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Jurnal Farmasi Sains dan Praktis
Published by Universitas Muhammadiyah Magelang
ISSN : 25499068     EISSN : 25794558     DOI : -
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Farmasi Sains dan Praktis aims to serve the updated scientific knowledge for international researchers in pharmaceutical sciences. Jurnal Farmasi Sains dan Praktis (JFSP) publishes review article, original article, as well as short communication in the all scopes of Pharmaceutical Science such as Pharmaceutics, Biopharmaceutics, Drug Delivery System, Physical Pharmacy, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Marketing, Alternative Medicines, Pharmaceutical Management, Pharmacoeconomic, Pharmacoepidemiology, Social Pharmacy, Pharmacy Policies.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 7 Documents
 1 
Search results for , issue "Vol 8 No 2 (May-August 2022)" : 7 Documents clear
THE INFLUENCES OF KNOWLEDGE, BEHAVIOUR AND ATTITUDE IN SELECTING POWDER TYPE: THE INCIDENCE OF ACNE VULGARIS Anggita Nur Fauzana; Indri Hapsari; Irsalina Nurul Putri; Githa Fungie Galistiani
Jurnal Farmasi Sains dan Praktis Vol 8 No 2 (May-August 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i2.4668

Abstract

Acne vulgaris is a chronic obstructive and inflammatory skin disease. It occurs in almost all adolescents with a prevalence of 90%. Powder is the most widely used cosmetic in the long term and one of the causes of Acne vulgaris which causes occlusion of pores on the skin surface. The purpose of this study was to analyze the effect of the level of knowledge, attitudes and behavior of choosing the type of powder on the incidence of acne vulgaris in Banyumas Regency. This study was an observational study with data collection techniques using cluster sampling and sampling technique by accidental sampling. The level of knowledge of women in the Banyumas Regency was dominated by the high category as many as 64 respondents (64.0%). The incidence of acne vulgaris out of 100 respondents, 67 (67.0%) of respondents had mild acne vulgaris, 22 respondents (22.0%) had moderate acne vulgaris and 1 respondent (1.0%) had severe acne vulgaris and the rest had no acne vulgaris. Chi-square analysis showed that there was a relationship between knowledge with behavior and attitude in choosing the type of powder to the incidence of acne vulgaris as evidenced by the p value of each variable, namely 0.044 and 0.028 (p <0.05). The level of knowledge with behavior and attitude in choosing the powder type had a significant relationship to the incidence of acne vulgaris in women in Banyumas Regency.
STABILITY AND SUNSCREEN ACTIVITY OF NUTMEG SEED OIL EMULGEL WITH CARBOPOL 940 VARIATION AS GEL BASE Ilma Nur Khafifa; Ayu Shabrina; M Fatchur Rochman
Jurnal Farmasi Sains dan Praktis Vol 8 No 2 (May-August 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i2.6085

Abstract

The nutmeg seed oil has antioxidant and sunscreen activity, but it is unstable in storage. The stability of nutmeg seed oil can be improved by developing the oil into an emulgel with carbopol 940. This study determined the stability of nutmeg seed oil emulgel (NSE) with carbopol 940 as a gel base. NSE contains of 10% nutmeg oil and variation of carbopol 940 were 0.60% (FI), 0.80% (FII), and 1.0% (FIII). NSE was tested for SPF value every week and physical stability, including organoleptic, homogeneity, adhesion, dispersibility, viscosity, and pH before and after 30 days of storage. NSE was stored at the climatic chamber at 30±2°C with RH 65±5%. Quantitative data from physical stability were analyzed by t-test dependent while SPF value and antioxidant were analyzed by univariate test. All the physical parameters showed no significant changes (p > 0.05). Emulgel was white thick, with a nutmeg seed oil odor. pH was in a safe range for skin (6.12-6.90). NSE had pseudo-plastic rheology, and it changed into pseudoplastic-thixotropic after 30 days of storage. The SPF value of NSE was above eight, and it did not show significant change after the storage from each week (p > 0.05). Nutmeg seed oil emulgel with carbopol 940 showed stable physical appearance and SPF value.
EFFECT OF GELATIN AS A BINDER ON TURMERIC EXTRACT TABLET FORMULATION Adi Permadi; Iis Wahyuningsih; Sapto Yuliani; Ibdal Satar; Ratna Wijayatri
Jurnal Farmasi Sains dan Praktis Vol 8 No 2 (May-August 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i2.6399

Abstract

In line with the progress of the times in which all aspects of many products are made easy and comfortable for the wearer. The main components for tablet formulations are the fillers, binders, crushers, thinners and lubricants. Among these components, the binders play a key role on the powder cohesion properties during the formation of tablet granules. Due to the effect of gelatin on the tablet properties are positive significant, therefore, this work tries to evaluate the effect of gelatin in the different formulation on the turmeric extract tablets. In this study, turmeric extract tablets were formulated using 15 g of turmeric extract, 35 g of aerosil, 12.8 g of lactose, 1% magnesium stearate, 200 ml of aquadest and gelatin as a binder. To evaluate the effect of gelatin on the tablet formulation, the gelatin was then prepared in different formulation namely 0.1 g (formulation A), 0.2 g (formulation B) and 0.5 g (formulation C), respectivley. Based on the tablet properties, the turmeric tablet with formulation C met the standard requirements of friability less than 1%, the hardness in the range of 4 -8 kg and disintegration time under 15 minutes.
SOME NATURAL FLAVONOIDS FROM GUAVA (PSIDIUM GUAJAVA L.) AGAINST SARS COV-2, INSILICO PREDICTION AND DRUGS EVALUATION Arief Kusuma Wardani
Jurnal Farmasi Sains dan Praktis Vol 8 No 2 (May-August 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i2.6441

Abstract

SARS-CoV-2 is a new virus that little is known about it, which has infected many people around the world. As COVID-19 cases continue to rise, it means more people are being infected, and there is still no targeted therapy for COVID-19 patients. Important for an emergency is to find the most potential Hesperidin, Kaempferol-3,4'-di-O-methyl ether (Ermanin); Myricetin-3-glucoside, Peonidine 3-(4’-arabinosylglucoside); Quercetin 3-(2G-rhamnosylrutinoside); and Rhamnetin 3-mannosyl-(1–2)-alloside as a lead compound from guava to develop new drugs from flavonoid analogue. Docking method through iGEMDOCK software was used to design a new lead compound candidate from several flavonoid and study its interaction with of 3CLpro (PDB ID: 7DPU). The docking method were carried out using the iGEMDOCK software version v2.1, also in the chimera-1.13.1 program is used to know the interaction profile. Druglike properties were calculated using Lipinski’s rule of five as calculated using SWISSADME prediction. Toxicity prediction herein used ADMETSAR webserver (http://lmmd.ecust.edu.cn:8000/predict/). Less toxic and showing greater affinity with a docking score stronger was found in Quercetin, is apart from good pharmacokinetic profile.
EVALUATION OF RESPONSE CORELLATION USING CHEMOMETRICS ANALYSIS FOR PRE-OPTIMIZATION QUERCETIN – SELF EMULSION FORMULATION Shaum Shiyan; Jessica Nathasia; Galih Pratiwi
Jurnal Farmasi Sains dan Praktis Vol 8 No 2 (May-August 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i2.6660

Abstract

The optimization approach using the simplex lattice design (SCD) has many advantages, including a minimized number of experiments and a good description of the interactions between components. However, modeling with the SCD approach has not evaluated between responses. Therefore, this study aims to apply chemometric analysis to evaluate the response from the optimization stage using the quercetin – self emulsion formulations (quercetin-SEFs) as a model. SEFs were prepared using grapeseed oil, croduret, and PEG 400. The evaluated responses included emulsification time and transmittance. Both responses were developed in endurance test by centrifugation method and stability test using freeze-thaw. Chemometric analysis on CA produced a dendrogram, while PCA produced score plots, loading plots, scree plots, and biplots. Emulsification time has a positive correlation with transmittance value. The quercetin-SEFs formula in SCD was classified into three groups based on the similarity of characters. Chemometric analysis was successfully applied in evaluating the response to the quercetin-SEFs optimization modeling.
DETERMINATION OF TOTAL FLAVONOID IN JAMU “X” WITH UV-VISIBLE SPECTROPHOTOMETRIC METHODS Perdana Priya Haresmita; Missya Putri Kurnia Pradani
Jurnal Farmasi Sains dan Praktis Vol 8 No 2 (May-August 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i2.6864

Abstract

Jamu is still the choice of Indonesian people as an alternative to modern medicine until now. As a cultural heritage of the Indonesian, jamu is still very popular from the west to the east of Indonesia. The enthusiasm of the Indonesian in consuming jamu has encouraged many traditional medicine industries to produce jamu with many kinds of claim. Jamu "X" is claimed to help maintain body health. This research was conducted to determine the total flavonoid content in jamu "X" calculated as rutin by UV-spectrophotometric method with aluminum chloride (AlCl3) reagent. Jamu "X" is a product with new formula that is expected to be marketed soon. The determination of the maximum absorbance wavelength of rutin was carried out at a wavelength of 400-800 nm and the resulting maximum absorbance wavelength of rutin was 416.5 nm. The determination of total flavonoid calculated as rutin determined using a linear regression equation from the rutin standard. The linear regression equation was determined from a rutin standard curve series with 10; 12.5; 15; 17.5 and 20 g/ml, respectively and the linear regression equation obtained y = 0.0275x + 0.093. The results of the determination of rutin in the jamu "X" were 1.474%; 1.474% and 1.469% with an average value of 1.472%.
THE EFFECT OF BETEL LEAF EXTRACT SPRAY ON HISTOPATHOLOGY OF WOUND HEALING Isabella Meliawati Sikumbang; Laela Hayu Nurani; Sapto Yuliani; Citra Aryani Edityaningrum
Jurnal Farmasi Sains dan Praktis Vol 8 No 2 (May-August 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i2.6902

Abstract

Wounds are referred to as 'Silent Epidemic' because they have a substantial impact if not treated properly. Betel leaf is known to contain compounds that may be used as wound healers. The purpose of this study was to test the spray activity of betel leaf extract (Piper betle L) in healing acute wounds in male Balb/C mice. Spray formula made with various concentrations of betel leaf extract by 3% (S1), 5% (S2) and 7% (S3). The acute wound healing activity test was 15 mice divided into 5 groups S1, S2, S3, P (positive control), and C (negative control). Interventions and observations were carried out for 14 days. The results of observational analysis by calculating the ratio of wound area then One Way ANOVA test and Post Hoc Tukey Cramer test. The results showed that spray of betel leaf extract with a concentration of 7% was not significantly different from P (p>0.05). The conclusion in this study is that sprays of betel leaf extract 3%, 5%, and 7% may be used as an acute wound healer, the best healing activity is shown at a concentration of 7%.

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