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Desy Ayu Irma Permatasari
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Prodi S1-Farmasi, Fakultas Ilmu Kesehatan Jl. KH Samanhudi, No.93 Sondakan, Laweyan, Surakarta, Jawa Tengah. Kode Pos 57145. Telp : (0271) 712826
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Duta Pharma Journal
Published by Universitas Duta Bangsa Surakarta
ISSN : 28307054     EISSN : 2829811X     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
Duta Pharma Journal berisikan hasil penelitian di bidang Farmasi sebagai upaya untuk memberikan informasi mengenai perkembangan ilmu farnasi yang didasarkan pada bukti. Penelitian dalam jurnal ini mencakup berbagai aspek ilmu farmasi, yang bermanfaat untuk meningkatkan pengetahuan bagi masyarakat, sejawat tenaga kesehatan dan membantu memecahkan masalah serta memberikan inovasi terbaru di dunia farmasi dalam mewujudkan kualitas pelayanan kesehatan yang lebih baik. Duta Pharma Journal merupakan kumpulan jurnal publikasi dari berbagai aspek ilmu Farmasi,seperti Ekstrak dan Standarisasi Herbal, Teknologi dan Formulasi Sediaan Farmasi, Analisis Farmasi, Kimia Farmasi, Mikrobiologi Farmasi, Penentuan aktivitas Farmakologis dari Natural Product serta Farmasi Klinis dan Komunitas.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 102 Documents
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Innovation of Colorimetric Test Strips to Detect Paracetamol and Dexamethasone in Jamu Preparation Angelina Bunga Rosari; Paramita Wahyu Septiani; Ischika Stefani; Odilia Dhea Christina
Duta Pharma Journal Vol. 6 No. 1 (2026): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/2t5z7q66

Abstract

Background: The addition of chemical drugs to traditional herbal medicines (jamu) remains a public health concern because consumers may unknowingly be exposed to substances that can cause harmful effects. Paracetamol and dexamethasone are among the chemical drugs commonly misused in jamu products for pain, rheumatism, and gout. Objective: This study aimed to develop colorimetric test strips for the rapid qualitative detection of paracetamol and dexamethasone in jamu preparations. Methods: Laboratory experimental research was conducted using Whatman No. 4 filter paper as the test-strip medium. The paper was immobilized with 10% iron (III) chloride (FeCl?) for paracetamol detection and a reagent mixture of anhydrous acetic acid, concentrated sulfuric acid, and iodine for dexamethasone detection. Five jamu samples for aches, pain, and gout obtained from Pasar Kliwon, Temanggung, Central Java, were tested. Standard paracetamol and dexamethasone solutions served as positive controls, while distilled water was used as a negative control. Results: Paracetamol produced a yellowish-green color response with FeCl?, whereas dexamethasone produced a dark brown to reddish-brown color response with the reagent mixture. Four of the five tested jamu samples showed positive results for at least one chemical drug, while one sample was negative for both analytes. Conclusion: The developed colorimetric test strips have potential as a practical, rapid, and economical preliminary screening method for detecting paracetamol and dexamethasone in jamu. Further validation is required to assess selectivity, accuracy, precision, detection limit, and stability.
ATR-FTIR Spectral Profiling and PCA of Red Ginger (Zingiber officinale var. rubrum) from Java, Indonesia Maria Serliati Ngongo; Novena Adi Yuhara; Ellsya Rawar
Duta Pharma Journal Vol. 6 No. 1 (2026): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/2jsq5e89

Abstract

Background: Red ginger (Zingiber officinale var. rubrum) is a herbal plant widely used in traditional medicine due to its various bioactive compounds, which are influenced by geographical and agroclimatic conditions. Objectives: This study aimed to distinguish the Fourier Transform Infrared (FTIR) spectral profiles of red ginger in Java, Indonesia using Principal Component Analysis (PCA). Methodology: Red ginger samples from six regions, namely Jatinangor, Ciamis, Trenggalek, Bogor, Sumedang, and Wonogiri, were dried, ground, and analysed using ATR-FTIR in the wavenumber range of 4000-400 cm?¹. The transmittance data were processed using PCA in XLSTAT. Dry weight loss was determined using an oven at 105°C to evaluate the water content of the medicinal plants. Results: The results of dry weight loss showed an average value ranging from 9.24% to 11.96%. Samples from Ciamis (11.76%), Sumedang (11.96%), Trenggalek (10.84%), and Bogor (10.15%) exceeded the required standard limit (<10%), while the other samples met the standard requirements. FTIR spectral analysis revealed the presence of O–H, C–H, C=O, C=C, and C–O functional groups associated with gingerol and shogaol compounds. PCA analysis showed that two principal components, PC1 and PC2, explained 96.798% of the total variation in the data. The score plot showed sample clustering by geographical origin, with Jatinangor, Trenggalek, and Bogor exhibiting relatively similar spectral characteristics, whereas Sumedang, Ciamis, and Wonogiri showed distinct profiles. Contribution analysis showed that Ciamis and Wonogiri contributed mostly to the formation of PC1, while Ciamis and Sumedang contributed significantly to PC2. PCA is used to distinguish the spectral profiles of red ginger based on the regional origin of the tested samples as an initial overview for explanation without a validated classification model. Conclusions: This study demonstrated that the combination of ATR-FTIR and PCA is an effective, rapid method for differentiating the spectral profiles of red gingers by geographical origin.

Page 11 of 11 | Total Record : 102

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