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Indonesian Journal of Cancer

ijoc
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Published by National Cancer Center-Dharmais Cancer Hospital

ISSN : 19783744 EISSN : 23556811 DOI : https://www.doi.org/ 10.33371

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

Indonesian Journal of Cancer is a peer-reviewed and open-access journal. This journal is published quarterly (in March, June, September, and December) by Dharmais Cancer Hospital - National Cancer Center. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted acceptance for publication. The journal publishes original research articles, case reports, and review articles under the following categories: cancer management, cancer prevention, cancer etiology, epidemiology, molecular oncology, cancer diagnosis and therapy, tumor pathology, surgical oncology, medical oncology, radiation oncology, interventional radiology, as well as early detection.

Arjuna Subject : Kedokteran - Onkologi

Articles 562 Documents

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Effect of Herbal Therapy on Intracellular Cytokine Expression of CD8 Cell in Nasopharingeal Cancer Patients Haryanto Reksodiputro; Asrul Harsal; Budianto Komari
Indonesian Journal of Cancer Vol 5, No 2 (2011): Apr - Jun 2011
Publisher : National Cancer Center - Dharmais Cancer Hospital

Tujuan: untuk mengetahui efek obat herbal terhadap respons imun pasien kanker nasofaring (KNF) dengan cara mengukur persentase sitokin intraselular (IFN-? dan TNF-?) sebelum dan sesudah pemberian THL. Juga untuk memperkenalkan metode pemeriksan sitokin intra sel sebagai alternatif lain dalam penilaian respons imun pasien.Metode: sebanyak 15 pasien KNF diikutsertakan secara konsekutif dalam penelitian ini dan menerima obat Tien Hsien Liquid (THL) sebanyak empat kali sehari selama empat minggu. Sebelum dan sesudah pemberian THL, dilakukan pengambilan darah sebanyak 10 mL untuk pengukuran kadar sitokin intraselular TNF-? dan IFN-?, baik secara spontan maupun setelah perangsanganphytohemagglutinin(PHA) dengan menggunakanflowcytometric assay.Hasil: kedua jenis sitokin (TNF-? dan IFN-?) baik sebelum maupun setelah perangsangan PHA mengalami kenaikan setelah pemberian THL. Persentase kenaikan IFN-? dan TNF-? sebelum perangsangan PHA adalah 4.62+1.39 dan 4.89+1.39; sedangkan persentase kenaikan setelah perangsangan PHA adalah 3.98+1.29 and 1.65+3.82.Pada laporan ini juga diperlihatkan bahwa pemeriksaan sitokin intra sel dapat dilakukan di laboratorium kami sebagai alternatif lain penilaian respons imun pasien. Pada pemeriksaan TNF-? and IFN dalam serum, kadar TNF-? and IFN yang diukur diproduksi oleh berbagai sel lain seperti makrofag, sel endotel, dan lain-lain, sedangkan dengan metode pemeriksaan sitokin intraseluler yang dikerjakan dalam laporan ini yang diukur adalah kadar protein yang diproduksi sel CD8.Kesimpulan:THL dapat memodulasi respons imun selular dengan meningkatkan sitokin intraselular (IFN-? dan TNF-?) dalam CD8+. Oleh karena itu, obat herbal ini dapat menjadi agenimmunoceuticalyang dapat digunakan sebagai terapi suportif pada pasien kanker, terutama pasien kanker nasofaring (KNF).Kata kunci: sitokin intraselular, kanker nasofaring, Tien Hsien Liquid (THL)

Kesesuaian Sistem TIRADS Dengan Hasil Pemeriksaan Patologi Anatomi Nodul Tiroid
Indonesian Journal of Cancer Vol 8, No 3 (2014): Jul - Sep 2014
Publisher : National Cancer Center - Dharmais Cancer Hospital

Thyroid ultrasonography is the modality of choice to detect, and to evaluate the morphology of thyroid nodule. ThyroidImaging Reporting and Data System (TIRADS) is a system to evaluate risk of malignancy of thyroid nodule, that firstproposed by Horvath et al. There are various TIRADS proposed by other authors. To the author knowledge, until thewriting of this study there is not yet found a study to evaluate implementation and diagnostic value of TIRADS inIndonesian.Methods: Diagnostic study with cross sectional approach using retrospective evaluation of thyroid ultrasonographydata and post operative histopathology data to evaluate conformity relationship between TIRADS and post operativehistopathological result of thyroid nodule.There is comparable result (p=0.065) between TIRADS result and post operativehistopathological result of thyroidnodule. TIRADS resulted in 96.4% sensitivity; 83.0% specificity; 85.7% positive predictive value; dan 95.7% negativepredictive value.Conclusion: TIRADS can be implemented in evaluation, and reporting of thyroid ultrasonography result with gooddiagnostic value.

Perbandingan Kesintasan Tiga Tahun pada Anak Leukemia Limfoblastik Akut antara Protokol Pengobatan 2006 dan 2013 RAHIMUL YAKIN; SYAHRIZAL SYARIF; EDI SETIAWAN TEHUTERU
Indonesian Journal of Cancer Vol 11, No 3 (2017): July - September 2017
Publisher : National Cancer Center - Dharmais Cancer Hospital

Treatment of children with Acute lymphoblastic leukemia was developing, currently in Indonesia there are several commonly used protocols such as National protocol (Jakarta), WK-LLA 2000 protocol, LLA protocol 2006 and protocol LLA 2013. The purpose of this study to determine the probability of survival 3 years In children with acute lymphoblastic leukemia between protocols 2006 and 2013. This study used a mix method of retrospective cohorts and in-depth interviews. The population in this study were LLA children aged 1–15 years who received protocol 2006 and 2013 in RSKD Jakarta from 2008–2016 is 68 children with research time from April 2016 until June 2016. Data were analyzed using Cox Regression. The result of this study shows that the 3-year survival probability of LLA remission based on the 2006 treatment protocol is 30% and the treatment protocol of 2013 is 27%. A 3-year survival event remission occurred between 2006 and 2013 treatment protocols of HR 1.57 (90% CI 0.577–4,299), but the difference between the two protocols was not statistically significant with p-value 0.456.The results of in-depth interviews were also obtained in protocols 2006 and 2013 in the same principle but there remain some differences between the both of the treatment schedule and doses are cumulatively increased. The conclusions of these two protocols are in principle the same and there is not much difference in inputs and processes. ABSTRAK Pengobatan pada anak leukemia limfoblastik akut terus dikembangkan. Saat ini, di Indonesia ada beberapa protokol yang lazim digunakan, yaitu protokol Nasional (Jakarta), protokol WK-LLA 2000, protokol LLA 2006, dan protokol LLA 2013. Tujuan studi ini untuk mengetahui probabilitas kesintasan hidup tiga tahun pada anak leukemia limfoblastik akut antara protokol 2006 dan 2013. Studi ini menggunakan mix method, yaitu kohort retrospektif dan wawancara mendalam. Populasi dalam penelitian ini adalah anak LLA usia 1–15 tahun yang mendapatkan protokol 2006 dan 2013 di Rumah Sakit Kanker “Dhramais”/RSKD, Jakarta, dari 2008–2016 sebanyak 68 anak dengan waktu penelitian dari April 2016 sampai Juni 2016. Data dianalisis dengan Cox Regression. Hasil studi menunjukkan probabilitas kesintasan tiga tahun terjadi remisi pada anak LLA berdasarkan protokol pengobatan 2006 sebesar 30% dan protokol pengobatan 2013 sebesar 27%. Peberdaan kesintasan tiga tahun terjadi remisi antara protokol pengobatan 2006 dan 2013 sebesar HR 1,57 (CI 90% 0,577–4,299). Namun, perbedaan antara kedua protokol ini tidak bermakna secara statistik dengan p-value 0,456. Hasil wawancara mendalam juga menunjukkan pada protokol 2006 dan 2013 secara prinsip sama, tetapi tetap ada beberapa perbedaan di antara keduanya, seperti jadwal pengobatan dan dosis secara kumulatif meningkat. Studi ini menyimpulkan bahwa secara prinsip kedua protokol ini sama dan tidak terdapat banyak perbedaan dalam hal input serta proses.

The Impact of Covid-19 Pandemic on Breast and Thyroid Cancer Surgery: An Advantage or Disadvantage Factor? Hermin Aminah Usman; Fauzan Ali Zainal Abidin; Akbar Maulana
Indonesian Journal of Cancer Vol 15, No 1 (2021): March
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: Breast cancer (BC) and thyroid cancer (TC) are the types of cancer mostly treated at the Surgical Oncology Department with 24.1% and 6.8%, respectively, of all malignancies at Dr. Hasan Sadikin General Hospital. The delay in managing patients for both types of cancer will increase the risk of cancer stage progression. This study was conducted to determine the Covid-19 pandemic’s impact on delayed surgery due to longer waiting times in BC and TC patients.Methods: This research is a descriptive study. The data were collected from BC and TC patients who received surgery in the Surgical Oncology Department from April to June 2020 at Dr. Hasan Sadikin General Hospital. These data include the time of surgery, gender, age, stage of the disease, chemotherapy history, management, time from diagnosis until surgery, last time receiving neoadjuvant chemotherapy until surgery, and time of surgery on schedule.Results: Thirty-seven patients had undergone surgery; the stages of BC and TC patients were IIIB (66.6%) and II (50.0%), respectively. There were 31 BC patients (93.9%) who received neoadjuvant chemotherapy and underwent surgery, and total thyroidectomy with dissection was performed in 75% of TC patients. Operative procedures that were performed earlier than the schedule have been done in 20 (60.6%) and three patients (75.0%) for BC and TC patients, respectively, while 2 (0.6%) of BC patients were delayed in their management and no patient experienced a delay in management on TC.Conclusions: The management of BC and TC patients with various stages has received operation procedures faster than the previously determined schedule in the period from April to June 2020. These results also suggest a possible advantage for cancer patients requiring surgery, particularly patients with advanced BC who have received neoadjuvant chemotherapy. In certain conditions, it turns out that a pandemic may positively impact, especially in the management surgery of breast and thyroid cancer patients. However, limited time at the early start of the pandemic may change these conclusions.

Rumah Sakit Kanker Dharmais (Pusat Kanker Nasional): Melangkah untuk Melaksanakan Program Penanggulangan Kanker di Indonesia Kardinah -; Dwipoyono -; Tehuteru -; Anwar -; Ajoedi -; Widjanarko -; Sutoto -
Indonesian Journal of Cancer Vol 2, No 3 (2008): Jul - Sep 2008
Publisher : National Cancer Center - Dharmais Cancer Hospital

Ketika anak terdiagnosis menderita kanker maka orangtua akan merasakan hal ini sebagai sesuatu yang mengejutkan dan pukulan yang berat, terutama bagi sang ibu, yang telah melahirkan dan umumnya menjadi pengasuh utama anak. Melalui penelitian ini, penulis membahas secara mendalam mengenai emosi-emosi yang dirasakan oleh ibu ditinjau dari teori Colin Murray Parkes. Parkes membagi emosi ke dalam empat fase yaitu: (a) shock, numbness, and disbelief; (b) acute distress, anger, and protest; (c) depression and despair; dan (d) acceptance and resolution. Dari penelitian didapatkan bahwa fase-fase tersebut timbul secara tidak berurutan dan berbeda untuk setiap individu. Perbedaan individu dipengaruhi oleh berbagai hal antara lain kepribadian subyek, dukungan sosial, kondisi fisik anak, dan prediksi yang dilakukan individu. Selain itu, reiigiusitas juga terbukti menjadi faktor penting untuk membantu ibu menerima kenyataan yang harus dihadapi.Kata kunci: ibu, anak penderita kanker, emosi.

Perbedaan Kesintasan 5 Tahun Pasien Leukemia Limfoblastik Akut dan Leukemia Mieloblastik Akut pada Anak di Rumah Sakit Kanker Dharmais, Jakarta, 1997-2008 Chandrayani Simanjorang; Nasrin Kodim; Edi Tehuteru
Indonesian Journal of Cancer Vol 7, No 1 (2013): Jan - Mar 2013
Publisher : National Cancer Center - Dharmais Cancer Hospital

Penelitian ini membahas tentang perbedaan kesintasan 5 tahun pasien leukemia akut tipe LLA dan LMA di RSKD dengan menggunakan desain kohort retrospektif. Data didapatkan dari data rekam medis dan register pasien leukemia anak di RSKD yang didiagnosis pada 1997-2008. Pengumpulan data dilakukan secara retrospektif dengan mengikuti subjek untuk meneliti kejadian yang belum terjadi sejak pertama didiagnosis di RSKD hingga pengamatan berakhir Juni 2012. Rancangan penelitian dibatasi waktu 5 tahun untuk terjadinya event. Dari 95 pasien leukemia akut pada anak didapatkan probabilitas kesintasan 5 tahun secara keseluruhan sebesar 22,6%; angka kesintasan 5 tahun untuk tipe LMA 4,6%; dan tipe LLA 28,9%. Risiko kematian (Hazard Ratio) setelah 5 tahun pada LMA 1,643 kali dibandingkan LLA.Kata kunci: kesintasan 5 tahun, tipe leukemia akut.

Hubungan antara Ekspresi Ki-67 dan Kaspase-3 dengan Respons Kemoterapi Neoajuvan pada Pasien Karsinoma Serviks Stadium IB2 dan IIA2 di Rumah Sakit Dr. Hasan Sadikin, Bandung I MADE WIDYALAKSANA MAHAYASA; MARINGAN DIAPARI LUMBAN TOBING; ALI BUDI HARSONO
Indonesian Journal of Cancer Vol 10, No 2 (2016): April - June 2016
Publisher : National Cancer Center - Dharmais Cancer Hospital

ABSTRACTCervical carcinoma is the second ranks cancer in women in developing countries. This study was a retrospective cohortstudy of the relationship between the role of Ki-67 expression and caspase-3 on tumor shrinkage response in cervical carcinoma stage IB2 and IIA2. A total of 41 cases have been done NACT with Cisplatin, Vincristine and Bleomycin. All samples showed expression in immunohistochemical staining for Ki-67 and caspase-3. Meanwhile, Pearson correlation analysis found no correlation between the expression levels of Ki-67 and caspase-3 with a diminution oftumor mass (p>0.05). While the correlation between the ratio of Ki-67 expression and caspase-3 with a significant diminution of tumor mass is obtained p 0.042, R-0.319, means that the higher the Ki-67 expression levels compared caspase-3 expression level then the response of the tumor mass size reduction will be better.ABSTRAKKarsinoma serviks merupakan kanker kedua terbanyak pada wanita di negara berkembang. Penelitian ini merupakan penelitian kohort retrospektif yang mempelajari hubungan antara peran ekspresi Ki-67 dan kaspase-3 terhadap respons pengecilan tumor pada karsinoma serviks stadium IB2 dan IIA2. Sebanyak 41 kasus telah dilakukan KTNA dengan Cisplatin, Vincristin, dan Bleomycin (PVB).Hasil penelitian menunjukkan seluruh sampel ekspresi pada pewarnaan imunohistokimia untuk Ki-67 dan kaspase-3. Sedangkan analisis korelasi Pearson tidak didapatkan korelasi antara tingkat ekspresi ki-67 dan kaspase-3 dengan pengecilan massa tumor dan nilai p>0,05. Sedangkan korelasi antara rasio ekspresi Ki-67 dan kaspase-3 dengan pengecilan massa tumor didapatkan bermakna dengan nilai p = 0,042 (p<0,05), R-0,319. Artinya, semakin tinggi proliferasi (tingkat ekspresi Ki-67) dibandingkan dengan apoptosis (tingkat ekspresi kaspase-3) maka respons pengecilan tumor akan semakin baik pada karsinoma serviks stadium IB2 dan IIA2

An Association Study of Cervical Cancer Correlated with The Age of Coitarche in Dr. Soetomo Hospital Surabaya Dewi Sulistyawati; Zakiyatul Faizah; Eighty Mardiyan Kurniawati
Indonesian Journal of Cancer Vol 14, No 1 (2020): March
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: Cervical cancer is one of the deadliest diseases for women’s lives. It is estimated that almost every hour, one died because of cervical cancer and 70% of new cases are found in an advanced stage. Many factors could cause cervical cancer, one of the risk factors is the age of the early coitarche. This study aims to determine the association between the age of coitarche and cervical cancer.Methods: This study was an analysis of observational study with a case-control design. There were two groups in this study; the case group of outpatients who were diagnosed with cervical cancer and the control group of outpatients who had normal cervical cytology by Papanicolaou screening. The 39 respondents of both the control and case groups, calculated using the Lemeshow’s formula for consecutive sampling, were interviewed for their details concerning reproductive and sexual histories, socio-economic status, hygiene, and education. The independent variable in this study was the age of coitarche; the dependent variable was cervical cancer. The data were analyzed descriptively and using the bivariate analysis (Chi-square) with α=0.05.Results: It is identified that 39 respondents for each group (case and control) have almost the same percentage of the age of coitarche in One-Stop Oncology Polyclinic (POSA’s outpatient); early coitarche of 43.6% and late coitarche of 56.4%. The age of early coitarche in Obstetrics and Gynecology’s outpatients, as a control group, is rare (4 of 39 respondents; 10.3%) and most of them did their sexual debut at the age of >18 years (89.7%). The chi-square test showed there was a correlation between the age of coitarche and cervical cancer (P=.002; OR=6.76; 95% CI 2.01–22.75).Conclusions: Early coitarche has a potential effect on cervical cancer.

Strategi RS. Kanker "Dharmais" sebagai Bagian dari Pusat Kanker Nasional dalam Mengimplementasikan Kebijakan Departemen Kesehatan Kardinah Kardinah; Sutoto Sutoto
Indonesian Journal of Cancer Vol 1, No 3 (2007): Jul - Sep 2007
Publisher : National Cancer Center - Dharmais Cancer Hospital

Pada bulan Oktober 2007 Rumah Sakit Kanker "Dharmais" genap berdiri selama 14 tahun dan merupakan tantangan bagi pihak rumah sakit untuk menjawab berbagai masalah yang timbul khususnya di bidang kanker. Kebijakan Departemen Kesehatan untuk menurunkan angka kesakitan dan kematian akibat penyakit kanker, memperpanjang umur harapan hidup serta meningkatkan kualitas hidup penderita dilaksanakan dengan strategi sebagai berikut; menggerakkan dan memberdayakan masyarakat untuk hidup sehat , meningkatkan akses masyarakat terhadap pelayanan kesehatan yang berkualitas, meningkatkan sistem surveilans, monitoring dan informasi kesehatan dan meningkatkan pembiayaan kesehatan.

Giant Renal Angiomyolipoma RIFKYA ULIA; SUNARYO HARDJOWIJOTO
Indonesian Journal of Cancer Vol 6, No 3 (2012): Jul - Sep 2012
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v6i3.207

Angiomyolipoma ginjal adalah tumor jinak ginjal yang tersusun atas jaringan lemak, otot polos dan pembuluh darah yang abnormal. Tumor ini jarang dijumpai dan bisa muncul sendiri (sporadis) atau juga berhubungan dengan tuberous sclerosis. Gambaran klinis dari angiomyolipoma adalah trias Lenk, yaitu massa pinggang, nyeri pinggang, dan gross haematuria. Kami melaporkan pasien pria usia 17 tahun yang dirawat di Rumah Sakit Dr. Soetomo, Surabaya, dengan keluhan utama benjolan pinggang kiri bawah sejak 1,5 tahun yang lalu yang bertambah besar.Diagnosis angiomyolipoma didasarkan atas hasil pemeriksaan Computerizad Tomography Scan abdomen. Pasien ini dilakukan terapi embolisasi arteri dan nefrektomi total, dengan hasil pemeriksaan Patologi Anatomi: angiomyolipoma.Kata kunci: ginjal, angiomyolipoma, embolisasi, nefrektomi

Page 25 of 57 | Total Record : 562

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

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Contact Name Bayu Brahma

Contact Email journal.cancer@gmail.com

Phone +628176389956

Journal Mail Official admin@indonesianjournalofcancer.or.id

Editorial Address National Cancer Center - Dharmais Cancer Hospital Research and Development Building, 3rd-floor Jl. Letjen S. Parman Kav. 84-86, Slipi West Jakarta

Location Kota adm. jakarta barat, Dki jakarta INDONESIA

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Abstract

Contact Name
Bayu Brahma

Contact Email
journal.cancer@gmail.com

Phone
+628176389956

Journal Mail Official
admin@indonesianjournalofcancer.or.id

Editorial Address
National Cancer Center - Dharmais Cancer Hospital Research and Development Building, 3rd-floor Jl. Letjen S. Parman Kav. 84-86, Slipi West Jakarta

Location
Kota adm. jakarta barat,

Dki jakarta

INDONESIA