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Sciences of Pharmacy
Published by ETFLIN
ISSN : 28307046     EISSN : 28307259     DOI : https://doi.org/10.58920/sciphar
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Health Professions Medicine & Pharmacology Public Health
Sciences of Pharmacy (SciPhar) is an international, peer-reviewed open-access journal of pharmacy. We offer a platform and place for researchers and intellectuals, especially the youth, to share their insights and works. Every year, we hold seminars/webinars under the ETFLIN Scientific Society to facilitate the exchange of information concerning pharmacist research progress. Publication on SciPhar is free of charge at any stage. Scope We are accepting articles related to drug development (preclinical and clinical drug development, drug delivery, and pharmaceutical formulation). Fundamental and clinical pharmacology (drug mechanisms, pharmacokinetics, pharmacodynamics, drug metabolism, and pharmacogenetics). Pharmaceuticals (gene-based, cell-based, protein-based therapy, other drug modalities, routes of administration, drug classes, drug nomenclature). Drug toxicity and safety (drug-drug interactions, adverse drug reactions, mechanisms of drug toxicity, pharmacovigilance). Pharmacoepidemiology, pharmacoeconomics, and pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 5 Documents
 1 
Search results for , issue "Volume 4 Issue 1" : 5 Documents clear
Praecitrullus fistulosus Fruit Extract Ameliorates Type II Diabetic Complications in Rats: In Silico, In Vitro, and In Vivo Investigation Mishra, Shanti Bhushan; Verma, Juhi; Sahu, Garima; Gupta, Nishi
Sciences of Pharmacy Volume 4 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0401291

Abstract

This study explored the safety and antidiabetic potential of a hydroalcoholic extract of Praecitrullus fistulosus fruits, along with qualitative and quantitative phytochemical analyses. The antidiabetic effect was evaluated using in vitro methods, including α-amylase and α-glucosidase inhibition assays, as well as an in vivo high-fat diet and low-dose streptozotocin-induced diabetic model. Molecular docking studies were conducted to identify phytochemicals responsible for the antidiabetic effects. The fruit extract exhibited maximum inhibition of 52.06% and 58.10% for α-amylase and α-glucosidase enzymes, respectively, at a concentration of 100 µg/mL. The extract also demonstrated a significant (p < 0.001) and dose-dependent antidiabetic effect at oral doses of 200 mg/kg and 400 mg/kg in the tested animals. In silico analysis revealed that α-tocopherol exhibited the best docking pose, with a docking energy of -8.2 kcal/mol. Based on the results, it can be concluded that the hydroalcoholic extract of Praecitrullus fistulosus contains phytochemicals effective in controlling glucose levels. This study also validates the traditional use of Praecitrullus fistulosus fruits in managing diabetes.
Exploring the Knowledge, Attitudes, and Practices of Libyan Community Pharmacists in Relation to Vitamin Supplements in Tripoli/Libya: A Cross-Sectional Study Rghebi, Nabila Ali; Elmzughi, Rima Farag; Alrgaei, Reham Abubaker; Belal, Malak Amar
Sciences of Pharmacy Volume 4 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0401303

Abstract

Vitamins are essential for many bodily functions and must be obtained through food or supplements. Community pharmacists play an active role in educating patients about vitamins and supplements, guiding their safe use, and helping avoid potential drug-vitamin interactions. This study employed a cross-sectional design, targeting Libyan community pharmacists in Tripoli between August and November 2024, to assess their knowledge, attitudes, practices, and opinions regarding vitamin supplements. The selected participants completed a self-administered questionnaire, and the collected data were entered and analyzed using SPSS version 27. Pearson’s correlation was used to assess the relationship between knowledge, attitude, practice, and opinion. A p-value of less than 0.05 was considered statistically significant. Of the 200 pharmacists who participated, more than half were female (118, 59%), and over two-thirds (139, 69.5%) held a Bachelor's degree in Pharmaceutical Sciences as their highest qualification. Nearly two-thirds (130, 65%) had less than five years of work experience. Based on their self-assessment, 95 (47.5%) of the pharmacists felt moderately confident in their knowledge of vitamin supplements. Notably, the majority of community pharmacists scored above average in all four domains: knowledge (122, 61%), attitude (142, 71%), practice (126, 63%), and opinion (150, 75%). A significant negative correlation was found between knowledge and attitude (p < 0.05). Regarding the dispensing of vitamins without a prescription, 71 (35.5%) of community pharmacists usually dispensed them to 50% of their patients, with adult patients (136, 68%) being the largest age category. Additionally, 78 (39%) of pharmacists relied on laboratory test results before dispensing. Focused educational initiatives aimed at enhancing pharmacists' understanding and improving their dispensing practices are necessary.
Recent Advances in Herbal Effervescent Formulations: Challenges and Opportunities Butar-Butar, Maria Elvina Tresia; Roni, Asep; Pahlevi, Muhamad Reza; Zaelani, Diki; Sagita, Novaliana Devianti; Pratama, Reza
Sciences of Pharmacy Volume 4 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0401311

Abstract

The growing demand for convenient and palatable delivery systems for herbal medicines has significantly increased the interest in herbal effervescent formulations as an alternative to conventional dosage forms. Effervescent dosage forms offer rapid dissolution and the potential for enhanced absorption while masking unpleasant tastes often associated with herbal extracts. However, the successful formulation of herbal effervescent tablets presents unique challenges, including managing the complex physicochemical properties of herbal extracts, ensuring their stability and antioxidant activity within the effervescent matrix, and optimizing taste without compromising efficacy. Various studies have explored the formulation of effervescent tablets from diverse herbal sources like Kelakai root, Kaempferia galanga, and red ginger, employing different formulation methods, excipients like binders, lubricants, and sweeteners, and optimization techniques to achieve desired physical attributes and dissolution profiles. Given the expanding research in this area and the inherent complexities of herbal effervescent formulation, a comprehensive review is crucial to synthesize current knowledge, address existing challenges, and provide a roadmap for future research aimed at designing more effective and patient-friendly herbal effervescent products with improved stability, palatability, and bioavailability.
Enhanced Anti-Inflammatory Activity of Passiflora edulis Leaf Extract Nanoparticle Gel in Carrageenan-Induced Rat Model Sandhiutami, Ni Made Dwi; Desmiaty, Yesi; Fahleni, Fahleni; Handayani, Rizqya Cahya; Ciang, Windy
Sciences of Pharmacy Volume 4 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0401301

Abstract

Passion fruit (Passiflora edulis) leaf extract is rich in flavonoids, which possess anti-inflammatory properties. This study aimed to enhance the anti-inflammatory effect of the extract through a nanoparticle gel formulation. Nanoparticles of the extract (NEP) were prepared using ionic gelation with a Carbomer 940 base. The anti-inflammatory efficacy of NEP was evaluated in vivo using a carrageenan-induced paw edema model in rats. Five groups (n=5) were tested: a negative control (Carbomer 940 gel base), a positive control (Sodium Diclofenac), and three NEP formulations with concentrations of 1% (NEP-1), 3% (NEP-2), and 5% (NEP-3). The NEP gels were homogeneous with a faint yellow color and a characteristic odor. Their spreadability ranged from 7.50 ± 0.67 cm to 7.69 ± 1.26 cm, viscosity exhibited plastic flow properties, and pH values were within 4.47 ± 0.06 to 5.20 ± 0.10. The anti-inflammatory effectiveness of NEP formulations increased with concentration, achieving edema inhibition rates of 3.66% (NEP-1), 68.47% (NEP-2), and 82.37% (NEP-3). In conclusion, the nanoparticle gel formulations of passion fruit leaf extract demonstrated good physical properties, with NEP-3 being the most effective in reducing carrageenan-induced paw edema in rats.
Antioxidant Properties, α-Amylase and α-Glucosidase Inhibitory Activities of Maesobotrya barteri Leaves Extracts in Rats Enin, Godwin Ndarake; Ita, Basil Nse; Thomas, Paul Sunday; Okokon, Jude Efiom; Lawson, Blessing Ofonime; Ohanaka, Chidera Getrude
Sciences of Pharmacy Volume 4 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0401294

Abstract

Maesobotrya barteri is widely used in Nigerian ethnomedicine to treat diabetes, arthritis, and infections. In this study, the methanol and aqueous leaf extracts' phytochemical constituents and antioxidant potentials were evaluated using standard procedures. At the same time, the enzyme inhibitory activity of methanol extract on α-amylase and α-glucosidase in rats was also investigated. The antioxidant properties of the extracts were evaluated by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and ferric reducing power (FRAP). Phytochemical screening of methanol and aqueous extracts revealed the presence of flavonoids, alkaloids, saponins, tannins, and cardiac glycosides. Total phenolics and flavonoids of the extracts ranged from 0.04 to 3.18 mg of GAE/g and from 27.70 to 57.70 mg of QE/g, respectively. Antioxidant analysis showed IC50 values of DPPH (192.95, 196.04, and 17.19 µg/mL) and FRAP (30.48, 37.64, and 38.15 µg/mL) for the methanolic extract, aqueous extract, and ascorbic acid, respectively. Assessment of the methanolic extract against α-amylase and α-glucosidase enzymes in rats at doses of 150, 300, and 450 mg/kg using starch, sucrose, and maltose as substrates, with acarbose as a reference drug, significantly reduced blood glucose levels (p < 0.05). These findings suggest that M. barteri leaf extract has antioxidant properties and inhibits both α-amylase and α-glucosidase enzymes in rats, likely due to the phytochemicals present in the extract.

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