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International Journal of Health and Pharmaceutical (IJHP)
Published by CV. Inara
ISSN : -     EISSN : 2808845X     DOI : https://doi.org/10.51601/ijhp
Core Subject : Health,
Nursing Public Health
International Journal of Health and Pharmaceutical (IJHP) e- ISSN : 2808-845X is a communication media and scientific publication in the health and pharmaceutical fields published by Inara Publisher. International Journal of Health and Pharmaceutical (IJHP) contains articles from research focusing on basic medicine, clinical medicine, epidemiology, preventive medicine (social medicine), pharmacy, and other medical fields. International Journal of Health and Pharmaceutical (IJHP) is published periodically four times a year (February, May, August and November).
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 426 Documents
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The Relationship Of Maternal Knowledge And Compliance With Giving Vitamin A Capsules To Toddlers At Posyandu Delima, Binuang Public Health Center, Serang Regency, 2023 Afriyanti, Lisa; Rismayanti, Tetin
International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 1 (2024): February 2024
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v4i1.315

Abstract

Background The WHO has classified vitamin A deficiency as a public health problem affecting approximately one-third of children aged 6 to 59 months in 2013. According to the data from the Health Office of Banten Province, the administration of vitamin A capsules to toddlers aged 6-59 months is 81.3%. In a preliminary study conducted at the Delima Posyandu of Binuang Public Health Center, there were 220 toddlers. The interview results from 15 mothers with toddlers revealed that 6 mothers (40%) were compliant in giving vitamin A capsules to their children, while 9 mother’s (60%) were not compliant. This non-compliance is attributed to the mothers' lack of knowledge regarding the benefits of administering vitamin A for the health of their toddlers. Research Objective: The purpose of this research is to determine the relationship between maternal knowledge and compliance with giving vitamin A capsules to toddlers at Posyandu Delima of Binuang Public Health Center Serang Regency in 2023. Research Methods: This study is a quantitative research with a cross-sectional design. The population comprises all mothers with toddlers who visit the Posyandu Delima at Binuang Public Health Center, Serang Regency. The sample size for this research was determined using the Slovin formula, resulting in a total of 69 individuals. Research Results: The results of this study indicate a significant relationship between maternal knowledge and compliance with giving vitamin A capsules to toddlers, with a regression coefficient value of 76.5%, using the binary logistic regression model equation = -4,096+0,765x. Conclusions and Suggestions: There is a significant relationship between maternal knowledge and compliance with giving vitamin A capsules to toddlers at Posyandu Delima, Binuang Public Health Center Serang Regency. It is hoped that mothers who have toddlers will always pay attention to their children's health by eating foods that contain vitamin A and consuming vitamin A capsules according to schedule to meet their vitamin A needs.
The Effectiveness Test Of Natural Hair Growth Tonic: Avemor (Aloe Vera And Moringa Oleifera) For Thickening Hair And Anti-Licknes Suhesti, Iin; Meitasari, Annisa Diyan; Sulistiana, Nila Efa; Azizah , Dinar
International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 1 (2024): February 2024
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v4i1.316

Abstract

Avemor (Aloe vera and Moringa oleifera) is a natural hair growth tonic manufactured with a combination of aloe vera gel and dried moringa leaf extract as its active ingredients. Aloe vera includes a variety of vitamins and minerals, including vitamins A and C, amino acids, copper, inositol, and others. The extract from moringa leaves also includes tanins, vital amino acids, vitamin C, vitamin E, and other nutrients. One of the products with 2% minoxidil is employed as a positive control. Several hair diseases are treated off-label with the powerful arteriol vasoconstrictor minoxidil, which can also promote hair growth. In order to determine the effectiveness of Natural Hair Growth Tonic, tests were done on male New Zealand white rabbit hair. Avemor (Aloe vera and Moringa oleifera) is one of the products containing 2% minoxidil, with variations in the content of dried moringa leaf extracts of 2%, 4%, and 6% in comparison to the positive control. On the backs of five rabbits, six test regions were created, and each area received a different treatment every day using a sample volume of 0.5 ml. Results of the Natural Hair Growth Tonic's physical evaluation: Avemor (Aloe vera and Moringa oleifera) has a liquid shape, a distinct aroma, a pH of 6, and is homogeneous with the yellow-golden color of the formulae 1 and 2 as well as the golden brown in the formula 3. It also varies in the concentration of the dried moringa leaf extracts. Formula 4 (negative control) has the appearance of a liquid, is dazzling white in color, and emits a distinct odor. Additionally, formula 5 (positive control) has a liquid-like consistency, a vivid yellowish color, and a distinguishable scent. The average reserve viscosity for formula 1 was 2.96 ± 0.14 cPs, for formula 2 it was 2.99 ± 0.10 cPs, and for formula 3 it was 4.05 ± 0.07 cPs. Formula 4 (negative control) had a value 2.96 ± 0.10 cPs, and formula 5 (positive control) had a value of 1.82 ± 0.03 cPs. The average result of rabbit hair growth on the seventh day for treatment 1 is 0.22 ± 0.17 cm, treatment 2 is 0.30 ± 0.23 cm, treatment 3 is 0.42 ± 0.42 cm, treatment 4 is 0.58 ± 0.47 cm, treatment 5 is 0.68 ± 0.36 cm, and treatment 6 is 0.90 ± 0.42 cm. On the 14th day of treatment 1, the average result of rabbit hair growth was 0.43 ± 0.06 cm; on the same day, treatment 2, 0.27± 0.18 cm; on the same day, treatment 3, 0.42 ± 0.33 cm; on the same day, treatment 4, 0.77 ± 0.22 cm; on the same day, treatment 5, 0.28 ± 0.24 cm; and on the same day, treatment 6, 0.43 ± 0.38 cm. The average length of rabbit hair on the 21st day for treatment 1 was 0.43 ± 0.26 cm, for treatment 2 was 0.73 ± 0.19 cm, for treatment 3 was 0.32 ± 0.23 cm, for treatment 4 was 0.48 ± 0.31 cm, for treatment 5 was 0.13 ± 0.17 cm, and for treatment 6 was 0,43 ± 0.30 cm.
Differences In The Effectiveness Of Green Belt Leaf Boiled Water And Soursop Leaves On Which White In Adolescent Girls At SMAN 4 Serang City, Banten, 2023 Anitasari Matanari, Uli; Rismayanti, Tetin
International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 2 (2024): May 2024
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v4i2.317

Abstract

In Indonesia, the problem most often experienced by young women is vaginal discharge. In medical circles, vaginal discharge is known as leukorrhea or fluor albus, which is a discharge from the vagina. Vaginal discharge is a candida fungal infection in female genitalia and is caused by organisms such as yeast, namely candida albicans. Under normal circumstances, the vagina produces fluid that is clear, odorless, colorless, not excessive in quantity and not accompanied by itching. Vaginal discharge is the most common complaint found in women. Vaginal discharge can occur in normal circumstances (physiological), but can also be a symptom of a disorder that must be treated (pathological). The research used was a Quasy Experiment type of research to determine the difference in the effectiveness of giving boiled water from green betel leaves and soursop leaves on vaginal discharge in young women at SMA Negeri 4 Serang Banten with a Two Group Pretest - Posttest research design. Respondents were divided into 2 groups, namely the betel leaf group and the soursop leaf group, each group numbering 45 people. With univariate and bivariate analysis. With the results of the Wilcoxon test, which obtained a significance value of 0.001 (p<0.05), it can be concluded "there is a significant difference in the effect of boiled green betel leaf water on vaginal discharge" and the results of the Wilcoxon test obtained a significance value of 0.000 (p<0.05 ), it can be concluded "there is a significant difference in the effect of boiled soursop water on vaginal discharge".
Effect of Moringa Flower Extract (Moringa Oleifera) on Collagenization and Histopathology of Skin Tissue in the Healing of Dermapen Scars in Obese Male Wistar White Rats Soraya Tanjung, Dian; Kurniawati, Rachmi; Adi Mylano, Tri
International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 2 (2024): May 2024
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v4i2.318

Abstract

Injury can be accidental, intentional, or disease-related. Moringa leaves may help heal wounds. The research aims to test and assess the effects of Moringa oleifera flower extract on dermapen wound healing collagenization in male Wistar strain white rats, an obese model, and their histological findings—quantitative True Experimental Study with Post-Test Only Control Group Design. Twenty-four male Wistar white rats (Rattus norvegicus) were sampled. Accumulation of Test Animals, Moringa Flower Extract Preparation, Phytochemical Screening / Secondary Metabolite Test, Treatment Process (200, 400, and mg/kgBW of Moringa flower extract), Wound Observation, Histopathological Skin Preparations, and Histopathological Examination of Preparations were the research procedures. Window data was analyzed using SPSS 25.0 and One Way ANOVA with a 95% confidence level (p < 0.05). The Post Hoc Test with LSD was used for further analysis. The research results found Moringa flower extract at 200mg/Kg BW, 400mg/KgBW, and 600mg/KgBW could expedite wound healing and improve collagen density in obese mice's dermapen wounds. The 600mg dose was most beneficial. Research conclusions: Moringa flower extract aids dermapen wound healing, collagenization, and obesity weight loss, according to a study.
The Effect of Giving Butterfly Pea Flower Extract (Clitoria ternatea) on Reducing Cholesterol Levels and Histopathological Features of White Rat Testes (Rattus norvegicus) Wistar Male Obesity Model Jaya, Risnaldo; Budi, Andre; Sihombing, Bungaran
International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 2 (2024): May 2024
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v4i2.319

Abstract

Obesity is a global, non-communicable condition that causes male infertility. Obesity impacts spermatogenesis and male fertility. Butterfly pea blossoms (Clitoria ternatea) contain antioxidants that fight free radicals and prevent obesity. This research looked at how butterfly pea flower extract (Clitoria ternatea) affected cholesterol levels, testicular function, and the histopathology of the testicles of obese male Wistar rats (Rattus norvegicus). This research is quantitative and uses a lab or actual experiment. The 24 test mice were randomly divided into four groups. The research data was analyzed using SPSS 25.0 for Windows. The normality test significance is 0.577. One-way ANOVA test results demonstrate 0.000 or greater than 0.05 significance. LSD post-hoc test values. The control and treatment groups 1–3 differed significantly (p = 0.000). No change was seen between treatment groups 2 and 3 (p = 0.088). The research found butterfly pea flower extract therapy (Clitoria ternatea) at 400mg and 600 mg/kgBW lowers cholesterol. Flavonoids, saponins, tannins, and triterpenoids reduce cholesterol and improve testicular function in obese white rats.
The Effect of Giving Black Rice Extract Ointment (Oryza Sativa L. Indica) on the Growth of Wistar Rat (Rattus Novergicus) Hair Follicles Kartini, Nancy; Denhara Wijaya, Cindy; Hidayat, Andri
International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 2 (2024): May 2024
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v4i2.320

Abstract

Hair loss affects many people worldwide. Hair loss is common and can be treated with vitamins and minerals. Black rice (Oryza sativa l. indica) contains phenolic and anthocyanin-rich flavonoids. The study examined whether black rice extract ointment accelerated Wistar rat (Rattus norvegicus) hair follicle growth. This was an actual experiment with 30 mice. The research involved acclimating test animals in the lab, manufacturing black rice extract, and making ointment. After an Ointment Evaluation Test, Phytochemical Screening was performed. Test the FT-IR Functional Group. DPPH testing will determine antioxidant activity. Finally, four groups (control group, treatment groups 1, 2, and 3 with 10%, 20%, and 30% ointments) received treatment for 21 days. Study results were handled using SPSS. The normality test showed 0.652 > 0.05 significance, while the Independent Samples T-Test showed 0.00 < 0.05 significance. Alkaloids, flavonoids, tannins, and steroids/triterpenoids make black rice an antioxidant, according to the active compound test. For average hair growth, 10% black rice ointment dose therapy yielded 0.681 cm, 20% 0.769 cm, and 30% 0.851 cm. The study found that black rice extract contains high antioxidants (ppm concentration value <50) that can prevent premature skin aging and promote hair and skin health.
The Effect of Swimming Aerobic Physical Exercise On White Rats (Rattus Novergicus) Of the Wistar Strain That Are Obese Altamira, Vita; Angie, Evelyn; Kunardi, Sidharta
International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 3 (2024): August 2024
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v4i2.321

Abstract

Women are more likely to be obese and at risk of hypertension and coronary heart disease than men. Genetic factors influence it. Physical exercise can reduce obesity, especially on endothelial factors such as ET-1 and NO. This research explores the effect of swimming physical training on the expression of endothelin-1 and receptor-A in obese mouse models. This type of research is a true experiment carried out on 12 adult female Wistar rats (Rattus norvegicus) as research samples. The research procedures were carried out by caring for test animals, raising rats until they were obese, not giving treatment (control), physical training in the form of swimming exercises, and finally, examination of ET-1, ET-A, blood sugar levels, and total cholesterol levels. The data obtained was analyzed using SPSS. The research results of the normality test for the treatment group were more significant than 0.05 in the ET-1 examination of 0.315 and ET-A of 0.261. ET-1 levels were 92.5 pg/ml and ET-A levels were 62.5 pg/ml. Their blood sugar level was 167 mg/dL. The research concluded that in mouse tests, physical training was better for increasing ET-1 levels and reducing ET-A levels. Swimming and aerobics are better at lowering blood sugar levels.
The Potential Of Avocado Seed Extract (Persea Americana) In Inhibiting The Release Of Metal Ions In Cuniti And Stainless Steel Based Orthodont Wire Sandra Devi, Leliana; Prijatmoko, Dwi; Joelijanto, Rudy; Prasetyarini, Swasthi; Herniyati; Soesetijo, FX Ady; Sutjiati, Rina; Sekar Asmarani Subagyo, Aura; Bayu Mustika Aji, Erlangga
International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 2 (2024): May 2024
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v4i2.322

Abstract

The release of ions is the initial stage of the corrosion process in an orthodontic wire. Continuous release of ions can reduce the effectiveness and performance of the orthodontic wire. Continuous release of ions in CuNiTi orthodontic wire can change the properties of the wire and trigger hypersensitivity reactions, also in stainless steel orthodontic wire which experiences continuous release of ions can reduce its stiffness. The tannin in avocado seeds is useful as a corrosion inhibitor it can inhibit the release of ions because they are able to bind with metal ions and form a passive layer also able to bind with Fe ions in stainless steel orthodontic wires to form a passive surface layer which is able to inhibit the release of ions when the corrosion process occurs. The aim of this research is to determine the effect of avocado seed extract as a corrosion inhibitor on the release of metal ions from CuNiTi and stainless steel orthodontic wires. Rectangular CuNiTi and stainless steel orthodontic wires measuring 0.017 x 0.025 inches were taken in 3 groups (1 control group soaked in artificial saliva and 2 treatment groups soaked in avocado seed extract). The samples were soaked in avocado seed extract with a concentration of 1.5 g/L and 2 g/L for 7 days. To see the release of ions, an X-Ray Fluorescence test is carried out. In CuNiTi orthodontic wire from the one way ANOVA test showed that there was a significant difference between the control group and all treatment groups on Cu, Ni and Ti ions. The Post Hoc LSD test showed that there were significant differences between the control group, treatment group 1 and treatment group 2 in Cu, Ni and Ti ions with a p value. In stainless steel orthodontic wire, the one way ANOVA test showed that there was a significant difference between the control group and all treatment groups in Fe and Ni ions but not significant in Cr ions in the ion release test with a p value <0.05. The Post Hoc LSD test showed that there were significant differences between the control group, treatment group 1 and treatment group 2 in Fe and Ni ions with a p value <0.05. Providing avocado seed extract with tannin content at concentrations of 1.5 g/L and 2 g/L can inhibit the rate of ion release in CuNiTi and stainless steel orthodontic wires due to the corrosion process.
Results from an Obesity Model in White Male Wistar Rats After Administration of Telang Flower (Clitoria Ternatea) Extract on Pancreatic Function and Histopathological Characteristics Yulisandra Rini, Weni; Azmi Tanjung, Fahrul; Wilvia, Wilvia
International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 2 (2024): May 2024
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v4i2.323

Abstract

Diabetes mellitus (DM) is a chronic disease affecting 95% of diabetics, characterized by high blood glucose levels due to decreased insulin production. Bioactive chemicals from plants like butterfly pea flower and Clitoria Ternatea can potentially treat DM, inhibit carbohydrate-digesting enzymes, and potentially regenerate pancreatic beta cells. This study tests butterfly pea flower extract on obesity-related pancreatic function in white rats. In obese rats given varied dosages of butterfly pea flower extract, the study evaluates pancreatic tissue histopathology and ethanol extract properties. The study examines male Wistar rats' acclimatization before treatment with butterfly pea flower extract, a high-fat diet, and butterfly pea flower extract, comparing the effects of the extract on rats. Pancreatic function is examined using enzymes amylase and lipase. Histopathological observation of pancreatic organs involves several steps, including fixation, washing, infiltration, embedding, cutting, attaching, deparaffinization, dealcoholization, staining, mounting, and scoring. A post-test-only control group design compared butterfly pea flower extract and pancreatic function in male white rats. Butterfly pea flower extract improved pancreatic histology in obese white rats at 600mg/KgWB, closer to the normal group. The extract contains secondary metabolites that repair cell tissue damaged by the rats' high-fat diet and obesity.
Effectiveness Of Onion Compress On The Event Swelling In Children After Pentabio Immunization At Puskesmas Plawad In 2023 Novitasari, Lilis; Mariyani, Mariyani
International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 1 (2024): February 2024
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v4i1.324

Abstract

Background : Immunization is an effort to actively generate/increase a person's immunity against a disease so that if one day they are exposed to the disease they will not get sick or only experience a mild illness. Swollen immunization marks are a normal side effect and are experienced by many people. This swelling is the body's reaction to the vaccine administration process and is a sign that the body is starting to form immunity to disease. Research purposes : Knowing the effectiveness of shallot compresses on the incidence of swelling in children after immunization at the Plawad Health Center in 2023. Research methods : This type of research is analytic observational with a case control design. The sample of this study were children who received DPT immunization. The sample technique uses accidental sampling technique. Data collection uses an observation sheet. The data analysis used was univariate analysis and bivariate analysis using the chi square test. Research result : The results of the chi square test with a p value of 0.000 <0.05 indicate that there is an effect of onion compresses on the incidence of swelling after immunization. Thus it can be seen that onion compresses are effective in alleviating the incidence of swelling in children after immunization. Based on the analysis of the Odds Ratio (OR) it was obtained at 8.250 (95% CI = 2.530-26.900). This shows that onion compresses are 8,250 times effective in overcoming swelling after immunization. Conclusion : Onion compresses are effective in overcoming the incidence of swelling in children after immunization.

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