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Arman Harahap
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International Journal of Health and Pharmaceutical (IJHP)
Published by CV. Inara
ISSN : -     EISSN : 2808845X     DOI : https://doi.org/10.51601/ijhp
Core Subject : Health,
Nursing Public Health
International Journal of Health and Pharmaceutical (IJHP) e- ISSN : 2808-845X is a communication media and scientific publication in the health and pharmaceutical fields published by Inara Publisher. International Journal of Health and Pharmaceutical (IJHP) contains articles from research focusing on basic medicine, clinical medicine, epidemiology, preventive medicine (social medicine), pharmacy, and other medical fields. International Journal of Health and Pharmaceutical (IJHP) is published periodically four times a year (February, May, August and November).
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 426 Documents
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Comparison Of Skin Hydration Levels Given Watermelon (Citrullus Lanatus) Fruit Extract Moisturizing Cream With Moisturizing Cream Supplemented With Saccharide Isomerates On Dry Skin Of Female Wistar Rats (Rattus Norvegicus) Yuliasari, Dinda; Yensuari, Yensuari; Isnanta, Rahmad
International Journal of Health and Pharmaceutical (IJHP) Vol. 3 No. 4 (2023): November 2023
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v3i4.303

Abstract

Starting early to care for your skin can prevent premature aging. Since the skin is the body's outermost organ, The skin protects interior organs from pollution, UV radiation, and diseasecausing microbes. Research is needed to confirm and maximize topical plant treatment and skin health medication benefits. This study employs an experimental approach, testing the effects of a moisturizing cream formulated with either watermelon (Citrullus lanatus) extract or a control group of saccharide isomerates on the skin of 25 rats (Rattus norvegicus). The research results show watermelon extract can be used as a medicine since it contains antioxidants and moisturizes the skin. A higher dose of watermelon extract and saccharide isomerate includes more chemical components that hydrate skin. 30% watermelon extract cream with 5% saccharide isomerate improved dry skin more after UVB exposure.
Test Of The Effectiveness Of Giving Aloe Vera Extract In Reducing Cholesterol In Male Wistar Rats (Rattus Norvegicus) With Hypercholesterolemia Gustian, Henni; Million, Hendy; Rajagukguk, Horas
International Journal of Health and Pharmaceutical (IJHP) Vol. 3 No. 4 (2023): November 2023
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v3i4.304

Abstract

Obesity prevention can be done with diet and exercise. Since plasma cholesterol levels are associated with diabetes, public interest in diabetes treatment in foods and herbal medicines has increased dramatically. This research wants to confirm and maximize topical plant treatment and diabetes medication benefits. This study employs a lab experiment. Aloe vera was examined for cholesterol-lowering capacity in hypercholesterolemic male Wistar rats (Rattus Norwegian) utilizing a pre-test-post-test control group. Aloe vera extract (Aloe vera) reduces cholesterol, body weight, and LDL in hypercholesterolemia-afflicted male Wistar white rats (Rattus norvegicus). One-way ANOVA test results show a significant value of 0.000 or less than 0.05. These statistics show a substantial difference between the control and treatment groups. This study's Post Hoc LSD test analysis indicated significance values of 0.000 and 0.018 or less than 0.05, indicating that all groups differed. Aloe vera extract reduces LDL significantly, and the group with a concentration of 4.5% reduced LDL levels more than the other groups in Wistar male white rats (Rattus norvegicus) with hypercholesterolemia.
Providing Of Mahkota Dewa Fruit Extract (Phaleria Macrocarpa) To Reduce Malondialdehyde Levels In The Blood Of White Rats (Rattus Norvegicus) Triggered By Excessive Physical Activity Agustin Riagara, Restoe; Janice, Janice; Sihombing, Bungaran
International Journal of Health and Pharmaceutical (IJHP) Vol. 3 No. 4 (2023): November 2023
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v3i4.305

Abstract

Anti-inflammatory, antioxidant, and apoptosis-modulating potential are just a few biological activities that have garnered much interest in natural food-derived components during the past two decades. Mahkota Dewa fruit (Phaleria macrocarpa) has several beneficial pharmacological activities. This study investigated whether Mahkota Dewa fruit extract (Phaleria macrocarpa) reduced malondialdehyde levels in blood samples of white rats (Rattus norvegicus) generated by excessive physical activity. The samples for this study were white rats (Rattus norvegicus) weighing 160-200 gr and 2-3 months old. The independent variable was the Mahkota Dewa fruit extract (Phaleria macrocarpa). The dependent variable was excessive physical activity-induced malondialdehyde levels in white rats (Rattus norvegicus). The average Malondialdehyde (MDA) levels show that the group given 5 ml of the Mahkota Dewa fruit extract (Phaleria macrocarpa) had tremendous success in lowering MDA levels compared to the other groups. The results of the observations and data analysis show that administration of the extract can reduce MDA levels significantly in male Wistar rats (Rattus norvegicus) because of too much exercise.
Analysis Of Iron (Fe) And Zinc Content (Zn) From Bay Leaves (Syzygium Polyanthum) Mutiara Devi, Rhisma; Magna Patriadi Nuhriawangsa, Adi; Sri Rahardjo, Setyo
International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 3 (2024): August 2024
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v3i4.307

Abstract

Background: Anemia is a nutritional problem in children, pregnant women, teenagers, and women of childbearing age. The prevalence of anemia in Indonesia in 2018 among young women was 48.9%. Bay leaves are widely known in various culinary and traditional medicine in Indonesia. Objective: This study analyzes the iron (Fe) and zinc (Zn) content in bay leaves (Syzygium polyanthum) growing in Karanganyar, Indonesia. Method: This research is an observational descriptive experiment with a laboratory approach carried out through a series of experiments. An Atomic Absorption Spectrophotometer (AAS) is used to analyze iron levels. Results: This research shows that the average concentration of Fe in bay leaves growing in Karanganyar is 294.28 mg/L per 100 grams of bay leaves. Meanwhile, the average concentration of Zn in bay leaves is 15.19 mg/L per 100 grams of bay leaves. According to TKPI 2017, bay leaves contain around 44.1 mg of iron per 100 g. Apart from that, the results of research conducted by Suharni 2021 show that 100 g of bay leaf extract contains around 30.09 mg of iron. Comparison with other plants shows that bay leaves contain much more iron and zinc. Higher than plants such as Moringa leaves. As an example of another plant that is often consumed, Moringa leaves have a lower iron and zinc content, namely 6 mg Fe/100 grams of Moringa leaves and 0.6mg/100 grams of zinc. In addition, this research opens up opportunities for application to experimental animals such as mice, which can be given bay leaf powder to understand its impact on iron and zinc levels in their bodies. Conclusion: The average test concentration of Fe in bay leaves is 294.28 mg/L. Meanwhile, the average concentration of Zn in bay leaves is 15.19 mg/L.
Effectiveness of Applying Anti-Aging Cream with Lemon Peel Extract (Citrus Limon) in Inhibiting the Skin Aging Process of Wistar Rats (Rattus Norvegicus) Exposed to Ultra Violet-B Rays Nurlatipah, Sifa; Halim, Yeni; Gunawan Sebayang, Robby
International Journal of Health and Pharmaceutical (IJHP) Vol. 3 No. 4 (2023): November 2023
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v3i4.308

Abstract

Aging is a gradual physiological change in an organism that results in senescence or a reduction in biological function and the ability of the organism to respond to metabolic stress. Aging occurs in cells, organs, or the entire organism over time; the study of the aging process seeks to understand and regulate all elements that contribute to an individual's life constraints. The predominant acute consequence of UV radiation on normal human skin is sunburn-induced inflammation (erythema). The overall goal of this study is to examine and test the efficacy of applying an anti-aging cream containing lemon peel extract (Citrus limon) in preventing the aging process of mouse skin. Wistar strain (Rattus norvegicus) exposed to ultraviolet-B light. The specific goal of this study is to investigate the efficacy of applying lemon peel extract (Citrus limon) cream at 5%, 10%, and 15% concentrations in preventing the aging process of rat skin exposed to UV-B radiation.
Test The Growth Process of Hair Follicles by Administering Coconut and Candlenut Oil to The Entire Back of White Rats (Rattus Norvegicus) Of the Wistar Strain Mulan, Mulan; Hendrianto, Hendrianto; Ferdinand, Sahna
International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 3 (2024): August 2024
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v3i4.309

Abstract

Hair serves a variety of purposes, including thermoregulation and protection. Hair regulates temperature in nonhuman animals, including primates, by holding heat or preventing cold. Hair can also be used for disguise and as a sexual attractant. Human hair is thinner and lighter than that of primates. The purpose of this study was to determine and test the efficacy of providing a coconut oil and candlenut oil mixture in the process of hair development in Wistar rats (Rattus norvegicus). The study's findings indicate that a combination containing 80% coconut oil and 20% candlenut oil is the most efficient in stimulating hair development in white rats (Rattus norvegicus) of the Wistar strain. This hair growth acceleration is possible because coconut oil contains a high concentration, precisely 80%. Because coconut has a high amount of lauric acid, it has numerous health benefits, including good hair.
The Effect of Giving Aloe Vera Gel on Collagen Growth in Wistar Rats (Rattus Norvegicus) with Exposure to Ultra Violet-B Light Fitria , Inola; Djamin, Djamin; Samin, Buter
International Journal of Health and Pharmaceutical (IJHP) Vol. 3 No. 4 (2023): November 2023
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v3i4.310

Abstract

Exposure to UV rays can cause photochemical damage to the DNA of cells in the body, triggering cancer formation, especially skin cancer in humans. The skin may lose elasticity. Research is needed to ensure that currently, we are still looking for plants or foods that contain collagen, which can prevent wrinkles. This research is an original experiment carried out in a laboratory. Two types of variables play a role in this research: independent variables and dependent variables. In this experiment, aloe vera gel was used as an independent variable as a substitute for UVB light exposure. Collagen development, measured in mouse skin, is the dependent variable here. This study found that the standard control group had no collagen growth and was stable. This was because the typical control treatment was not exposed to UVB rays; hence, collagen formation was stable. The group administered 15% aloe vera extract gel had a more substantial effect on rat skin tissue collagen development after UVB light exposure than the 5% and 10% groups. This is because a higher dose of aloe vera extract includes more chemical components that promote mouse skin collagen formation.
Effectiveness of Dermapen Action Using Green Belt Leaf Extract Cream (Piper betle L) On Hair Growth on The Skin Surface of Female Wistar Strain Rats (Rattus Norvegicus) Hardianti, Novy; Henny, Henny; Delfian, Taufik
International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 3 (2024): August 2024
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v3i4.311

Abstract

Hair loss is a very prevalent hair issue. Hair loss is typical for all humans, but if it becomes severe, it can lead to baldness. Hair goes through a unique cycle of development and loss for each strand, and one herbal plant that has the activity of fertilizing hair growth and overcoming the problem of hair loss is green betel leaf (Piper betle L). The purpose of this study was to determine the efficacy of a derma pen utilizing green betel leaf extract cream (Piper betle L) on hair development on the skin surface of female Wistar rats (Rattus norvegicus). Betel leaves have been shown to help with issues such as hair loss. Using betel leaves regularly aids in It promotes hair growth, conditions hair, and makes it thick and long. Betel leaves can also assist with itching, dandruff, and broken ends. The polyphenol and flavonoid content in betel leaves is an antioxidant and anti-inflammatory, protecting hair from damage caused by inflammatory skin illnesses and free radicals that cause hair loss on the head.
Toxity Test Of Primary And Secondary Metabolite Extracts On Caulerpasp. Which Is Cultivated By The Community Of The District Takalar Sugrani, Andis; Taufiq, Nuramaniyah; Khusnul Khatimah, Qurrata; Tiwa Patanduk, Valen; Wahyuni Pakayya, Sri
International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 3 (2024): August 2024
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v3i4.312

Abstract

Lawi-lawi (Caulerpa sp) has economic value for some coastal communities who cultivate it. Apart from having the opportunity to be exported abroad as a complement to processed seafood, it turns out that lawi-lawi can also be used as an antidote to cancer or malignant diseases. This research is about the level of toxicity of the seaweed extract fraction (Caulerpa sp) on Artemia salina Leach larvae, method while for screening anticancer activity used the Brine Shrimp Lethality Test (BSLT) method. In methanol extract Caulerpa sp based on the results of toxicity test measurements using the BSLT method, it is included in the toxic category. Primary extract In Caulerpa sp based on the results of toxicity test measurements using the BSLT method, it is included in the very toxic category.
The Effect Of A Combination Of Speos (Endorphine Massage Stimulation, Oxytocin Massage And Suggestion) On The Success Of The Let Down Reflex And The Production Of The Mother's Milk Production Post Sectio Caesarea At Dr. Hospital. H. Slamet Martodirdjo Pam Noviandry R, Hilmah; C, Elisa; Setya F, Cucun; R, Sylvina
International Journal of Health and Pharmaceutical (IJHP) Vol. 3 No. 4 (2023): November 2023
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v3i4.313

Abstract

Exclusive breastfeeding has a major impact on a baby's growth and development, as breast milk contains immune system proteins and high levels of bactericides, and breastfeeding can reduce the risk of a baby dying. At the 65th World Health Assembly, member countries of the World Health Organisation (WHO) set a target for at least 50% of babies under six months to be exclusively breastfed by 2025. With massage stimulation that stimulates the release of endorphins and oxytocin, as well as suggestions from the SPEOS method, it will create feelings of calm and strong confidence in the mother, which will influence the let-down reflex. The combination of endorphin massage, oxytocin and suggestive massage can lead to a smooth flow of breast milk, which will help the mother to meet the nutritional needs of the baby for its growth and development. The aim of this research is to determine the success of the let down reflex and the smooth production of breast milk (ASI) after a combination of endorphin massage, oxytocin and suggestive massage intervention. This research uses a post-test only control design, which is a type of true experimental design methodology. The study population consisted of thirty mothers after caesarean section on the first and second day in the delivery and postpartum room of Dr. RSUD. H. Slamet Martodirdjo Pamekasan. The sampling technique used in this study was purposive quota sampling. Data analysis in this study used bivariate and multivariate analysis, namely T-test. In this research design, there were 2 groups, namely the intervention group, namely post caesarean mothers who were given SPEOS intervention and the control group, namely post caesarean mothers who were not given SPEOS intervention. The results of statistical tests using a paired sample t-test on the control group showed results of sig-2 tailed = 1,000 > 0.05, meaning that there was no difference in the let down reflex and smoothness of breast milk production in the control group. The results of statistical tests using a paired sample t-test on the treatment group showed results of sig-2 tailed = 0.000 < 0.05, meaning that there was a difference in the let down reflex and smoothness of breast milk production in the treatment group after receiving the SPEOS intervention, so the hypothesis was accepted, meaning that there was a combination effect of SPEOS (stimulation). endorphin massage, oxytocin and suggestive massage) on the success of the let down reflex and the smoothness of the mother's breast milk production after caesarean section at RSUD Dr H. Slamet Martodirdjo Pamekasan in 2023.

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