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Jurnal Farmasi Sains dan Praktis
Published by Universitas Muhammadiyah Magelang
ISSN : 25499068     EISSN : 25794558     DOI : -
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Farmasi Sains dan Praktis aims to serve the updated scientific knowledge for international researchers in pharmaceutical sciences. Jurnal Farmasi Sains dan Praktis (JFSP) publishes review article, original article, as well as short communication in the all scopes of Pharmaceutical Science such as Pharmaceutics, Biopharmaceutics, Drug Delivery System, Physical Pharmacy, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Marketing, Alternative Medicines, Pharmaceutical Management, Pharmacoeconomic, Pharmacoepidemiology, Social Pharmacy, Pharmacy Policies.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 7 Documents
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Search results for , issue "Vol 5 No 2 (2019)" : 7 Documents clear
Determination Of Total Flavonoid Levels Of Ridge Gourd Fruit With Uv-Vis Spectrumfotometry Method Indriani Estikawati; Novena Yety Lindawati
Jurnal Farmasi Sains dan Praktis Vol 5 No 2 (2019)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v5i2.2684

Abstract

Ridge gourd fruit (Luffa acutangula (L.) Roxb.) is one kind of tuber plants that grows in many tropical and various kinds. Ridge gourd fruit are widely consumed by the people of Indonesia. Chemical content of ridge gourd fruit such as flavonoids has the potential as antidiabetic. The purpose of this study is to determine the total flavonoid levels found in ridge gourd fruit by uv-vis spectropotometric method. Ridge gourd fruit extracted with metanol:cloroform (4:1) mixture by maceration method. Analysis qualitative of flavonoid content were carried out with Wilstater, Smith Metacalfe, and Thin Layer Kromatgrafi (TLC). Quantitative analysis of total flavonoids using UV-Vis spectrophotometric method at wavelength 413,2 nm with complex forming reactions AlCl3. The results of qualitative tests show that ridge gourd fruit contain flavonoids positive. The average level of total flavonoids of ridge gourd fruit is 10,08 and the coeficient of variation (CV) with the result of 0,69%
Wuluh Starfruit (Averrhoa Bilimbi) Extract Gel For Recurrent Aftosa Stomatitis Umaimatun Nakhil; Isabella Meliawati Sikumbang; Nugrahani Hendra Putri; Heni Lutfiyati
Jurnal Farmasi Sains dan Praktis Vol 5 No 2 (2019)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v5i2.2713

Abstract

The purpose of this study was to test the antibacterial activity of the gel extract of Wuluh starfruit (Averrhoa bilimbi L.). So that it can provide a representation of the use of starfruit in medicine and as an enrichment of insight. Averrhoa bilimbi L contains flavonoids, tannins and saponins which have antibacterial properties. The stages that have been carried out include identification and determination of the starfruit fruit plant, then the simplicia powder of starfruit is extracted using 70% ethanol by maceration which is then carried out evaporation on the waterbath to obtain thick extract. Then made the gel preparation with a concentration of b / v 40%, 45% and 50%. Evaluation of stability physical gel includes organoleptic test, homogeneity, pH, viscosity and spreading ability. The result showed that the three formulas were thick, brown with a characteristics smell of starfruit, homogeny, pH 5, viscosity 190-260 dPas and the spreadability test was 2,5-4,2 cm. Then a bacterial suspension was made by being immersed for 24 hours at 37 ℃. Then tested by dividing into 5 treatment groups, with positive controls Amoxicillin and negative control gel basis. The results showed that the average inhibition zone for each treatment was positive control 4.66 cm, negative control 0 cm, gel 40% 1.77 cm, gel 45% 1.93 cm, and gel 50% 2.67 cm. From the average inhibitory zone it can be seen that gel wuluh starfruit extract has antibacterial activity.
The Combined Effect Of Extract Of Tamarindus Indica L. Leaves And Annona Muricata L. Leaves On Blood Glucose Levels In Male Rats Wistar Strain Induced Alloxan Eka Wisnu Kusuma; Eka Safarini; Devina Ingrid Anggraini
Jurnal Farmasi Sains dan Praktis Vol 5 No 2 (2019)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v5i2.2952

Abstract

A recent study States that the leaves of the tamarind and soursop can lower blood glucose levels with a single dose. This research was conducted to find out the influence of the combination of ethanol extracts of leaves of the tamarind and soursop leaf in mice induced aloksan. Test treatment consists of 8 groups, normal, negative control (aloksan), positive (glibenklamid), the dose I (tamarind), dose II (soursop), AJ III dosage: SIR 25:75 dose), IV (AJ: SIR 50:50), dosage V (AJ: SIR 75:25). All groups (except normal) induced with aloksan 160 mg/KgBB. Then proceed with a test of treatment of each group of the drug start day 0 up to 14 in per-oral. The taking of blood glucose levels is done on the day 0, 7 and 14. Administering ethanol extracts of leaves of tamarind and soursop both single and combination capable of lowering blood glucose levels seen from the average hypoglycemic
Analysis Of Drug Indicator At The Procurement Stage In The National Health Insurance Era: A study in Advance Health Facility Indriyati Hadi Sulistyaningrum; Arifin Santoso; Sri Intan Lestari; Kusuma Arbianti
Jurnal Farmasi Sains dan Praktis Vol 5 No 2 (2019)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v5i2.2964

Abstract

Drug procurement is part of an important hospital management to support the availability of the pharmaceutical logistic in hospital to provide good services for the patients. ineffective procurement can result in not achieving the availability of each drug in the amount which are in accordance with the price and budgeting. This research was conducted to obtain an overview of drug management at the procurement stage in Sultan Agung Islamic Hospital (RSIA SA) for the 2017 – 2018 period. Descriptive Observational research methods were used to collect the qualitative and quantitative data. Qualitative data were obtained through interview, and the quantitative data were collected from the document observation provided in Pharmaceutical installation Sultan Agung Islamic Hospital (IFRSISA). The result showed the percentage of the allocation of drug procurement funds in 2017 was 47,6%, and in 2018 it was 37,1%, the frequency of procurement of each drug type was < 76% at 12 times / year, the frequency of delayed payment by the hospital based on the time agreed was 100%. The conclusion of this study shows that the indicator of drug procurement in IFRSISA categorized as good because it is in line with the quality of drug procurement indicators.
Antibacterial Activity of Acetone and Ethyl Acetate Leaves, Stems and Rhizomes Extract of White Water Lily (Nymphaeae alba) Against Staphylococcus aureus and Escherichia coli Mariam Ulfah; Ade Irawan; Teguh Adiyas Putra
Jurnal Farmasi Sains dan Praktis Vol 5 No 2 (2019)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v5i2.2999

Abstract

White water lily (Nymphaeae alba) is one of the aquatic plants that is often used for traditional medicine. This plant has anticancer and antioxidant activity. The final result of this experiment is to determine the antibacterial activity of acetone and ethyl acetate extract from several parts of this plant, including leaves, stems and rhizomes againts several types of bacterial including Staphylococcus aureus and Escherichia coli. Kirby-Bauer diffusion Disc method is used in this study. Simplicia of leaves, stems and rhizomes of white water lily were macerated with acetone and ethyl acetate for 3 x 24 hours. Antibacterial tests were carried out to acetone and ethyl acetate leaves, stems and rhizome extract of white water lily. Amoxicillin was used as a positive control and dimethyl sulfoxide (DMSO) with concentration 20% as a negative control. The extract and amoxicillin were diluted with 20% DMSO. Each disk contained 100 µg of extract and 10 µg of amoxicillin. Antibacterial tests that have been carried out show that the acetone extract of leaves, stems and rhizomes white water lily has the highest attack value against bacteria, the diameter of the inhibition zone is 20 mm against S. aureus Acetone and ethyl acetate leaves, stems and rhizomes extract of white water lily did not have inhibitory effect on E. coli.
Anthelmintic Potential Of Moringa Oleifera As Inhibitor Mitochondrial Rhodoquinol-Fumarate Reductase From Ascaris Suum Using The Docking Method Dede Rival Novian
Jurnal Farmasi Sains dan Praktis Vol 5 No 2 (2019)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v5i2.3000

Abstract

One of the parasitic nematodes that can cause malnutrition, even death in humans, is Ascaris suum. The parasite can survive in its host cell by metabolizing using the fumarate reductase enzyme. With this metabolism, the parasite can produce energy to survive in its host cell. Rhodoquinone (RQ) plays a part in helping the fumarate reductase reaction in parasite metabolism, and energy from metabolism was not produced when the enzyme was disrupted. Thus Mitochondrial rhodoquinol-fumarate reductase can be a good target of anthelmintic drug receptors. The results of investigations using in vitro and in vivo methods showed that Moringa oleifera has various medicinal functions including anti-inflammatory, antimicrobial, antidiabetic, antioxidant, anti-tumour, anti-cancer, and anti-clastogenic properties. However, the potential of the drug Moringa oleifera against anthelmintics has not been further investigated. Simulation docking is the research method used to find the anthelmintic potential of Moringa oleifera as the Ascaris suum inhibitor of Mitochondrial rhodoquinol-fumarate reductase. This study aims to examine the potency of Moringa oleifera bioactive compounds on the anthelmintic receptor Mitochondrial rhodoquinol-fumarate reductase by using efficient and effective research time with the docking simulation model. The results showed the bioactive compound 3,5-bis (1,1-dimethylethyl) -phenol from Moringa oleifera had potential as a new anthelmintic drug compound, 3,5-bis (1,1-dimethylethyl) -phenol activity had affinity energy of - 7.0 kcal / mol and has physicochemical properties that are not contrary to the rules of the drug compounds from Lipinski.
Antibacterial Activity of Etil Acetate Fraction of Chili Leaf Against Streptococcus Pyogenes and Bioautografy Ade Irawan; Nurkhasanah Nurkhasanah; Nanik Sulistyani
Jurnal Farmasi Sains dan Praktis Vol 5 No 2 (2019)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v5i2.3002

Abstract

One of the plant that has antibacterial activity is chili leaf (Capsicum frutescens L.). The purpose of this study was to determine the antibacterial activity of ethyl acetate fraction of chili leaf against Streptococcus pyogenes bacteria and conduct bioautography to see compounds that have antibacterial activity. In this study an antibacterial test for ethyl acetate fraction of chili leaf with a concentration of 5%, 10%, 20%, 40%, 80% to Streptococcus pyogenes. From the results of the inhibition zone test 5% ethyl acetate fraction produces an average inhibition zone of 6.3 mm, 10% average inhibition zone 10.3 mm, 20% average inhibition zone of 14 mm, 40% average inhibition zone 18 mm and 80% have 22.7 an average inhibition zone. In the silent phase bioautographic was used test silica gel GF 254 and for the mobile phase was used chloroform : ethyl acetate (3: 7), indicating the presence of inhibition zones on the media which had been inoculated by Streptococcus pyogenes bacteria, namely at RF 0.88. From the research that has been done, the results show that the ethyl acetate fraction of chili leaf has inhibitory zone against Streptococcus pyogenes bacteria and the spotting of compounds which have inhibitory zone has an RF of 0.88.

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