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All Journal VALENSI Biotika: Jurnal Ilmiah Biologi Alchemy : Journal of Chemistry EduChemia: Jurnal Kimia dan Pendidikan Science and Technology Indonesia Jurnal Kimia Terapan Indonesia JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Kartika Kimia FITOFARMAKA: Jurnal Ilmiah Farmasi Indonesian Journal of Halal Research Pharmacoscript Jurnal Abdimas Kartika Wijayakusuma Pharmaceutical And Biomedical Sciences Journal (PBSJ) Jurnal Akademika Kimia Jurnal Farmasi Sains dan Praktis Jurnal Pengabdian Pada Masyarakat Jurnal Akademika Kimia KOPEMAS Jurnal Pengabdian Ilmu Kesehatan
Tarso Rudiana, Tarso
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Profil Fraksi Sitotoksik terhadap Sel Murine Leukemia P-388 dari Ekstrak Biji Honje (Etlingera elatior) Alfindah Rusanti; Dede Sukandar; Tarso Rudiana; Adawiah Adawiah
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 3, No. 1, Mei 2017
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v3i1.3640

Abstract

The research characterization of cytotoxic fraction against P-388 leukemia murine cells from the extract honje (Etlingera elatior) seed have been reported. This research lead to isolated and characterization of cytotoxic compounds against P-388 leukemia murine cells from the extract E. elantior seed. The extract of E. elantior seed was maserated by methanol, n-hexane, and ethyl acetate, respectively and estimated their cytotoxic activity against P-388 leukemia murine cell with 3- (4, 5-dimetiltiazol-2-yl) -2,5-difeniltetrazolium bromide (MTT) assay guided toxicity test against of shrimp Artemia salina Leach. Brine shirmp Lethality Test (BSLT) method. The active extracts will be separated by fractionation using column chromatography, radial chromatography, and for analyzing the purity of isolate will estimate by HPLC. The chemical structure of pure isolate will be identified by spectroscopies data UV Vis, FTIR, NMR and MS. The ethyl acetate extract from honje seed have cytotoxic activity by leukemia P-388 cell  with IC50 19.21 µg/mL. The compound toxic as cytotoxicagainst P-388 leukemia murine cells is flavonoid compouds their is resveratrol, lapachol, apigenin, methylated chrysin, 6,2’-dihydroxyflavanone, 3-hydroxy-3,4’-dymethoxyflavone and 4’-hydroxy-5,7-dimethoxyflavanone.DOI: http://dx.doi.org/10.15408/jkv.v0i0.3640
Antioxidant Activities and Profile of Amino Acid of Yoghurt from Beef Milk Fermentation with Dadih Starter Sri Yadial Chalid; Pratiwi Nur Kinasih; Fitriah Hatiningsih; Tarso Rudiana
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 7, No. 1, May 2021
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v7i1.20425

Abstract

Dadih is naturally fermented buffalo milk in bamboo tubes and known to have antioxidant, antibacterial, and antihypertensive activity. Lactic acid bacteria in dadih can use as a starter to produce yogurt. The study aimed to produce yogurt of cow's milk with dadih as a starter, to determine the antioxidant activity and amino acid composition. Dadih is added with concentration variation of  2.5; 5; 7.5 and 10% (v/v) and it fermented for 48 hours at room temperature. Lactic acid bacteria cell counts of dadih were calculated by the total plate count method. Yogurt was tested by organoleptics with 33 panelists and proximate analysis water, ash, fat and protein contens based on the Association of Official Analytical Chemist (AOAC) in 2005. Antioxidant activities of yogurt were tested by DPPH method (1,1-diphenyl-2-picrylhydrazyl). Amino acid composition of yogurt was analyzed using ultra performance liquid chromatography (UPLC). The research result of amount of LAB on dadih are 1.01 x 1011 CFU/mL, has fulfilled the requirements of SNI 2981: 2009. Yogurt produced with the addition of dadih by 10% (v/v) is most accepted by panelists. The highest antioxidant activity was obtained by yogurt with 2.5% addition of dadih with IC50 value of 78.28 ppm. Yogurt almost contain all essential and non-essensial amino acids including tyrosine and phenylalanine as the antioxidants. Measurement of water, ash, protein and fat content in the sample meets the requirements of SNI 2981: 2009. 
INHIBISI EKSTRAK ETIL ASETAT KULIT BATANG BINTARO (Cerbera odollam Gaertn) TERHADAP PERTUMBUHAN BAKTERI PENYEBAB PLAK GIGI (Streptococcus mutans) Nani Suryani; Tarso Rudiana
BIOTIKA Jurnal Ilmiah Biologi Vol 16, No 1 (2018): BIOTIKA JUNI 2018
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/bjib.v16i1.17476

Abstract

Senyawa 5,3'-Dihidroksi-7,4'-Dimetoksiflavon dari Kulit Batang Tanaman Akway (Drimys beccariana Gibs) dan Aktivitas Antimalarianya Tarso Rudiana; Tati Herlina; Euis Julaeha
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 4, No. 2, November 2018
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (602.007 KB) | DOI: 10.15408/jkv.v4i2.7775

Abstract

Akway (Drimys beccariana Gibs) is an endemic plant of Papua. Ethnobotany is used as a medicinal plant, one of which is used as a malaria drug. This study aims to isolate, determine the chemical structure and evaluate the antimalarial activity of D. beccariana stem bark. Powder of D. beccariana bark is macerated with methanol and fractionated using n-hexane and ethyl acetate. Ethyl acetate extract was fractionated using gradient liquid chromatography (KCV) (n-hexane: ethyl acetate: methanol). The KCV fraction was separated by repeated gravity column chromatography and preparative thin layer chromatography (TLC-P) to obtain Isolate 1. Isolate 1 was determined by spectroscopic methods including UV-Vis, IR, 1D NMR, and 2D. Isolate 1 is determined by its compound structure which is 5,3'-dihydroxy-7,4'-dimethoxyflavone. 5,3'-dihydroxy-7,4'-dimethoxyflavone compounds evaluated antimalarial activity against Plasmodium falciparum in vitro with antimalarial activity better than artemisinin.
Asam Protokatekuat dari Ekstrak Etil Asetatbiji Honje (Etlingera elatior) dan Uji Aktivitas Antioksidannya Dede Sukandar; Ibnu Umarudin Umedi; Siti Nurbayti; Tarso Rudiana; Ahmad Fathoni
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 4, No. 1, Mei 2018
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (500.049 KB) | DOI: 10.15408/jkv.v4i1.7225

Abstract

Telah dilakukan penelitian untuk mengetahui struktur senyawa fenolik yang memiliki aktivitas antioksidan dari ekstrak etil asetat biji honje (E. elatior). Isolasi senyawa fenolik dilakukan dengan metode maserasi, fraksinasi dengan kromatografi kolom gravitasi (KKG), dan kromatografi lapis tipis (KLT). Uji aktivitas antioksidan menggunakan metode DPPH (2,2-diphenyl-1-picrylhydrazyl) dan penentuan struktur senyawa menggunakan spektroskopi UV-Vis, FTIR, NMR, dan MS. Isolat yang diperoleh berupa gum kuning sebanyak 18 mg dari 3 kg sampel kering. Hasil uji aktivitas antioksidan menunjukkan isolat dari ekstrak etil asetat memiliki aktivitas yang sangat kuat dengan IC50 1,32 µg/mL. Hasil analisis dengan spektroskopi UV-Vis, FTIR, NMR, dan MS menunjukkan isolat sesuai dengan rumus molekul C7H6O4 yang dikenal dengan asam protokatekuat (asam 3,4-dihidroksi benzoat).DOI:http://dx.doi.org/10.15408/jkv.v4i1.7225
Aktivitas Antioksidan dari Batang Gandaria (Bouea macrophylla Griff) Tarso Rudiana; Fitriyanti Fitriyanti; Adawiah Adawiah
EduChemia (Jurnal Kimia dan Pendidikan) Vol 3, No 2 (2018)
Publisher : Department of Chemical Education Faculty of Teacher Training and Education Universitas Su

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (237.564 KB) | DOI: 10.30870/educhemia.v3i2.3328

Abstract

Abstrak. Tumbuhan memiliki senyawa golongan metabolit sekunder yang dapat dimanfaatkan sebagai antioksidan. Gandaria (Bouea macrophylla Griff) merupakan salah satu tanaman asli Indonesia yang dapat dimanfaatkan sebagai sumber senyawa antioksidan. Penelitian ini bertujuan menentukan aktivitas antioksidan dari batang tumbuhan B. macrophylla melalui metode DPPH. Sampel batang B. macrophylla dibersihkan, dikeringkan, dan dihaluskan. Sampel halus batang B. macrophylla diekstraksi secara bertahap dengan pelarut n-heksana, etil asetat, dan metanol. Masing-masing ekstrak diuji total fenolik dan total flavonoidnya serta diuji aktivitas antioksidan dengan metode 2,2-diphenyl-1 picrylhydrazyl (DPPH) Free Radical Scavenger. Hasil pengujian menunjukkan ekstrak etil asetat memiliki aktivitas antioksidan paling baik yaitu sebesar IC50 4,89 μg/mL, dengan nilai total feolik dan flavonoid sebesar 22,62 mg GAE/g dan 32,28 mg kuersetin/g.
PENETAPAN ALPHA HYDROXY ACID SARI BUAH CEREMAI (Phyllanthus acidus L.) DENGAN METODE KROMATOGRAFI CAIR KINERJA TINGGI Dimas Danang Indriatmoko; Nani Suryani; Tarso Rudiana; Mila Kurniah
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 11, No 1 (2021): FITOFARMAKA | Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v11i1.2663

Abstract

Alpha Hydroxy Acid (AHA) adalah asam organik yang terdiri dari 2 (dua) rantai karbon atau lebih yang semakin panjang rantai karbonnya akan semakin besar berat molekulnya. AHA adalah kelas senyawa kimia yang sering digunakan dalam kosmetik dan dermatologi. Beberapa buah dilaporkan mengandung senyawa AHA yaitu, asam sitrat dalam buah jeruk dan nanas, asam glikolat dalam tebu, asam laktat dalam tomat, asam malat dalam apel dan anggur, dan asam tartrat dalam anggur. Penelitian ini dilakukan untuk menetapkan kadar AHA yang terkandung dalam buah ceremai (Phyllanthus acidus L.) dengan menggunakan metode Kromatografi Cair Kinerja Tinggi (KCKT). Sari buah P.acidus dikeringkan dengan metode pengeringan beku. Kemudian senyawa AHA dalam ekstrak kering P.acidus yaitu asam glikolat dan asam sitrat dianalisis menggunakan KCKT dengan jenis kolom Capcell PAK C18 UG120S-5mm(4,6 X 250 mm); detektor UV Vis 210 nm; kecepatan alir 0,5 ml/menit; fase gerak asam fosfat dan asetonitril. Hasil penetapan kadar menunjukkan bahwa kadar asam glikolat dan asam sitrat masing-masing adalah 27,8 % dan 39,8 %.
Isolation and Structure Determination of Antioxidants Active Compounds from Ethyl Acetate Extract of Heartwood Namnam (Cynometra cauliflora L.) Dede Sukandar; Siti Nurbayti; Tarso Rudiana; Tsalats Wahyul Husna
Jurnal Kimia Terapan Indonesia Vol 19, No 1 (2017)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (719.193 KB) | DOI: 10.14203/jkti.v19i1.325

Abstract

Active compounds with antioxidant activity were isolated from ethyl acetate extract of namnam stem (C. cauliflora L.) that had undergone maceration and fractionation by gravity column chromatography. The compounds were later identified by by using UV-Vis Spectrophotometry, FTIR, LCMS and 1H-NMR. Ethyl acetate extract of namnam stem showed considerably high antioxidant activity (IC50 value 4.68 ± 0.035 ppm). The results of analysis by UV-Vis and FTIR showed carbonyl group conjugated with an aromatic ring at band I (λmax 330.22 nm), chromophore group of alkene (C=C) at band II (λmax 268.67 nm) and functional groups such as O−H (3343.91 cm-1), C=O (1729.23 cm-1), C=C (1652.64 and 1611.99 cm-1), C−O (1269.89) and C−H ortho (738.23 cm-1). LCMS (m/z 270.9246) and 1H-NMR data showed seven proton signals on the aromatic ring at carbon position C-3 at δH 6.86 ppm (1H, s), C-6 at δH 5.95 ppm (1H, d, J=1.95 Hz), C-8 at δH 6.25 ppm (1H, d, J= 1.95 Hz), C-2’ and C-6’ at δH 7.03 ppm (2H, d, J=7.87 Hz), C-3’ and C-5’ at δH 6.87 ppm (2H, d, J= 7.87 Hz) so that the structure was identified as a flavonoid which was 4 ', 5,7-trihydroxy-flavones or known as apigenin. The isolated apigenin had very strong antioxidant activity, as shown by IC50 value of 5.18 ± 0.014 ppm.
Profile Secondary Metabolite Compounds and Antioxidant Activities of Stem Bark Jambu Mete (Anacardium occidantale L.) Extract Tarso Rudiana; Dhyneu Dwi Jayanti; Siti Solehah
Jurnal Akademika Kimia Vol. 10 No. 3 (2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (243.601 KB) | DOI: 10.22487/j24775185.2021.v10.i3.pp133-138

Abstract

Oxidative stress is a condition in which the amount of free radicals and antioxidants in the body is not balanced, causing various diseases. One of them is a degenerative disease. Oxidative stress can be reduced by antioxidant compounds. Anacardium occidentale L. is a type of plant from the Anacardiaceae family. This plant is found in many trophic countries included Indonesia, and is believed to ward off degenerative diseases caused by oxidative stress. The purpose of this study was to analyze the activity of A. occidentale stem bark extract against DPPH radical inhibition (1,1-Diphenyl-2-Picrilhidrazil) and the profiling of secondary metabolites in their active fraction. The bark of A. occidentale was extracted by a gradient maceration method. The solvents used were n-hexane (nonpolar), ethyl acetate (semi-polar), and methanol (polar). The macerate was concentrated using a rotary vacuum evaporator, followed by DPPH radical inhibition analysis using a spectrophotometer. The most active extract was analyzed for chemical content by LC-MS/MS. The results showed that the extract of A. occidentale stem bark had antioxidant activity. Methanol extract obtained very strong and best antioxidant activity with an IC50 value of 47.13 ppm compared to ethyl acetate extract and n-hexane extract, which had IC50 values of 163.92 ppm and 501.72 ppm, respectively. Secondary metabolites that are thought to have antioxidant activity in the methanol extract of A. occidentale stem bark were epigallocatechin (EC) and epigallocatechin gallate (EGCG) compounds.
Pendampingan Peningkatan Potensi Desa Wisata Ramea Kabupaten Pandeglang berbasis Ekonomi Kreatif Tuti Rostianti Maulani; Agung Sugiarto; Tarso Rudiana; Nenden Suciyati Sartika
Jurnal Pengabdian Pada Masyarakat Vol 8 No 1 (2023): Jurnal Pengabdian Pada Masyarakat
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30653/jppm.v8i1.433

Abstract

Desa wisata merupakan sebuah kawasan pedesaan yang memiliki keunikan dan karakteristik khusus untuk menjadi destinasi wisata. Masyarakat disekitar desa wisata akan melakukan persiapan untuk memperbaiki kondisi desanya bersama-sama dengan aparat desa dan mempersiapkan diri menghadapi kedatangan wisatawan yang akan datang ke desa mereka. Ramea merupakan desa wisata yang dikembangkan di Kabupaten Pandeglang. Tujuan pengabdian ini adalah mengembangkan desa wisata Ramea melalui pengembangan ekonomi kreatif masyarakat dengan menggali potensi desa untuk menjadi desa wisata yang unggul. Pemberdayaan desa wisata Ramea dilakukan dengan pemberdayaan masyarakat melalui peningkatan usaha kecil mikro, pengembangan fasilitas infrastruktur penunjang wisata dan pengembangan aktivitas masyarakat dalam pengembangan pengelolaan desa wisata berkesanambungan. Proses dilakukan secara bertahap dan berkelanjutan. Hasil yang dicapai pemberdayaan yang dilakukan diikuti oleh sebagian masyarakat menjadikan harapan kesejahteraan dan akan timbul suasana yang baru dan meraka siap menerima wisatawan yang akan dating ke desa mereka. Analisis SWOT memperlihatkan bagaiamana desa Ramea dapat mengembangkan desa nya menjadi desa wisata yang mendatangkan kesejahteraan bagi masyarakat. A tourist village is a rural area that has uniqueness and special characteristics to become a tourist destination. The people around the tourist village will make preparations to improve the condition of their village together with village officials and prepare themselves for the arrival of tourists who will come to their village. Ramea is a tourist village developed in Pandeglang Regency. The purpose of community service is to develop the Ramea tourism village through the development of the community's creative economy by exploring the potential of the village to become a superior tourist village. The empowerment of Ramea tourism village is carried out by empowering the community through the improvement of micro-small businesses, the development of infrastructure facilities to support tourism and the development of community activities in the development of tourism village management. The process is carried out gradually and continuously. The results achieved by the empowerment carried out were followed by some communities making hopes of well-being and a new atmosphere will arise and ready to accept tourists who will come to their village The SWOT analysis shows how Ramea village can develop its village into a tourist village that brings prosperity to the community.
Co-Authors Abbas, Jamillah Adawiah Adawiah Adawiah Adawiah Adnan, Aditya Agung Sugiarto Agus Setiawan Ahmad Fathoni Ahmad Fathoni Ahmad, Syadzwina Nurdzakiyyah Alfindah Rusanti Amilia, Nurul Andree Saylendra Andree Saylendra, Andree Ani Susilawati Annastaya Novariyan Anriani, Nurul Arini Khaerunnisa Ashari, Tiara Hadi Asih Widi Wisudawati Ayu Sunayah Candra Junaedi Cory Novi Dede Sukandar Dhyneu Dwi Jayanti Dhyneu Dwi Jayantie Dimas Danang Indriatmoko Dimas Danang Indriatmoko Dimas Danang Indriatmoko Ditta Ahmad Herviana Djamil, Ratna Dwi Marwati Juli Siswanti Eka Yulli Kartika Eneng Elda Ernawati Eneng Elda Ernawati Erica Mutiara Putri Erwin Erwin Erwin Erwin Euis Julaeha Fachrudin Perdana Farhan Riza Afandi Firdaus, Rizki Amsyarul Fitriah Hatiningsih Fitriyani Fitriyani fitriyanti fitriyanti Frida Elasjulia Gina Siti Nurhayati Habibah, Nurfitriany Haddiana Hadi Susilo Haerul Anwar Hasanah Hasanah hasanah hasanah Herviana, Ditta Ahmad Ibnu Umarudin Umedi Iip Pahrudin Indriatmoko, Dimas Danang Irwan Irwan Irwanto Irwanto Jarinah, Jarinah Jayantie, Dhyneu Dwi Ken Virginia Komalasari Komalasari Komarudin, Nanang Kuncoroyekti, Prasetyo Alfaridzi Lia Permatasari Lilik Sulastri Maidah Nopiana Mila Kurniah Muda, Nurhali Muhammad Ihda Hamlu Liwatu Zein Mulyaningsih, Asih Nani Suryani Nani Suryani Nani Suryani Nenden Suciyati Sartika Neneng Rohimah Nur Azizah, Yulyani Nur Thooyibah Nuramalia, Sifa Nurgraha, Auliyah Aisyah Nurhakiki, M. Nurul Anriani Nuzulia Romadlotun Nikmah Partomuan Simanjuntak Partomuan Simanjuntak Pratiwi Nur Kinasih Putri, Widiya Ratna Djamil Renaldy, Renaldy Saeful Rohman Salma, Aninda Sandra Hermanto Siti Nurbayti Siti Nurbayti Siti Nurbayti Siti Nurbayti Siti Sawalia Siti Solehah Slamet Wiyono Sri Yadial Chalid Suhroji Adha Sulistriyani, Sulistriyani Swastika Oktavia Syadzwina Nurdzakiyyah Ahmad Tati Herlina Tsalats Wahyul Husna Tuti Rostianti Maulani Ucu Wandi Somantri Widiya Putri Wiyono, Slamet Zein, Muhammad Ihda Hamlu Liwaissunati Zhorif, Sherina Arestia