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Jurnal Farmasi Sains dan Praktis
Published by Universitas Muhammadiyah Magelang
ISSN : 25499068     EISSN : 25794558     DOI : -
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Farmasi Sains dan Praktis aims to serve the updated scientific knowledge for international researchers in pharmaceutical sciences. Jurnal Farmasi Sains dan Praktis (JFSP) publishes review article, original article, as well as short communication in the all scopes of Pharmaceutical Science such as Pharmaceutics, Biopharmaceutics, Drug Delivery System, Physical Pharmacy, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Marketing, Alternative Medicines, Pharmaceutical Management, Pharmacoeconomic, Pharmacoepidemiology, Social Pharmacy, Pharmacy Policies.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 15 Documents
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Search results for , issue "Vol 8 No 1 (January-April 2022)" : 15 Documents clear
THE POTENCY OF CUCUMBER (CUCUMIS SATIVUS L.) PEEL EXTRACT AS ANTICHOLESTEROL Resita Putri; Devina Ingrid Anggraini
Jurnal Farmasi Sains dan Praktis Vol 8 No 1 (January-April 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i1.3493

Abstract

The liver has a very important role in the human body. However, these organ tissues are also very susceptible to be tissue damage. Fatty liver disease (steatosis) is a disease caused by high cholesterol. Physically, cholesterol is a yellowish subtance, lumps like wax, and is an arrangement of steroid groups. Non-alcoholic steatohepatitis (NASH) occurs due to excess cholesterol levels in the liver. Liver function can be affected as a result of liver damage. So, a hepatoprotector is needed. The flavonoid content of cucumber skin has potential as an anticholesterol. The purpose of this research is to analyze the ability of the ethanol extract of cucumber peel (Cucumis sativus L.) as a cholesterol lowering agents as indicated by the EC50 value. Maceration extraction method used in this study using 96% ethanol as solvent. Qualitative analysis of ethanolic extract of cucumber peel is known to have flavonoids, steroids, alkaloids as indicated by the appearance of color changes, and saponins which are indicated by the appearance of foam. Lieberman-burchad reagent was used for quantitative analysis of anticholesterol using a UV-Visible spectrophotometer. The analysis was carried out at a maximum wavelength of 665,0 nm with an incubation time of 15 minutes. The concentration variations of the extract used were between 25-150 with a range of 25 ppm. The results showed that the ethanolic extract of cucumber peel could potentially be an anticholesterol with the percentage reduction of 28.50%; 35.45%; 39.59%; 45.82%; 51.24%; and 55.12% at 5 variations of concentration. The EC50 value was achieved at a concentration of 122.04 ppm.
LITERATURE REVIEW: CHEMICAL CONTENT AND PHARMACOLOGICAL ACTIVITY OF KERSEN LEAF (Muntingia calabura L.) Asman Sadino; Sri Adi Sumiwi; Sari Sumarni
Jurnal Farmasi Sains dan Praktis Vol 8 No 1 (January-April 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i1.3802

Abstract

Kersen (Muntingia calabura L.) is known as a plant that is often used as a tree to absorb air pollution and shade on the roadside. Low economic value and public knowledge about the benefits of cherry as a medicinal and food ingredient is still minimal. The part that can be used as a medicinal ingredient comes from cherry leaves. The purpose of this review article is to provide information related to the chemical content and pharmacological activity of cherry leaves that can treat various diseases. The method used in making this article review is a literature study. The literature sources in this article review were obtained from national journals and international journals published in the last 10 years (2010-2020), which were carried out online through the search engines Google Scholar, Pubmed, and NCBI, using the keywords "Kersen leaves", "Activities cherry leaf”, “Pharmacological activity of Muntingia calabura”, “Chemical content of cherry leaf”, “Muntingia calabura L.”. Journals that enter the inclusion criteria are national and international journals that discuss the pharmacological activity and chemical content of cherry leaves, journals published in the last 10 years (2010-2020), and journals in full text. The chemical constituents contained in cherry leaves are flavonoids, saponins, tannins, and terpenoids. Cherry leaves are scientifically proven to have several pharmacological activities as antidiabetic, antioxidant, antibacterial, anthelmintic, antihyperlipidemic, and anti-inflammatory.
ANALGESIC TEST AND TOXICITY OF n-HEXANA FRACTION TREMBESI LEAVES (Samanea saman (Jacq.) Merr.) IN MICE (Mus musculus L.) Rosa Juwita Hesturini; Krisna Kharisma Pertiwi; Meylisa Nurvita Astari; Adellia Ayu Febriana
Jurnal Farmasi Sains dan Praktis Vol 8 No 1 (January-April 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i1.3867

Abstract

Trembesi plant (Samanea saman (Jacq.) are used for traditional medicine as an antibacterial, an analgesic, treat headaches and diarrhea. The aims of this research were to determine analgesic activity and toxicity of n-hexana fraction of trembesi leaves in mice. Extraction using maceration method with 70% ethanol solvent, then solid-liquid partitioned. The activity of an analgesic test by induction acetic acid 1% using negative control CMC Na 0,5%, positive control acetosal dose of 360 mg/kgBW, the treatment group n-heksana fraction doses of 200, 350 and 500 mg/kgBW, while the toxicity test used negative CMC Na 0,5%, with the treatment group dose 5, 50, 500 and 5000 mg/kgBW. Analysis analgesic test data using the Hendersot and Forsaith equations for know the amount of stretching mice. Observation irritation gastric done by observation in makroskopis. While the toxicity test is done within 24 hours for calculated LD50 and make observations and Kruskal-Walli’s test in time 7 days to find out the delayed toxic effects. The results obtained the percent of the analgesic of the n-heksana fraction by 37.86%, 55.78% and 70.9% and LD50 values of 5000 mg/kgBW with the results observations made no significant difference (p>0.05). This research conclusion was the n-hexana fraction trembesi leaves having an analgesic doses activity with effective 350 mg/kgBW with a 55,78% analgetika potential and a toxic effect are categorized as toxic mild and there is no on the irritation.
IMPROVING PKK CADRES LEVEL OF KNOWLEDGE OF ANTIBIOTIC MANAGEMENT THROUGH PHARMACISTS-DELIVERED EDUCATION INTERVENTION IN BOJONGSARI, BANYUMAS Masita Wulandari Suryoputri; Heny Ekowati; Ika Mustikaningtias; Laksmi Maharani; Nialiana Endah
Jurnal Farmasi Sains dan Praktis Vol 8 No 1 (January-April 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i1.4357

Abstract

The prevalence of infectious diseases in Indonesia is high, so it can increase the use of antibiotics. The use of antibiotics which is around 40-60%. Inaddition to relatively long antibiotic therapy regimen, the lack of public knowledge in the rational use of antibiotics can cause patients to be less the risk of occurrence of antibiotic resistance, this study aims to determine the level of knowledge of PKK Cadres and to determine the level of community knowledge after providing PKK Cadres education with pharmacist assitance on antibiotic management. PKK cadres are the driving force behind village communities to carry out local health programs. The research method is a comparative descriptive with a cross sectional approach using an instrument in the form of a questionnaire and it is carried out before and after the implementation of pharmacist education. Collecting data by purposive sampling. Knowledge data of pretest and posttest were analyzed bivariately. The results of the evaluation of the education process indicated that there was an increase in the knowledge of PKK Caders. The results of pre-test dan post-test average showed increased of knowledge among PKK cadres from 69.28 to 85. The results of Wilcoxon test showed a significant difference in the PKK cadres level knowledge from the pre-test and post-test data of antibiotic management after receiving education from the pharmacist (p<0.005). Providing education on antibiotic management to PKK cadres by pharmacists has increased PKK cadres’ knowledge of antibiotic management. It is hoped that PKK cadres can disseminate this knowledge to the wider community to preventing antibiotic resistance.
THE EVALUATION OF ANTI-EPILEPTIC DRUGS DOSAGE IN MALNOURISHED CHILDREN: CASES IN INDONESIAN COMMUNITY OF EPILEPSY Nialiana Endah Endriastuti; Masita Wulandari Suryoputri; Dewi Latifatul Ilma
Jurnal Farmasi Sains dan Praktis Vol 8 No 1 (January-April 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i1.4662

Abstract

Anti-epileptic drug (AED) has a narrow therapeutic index of drugs that a slight increase in dosage showed toxic effects. The therapeutic response is difficult to predict in malnutrition status because the patient with nutritional deficiency have more complicated problems likes hypoalbuminemia, macronutrient and micronutrients deficiency that affected the levels of AEDs. The nutritional deficiency could be a direct and indirect cause of ineffective AEDs therapy and also recurrent epilepsy. This study aims to describe the use of antiepileptic drugs in Indonesian children with poor nutritional status. The research design was observational studies with cross sectional random sampling to evaluate the AED doses of malnutrition status in children. All information was collected by spreading electronic forms and interviewing the parents by phone. The data were analyzed descriptively. Total of 8 malnourished children mostly included in the range of ages from >2 to 12 years (n=5; 62.50%) with means 3,9±2,7 years. The study showed valproic acid was bigger used in monotherapy (n=5; 62,50%) than polytherapy with carbamazepine or sodium phenytoin and phenobarbital. The means estimation of valproic acid monotherapy concentration in females’ group (n=2; 33,33%) showed sub-therapeutics level were Cssmin 26,09±0,57 mg/L and Cssmax 64,17±1,39 mg/L, also the means in males’ group (n=2; 33,33%) of valproic acid monotherapy were Cssmin 22.07±2,71 mg/L and Cssmax 54.27±6.66 mg/L. All of them included in good clinical outcome of free seizure > 6 months.
ANALYSIS OF TOTAL FLAVANOID LEVELS OF FENNEL LEAVES (FOENICULUM VULGARE) ETHANOL EXTRACT BY SPECTROPHOTOMETRY VISIBEL Alifia Ni’ma; Novena Yety Lindawati
Jurnal Farmasi Sains dan Praktis Vol 8 No 1 (January-April 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i1.4972

Abstract

Flavonoid is the compounds in nature that play a role in increasing body immunity. Flavonoids in green plants can be sourced from fennel leaves. The aims of the study were to determine the total levels of flavonoids in fennel leaves (Foeniculum vulgare) using Visible Spectrophotometry. Maceration extracted samples using ethanol 96% solvent. Qualitative analysis of flavonoids using dilute NaOH, Wilstater-cyanidin method, and AlCl3. Quersetin used as standard solution. Quantitative analysis was carried out by colorimetric method with ALCl3 reagent as a complex compound. Quantitative analysis was continued with Visible Spectrophotometry on operating time at the 28th minute and a wavelength of 430.5 nm. Qualitative analysis indicate that the ethanol extract of fennel leaves was positive flavonoids. The total flavonoid content of fennel leaves ethanol extract was 99.2 mg QE/g extract with a coefficient of variation 1.27%.
FORMULATIONS AND PHYSICAL STABILITY TEST OF OLIVE OIL (Olea europaea L.) LIP BALM WITH ILLIPE BUTTER Rise Desnita; Desy Siska Anastasia; Mutiara Dinda Putri
Jurnal Farmasi Sains dan Praktis Vol 8 No 1 (January-April 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i1.4977

Abstract

Lip balm is a preparation that is applied on the lips to protect the lips from damage. Olive oil is an oil that has emollient properties that are able to maintain moisture, flexibility, and smoothness in the skin. Oleic acid content in olive oil has the ability to improve skin permeability. Tengkawang fat is known to have characteristics similar to cocoa fat so it is used as a base. This study will provide an overview of the physical properties of olive oil lip balm (olive oil) with tengkawang fat based on storage for 28 days. Lip balm preparations are made in three concentration variations for 10%, 15%, and 20%, Then the preparation will be observed organoleptically changes, homogeneity of the preparation, pH and temperature of the melting point. The results ANOVA test of pH showed there was no significant difference between storage time to pH for each formula. Organoleptic and homogeneity test show good results in the absence of discoloration, odor, and texture and homogeneity during the storage period. The evaluation of lip balm preparations for each formula showed that the preparations were physically stable during the 28-day storage period.
QUALITATIVE AND QUANTITATIVE ANALYSIS OF PARACETAMOL CONTAMINATION IN RHEUMATIC PAIN TRADITIONAL MEDICINE Desy Ayu Irma Permatasari; Rini Setyowati; Muladi Putra Mahardika
Jurnal Farmasi Sains dan Praktis Vol 8 No 1 (January-April 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i1.5497

Abstract

Analgesic drugs are often added illegally in rheumatic pain traditional medicine. Paracetamol is one of chemical drugs that have a large possibillity to be added in rheumatic pain traditional medicine. The aims this research were to know paracetamol and concentration of paracetamol in rheumatic pain traditional medicine in Borobudur District. This research is experimental research, the analysis data were used microsoft excel and linear regression. Qualitative analysis method using organoleptic test to description the sample, TLC test to evaluation Rf value and FTIR test for characterization. Quantitative analysis method using LC-MS test to know the paracetamol concentration contained on the rheumatic pain traditional medicine. Organoleptic test the results show description the shape, color, smell and taste of sample A, B and C. The results of the TLC evaluation showed sample A and B were positive, indicated by a purple spot and the Rf value of the sample was exactly same compared to Rf value of standard paracetamol, while sample C is negative. The result of the FTIR spectra showed that sample A and B have same functional group as the standard paracetamol, while sample C showed none. LC-MS test results after calculating the concentration in samples A and C the concentration was obtained < 4,4 μg/kg below the Detection Limit (LoD): 4,4 μg/kg, while sample B the concentration was obtained 2,22%. Based on the results of all three samples tested, the sample A and sample B were positively contaminated by chemical medicine paracetamol while sample C were negative.
ANALYSIS BETWEEN THE NUMBER OF ANTIHYPERTENSIVE WITH MEDICATION ADHERENCE IN END STAGE RENAL DISEASE Ratnasari, Pande Made Desy; Yani, Ketut Lia Pran Anggar; Arini, Heny Dwi
Jurnal Farmasi Sains dan Praktis Vol 8 No 1 (January-April 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i1.5611

Abstract

End-Stage Renal Disease (ESRD) is a condition of severe renal damage associated with a higher incidence of hypertension that requires antihypertensive therapy to prevent the worsening disease. Therefore, patients who received more than two types of antihypertensives have affected medication adherence. This study aimed to analyze relationship between the number of antihypertensives and medication adherence in ESRD patients. The study was a cross-sectional design involving 77 participants selected by a purposive sampling technique at Outpatient Private Hospital Buleleng Bali in July-September 2020. Data were collected based on patient’s medical records and the Probabilistic Medication Adherence Scale (ProMAS) questionnaire. The inclusion criteria were ESRD patients aged ≥18 years, with hypertension history, taking the same antihypertensive for three months before the study, sign informed consent, and completed medical record data. Those who were a weak general condition and cognitive impairment were excluded from the study. Data were analyzed using a Kruskal-Wallis test. The results showed that overall, of patients were <65 years old (80.52%), male (70.13%), duration of ESRD <5 years (89.61%), primarily high school (57.14%), and without complications (57.1%). Most patients used a combination of two antihypertensives (35.07%), and 61.04% has a high medication adherence. There was no significant relationship between the number of antihypertensives and medication adherence (p=0.847). Nevertheless, it was still shown that the higher number of antihypertensives in ESRD patients was directly proportional to the lower medication adherence.
FORMULATION OF CHEWABLE TABLET PREPARATIONS FROM THE COMBINATION OF Azadirachta Indica A. Juss. AND Gynura Procumbens (Merr.) Nofran Putra Pratama; Kurnia Rahayu Purnomo Sari; Endah Kurniawati
Jurnal Farmasi Sains dan Praktis Vol 8 No 1 (January-April 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i1.5918

Abstract

Azadirachta indica A. Juss. and Gynura procumbens (Merr.) are one type of potential medicinal plants because they have various properties. One of the properties of these two plants is as an antioxidant. The combination of the two plants has a strong category of antioxidant activity, does not cause death and physical changes in test animals. This study aimed to make an antioxidant chewable Tablet containing a combination of Azadirachta indica A. Juss. and Gynura procumbens (Merr.) extract with a variation of mannitol-sorbitol as a filler. This variation has the advantage of covering the bitter taste of the active substance so that it is expected to provide a pleasant taste and is easy to swallow. The extract obtained was formulated into chewable Tablets with variations of mannitol-sorbitol (90%:10%), (80%:20%), and (70%:30%). The method used is wet granulation. The granules obtained were tested for their physical properties, namely flow velocity, angle of repose, and compressibility. The physical properties of the Tablets tested included uniformity of weight, size, hardness, friability, disintegration time, quality of taste, shape, and odor. Based on the test results of the physical properties of the granules, the three formulas met the requirements. While the physical properties of Tablets that do not meet the criteria are uniformity of size and disintegration time. This research concludes that the extracts of Azadirachta indica A. Juss. and Gynura procumbens (Merr.) be formulated into chewable Tablets where formula two with variations of mannitol:sorbitol (80:20%) is the best formula by fulfilling 9 of 11 requirements

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