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Ivandini Tribidasari A.
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Makara Journal of Science
Published by Universitas Indonesia
ISSN : 23391995     EISSN : 23560851     DOI : https://doi.org/10.7454/mss
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Makara Journal of Science publishes original research or theoretical papers, notes, and minireviews on new knowledge and research or research applications on current issues in basic sciences, namely: Material Sciences (including: physics, biology, and chemistry); Biochemistry, Genetics, and Molecular Biology (including: microbiology, physiology, ecology, taxonomy and evolution); and Biotechnology.
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Articles 10 Documents
 1 
Search results for , issue "Vol. 28, No. 3" : 10 Documents clear
Authentication of Shallots from Brebes using Gas Chromatography Fingerprinting Technique Combined with Chemometrics Pradina, Yana Setyani; Puteri, Adelia; Rachma, Gina Fauzia; Balqis, Nazwa; Anggraini, Gerli Puspita; Wasito, Hendri
Makara Journal of Science Vol. 28, No. 3
Publisher : UI Scholars Hub

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Abstract

Shallots from Brebes, also called Bima Brebes, have a more pungent aroma compared to other varieties. Its high demand results in increased prices in the market, leading to frequent cases of fraud wherein Bima Brebes shallots are replaced with other types of shallots. This study aimed to develop an analytical method using gas chromatography–flame ionization detector (GC-FID) fingerprinting combined with chemometrics to authenticate Bima Brebes shallots. Essential oils were extracted through ultrasonic hydrodistillation, followed by organoleptic, refractive index, GC-FID fingerprinting and chemometric analysis. The yield value of the five studied shallot varieties ranged from 0.02% to 0.08% w/w. Meanwhile, the organoleptic tests and refractive index values showed minimal differences among the five varieties. The GC-FID analysis revealed approximately 149 chromatogram peaks, and chemometric analysis, including principal component analysis, partial least squares-discriminant analysis, and hierarchical cluster analysis, was used to group and differentiate the chromatogram profiles of the five shallot varieties based on their types. Therefore, this method can be used as an alternative analysis technique for authenticating Bima Brebes shallots.
Preliminary Molecular Study of Chloramphenicol Anchoring on Laccase Enzyme from Trametes hirsuta Riyanto, Hanzhola Gusman; Sanjaya, Afiten Rahmin
Makara Journal of Science Vol. 28, No. 3
Publisher : UI Scholars Hub

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Abstract

Antibiotics are one of emerging pollutants generally emitted from livestock production and the food industry to the environment. The presence of this pollutant could initiate the development of resistant bacteria that can be fatal to human health. The degradation of antibiotics using enzymes or microbe could be an alternative because the residue or intermediate product is less harmful than of the conventional method. This research aims to support a preliminary study of the degradation of antibiotics using enzyme through molecular docking via Molecular Operating Environment software and molecular dynamics (MD) study via CABSFLEX 2.0 and WebGro macromolecular simulations. The molecular docking of the laccase-chloramphenicol complex has low binding energies of approximately −8.1350 and −8.2290 kcal/mol for both rigid and flexible methods, respectively, indicating that the formation of the complex is advantegous. MD simulation further revealed a decrease in rigidity after the interaction with the ligand. Hydrogen bonding analysis indicated up to five hydrogen bonds in the complex, underscoring the robustness of the enzyme--ligand interaction. These results collectively contribute to our understanding of the efficacy of enzyme-mediated antibiotic degradation and emphasize the potential for this approach to mitigate environmental and health concerns associated with antibiotic pollution
Evaluation of the Water Quality and Distribution of Heavy Metals in the Gomti River Flowing Through the Urban Region of Lucknow, India Gondial, Neha; Bharti, Sandhya
Makara Journal of Science Vol. 28, No. 3
Publisher : UI Scholars Hub

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Abstract

The physicochemical properties and heavy metals contents of the Gomti River water (GRW) samples collected from five selected sites covering a stretch of ~31 km in Lucknow, Uttar Pradesh, India were ascertained. The sites were Ghaila Pul, Mehndi Ghat, Shaheed Smarak, Kukrail Junction, and Bande Dam, represented as S1, S2, S3, S4, and S5, respectively, following from upstream to downstream. S1 was considered as a reference site. The values of pH, temperature, total dissolved solids (TDS), electrical conductivity (EC), turbidity, dissolved oxygen (DO), biochemical oxygen demand (BOD), total hardness (TH), total chloride (TC), total alkalinity (TA), total acidity (TAC), total free CO2, total NO3, and NO2 differed with sites. The Fe, Co, Ni, Cu, Al, Zn, As, Mo, Cd, Cr, and Pb levels were also investigated. Except for Zn and Cu, all other metals were detected beyond the levels allowed by the BIS (2012) and Organization of Economic Corporation and Development (OECD, 2020) for water bodies. Further, the current finding suggests that the discharge of untreated industrial, agricultural, and domestic effluents into the Gomti River is unendurable.
Immobilization of Ni(II) on Amine-Functionalized Mesoporous Silica as Catalyst for Benzyl Alcohol Acetylation Reaction Nabilah, Wardah; Kunarti, Eko Sri; Pambudi, Fajar Inggit
Makara Journal of Science Vol. 28, No. 3
Publisher : UI Scholars Hub

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Abstract

In this study, amine-functionalized and Ni(II)-immobilized mesoporous silica materials were synthesized. This research aimed to synthesize mesoporous silica based on rice husk ash functionalized with amine and immobilized with Ni(II). The activity of amine-functionalized and Ni(II)-immobilized mesoporous silica materials was studied for the acetylation of benzyl alcohol with acetic anhydride as the acetylating agent. First, mesoporous silica was synthesized using rice husk ash using the sol–gel method, followed by amine functionalization using (3-aminopropyl)triethoxysilane (APTES) and Ni(II) immobilization through ultrasonic treatment. The results obtained showed that amine-functionalized and Ni(II)-immobilized mesoporous silica (SiO2/APTES/Ni(II)) were successfully synthesized, confirmed by Fourier transform infrared and Energy-dispersive X-ray spectrometry data. In addition, the synthesized materials had an average pore diameter of 12.83 nm. Afterward, the catalytic activity test showed that SiO2/APTES/Ni(II) was able to convert 98.34% of benzyl alcohol in the acetylation reaction at 45 °C for 5 h. The use of the SiO2/APTES/Ni(II) catalyst for three cycles obtained percent conversion values with a slight decreases (98.34%, 95.20%, and 90.61%).
Phenotypic Correlation, Path Analysis, and Quantitative Trait-Based Selection of Elite Wheat Genotypes Under Heat Stress Conditions in The Terai Region of Nepal Bhandari, Radhakrishna; Panthi, Binod; Nyaupane, Shivalal; Shrestha, Sandesh; Sharma, Prabin; Gupta, Rajesh Kumar; Sahani, Sansar; Poudel, Mukti Ram
Makara Journal of Science Vol. 28, No. 3
Publisher : UI Scholars Hub

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Abstract

Wheat is one of the most important cereal crops worldwide, but the production and productivity of wheat is affected by heat stress. A field experiment using an alpha lattice design with seven blocks was conducted on 35 elite wheat genotypes in the Terai region of Nepal to identify the most appropriate trait resulting in a high-yielding wheat genotype with high tolerance to heat stress. Correlation analysis revealed that booting-to-heading duration (BtoH), booting-to-anthesis duration (BtoA), plant height (Ph), spike length (SL), spike weight (SW), thousand grain weight (TGW), straw yield (SY), and total biomass yield (TY) had a significant positive correlation with grain yield (GY), whereas days to booting (DTB), days to heading (DTH), and days to anthesis (DTA) had significant negative correlations with GY (p ≤ 0.05). Path analysis revealed that DTB and DTA had a direct negative effect on the GY, whereas DTH had an indirect negative effect on yield via DTB. BtoA, Ph, SL, SW, and TGW had direct positive effects on yield, whereas BtoH had an indirect positive effect on yield via DTB. Principal component analysis demonstrated that high-yielding genotypes can be selected using DTB, DTH, DTA, BtoH, BtoA, and Ph. Taller and earlier genotype with long BtoH and BtoA would produce high yield under heat stress.
First-Principles Calculations of Thermoelectric Properties of Fe-Based Full- Heusler Fe2CuSi Nurlaela, Ai; Nanto, Dwi; Azhar, Anugrah; Yuniarti, Elvan; Kristiantoro, Tony; Dedi, Dedi
Makara Journal of Science Vol. 28, No. 3
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Abstract

A first-principle study using density functional theory (DFT) and Boltzmann transport was conducted to evaluate the thermoelectric (TE) properties of an Fe-based full-Heusler alloy. The compound studied is Fe2CuSi with a Cu2MnAl-type structure. The electronic properties of Fe2CuSi were obtained using DFT calculations by running the Quantum ESPRESSO (QE) package. By contrast, TE properties, including electron thermal conductivity, electric conductivity, and Seebeck coefficient, were computed using a semi-empirical Boltzmann transport model solved through the BoltzTraP software at 50–1,500 K temperature range. The spin-orbit coupling effect on these properties was also evaluated, demonstrating notable effects on the results. Multiple electronic bands crossing the Fermi level for both spin directions were confirmed by the density of state curve, indicating the metallic behavior of Fe2CuSi. The magnitude of the figure of merit was determined by the Seebeck coefficient, electric conductivity, and electron thermal conductivity. In this study, the maximum dimensionless figure of merit was 0.027, reached at 1,000 K for the spin-down channel.
Polyvinyl Alcohol–Red Cabbage Nanofibers as pH-Responsive Freshness Sensors for Advanced Food Packaging Technology Foliatini, Foliatini; Wibowo, Singgih; Rochaeni, Henny; Suhartini, Suhartini; Fachrurrazie, Fachrurrazie; Prianditya, Arzzaq Imanda; Hadriansyah, Pradnadia Putri; Siregar, Naura Athira Putri; Nurpadilah, Novi; Alfiani, Putri; Rahim, Maudi; Sriwahyuni, Endah
Makara Journal of Science Vol. 28, No. 3
Publisher : UI Scholars Hub

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Abstract

The development of innovative food packaging technologies, particularly those capable of monitoring freshness, has become increasingly important in the food industry. This research explores the development of a pH-responsive freshness sensor using polyvinyl alcohol–red cabbage (PVA/RC) nanofibers. The nanofibers are fabricated through the electrospinning technique and meticulously analyzed via scanning electron microscopy, Fourier-transform infrared (FTIR) spectroscopy, and differential scanning calorimetry (DSC). The results underscore the fine structure of the nanofiber matrix, with an average diameter of ~68 nm. FTIR analysis substantiates the presence of anthocyanin compounds from RC within the PVA/RC nanofibers, which confirms the integration of beneficial components into the nanofiber matrix. Moreover, DSC investigations reveal the outstanding thermal properties of PVA/RC, which demonstrates the resilience of the nanofibers to higher temperatures, with a melting point of ~223 °C. Notably, the PVA/RC nanofibers with a 3:1 ratio exhibit excellent thermal stability, although the color change due to pH fluctuations shifts toward transparency. This study lays down the foundation for future exploration and the potential for a diverse array of applications and material enhancements. The findings presented herein open up new opportunities for the use of PVA/RC nanofibers in the development of freshness sensors, heralding a new era in smart food packaging technology.
Antibacterial Activities and Chemical Composition of Essential Oils from Sweet Orange (Citrus sinensis), Lemon Grass (Cymbopogon citratus), and Lime (Citrus aurantifolia) Peels Omoboye, Olumide; Sotola, Toyosi; Balogun, Olaoye; Bamigbade, Ololade; Oluwole, Olusola; Odeyemi, Adebowale; Oluduro, Anthonia
Makara Journal of Science Vol. 28, No. 3
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This study investigated the chemical composition and antibacterial activities of lime Citrus aurantifolia (Cc) and lemon grass Cymbopogon citratus (Ca) essential oils (EOs). Standard methods were used to determine their minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC), and gas chromatography–mass spectrometry was used to determine their composition. Each EO and their combination showed promising results in treating test bacterial infections. Cc EO showed the largest inhibition zone diameter (43 mm) against Staphylococcus aureus and Serratia marcescens, and Ca EO showed the largest (30 mm) and smallest (12 mm) inhibition zone diameters against Bacillus stearothermophilus and S. marcescens, respectively. The combination of Cc EO and Ca EO (1:1) resulted in the largest (45 mm) and smallest (8 mm) inhibition zone diameters against Klebsiella pneumoniae and Salmonella typhimurium, respectively. The MIC of Cc EO ranged from 0.78% to 6.25%, and its MBC ranged from 3.13% to 12.50%. The MIC and MBC of combined Cc EO and Ca EO ranged from 0.78% to 6.25% and from 1.56% to 12.5%, respectively. The major components of Cc EO and Ca EO were neral (44.98%) and D-limonene (56.02%). Overall, the combination of lime and lemon grass EOs performed well compared to streptomycin, making them suitable for treating test bacterial infections.
Cellular Uptake and Computational Analysis of [131I]-Xanthine and [131I]-Hypoxanthine in Human Prostate Cancer Cell Line (LNCaP) Wongso, Hendris; Mahendra, Isa; Setiadi, Yanuar; Rattyananda, Badra Sanditya; Rizaludin, Asep; Pranisuari, Ni Made Yuktikamura Galih; Kusumaningrum, Crhisterra Ellen
Makara Journal of Science Vol. 28, No. 3
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Abstract

Potent radiolabelled compounds eligible for therapy of prostate cancer need to be developed. Hence, we developed two candidate therapeutic agents bearing the iodine-131 (131I) radionuclide, namely, [131I]-xanthine (3,7-dihydropurine-2,6-dione) and [131I]-hypoxanthine (1,9-dihydro-6H-purin-6-one). The radiolabelled compounds were subjected to a cellular uptake study, which was accomplished by incubating [131I]-xanthine and [131I]-hypoxanthine with the human prostate cancer cell line (LNCaP) for 5, 15, 30, 60, and 90 min. Results showed that the accumulation of both [131I]-xanthine and [131I]-hypoxanthine in prostate cancer cells was significantly higher than the control group (131I). [131I]-xanthine rapidly accumulated in prostate cancer cells, with the highest percentage of cellular uptake of 2.73% ± 0.40% observed at 30 min of incubation. By contrast, [131I]-hypoxanthine exhibited more efficient accumulation in prostate cancer cells, especially at 60 and 90 min of incubation, with cellular uptake values of 11.5% ± 3.14% and 11.9% ± 1.83%, respectively. Furthermore, the computational analysis showed that radioiodinated xanthine and hypoxanthine provide potential binding affinities and interaction on both androgen and prostate-specific membrane antigen receptors. Overall, this study indicates that [131I]-xanthine and [131I]-hypoxanthine can be potentially developed as therapeutic agents for prostate cancer.
Modeling of Benzimidazole Derivatives as Antimalarial Agents using QSAR Analysis Hadanu, Ruslin; Sitorus, Marham
Makara Journal of Science Vol. 28, No. 3
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In this study, quantitative structure–activity relationship (QSAR) analysis was conducted on 20 homologous compounds of benzimidazole derivatives. The structures of the benzimidazole derivatives were optimized using the semiempirical Parameterized Model 3 method of HyperChem for Windows 8.0 to obtain 14 descriptors. Then, multiple linear regression (MLR) analysis was performed using the backward method. The results of the MLR analysis obtained four new QSAR equation models. Based on statistical criteria, model 1 was determined as the best QSAR equation model in predicting the theoretical IC50 values of the new benzimidazole derivatives. As many as 20 new compounds of benzimidazole derivatives were modeled, of which 13 new compounds (23, 24, 25, 26, 27, 28, 29, 30, 31, 37, 38, 39, and 40 compounds) were recommended for synthesis in the laboratory because these compounds of benzimidazole derivatives havethey theoretically had higher antimalarial activity than chloroquine

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