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Jurnal Farmasi Sains dan Praktis
Published by Universitas Muhammadiyah Magelang
ISSN : 25499068     EISSN : 25794558     DOI : -
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Farmasi Sains dan Praktis aims to serve the updated scientific knowledge for international researchers in pharmaceutical sciences. Jurnal Farmasi Sains dan Praktis (JFSP) publishes review article, original article, as well as short communication in the all scopes of Pharmaceutical Science such as Pharmaceutics, Biopharmaceutics, Drug Delivery System, Physical Pharmacy, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Marketing, Alternative Medicines, Pharmaceutical Management, Pharmacoeconomic, Pharmacoepidemiology, Social Pharmacy, Pharmacy Policies.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 15 Documents
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Search results for , issue "Vol 9 No 2 (May-August 2023)" : 15 Documents clear
ANTIOXIDANT ACTIVITY OF THE COMBINATION OF AMBARELLA LEAVES (Spondias dulcis Parkinson) AND SOURSOP LEAVES (Annona muricata Linn) EXTRACT Tarso Rudiana; Dimas Danang Indriatmoko; Ken Virginia
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.5082

Abstract

Degenerative diseases can be caused by free radicals, whereas antioxidants can overcome free radicals. Kedondong leaves (Spondias dulcis Parkinson) and soursop leaves (Annona muricata Linn.) are potential sources of suitable antioxidant compounds. This study aims to determine the antioxidant activity and the relationship between antioxidants and total phenolics from the combination of S. dulcis and A. muricata leaf extracts. S. dulcis leaves, and A. muricata leaves were macerated with 96% ethanol and then formulated with a combination of extracts (1:1, 2:1, and 1:2). Each was tested for its antioxidant activity by the DPPH method. The ethanol extract of S. dulcis leaves had an antioxidant activity value of 36.72±4.01 ppm with a total phenol of 76.84±0.50 mgGAE/g extract, an ethanol extract of A. muricata leaves of 81.45±8.19 ppm with a total phenol of 104.48±7.55 mg GAE/g extract and a combination of extracts with a ratio of ethanol extract of S. dulcis leaves and ethanol extract of A. muricata leaves (2:1) of 29.98 ± 0.37 ppm with a total phenol of 36.99 ± 0.98 mgGAE/g extract. The results showed that the phenolic content of the ethanol extract of A. muricata leaves was more significant than the combination (2:1), which had the most excellent antioxidant activity among the other comparisons. Total phenolic is inversely related to antioxidant activity. Antioxidant activity is not only played by phenolic compounds.
PRESCRIPTION COST ANALYSIS IN PATIENTS OF TYPE 2 DM AND HYPERTENSION JOINING CHRONIC DISEASE MANAGEMENT PROGRAM (PROLANIS) AT PUSKESMAS AFTER THE IMPLEMENTATION OF NATIONAL HEALTH INSURANCE Arifin Santoso; Indriyati Hadi Sulistyaningrum; Hesti Dwi Widaryanti; Kusuma Arbianti; Chilmia Nurul Fatiha; Elmiawati Latifah
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.5234

Abstract

To improve the status of public health and carry out social security programs in the health sector, the government started to implement the National Health Insurance. This program covers the participants’ medical care expenses using the capitation system applied in health centers as the First-Level Health Facilities. BPJS Kesehatan has allocated some budget in the form of a capitation rate to first-level health facilities for hypertension and type 2 diabetes mellitus patients after the implementation of National Health Insurance. This research was carried out in 4 health centers, namely Lamper Tengah Health Center, Mangkang Health Center, Mijen Health Center, and Karanganyar Health Center. The data were collected retrospectively from the medical records of 800 patients. The data were analyzed descriptively to determine the prescription cost and Spearman's rho test was used to find the factors that influence the prescription cost. It was revealed that the average prescription cost for type 2 DM patients was IDR 142,293, and for hypertensive patients was IDR 112,735. The prescribing pattern in patients covered by Prolanis program for type 2 DM patients is a combination of glimepiride, metformin with a drug price of IDR 20,670. Factors that have an influence on prescription costs are diagnosis p= 0.033, type of drug (p= 0.000) and drug item (p= 0.000). This study concludes that the factors to influence the drug costs of Prolanis patients at the health centers of Semarang City were the patient's diagnosis, the type of drug given, and the number of drug items given.
A LITERATURE REVIEW: THE POTENTIAL OF KARAMUNTING PLANT (Rhodomyrtus tomentosa) AS ANTIBACTERIAL AGENT Gilang Ramadhan; Annisa Krisridwany; Andy Eko Wibowo; Muhammad Fariez Kurniawan; Vella Lailli Damarwati
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.6415

Abstract

Infectious disease is a major health problem with a relatively high mortality rate. Indonesia is rich in natural ingredients that have potential as antibacterials, one of which is the Karamunting plant (Rhodomyrtus tomentosa). Several studies on this plant have been conducted to observe its activity as an antibacterial. This study aims to determine the antibacterial activity of Karamunting plants using the literature review method. The literature search method uses journals from the Google Scholar, Pub Med and Elsevier databases. Each journal is determined based on inclusion and exclusion criteria. Journals that meet the inclusion criteria are descriptive and explained in detail. From the journals obtained, there were 11 journals that met the criteria. Karamunting plants (Rhodomyrtus tomentosa) contain secondary metabolites namely flavonoids, glycosides, saponins, tannins, triterpenoids, steroids, acylphloroglucinol (rhodomyrtone, tomentosone, rhodomyrtosone) and meroterpenoids (rhotomentodiones). Antibacterial activity test using the diffusion method showed an optimum inhibition zone diameter of 21.5 mm against Staphylococcus aureus bacteria in the ethyl acetate fraction of Karamunting leaves with a concentration of 600 mg/ml, while using the microdilution method of ethanol extract of Karamunting leaves the minimum inhibition level was 0.5 µg/ml on Staphylococcus aureus bacteria. The leaves’ part presents the best antibacterial activity.
ANALGETIC ACTIVITY TEST OF ETHANOL EXTRACT SUNGKAI LEAF (Peronema canescens Jack) IN WHITE MALE MOUSE (Mus musculus) INDUCED WITH ACETIC ACID Lia Wahyuni; Dona Muin; Defirson Defirson; Andy Brata
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.7374

Abstract

Traditional medicine, which is generally considered safer than modern medicine, makes people choose alternative treatments using medicinal plants, one of which is to treat pain. One of the medicinal plants used to treat pain is a plant that contains flavonoids, one of which is the Sungkai plant (Penorema canescens Jack). The research design used was The Static Group Comparison, where the test animals used were divided into 5 groups, each group consisting of 5 mice. Group 1 was given 1 percent of CMC. Group II was given ethanol extract of Sungkai leaves at a dose of 300 mg/Kg BW. Group III was given EEDS at a dose of 600 mg/kg BW. Group IV was given EEDS at a dose of 900 mg/Kg BW. Group V was given paracetamol suspension. The results showed that there was an analgesic activity in the EEDS group, dose I was 50 percentage, dose II was 55,798 percentage, and dose III was 69,564 percentage. The study concluded that statisti-cally there was no significant difference in analgesic activity in white male mice between the EEDS doses I, II, and III groups and the paracetamol group.
PHYSICAL STABILITY TEST HAIR TONIC COMBINATION Cinnamon (Cinnamomum burmanii) ESSENTIAL OIL AND VCO (VIRGIN COCONUT OIL) WITH CYCLING TEST METHOD AND IRRITATION TEST ON THE RABBIT Junvidya Heroweti; Danang Novianto Wibowo; Arini Najikhatal Ulya; Desmita Linda
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.7903

Abstract

Cinnamon (Cinnamomum burmanii) and VCO (Virgin Coconut Oil) essential oils contain cinnamaldehyde and lauric acid which have potential for hair growth, they can affect the physical stability of hair tonic preparations. This study aims to determine the physical stability and determine the effect of the irritation effect on hair tonic preparations of a combination of cinnamon essential oil and VCO. Cinnamon essential oil hair tonic preparations were made with a concentration of 1% (F1), 3% (F2), and 5% (F3) and then tested for physical characteristics including organoleptic tests, homogeneity, pH, density test, and viscosity. Evaluation of physical stability was carried out using the cycling test method. Data were statistically analyzed using One Way Anova. The results of the irritation test were analyzed descriptively using the primary irritation index obtained from the appearance of erythema and edema on the rabbit's skin. Observation of the physical stability test on organoleptic and homogeneity showed that formula I had a cloudy white color, a characteristic cinnamon aroma, a slightly thick liquid, and was homogeneous; formula 2 and 3 has a clear color, characteristic of cinnamon aroma, slightly viscous and homogeneous liquid; stable pH in formula 2; stable density in formulas 1, 2 and 3; and stable viscosity in formulas 2 and 3. The results of the hair tonic irritation test showed that the primary irritation index for F1, F2, and F3 was 0.0; 0.3; 0.3 and it can be concluded that F2 and F3 can irritate with very mild categories.
ROOT CAUSE ANALYSIS (RCA) OF E-CATALOGUE PROCUREMENT OF MEDICINE USING E-PURCHASING IN PUBLIC HEALTH CENTER IN KLATEN REGENCY OF CENTRAL JAVA Liana Roh Widiyani; Enade Perdana Istyastono; Nunung Priyatni
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.7970

Abstract

E-catalogue procurement of medicine is a method of electronic procurement using a particular website developed by the Government to increase the effectiveness, efficiency, and transparency of medicine procurement. In Klaten Regency, e-catalogue procurement of medicine in the Public Health Center (PHC) experiences obstacles. The study aimed to evaluate performance of e-catalogue procurement of medicine, analyze the root problem and formulate strategies to improve the performance based on the root problems. This descriptive study involved seven PHCs with data on medicine procurement in 2021. Quantitative data analysis was conducted by evaluating six performance indicators of medicine procurement. Qualitative data analysis was conducted by interviewing 17 respondents, analyzing root problems, and formulating improvement strategies The study showed that all PHCs had good medicine availability at 87.71% average, but low realization of e-catalogue procurement occurred in two PHCs. Lead time beyond the contract period occurred in two PHCs. All PHCs experienced low suitability of procurement funds and percentage of procurement through e-catalogue. Percentage of budget allocation for medicine procurement varied between 1.59% to 7.29%. Analysis of the root problem showed obstacles in human resources, mechanism of procurement, policies, system, budget, and environment aspect. It was concluded that the obstacles rooted on the lack of team role and synergy of PHC, District Pharmacy Unit, and District Health Office according to their authority, the lack of pharmaceutical industry and distributor commitments in the provision of e-catalogue medicine for PHC, and also the urgent needs of system and regulatory improvement by the Government.
NARINGIN'S POTENTIAL AS A HEPATITIS B VIRUS REPLICATION INHIBITOR: AN IN-SILICO STUDY OF SECONDARY METABOLITE COMPOUND Muhammad Khalil; Muh. Nur Akbar; Ardiyas Robi Saputra; Subhan Hadi Kusuma
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.8564

Abstract

Naringin is a secondary metabolite compound of the flavonoid group which is generally found in plants that are consumed and traditionally used as medicine. The aim of this study was to examine the potential of naringin as a candidate for hepatitis B virus replication inhibitor using an in-silico approach. This research uses exploratory descriptive method with molecular docking analysis was carried out using the blind docking technique. The 3D structures of naringin and reference ligands were collected from the PubChem database, and the 3D structures of target proteins were collected from the PDB database. The target protein used is the hepatitis B virus capsid protein with PDB ID: 5GMZ. Docking analysis was performed using AutoDock Vina which is integrated into PyRx. Docking results were visualized using the PyMol software and Biovia Discovery Studio 2019. The results of the analysis showed that the binding affinity of all simulation models between naringin and the HBV capsid protein ranged from -7.1 to -7.9 kcal/mol. The binding site formed between naringin and the receptor corresponds to the reference ligand, involving the same 12 amino acid residues, namely PHE 23, PRO 25, LEU 30, THR 33, TRP 102, ILE 105, SER 106, PHE 110, TYR 118, ILE 139, LEU 140, and SER 141. Based on these results, it can be concluded that the naringin compound has the same bioactivity as the reference ligand in inhibiting viral replication, so that naringin has the potential as a candidate for hepatitis B virus replication inhibitor
USE OF ANTICOAGULANT IN COVID-19 PATIENTS AT PKU MUHAMMADIYAH GAMPING HOSPITAL YOGYAKARTA Nurhasani -; Woro Supadmi; Endang Yuniarti
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.7038

Abstract

Based on WHO data, there is about 14% average of patients who suffer from a severe level of Covid-19 disease and 5% of patients admitted to the ICU (Intensive Care Unit) are known to have symptoms of thromboembolism and coagulopathy disorders. The current management of Covid-19 therapy requires heparin. This research aims to find out the accuracy of the heparin regimen, to determine the improvement of the patient's clinical condition, the side effects of heparin based on clinical response, to analyze the relationship between the accuracy of the therapeutic regimen and the improvement of the patient's clinical condition, and also to know the incidence of side effects after heparin use. The type of this research was descriptive-analytic with a cohort design with retrospective data collection. The data were collected by taking medical records at PKU Muhammadiyah Gamping Hospital Yogyakarta. Moreover, the data were collected including heparin therapy regimens with subjective condition and patient objective during the therapy. The data obtained were analyzed by using univariate analysis technique and bivariate analysis technique. The results showed there were 61 patients who fulfilled the inclusion criteria. The evaluation of the accuracy the heparin therapy regimen obtained 95.08% correct results and 4.92% incorrect results. The analysis result of the accuracy the therapeutic regimen showed a significant relationship with clinical improvement with parameters APTT number (p=0.006; RR=0.155; CI = 0.085-0.283). Whereas, there was not found a significant relationship between the accuracy of the therapeutic regimen with the incidence of side effects (p>0.05).
FORMULATION AND TESTING OF ANTI DANDRUFF HAIR TONIC LEAF EXTRACT OF GEDONG MANGO (Mangifera indica L.var.Gedong) AGAINST MUSHROOMS Pityrosporum ovale Yayan Rizikiyan; Lela Sulastri; Yuniarti Falya; Rima Yulia Senja; Hudzaifah Famera Fosanda; Atiqoh Nurul Hakim
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.7911

Abstract

Gedong mango plant (Mangifera indica L.var.Gedong) is a plant that has potential as herbal medicine, especially in its leaves because it contains many secondary metabolites such as flavonoids, saponins, gallic tannins, catecat tannins, quinones and steroids or triterpenoids which can be used as antioxidants, antimicrobial and dandruff. This study aims to gedong mango leaf extract concentrations of 5%, 7%, and 10% in hair tonic preparations and to test the antidandruff activity. Gedong mango leaf simplicia (Mangifera indica L.var.Gedong) was extracted using the Microwave Assisted Extraction (MAE) method with Natural Deep Eutectic Solvents (NADES) sodium acetate dan lactic acid solvents with a molar ratlactic1:3. Hair tonic preparations are made in three formulas with the active ingredient of mango gedong leaf extract at a concentration of 5%, 7%, and 10%. Evaluation of hair tonic pr, separation air tonic preparation evaluation includes organ anoleptic, homogeneity, pH, and viscosity and eststy test of hair tonic anti-dandruffas carriedtestt by the healthy method against the fungus Pityrosporhealthyvale. Hair tonic of mango gedong leaf extract with concentrations of 5%, 7%, and 10% on organoleptic observations, homogeneity, pH, and viscosity met the requirements. The hair tonic has the potential as an antidandruff because it has antidandruff activity against the fungus Pityrosporum ovale and is classified as moderate to strong.
OPTIMIZATION AND PHYSICAL STABILITY OF KEMBANG BULAN (Tithonia diversifolia [A.Gray] EXTRACT CREAM FORMULA Diah Nur Kurnianingrum; Abdul Karim Zulkarnain
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.8404

Abstract

Based on recent studies, the ethanolic extract of Kembang Bulan leaves (Tithonia diversifolia[A.Gray]) has an anti-keloid effect. This study aims to determine the optimum formula for cream preparations with paraffinum liquidum, cetyl alcohol, and stearyl alcohol. Inappropriate comparison of additional ingredients results in the physical properties of the preparation becoming unstable during storage. The optimum formula was obtained from the optimization using Simplex Lattice Design (SLD) by software Design Expert version 10.0. The parameters measured were viscosity, pH, spreadability, adhesive ability, and accelerated study (centrifugation). The optimum cream formula consists of 19.11% b / b; Cetyl alcohol with a level of 2.01% b / b; stearyl alcohol with a level of 1.49% b / b with a viscosity of 134.35 dPa.s, a spread of 5.78 cm, pH 6.243, and adhesive ability of 13.61 seconds. The cream base produced is milky white, has a viscosity of 143.99 dPa.s, a spread of 5.7 cm, pH 6.305, and adhesion to 14.57 seconds. There is a significant difference in viscosity and pH of the experimental and software prediction. However, there is no significant difference in adhesive ability and spreadability response. The cream base and ethanolic extract of Kembang Bulan leaves have a significant difference in physical stability except for its spreadability. During the 4 weeks of storage, both of the creams are relatively stable. The cream is stable after centrifugation.

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