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The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy

jghe
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Published by The Indonesian Society for Digestive Endoscopy

ISSN : 14114801 EISSN : 23028181 DOI : -

Core Subject : Health,

Medicine & Pharmacology

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy is an academic journal which has been published since 2000 and owned by 3 Societies: The Indonesian Society of Gastroenterology; Indonesian Association for the Study of the Liver; The Indonesian Society for Digestive Endoscopy. The aim of our journal is to advance knowledge in Gastroenterology, Hepatology, and Digestive Endoscopy fields. We welcome authors for original articles, review articles, and case reports in the fields of Gastroenterology, Hepatology, and Digestive Endoscopy.

Arjuna Subject : Kedokteran - Ilmu Pencernaan

Articles 11 Documents

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Search results for , issue "VOLUME 13, NUMBER 2, August 2012" : 11 Documents clear

Helicobacter pylori Infection in Superficial Gastritis, Erosive Gastritis and Gastric Ulcer Jacobus Albertus; Abdul Aziz Rani; Marcellus Simadibrata; Murdani Abdullah; Ari Fahrial Syam
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 13, NUMBER 2, August 2012
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Helicobacter pylori (H. pylori) infection leads to inflammation of the gastric mucosa. It damages the gastric epithelium and related to the risk of developing gastric cancer. Over time, it may develop into the development of glandular atrophy and intestinal metaplasia. This study was aimed to evaluate the histological features of gastric mucosa, including H. pylori infection in patients with endoscopically found superficial gastritis, erosive gastritis and gastric ulcer. Method: Subjects with abdominal complaints who underwent consecutive upper gastrointestinal endoscopy were prospectively selected at Tugurejo Hospital between November 2004 and December 2010. Eligible subjects were those with endoscopic diagnosis of superficial gastritis, erosive gastritis or gastric ulcer. The biopsy specimens were taken from the corpus, angulus and antrum of all the patients. Giemsa and hematoxylin-eosin staining were used for the histological diagnosis H. pylori and gastric mucosa inflammation. Results: The overall prevalence of H. pylori infection in superficial gastritis, erosive gastritis and gastric ulcer were 24.3%. There was significant difference between H. pylori infection rate in antrum of patients with superficial gastritis 19.4%, erosive gastritis 26.3%, and gastric ulcer 34.7%. The positivity rate of glandular atrophy and intestinal metaplasia of superficial gastritis with H. pylori- positivity was 12.5%, 14.0%; erosive gastritis 26.3%, 16.6%; and of gastric ulcer 38.9%, 29.3%; respectively. However, there was no significant difference. Conclusion: Patients with gastric ulcer have H. pylori infection, atrophic gastritis and metaplasia intestinal more than superficial gastritis and erosive gastritis. Progression of the gastric ulcer to atrophic gastritis and intestinal metaplasia is related to H. pylori infection. Keywords: Helicobacter pylori infection, superficial gastritis, erosion and ulcer

Management of Nutrition in Gastric Emptying Preparation before Medical Procedures Stella Evangeline Bela; Ari Fahrial Syam; Luciana Budiati Sutanto
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 13, NUMBER 2, August 2012
Publisher : The Indonesian Society for Digestive Endoscopy

Patient preparation before medical procedures, for example in elective surgery, abdominal ultrasonograhy (USG), endoscopy, intubation, etc., is by emptying the stomach. Attempt in emptying stomach is by fasting since the night before medical procedure with the intention to decrease the risk of aspiration. Management of nutrition guidelines in preparation of medical procedures currently refers to pre- surgery fasting which is recommended by American Society of Anaesthesiologist (ASA) and the Canadian Anaesthetists Society (CAS). In Indonesia, pre-surgery fasting guideline is suggested by Indonesia Society of Anesthesiology and Intensive Care. However, in various unit of service, fasting the patient since the night before is still performed. Development of nutrition management in medical procedures has experienced many changes, such as surgery which is aimed to restore organ normal function and to accelerate the healing of patients. Various studies on nutrition are developed in conjunction with the programs development to optimize pre-surgery preparation. Keywords: nutrition management, pre-surgery nutrition, aspiration

Approach for Diagnostic and Treatment of Chronic Diarrhea Caused by Hookworm Infection Cekli Wahyuwidowati; Achmad Fauzi
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 13, NUMBER 2, August 2012
Publisher : The Indonesian Society for Digestive Endoscopy

Chronic diarrhea has various etiologies. One of the causes includes parasitic infection, such as hookworm. Human hookworm infections are caused by the blood-feeding intestinal nematodes (Ancylostoma duodenale and Necator americanus). A 54-year-old male was admitted to Cipto Mangunkusumo Hospital with a chief complaint of diarrhea since one month before hospital admission. He experienced diarrhea more than five times a day, without blood and mucus. The stool appearance was yellow without bubbles. He also noted decreased appetite and weight loss. The remarkable physical finding was pain in whole abdomen. Laboratory results showed leukocytosis; while the feces analysis showed bacteria, leukocytes and Gram-negative bacilli. Colonoscopy examination revealed a lot of worms in the colon with multiple ulcers. Histopathological findings indicated colitis with plasma and eosinophils cells in the lamina propia. Parasitology analysis confirmed the hookworms (Necator americanus). The patient was given intravenous fluid, albendazole 400 mg in three consecutive days. The patient’s clinical condition was improved and he was subsequently discharged after seven days of hospitalization. During the follow up at outpatient clinic, the patient was in healthy condition. This is a demonstrative case of human hookworm infection that cause chronic diarrhea. Colonoscopy plays important role for evaluating and finding the etiology of chronic diarrhea. Proper treatment with albendazole has been proven to be effective in eradicating hookworm infection. Keywords: diarrhea, parasite, hookworm

Zinc Supplementation in Children with Acute Diarrhea of Invasive Bacterial and Non-bacterial Infection Endang Poerwati; Badriul Hegar
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 13, NUMBER 2, August 2012
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Diarrhea is one of the manifestations of gastrointestinal disorder. In Indonesia, diarrhea is still one of the leading causes of death in infants and children. Diarrhea requires a rational and comprehensive management to deliver an optimal result. This study was aimed to assess the effectiveness of zinc supplementation in children with acute diarrhea of invasive bacterial infection. Method: A cross-sectional study was performed in 74 children aged 2-14 years with acute diarrhea, who visited the Outpatient Clinic, Pasar Rebo Hospital Jakarta, between January and June 2011. The inclusion criteria were patients had suffered diarrhea for 1-7 days. Based on fecal analysis Results, subjects were divided into group A (non-infectious) and group B (infectious). All children received zinc supplementation. Results: The mean value of subject age was 46.6 months in group A and 81.3 months in group B. The mean frequency of diarrhea prior to zinc supplementation was 7.5 times/day in group A and 7.8 times/day in group B. Duration of diarrhea before zinc supplementation was 52.6 hours in group A and 45.4 hours in group B. On the seventh day, there was no subject of both groups who still suffered from diarrhea. Although the duration of diarrhea in group A was shorter than group B, no significant difference was found (62.4 hours vs 66.8 hours, p = 0.07). Conclusion: Zinc supplementation shows similar efficacy in children with acute diarrhea caused by invasive bacterial infection and those without bacterial infection as well. Keywords: acute diarrhea, invasive diarrhea, zinc supplementation

Acute Pancreatitis as a Complication of Choledochal Cyst Hendra Koncoro; I Dewa Nyoman Wibawa
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 13, NUMBER 2, August 2012
Publisher : The Indonesian Society for Digestive Endoscopy

Choledochal cysts (CCs) are rare congenital disorders of the biliary tree which are associated with biliary tract and pancreatic complications. Its etiology is still unknown, but some evidences suggest that CCs are caused by infection during embryogenesis. The laboratory evaluation reveals abnormalities due to pancreatobiliary complications, such as ascending cholangitis, cholecystitis, and pancreatitis. Radiologic examination may delineate the structural abnormalities occured in CCs and confirm the diagnosis. The major mortality is caused by cholangiocarcinoma. This case discussed the diagnosis and treatment of a 20-year-old male with choledochal cyst and its complications. Management consists of therapy on complication and definitive therapy. Keywords: choledochal cyst, acute pancreatitis, cholecystitis

Improvement of Nutritional Status in Liver Cirrhotic Patients with Adequate Dietary Feeding and High Branched-chain Amino Acids Supplementation Suzanna Ndraha; Marcellus Simadibrata
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 13, NUMBER 2, August 2012
Publisher : The Indonesian Society for Digestive Endoscopy

Background: There is still a high prevalence of malnutrition among liver cirrhotic patients despite the fact that it deteriorates their prognosis. Pre-albumin can be used as a parameter to evaluate short-term nutritional status. This study was conducted to find out the overall outcome of calories and protein diet, and substitution of branched-chain amino acids (BCAA) to enhance pre-albumin serum level in cirrhotic patients with malnutrition. Method: This was a quasi-experimental study conducted in liver cirrhotic patients who visited Koja Hospital between April and September 2009. Mid-arm muscle circumference (MAMC) was used to evaluate nutritional status. Those with MAMC below the 15th percentile were considered as malnourished. Diet of adequate calories and protein with the substitution of 2 x 4 scoop (± 60 g) BCAA milk powder in 200 mL warm water twice daily (± 7.3 g BCAA) was given for two weeks. Pre-albumin serum level was subsequently monitored (before and after intervention) to see if there were any nutritional status changes. Data was analyzed using dependent student T-test with SPSS version 15.0. Results: There were eligible 16 patients. The average pre-albumin level after diet intervention for two weeks was significantly higher than those before the intervention; i.e. from 5.8 (2.2) mg/dL to 6.8 (2.1) mg/dL, with p = 0.004. Conclusion: Diet of adequate calories and branched-chain amino acid can improve the pre-albumin serum level in liver cirrhotic patients with malnutrition. Keywords: cirrhosis, malnutrition, pre-albumin, BCAA

Etiology Profile of Lower Gastrointestinal Bleeding Masrul Lubis; Lukman Hakim Zain
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 13, NUMBER 2, August 2012
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Lower gastrointestinal bleeding (LGIB) is still a significant health problem since the unknown etiology had not existed until now. Similar condition occurs at Adam Malik Hospital. No data about the etiology of LGIB has been defined. Therefore, this study was aimed to recognize the etiology profile of LGIB at Adam Malik Hospital, Medan. Method: A retrospective descriptive study was conducted on medical records of patients who had undergone lower gastrointestinal tract endoscopy (colonoscopy) at Adam Malik Hospital, Medan between January 2009 and December 2010 based on their complaint of hematochezia. Data was analyzed using SPSS version 19. The data was categorized based on subjects’ age, sex and etiology of their hematochezia. Results: There were 116 patients consisted of 61 (52.6%) males and 55 (47.4%) females with mean age of 50.52 (17-84) years. The colonoscopy revealed 52 (44.7%) cases of hemorrhoidal varices, 17 (14.7%) cases of rectal carcinoma, 17 (14.7%) normal endoscopic results, 8 (6.9%) cases of sigmoid carcinoma, 8 (6.9%) of proctitis, 6 (5.1%) cases of colitis, 4 (3.5%) cases of colon carcinoma, and 4 (3.5%) cases of rectosigmoid carcinoma. Conclusion: This study found that hemorrhoidal varices is the most common etiology of LGIB. Keywords: LGIB, colonoscopy, hemorrhoids

Detection of HBV-DNA and Its Correlation with the HBeAg/Anti-HBe Serological Status in HBsAg-positive Patients Haris Widita; Soewignjo Soemohardjo; Zainul Muttaqin; Putu Aditya Wiguna; Shelly Olivia Rhamdiani; Mahendra Wijaya; Stephanus Gunawan
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 13, NUMBER 2, August 2012
Publisher : The Indonesian Society for Digestive Endoscopy

Background: In the past years, HBeAg and anti-HBe status in individuals with positive HBsAg were often correlated to viral replication. This study was aimed to find correlation between the HBV viremia and HBeAg/anti-HBe serological status in HBsAg-positive individuals. Method: An observational-analytic design was performed in this study. The sera of all positive HBsAg patients at Biomedika Hospital Laboratory were collected and examined for HBeAg and anti-HBe using immunochromatography technique between January and April 2012. The sampling method was purposive sampling. Afterwards, the sera were examined for HBV-DNA by polymerase chain reaction (PCR). Results: Sufficient amount of sera were collected from 44 patients consisting of 33 males and 11 females. The mean age was 15-68 years. Positive HBeAg and negative anti-HBe status was found in 11 (42%) patients. Negative HBeAg and positive anti-HBe was found in 26 (59.1%) patients. Both HBeAg and anti-HBe were negative in 7 (16.3%) patients. HBV-DNA was detected in all 11 (100%) patients with positive HBeAg and negative anti-HBe. HBV-DNA was also detected in 11 (42%) patients with negative HBeAg and positive anti-HBe. However, there was only one patient (14.3%) with both negative HBeAg and anti-HBe status, who had detectable HBV-DNA. Conclusion: Positive HBeAg can be used as an indicator of viremia, but negative HBeAg cannot be used as an indicator of the absence of viremia without further HBV-DNA testing. Patients with negative HBeAg and positive HBV-DNA were suspected for having pre-core mutant. Keywords: HBV-DNA, positive HBsAg, HBeAg, anti-HBe, pre-core mutant

The Effect of Pediococcus pentosaceus on Stool Frequency, TNF-α Level, Gut Microflora Balance in Diarrhea-induced Mice Yuliawati Yuliawati; Yusri Dianne Jurnalis; Endang Purwati; Gustina Lubis
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 13, NUMBER 2, August 2012
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Enteropathogenic Escherichia coli (EPEC) are pathogenic microorganisms causing inflammation and imbalanced gut microflora that may result in diarrhea. Pediococcus pentosaceus (P. pentosaceus) isolated from “dadih” (milk curd) are used as probiotics containing lactic acid bacteria (LAB), which are useful to improve the balance of intestinal microflora and inhibit the growth of pathogenic microorganisms. This study was aimed to recognize the effect of P. pentosaceus supplementation on stool frequency, tumor necrosis factor-α (TNF-α) and gut microflora balance in experimental mice with EPEC-induced diarrhea. Method: The study was conducted in 60 white mice (Mus muscullus) at Biomedical Laboratory, Biotechnology/Production and Animal Husbandry Technology Institute, University of Andalas, Padang in April 2012. The frequency of stool, TNF-α level and microflora balance of the mice were measured before and after the EPEC-induced diarrhea and following the administration of antibiotics. Statistical analysis was performed using ANOVA and Duncan test. Results: The highest mean stool frequency was found in positive control group, i.e. 55 times, which was reduced significantly after 12-hour P. pentosaceus supplementation in a dose of 2 x 108 cfu/g into 18 times. The mean TNF-α level in positive control group was 128.17 pg/mL that lowered significantly to 48.0 pg/mL. The highest mean total number of LAB was 97.0 x 107 cfu/g, which was significantly different from positive control group of 7 x 107 cfu/g. Conclusion: P. pentosaceus supplementation in a dose of 2 x 108 cfu/g may reduce the stool frequency, lower TNF-α and improve the gut microflora balance following 12-hour supplementation in diarrhea-induced mice. Keywords: Pediococcus pentosaceus, TNF-α, diarrhea, EPEC, gut microflora

The Prevalence and Factors Associated with Drug-induced Hepatitis in HIV-positive Tuberculosis Patients Gurmeet Singh; Ceva Wicaksono Pitoyo
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 13, NUMBER 2, August 2012
Publisher : The Indonesian Society for Digestive Endoscopy

Introduction: Tuberculosis (TB) have demonstrated a global increase since 1990 along with the increase of world’s population and the transmission of human immunodeficiency virus (HIV). Anti- tuberculosis drugs are very effective, but it may cause drug-induced hepatitis (DIH). The aim of this study was to assess the prevalence and association of several risk factos with the occurence of drug-induced hepatitis in HIV-positive tuberculosis patients. Method: We conducted a retrospective case-control study based on medical records of HIV-positive TB patients who seek medical attention to HIV Referral Center at Cipto Mangunkusumo Hospital between July 2008 and December 2010. Overall, we enrolled 168 medical records with 42 cases and 126 controls. Chi-square and logistic regression test analysis were conducted for analyzing risk factors of drug-induced hepatitis in HIV-positive tuberculosis patients. Results: Drug-induced hepatitis were found in 42 (8.04%) patients.The prevalence of DIH was highest among 35 (25.2%) male patients, aged 35 years old in 32 (26.0%) patients, with albumin level 3.5 g% in 10 (11.2%) patients, body mass index (BMI) 18.5 kg/m2 in 14 (18.4%) patients, CD4+ count 100 cells/mm3 in 29 (24.4%) patients, and those who received rifampicin (R), isoniazid (H), and pirazinamid (Z) regiments for their anti-tuberculosis drugs 24 (31.2%) patients. No risk factors were found to have statistically significant association with DIH. Conclusion: The prevalence of DIH is quite high. Although no risk factor was found statistically significant, but evaluation and liver biochemical examination should be carried out regularly in patients with DIH risk factors. Keywords: drug-induced hepatitis, tuberculosis, human immunodeficiency virus

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Contact Name
Murdani Abdullah

Contact Email
ina.jghe@gmail.com

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+6285891498517

Journal Mail Official
ina.jghe@gmail.com

Editorial Address
Divisi Gastroenterologi, Departemen Ilmu Penyakit Dalam, FKUI/RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71 Jakarta 10430 Indonesia

Location
Kota adm. jakarta pusat,

Dki jakarta

INDONESIA

Abstract

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Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Murdani Abdullah

Contact Email ina.jghe@gmail.com

Phone +6285891498517

Journal Mail Official ina.jghe@gmail.com

Editorial Address Divisi Gastroenterologi, Departemen Ilmu Penyakit Dalam, FKUI/RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71 Jakarta 10430 Indonesia

Location Kota adm. jakarta pusat, Dki jakarta INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Murdani Abdullah

Contact Email
ina.jghe@gmail.com

Phone
+6285891498517

Journal Mail Official
ina.jghe@gmail.com

Editorial Address
Divisi Gastroenterologi, Departemen Ilmu Penyakit Dalam, FKUI/RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71 Jakarta 10430 Indonesia

Location
Kota adm. jakarta pusat,

Dki jakarta

INDONESIA