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Indonesian Journal of Cancer

ijoc
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Published by National Cancer Center-Dharmais Cancer Hospital

ISSN : 19783744 EISSN : 23556811 DOI : https://www.doi.org/ 10.33371

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

Indonesian Journal of Cancer is a peer-reviewed and open-access journal. This journal is published quarterly (in March, June, September, and December) by Dharmais Cancer Hospital - National Cancer Center. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted acceptance for publication. The journal publishes original research articles, case reports, and review articles under the following categories: cancer management, cancer prevention, cancer etiology, epidemiology, molecular oncology, cancer diagnosis and therapy, tumor pathology, surgical oncology, medical oncology, radiation oncology, interventional radiology, as well as early detection.

Arjuna Subject : Kedokteran - Onkologi

Articles 562 Documents

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Comparison of TNF-α and TGF-β Expression in Breast Cancer Tissues-with and without Axillary Lymph Node Metastasis Ayu Tyasmara; Willy Sandhika
Indonesian Journal of Cancer Vol 12, No 1 (2018): Jan - Mar
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: Breast carcinoma dynamics can be seen from the inflammatory mediator produced and some of expressed cytokine mediators mostly found in breast cancer tissues are TNF-α and TGF-β. This research analyzed TNF-α and TGF-β influence in axillary lymph nodes metastasis to prove the role of cytokines in breast cancer dynamics and to be taken as prognosis. Methods: This research used paraffin block of breast carcinoma in various stages of axillary lymph nodes metastasis and TNF-α and TGF-β antibody to observe the expressions. Result: There were significant differences in TNF-α expressions improvement with p < 0.05 in lymph nodes metastasis N1 (13.18%) and TNF-α expressions reduction in lymph nodes metastasis N2 (52.27%) and N3 (27.27%) compared with lymph nodes without metastasis (52.73%). There were no significant differences in TGF-β expressions of all N groups. Conclusion: The result stated that TNF-α cytokines can be used as biomarker independently predicting breast carcinoma prognosis and progressivity. ABSTRAKLatar Belakang: Dinamika karsinoma payudara tercermin dari mediator inflamasi yang dihasilkannya dan salah satu mediator sitokin yang terekspresi banyak pada jaringan tumor payudara adalah TNF-α and TGF-β. Kami menganalisis pengaruh TNF-α dan TGF-β pada metastasis kelenjar getah bening aksila untuk membuktikan peran sitokin dalam dinamika kanker payudara dan untuk dimanfaatkan sebagai alat prognosis. Metode: Penelitian ini menggunakan blok parafin karsinoma payudara pada berbagai stadium metastasis kelenjar getah bening aksila dan menggunakan antibodi TNF-α dan TGF-β untuk mendeteksi ekspresinya. Hasil: Hasil penelitian ini didapatkan perbedaan peningkatan ekspresi TNF-α yang signifikan dengan p < 0,05 pada metastasis kelenjar getah bening N1 (73,18%) dan penurunan ekspresi TNF-α pada metastasis kelenjar N2 (52,27%) dan N3 (27,27%) dibandingkan dengan tanpa metastasis (52,73%). Tidak ada perbedaan signifika n pada ekspresi TGF-β antar semua kelompok N. Kesimpulan: Hasil ini menyatakan sitokin TNF-α dapat dipakai sebagai biomarker untuk memprediksi progresifitas dan prognosis karsinoma payudara secara independen

Myasthenia Gravis in Patients with Histopathologically Diagnosed Thymoma at Sanglah General Hospital: A Case Series Desak Putu Gayatri Saraswati Seputra; I Gusti Ayu Sri Mahendra Dewi
Indonesian Journal of Cancer Vol 15, No 2 (2021): June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Introduction: Thymoma is a neoplasm of the thymus gland which arises from the epithelial tissue. Thymoma is frequently related to various paraneoplastic syndromes, most commonly myasthenia gravis. Up to 50% of patients with thymoma are reported to develop myasthenia gravis, whereas 10–15% of patients with myasthenia gravis are found to have thymoma. Case Presentation: This case series reported 3 patients with myasthenia gravis which co-occurred with thymoma at Sanglah General Hospital from 2018 to 2019. The patients’ ages range from 33 to 61 years (mean age 46 ± 11 years) with a 2:1 male-to-female ratio. The diagnosis of myasthenia gravis was made by the presentation of typical myasthenia gravis appearances, the fluctuating intensity of ocular and bulbar muscle weakness (all three cases), and limbs and axial muscle weakness (one case); no respiratory muscle involvement was found. Physical and supporting examinations including electroneuromyography results were coherent with myasthenia gravis. The diagnosis of thymoma was made by highly suggestive appearance in Thorax Multi Sliced Computed Tomography (MSCT) scan examination and histopathologic findings. MSCT scan examination showed a well-circumscribed ovoid solid mass in the mediastinum (left anterosuperior, superior, and anterior to middle right mediastinum) sized from 1.8x1.5x2.9 cm to 8.1x9.9x9.7 cm, enhanced with contrast injection with areas of calcification and central necrotic (1 case) and no dissemination to regional lymph node and neighboring organs. All cases received acetylcholinesterase inhibitors and underwent extended thymectomy. Histopathological examination showed accordance with thymoma features of subtype A, AB, and B1.Conclusions: Clinicians should be aware of the thymoma and myasthenia gravis co-existence possibility to ensure early recognition and appropriate management.

Evaluasi Penggunaan Antibiotika Profilaksis di Ruang Bedah Rumah Sakit Kanker Dharmais Jakarta dan Hubungannya dengan Kejadian Infeksi Daerah Operasi Lydia Septa Desiyana; Ajoedi Soemardi; Maksum Radji
Indonesian Journal of Cancer Vol 2, No 4 (2008): Oct - Dec 2008
Publisher : National Cancer Center - Dharmais Cancer Hospital

Infeksi daerah operasi (IDO) merupakan salah satu infeksi nosokomial yang menyebabkan morbiditas, mortalitas dan peningkatan biaya perawatan. Faktor resiko terjadinya IDO dapat berasal dari pasien sendiri, lingkungan, operasi dan perawatan pasca operasi. Penggunaan antibiotika profilaksis merupakan salah satu cara menurunkan kejadian IDO.Dilakukan penelitian di ruang bedah RS. Kanker "Dharmais" dengan metode cross-sectional dan prospektif. Metode pengambilan sampel yang dilakukan adalah total sampling. Data dari seluruh pasien yang menjalani operasi pada 10 April -9 Mei 2008 diambil, kemudian dilakukan pemantauan kejadian IDO sampai dengan 30 hari pasca operasi.Dari 150 pasien yang menjalani operasi, sejumlah 131 pasien yang dapat dipantau hingga 30 hari pasca operasi. Antibiotika profilaksis digunakan pada 111 dari 131 operasi yang dilakukan (84,73%). Antibiotika yang paling banyak digunakan adalah sefalosporin generasi III, yaitu ceftriaxone (52,25%). 84,68% pasien menerima antibiotika profilaksis tidak tepat waktu dan 81,98% menerima antibiotika profilaksis > 24 jam. IDO terjadi pada 3 dari 131 (2,29%) pasien tersebut. Hasil analisa multivariat menunjukkan lama rawat sebelum operasi merupakan faktor risiko yang berpengaruh terhadap kejadian IDO pada penelitian ini (p = 0,031, OR = 3,259).Antibiotikan profilaksis yang paling banyak digunakan di instalasi bedah RS. Kanker "Dharmais" adalah ceftriaxone, waktu pemberiannya sebagian besar tidak tepat dan digunakan lebih dari 24 jam. Ceftriaxone merupakan antibiotika spektrum luas yang mempunyai efekstivitas terhadap gram positif dan negatif.Penilaian kesesuaian pemilihan jenis antibiotika profilaksis dilakukan dengan menggunakan data sensitivitas ruangan tahun 2007 dengan hasil bahwa antibiotika profilaksis yang digunakan masih sensitif terhadap bakteri yang ada diruangan ICU, kelas II dan kelas III. Kejadian IDO di RS. Kanker "Dharmais" adalah 2,29%. Hasil analisa bivariat dengan chi-square menunjukkan bahwa sifat operasi, durasi operasi dan lama rawat sebelum operasi mempunyai hubungan bermakna dengan kejadian IDO (p < 0,05). Sementara itu hasil analisa multivariate menunjukkan jumlah hari rawat sebelum operasi merupakan faktor risiko terjadinya IDO.Kata kunci: antibiotika profilaksis, infeksi luka operasi, operasi.

ABVD versus Stanford V Regimen in Unfavorable Classical Hodgkins Lymphoma TOMMY SUPIT; ZULKIFLI AMIN
Indonesian Journal of Cancer Vol 7, No 4 (2013): Oct - Dec 2013
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v7i4.314

Latar belakang: dilaporkan pasien yang terdiagnosis unfavorable limfoma Hodgkin klasik stadium IIB. Pedoman terapi onkologi memasukkan regimen doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD) dan Standford V sebagai pilihan pengobatan. Namun, sampai saat ini tidak ada tinjauan sistematis atau analisis-meta yang membandingakan kedua rejimen tersebut yang spesifik untuk kasus ini. Studi kasus ini akan menganalisis hasil uji klinis untuk mengetahui apakah salah satu dari rejimen yang tersebut lebih unggul berdasarkan efikasi klinis dan profil toksisitas.Metodologi: pencarian sistematis dilakukan melalui database EMBASE and Cochrane.Laporan kasus ini menelaah beberapa publikasi dalam bahasa Inggris yang berdasarkan uji klinik acak terkendali.Hasil: tiga hasil uji klinik acak terkendali dengan ketersediaan teks lengkap dievaluasi dalam laporan ini. Dua penelitian telah menunjukkan keunggulan ABVD dibandingkan dengan rejimen Standford V yang dimodifikasi, sementara studi lain menunjukkan keunggulan ABVD yang tidak signifikan. Namun, komponen radioterapi regimen Standford V yang digunakan dalam ketiga penelitian tersebut lebih restriktif dibanding dengan rejimen Standford V yang standar.Kesimpulan: ABVD dan rejimen Standford V merupakan dua pilihan yang dapat digunakan untuk mengobati limfoma Hodgkin klasik.Kata Kunci: limfoma Hodgkin, ABVD, Stanford V, perbandingan, efikasi klinik, toksisitas, NCCN, ESMO

Terapi Sistemik Terkini pada Karsinoma Sel Ginjal Metastatik Dodi Hami Seno; Chaidir Arif Mochtar; Rainy Umbas
Indonesian Journal of Cancer Vol 5, No 3 (2011): Jul - Sep 2011
Publisher : National Cancer Center - Dharmais Cancer Hospital

Kurang lebih sepertiga pasien dengan karsinoma sel ginjal (KSG) telah mengalami metastasis pada saat pertama kali didiagnosis dan 40-50% akan mengalami metastasis jauh setelah diagnosis awal. Karsinoma sel ginjal resistan terhadap sebagian besar kemoterapi dan obat sitotoksik konvensional. Namun demikian, selama beberapa tahun terakhir pengobatan kanker ini menunjukkan kemajuan yang spektakuler karena berkembangnyatargeted therapybagi karsinoma sel ginjal metastatik (KSGm). Tujuan dari penulisan makalah ini adalah untuk menelaah tata laksana terkini KSGm. Hingga saat ini, terdapat enam obat yang telah disetujui oleh FDA dan beberapa asosiasi urologi internasional untuk digunakan sebagai terapi KSGm lini pertama dan kedua. Lini pertama terdiri dari sunitinib (progression-free survival, PFS, 11 bulan dibandingkan dengan 5 bulan pada IFN-?, danoverall survival, OS, 26,4 bulan dibandingkan dengan 21,8 bulan pada IFN-?), kombinasi bevacizumab dan IFN-? (PFS 10,2 bulan dibandingkan dengan 5,4 bulan pada kombinasi plasebo dan IFN-?, OS 23,3 bulan dibandingkan dengan 21,3 bulan pada kombinasi plasebo dan IFN- ?), pazopanib (PFS 9,2 bulan dibandingkan dengan 4,2 bulan pada plasebo), serta temsirolimus (OS 10,9 bulan dibandingkan dengan 7,3 bulan pada IFN-?), sedangkan lini kedua terdiri dari sorafenib (PFS 5,5 bulan dibandingkan dengan 2,8 bulan pada plasebo) dan everolimus (PFS 4,0 bulan dibandingkan dengan 1,9 bulan pada plasebo).Katakunci: Karsinoma sel ginjal metastatik terapi target, terapi sistemik

Perbandingan Verifikasi Akurasi Posisi Pasien Radioterapi Secara Manual dan Semiotomatis Berbasis Citra DRR/EPID SUSI NOFRIDIANITA; HERU PRASETIO; SUPRIYANTO A PAWIRO
Indonesian Journal of Cancer Vol 10, No 3 (2016): July - September 2016
Publisher : National Cancer Center - Dharmais Cancer Hospital

ABSTRACTRadiotherapy is one of common treatment modality for Nasopharyngeal Cancer. The development of intensity modulated radiotherapy (IMRT technique) gives satisfactory results in the nasopharyngeal cancer treatment, both clinically and dosimetry. IMRT can reduce the effects of acute and chronic, with a maximum dose coverage to the tumor and minimal dose to the organ or normal tissue surrounding target value. The purpose of this study is to compare theaccuracy of patient positioning verification of Nasopharyngeal Cancer IMRT with DRR / EPID image registration. Retrospective data analysis of the AP and Lateral projections DRR and EPID images 35 patients (140 images) were then manually verified by simulative applied fusion semiautomatic with FIJI program. FIJI program improved the image quality of the DRR and EPID to facilitate the image registration. Results of this study shows no statistically significantdifference between the manual verification and semiautomatic fusion method of nasopharyngeal cancer patients, but there is a tendency that the semiautomatic method with FIJI program provides verification geometry radiotherapy better a result than manual methods.ABSTRAKTeknik Intensity Modulated Radiotherapy (IMRT) dapat mengurangi efek akut dan kronik, dengan cakupan dosis maksimal pada tumor dan dosis minimal pada organ/jaringan sehat di sekitarnya. Tujuan dari penelitian ini adalah untuk mengetahui perbandingan verifikasi akurasi posisi pasien IMRT Kanker Nasofaring dengan registrasi citra DRR/ EPID. Analisis data retrospektif terhadap citra DRR/EPID dari 35 pasien proyeksi AP dan Lateral (140 citra) yang telah diverifikasi secara manual kemudian secara simulatif diterapkan metode fusi semiotomatis dengan program FIJI. Penggunaan program FIJI dapat memperbaiki kualitas citra DRR/EPID sehingga memudahkan dalam verifikasi geometri radioterapi. Hasil penelitian ini secara statistik menunjukkan tidak terdapat perbedaan antara verifikasi manual denganmetode fusi pada radioterapi pasien kanker nasofaring, namun secara deskriptif terdapat kecenderungan bahwa metode fusi dengan program FIJI memberikan verifikasi geometri radioterapi yang lebih baik dibandingkan metode manual.

Giant Breast Hypertrophy in Juvenile: A Rare Case Dila Junita; Edmond Rukmana Wikanta
Indonesian Journal of Cancer Vol 14, No 2 (2020): June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Introduction: Juvenile hypertrophy of the breast (JHB) is a benign condition that can lead to gigantomastia in adolescence. The development of breast enlargement in adolescence can cause both physical and psychosocial problems. Therefore, appropriate investigation and proper management at an early stage of the disease are very important. One of the treatment modalities is breast reduction surgery which ideal and offers an improvement in the quality of life. Case Presentation: A 13-year-old female with massive bilateral breast enlargement for a period of 8 months. The patient also complained of severe back pain and neck discomfort since her breast progressively enlarged. Psychosocial problems were recorded. Right breast reduction was performed and closed with inverted-T mammoplasty. The post-operative period was uneventful, and the patient was discharged on day 5 after the operation. Conclusions: Reduction mammoplasty is well accepted by adolescents with juvenile breast hypertrophy and can improve physical and psychological outcomes.

Tata Laksana Farmakologis Nyeri Kanker Gardian Lukman; Eddy Harjanto
Indonesian Journal of Cancer Vol 1, No 3 (2007): Jul - Sep 2007
Publisher : National Cancer Center - Dharmais Cancer Hospital

Diperkirakan akan ada 15 juta kasus kanker baru seperti yang diprediksi oleh Badan Kesehatan Dunia. Sayangnya tata laksana nyeri kanker masih di bawah standar. Hal yang terpenting dalam mengobati nyeri kanker adalah menentukan nyeri macam apa yang diderita oleh pasien. Setelah itu pengobatan dilakukan dengan penggunaan anak tangga nyeri. Opioid terutama morfin masih merupakan obat utama dalam tata laksana kanker.

Colchicine as A Potential Therapy in Hepatocellular Carcinoma: A Review Gembong Satria Mahardhika; Azizah Nurul Ilmi; I Gede Arinton; Suharno Suharno
Indonesian Journal of Cancer Vol 16, No 2 (2022): June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: Liver cancer is the seventh most common cancer and the fourth leading cause of cancer death worldwide. Hepatocellular carcinoma (HCC) is a challenging disease to treat and has a poor prognosis. Colchicine is an old drug that was recently found to have anticancer activities towards several cancer cells. This article aimed to review the potential properties of colchicine as chemotherapy for HCC.Methods: The literature review was done by searching databases from PubMed, Cochrane, and ProQuest from June 4th to 26th, 2021. Full-text articles were searched by literature search strategies. The articles were screened by abstract and title. Studies that met the criteria were screened for full text.Results: Forty-six articles were identified, seven articles were screened for titles and abstracts, and three articles were excluded owing to full-text unavailability. Four articles were reviewed.Conclusions: The potential of colchicine as a preventive therapy in HCC needs to be further explored, and additional tests need to be done, especially in vivo. Larger population studies should also be done to evaluate the safety, usefulness, and feasibility of colchicine, especially in HCC.

Faktor yang Berhubungan dengan Terinfiltrasinya Areola dan Papilla pada Karsinoma Payudara Operabel YUSUF HERIADY; DIMYATI ACHMAD
Indonesian Journal of Cancer Vol 8, No 1 (2014): Jan - Mar 2014
Publisher : National Cancer Center - Dharmais Cancer Hospital

Mastectomy is one of the most frequent surgery performed for operable breast cancer and included resection of the nipple-areola complex (NAC). The risk of local recurrence behind the nipple areolar complex (NAC) is the main limitating of the nipple-sparing mastectomy (NSM) procedure. The aim of this study is to investigate the incidence and to determine associated risk factors with cancer infiltration to nipple-areola complex (NAC) in operable breast cancer patients. This is an observational analytic, cross sectional study using retrospective medical record of patients with mastectomy, at Soedarso Hospital Pontianak from 2006 to 2013. Results: In a period of 7 year, we included 310 patients, the mean age is 47,3 years (24-78 years). The NAC involvements 30,6%. In bivariate analysis showed that age, tumor size, tumor stage, lymh node status, lymvovascular invasion and tumor distance are associated with NAC involvement. In the multivariate analysis showed that only lymh node status (p = 0,001; prevalence odds ratio [POR], 1.52; 95% confidence interval [CI], 1.18?1.95), tumor distance (p<0.001; POR, 0.47; CI, 0.36?0.61) and tumor size (p = 0.012; POR, 2.05; CI, 1.17?3.60) are the only variables that remain significant predictors of NAC involvement. In the logistic regression analysis showed that high risks of NAC involvement are tumor distance >1?2 cm with T2 and lymph node status > 4 or with T3 and lymph node status negative or positive> 1; tumor distance >2?3 cm with T3 and lymph node status > 4. Conclusions: NAC involvement is 30,6%. Predictor factors of NAC involvement are lymh node status, tumor distance and tumor size. High risks of NAC involvement are tumor distance >1?2 cm with T2 and lymph node status > 4 or with T3 and lymph node status negative or positive> 1; tumor distance >2?3 cm with T3 and lymph node status > 4.

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Home Page

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Editorial Team

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Contact Name Bayu Brahma

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Editorial Address National Cancer Center - Dharmais Cancer Hospital Research and Development Building, 3rd-floor Jl. Letjen S. Parman Kav. 84-86, Slipi West Jakarta

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Contact Name
Bayu Brahma

Contact Email
journal.cancer@gmail.com

Phone
+628176389956

Journal Mail Official
admin@indonesianjournalofcancer.or.id

Editorial Address
National Cancer Center - Dharmais Cancer Hospital Research and Development Building, 3rd-floor Jl. Letjen S. Parman Kav. 84-86, Slipi West Jakarta

Location
Kota adm. jakarta barat,

Dki jakarta

INDONESIA