalam setiap layanan kesehatan ketika usaha untuk mencapai kesembuhan tidak lagi memungkinkan. Oleh karena itu, setiap tenaga kesehatan memiliki tanggung jawab untuk menyediakannya bila indikasi ditemukan"Integrasi perawatan paliatif ke dalam penatalaksanaan kanker terpadu telah lama dianjurkan seiring dengan terus meningkatnya jumlah pasien kanker sampai beberapa dekade mendatang sebagai akibat dari meningkatnya harapan hidup manusia. Pada saat pengobatan kuratif belum mampu memberikan kesembuhan yang diharapakan dan tersedia di seluruh wilayah dan usaha preventif baik primer maupun sekunder belum terlaksana dengan baik sehingga sebagian besar pasien ditemukan dalam stadium lanjut, perawatan paliatif sudah semestinya menjadi satu satunya layanan fragmatis dan jawaban yang manusiawi bagi mereka yang menderita akibat penyakit kanker. Walaupun perawatan paliatif merupakan layanan yang sudah terbukti secara ilmiah bermanfaat, efektif dan relatif murah, pada kenyataanya masih diabaikan dan dipandang sebagai usaha yang paling akhir dalam perjalanan penatalaksanaan kanker. Usaha dan sumber yang lebih besar masih sangat diperlukan agar perawatan paliatif dapat diterima, dan berkembang baik secara kuantitas maupun kualitas sehingga mampu menjadi bagian yang mampu mendukung program penatalaksanaan kanker yang efektif dan efisien dan menjangkau sebagian besar mereka yang seharusnya mendapat manfaat dari layanan ini.Tulisan ini membahas tantangan yang dihadapi dan kesempatan yang tersedia untuk mengintegrasikan perawatan paliatif ke dalam program penatalaksanaan kanker terpadu di Indonesia dan peran berbagai pihak dalam membangun dan mengembangkan perawatan paliatif.Kata kunci: perawatan paliatif, penanggulangan kanker, tantangan dan kesempatan

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