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Duta Pharma Journal
Published by Universitas Duta Bangsa Surakarta
ISSN : 28307054     EISSN : 2829811X     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
Duta Pharma Journal berisikan hasil penelitian di bidang Farmasi sebagai upaya untuk memberikan informasi mengenai perkembangan ilmu farnasi yang didasarkan pada bukti. Penelitian dalam jurnal ini mencakup berbagai aspek ilmu farmasi, yang bermanfaat untuk meningkatkan pengetahuan bagi masyarakat, sejawat tenaga kesehatan dan membantu memecahkan masalah serta memberikan inovasi terbaru di dunia farmasi dalam mewujudkan kualitas pelayanan kesehatan yang lebih baik. Duta Pharma Journal merupakan kumpulan jurnal publikasi dari berbagai aspek ilmu Farmasi,seperti Ekstrak dan Standarisasi Herbal, Teknologi dan Formulasi Sediaan Farmasi, Analisis Farmasi, Kimia Farmasi, Mikrobiologi Farmasi, Penentuan aktivitas Farmakologis dari Natural Product serta Farmasi Klinis dan Komunitas.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 102 Documents
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PENETAPAN KADAR FLAVONOID TOTAL DAN UJI AKTIVITAS ANTIOKSIDAN INFUSA BUNGA KERTAS (Bougenvillea glabra) DENGAN SPEKTROFOTOMETER UV-Vis Rawar, Ellsya; Charis, Jesisca; Adi Yuhara, Novena
Duta Pharma Journal Vol. 5 No. 2 (2025): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/whnsee23

Abstract

Latar Belakang : Pola makan yang tidak sehat serta paparan stres dapat meningkatkan risiko penyakit degeneratif. Salah satu mekanismenya adalah stres oksidatif yang terjadi ketika jumlah radikal bebas dalam tubuh melebihi kapasitas antioksidan endogen. Flavonoid merupakan metabolit sekunder yang berperan sebagai antioksidan alami dan banyak ditemukan pada tumbuhan, termasuk bunga kertas (Bougainvillea glabra). Tujuan: Penelitian ini bertujuan untuk menentukan kadar flavonoid total serta nilai IC50 sebagai indikator aktivitas antioksidan infusa bunga kertas. Metode: Penelitian diawali dengan penyiapan simplisia melalui proses pengeringan dan penghalusan bunga, kemudian pembuatan infusa pada suhu 90 °C selama 15 menit. Identifikasi flavonoid dilakukan secara kualitatif menggunakan reagen spesifik. Penetapan kadar flavonoid total menggunakan metode kolorimetri dengan reagen AlCl? dan CH3COOK pada infusa 10% (10 g/100 mL). Aktivitas antioksidan diuji menggunakan metode DPPH untuk memperoleh nilai IC50. Hasil: Uji kualitatif menunjukkan adanya flavonoid yang ditandai dengan perubahan warna larutan menjadi jingga. Infusa bunga kertas 10% memiliki kadar flavonoid total sebesar 12,10±0,55 mgEK/10 g. Uji aktivitas antioksidan menunjukkan bahwa nilai IC?? infusa sebesar 703,34±12,37 µg/mL, yang mengindikasikan aktivitas antioksidan sangat lemah. Rendahnya aktivitas ini diduga terkait dengan kelarutan flavonoid yang kurang optimal dalam air serta kemungkinan degradasi senyawa pada pemanasan 90 °C. Kesimpulan: Infusa bunga kertas mengandung flavonoid, namun memiliki aktivitas antioksidan yang sangat lemah. Rendahnya kadar flavonoid terlarut dan potensi kerusakan senyawa akibat pemanasan menjadi faktor yang memengaruhi rendahnya aktivitas antioksidan.
ANALISIS DOCKING MOLEKULER BESERTA PREDIKSI ADME DERIVAT FLAVONOID SENYAWA KOMPOSISI KIMIA EKSTRAK BUNGA ROSELA (Hisbiscus Sabdariffa L.) SEBAGAI ANTIOBESITAS Listyani, Tiara Ajeng; Azizah, Dinar
Duta Pharma Journal Vol. 5 No. 2 (2025): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/pbz5mq71

Abstract

Latar Belakang: Pemanfaatan bunga rosela dapat mengobati salah satunya yaitu obesitas. Tujuan: Penelitian ini bertujuan untuk mengetahui senyawa berkhasiat antiobesitas yang terkandung dalam bunga rosela melalui ekstraknya dengan melihat nilai binding affinity dan interaksi asam amino dari komposisi ekstrak bunga rosela. Metode: Senyawa uji digambar lalu diubah ke 3D menggunakan software ChemOffice dan target uji yang telah dipreparasi menggunakan aplikasi Biovia Discovery Studio selanjutnya dipreparasi menggunakan aplikasi VegaZZ. Target yang telah dipreparasi ditambatkan dengan ligan native menggunakan software Pyrx-Phyton 0.8 Autodock Vina untuk melakukan validasi metode docking selanjutnya dilakukan analisis docking terhadap semua ligan uji dan dilihat interaksi asam amino melalui aplikasi Biovia Discovery Studio. Seluruh ligan uji dilakukan prediksi ADME menggunakan progam SwissADME . Hasil: docking 11 struktur senyawa ekstrak bunga rosela (Hibiscus sabdariffa L.) derivat flavonoid ditemukan dua senyawa yang berpotensi sebagai antiobesitas berdasarkan nilai binding affinity dan asam amino yang berkontribusi terhadap interkasi dengan ikatan hydrogen asam amino dimana interaksi tersebut mirip senyawa NAG yang merupakan ligan asli protein target yaitu Kaempferol-3-rutinosid dan Quercetin-3-rutinosid. Kesimpulan: Prediksi ADME semua struktur senyawa memenuhi persyaratan Lipinski’s rule of five sehingga dapat diprediksi memiliki peluang untuk menjadi obat oral.
Analysis of Pharmacists Duties And Functions in The Implementation of Good Cosmetics Manufacturing Practices in The Cosmetics Industry: A 4m + 1e Fishbone Analysis Ni Made Widi Astuti; Natalie Christanti Sukandar; Grasia Laura Boru Sihombing; Ni Nyoman Ayu Budhi Erlangga Santhi
Duta Pharma Journal Vol. 6 No. 1 (2026): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/sb658g09

Abstract

Backgorund: The implementation of Good Manufacturing Practices (GMP), or Good Cosmetic Manufacturing Practices (CPKB), is essential to ensure the quality, safety, and consistency of cosmetic products. Pharmacists play a crucial role in quality assurance, validation, documentation, and production process control. Objective: This study aimed to evaluate the contribution of pharmacists' roles and responsibilities to the implementation of GMP/CPKB and to identify the causes of nonconformities using a fishbone diagram based on the 4M + 1E approach. Method: A descriptive mixed-methods design was employed through in-depth interviews and a Likert-scale questionnaire (1–5) administered to three responsible pharmacists from PT ABC, PT DEF, and PT XYZ. The research instrument consisted of 10 assessment items covering the aspects of man, method, material, machine, and environment. The level of GMP/CPKB implementation was calculated by comparing the actual score with the maximum possible score and expressing the result as a percentage. Results: The results showed that the average GMP/CPKB implementation scores were 4.96 (99.2%) for PT ABC, 4.92 (98.4%) for PT DEF, and 4.88 (97.6%) for PT XYZ, out of a maximum score of 5. All companies were classified in the good category (81-100%). However, several nonconformities were still identified in the areas of human resources, work methods, raw materials, equipment, and the production environment. Fishbone analysis revealed that the main contributing factors included inconsistent personnel discipline, delays in updating Standard Operating Procedures (SOPs), variations in raw material quality, limitations in equipment facilities, and suboptimal environmental control. Conclusion: This study highlights the importance of pharmacists' contributions in supporting GMP/CPKB implementation through quality system supervision and control. Nevertheless, the findings remain descriptive in nature due to the limited number of respondents, consisting of only three participants.
Analysis of The Relationship Between Polypharmacy and Potentially Inappropriate Medications (PIMs) Based on The 2023 Beers Criteria in Geriatric Diabetes Mellitus Patients Oktavian Asyon Herlambang; Aprilia Puteri Santika; Septian Maulid Wicahyo
Duta Pharma Journal Vol. 6 No. 1 (2026): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/pqjb4t96

Abstract

Background: Diabetes mellitus can cause various complications if it is not controlled, resulting in the risk of increasing the number drugs prescribed. The number of medications is one factor that can describe the incidence of Potentially Inappropriate Medications (PIMs). Objectives: This Research is to determine the percentage of PIMs based on the Beers Criteria 2023 and to determine the relationship between the number of drug prescriptions and the incidence of PIMs. Methods: used is descriptive observational. A sample of 120 recipes was carried out using purposive sampling which met the inclusion criteria. Data analysis using the chi square test and correlative contingency coefficient test. Results: the research showed that the demographic characteristics of geriatric diabetes mellitus patients at RSU Asy Syifa' Sambi Boyolali for the period January-March 2025 were dominated by female patients of 76 patients (63.33%), the majority aged 60-69 years, namely 83 patients (69.17%), the number of drugs ? 5 namely of  78 patients (65%), and 114 patients (95%) had comorbidities.There is a percentage of PIMs in the amount of 32.24% of the total drug items, the highest number of PIMs is category 2, namely 32.49%. Based on the results of statistical tests, it shows a p-value of 0.217 (p > 0.05), which means there is no statistically significant relationship between the amount of medication and the incidence of PIMs. Apart from that, the correlation coefficient value for the two variables is 0.112, indicating that the level of strength of the relationship is in the very weak category. Conclusion: An increasing the number of prescribed medications is not the only factor contributing to PIMs. The association between polypharmacy and PIM was not statistically significant (p=0.217) and showed a very weak value. These findings emphasize that in geriatric diabetes care, quality prescribing, appropriate management of complex comorbidities, and regular clinical monitoring effectively reduce the risk of polypharmacy. Therefore, evaluating the appropriateness of therapy is far more important than simply limiting the number of medications.
The Relationship Between ARV Therapy Adherence And Clinical Outcomes in HIV Patients at Dr Moewardi Hospital Putri Eka Prasetya; Niken Luthfiyanti; Vivin Marwiyati Rohmana; Angelina da Costa Fernandes
Duta Pharma Journal Vol. 6 No. 1 (2026): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/s04wca81

Abstract

Background: Human immunodeficiency virus (HIV) remains a major global public health problem with the number of people living with HIV continuing to increase, including in Indonesia. Antiretroviral therapy (ART) is the main treatment to suppress viral replication and improve immune function, however its success is highly dependent on patient adherence. Objective: This study aimed to determine the level of adherence to ART, evaluate clinical outcomes and analyze the relationship between ART adherence and clinical outcomes among HIV patients at Dr. Moewardi Hospital. Methods: This study employed a quantitative analytical design with a cross-sectional approach. A total of 83 patients (n=83) undergoing ART were included in this study. Data were collected using the Morisky Medication Adherence Scale (MMAS-8) and medical records. Data analysis was performed using univariate and bivariate methods. Results: The majority of patients demonstrated high adherence to ART (60.2%), followed by moderate adherence (34.9%) and low adherence (4.8%). Most patients achieved favorable clinical outcome with 89.2% having undetectable viral load and 10.8% having detectable viral load. CD4 levels were categorized as good (51.8%), very good (33.7%) and poor (14.5%). Bivariate analysis showed a significant relationship between ARV adherence and CD4 outcomes (p = 0.007) as well as viral load outcomes (p < 0.000). Conclusion: There is a significant relationship between ART adherence and clinical outcomes in HIV patients. Higher adherence is associated with improved CD4 levels and viral load suppression.
Effect of Olive Oil and Almond Oil Ratios on the Physicochemical and Sensory Characteristics of Aromatherapy Massage Oil chennia Ofta Fianes; Nur Ermawati
Duta Pharma Journal Vol. 6 No. 1 (2026): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/kf3dfa20

Abstract

Background: Aromatherapy massage oil is a topical preparation in which carrier oil selection critically determines physicochemical performance and sensory acceptance. Studies evaluating olive oil and almond oil combinations as carrier oils in multi-essential oil aromatherapy systems remain limited. Aim: This study aimed to evaluate the effect of different olive oil (Olea europaea) and almond oil (Prunus amygdalus) ratios on the physicochemical characteristics, stability, sensory properties, and skin safety of aromatherapy massage oil containing lavender (Lavandula angustifolia), citronella (Cymbopogon nardus), and chamomile (Matricaria recutita) essential oils. Methods: Three formulations were prepared using a Completely Randomized Design (CRD) with two replications: F1 (50:5 mL), F2 (5:50 mL), and F3 (27.5:27.5 mL). Evaluations included organoleptic characteristics, pH, viscosity, specific gravity, 28-day stability, hedonic test (30 panelists), and skin irritation test (closed patch test, 10 volunteers, 8 hours), analyzed using one-way ANOVA and repeated-measures ANOVA with post-hoc Tukey HSD (? = 0.05, SPSS v.23.0). Results: All formulations were stable over 28 days with consistent organoleptic properties and pH 5.00. Viscosity ranged from 4.106 ± 0.004 cP (F1) to 4.321 ± 0.004 cP (F3), all within 2.3-6.0 cP. Statistically significant viscosity changes were observed (p < 0.05) but were not practically meaningful. No significant difference in sensory preference was found (p = 0.825), with F3 descriptively obtaining the highest score (12.233). All formulations were non-irritating (ICDRG score 0). Conclusion: Carrier oil ratio variation influenced viscosity and specific gravity but not organoleptic stability, pH, or sensory acceptance. F3 was selected as the most optimal formulation based on combined viscosity profile, stability, and descriptive sensory preference. Limitations include short stability duration, absence of microbiological testing, and use of pH indicator paper in an oil-based system.
Antihyperglycemic Potential of 70% Ethanol Extract of Kersen (Muntingia calabura L.) Fruit in Mice: An In Vivo Study Belinda Arbitya Dewi; Rony Setianto; Norma Winata; Masyrobatin; Irfan Ahsani; Cinthya Farah; Faradina Rosita
Duta Pharma Journal Vol. 6 No. 1 (2026): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/pktnm141

Abstract

Background: Diabetes mellitus requires affordable therapeutic alternatives. Kersen (Muntingia calabura L.) fruit contains secondary metabolites with antioxidant and potential antihyperglycemic properties. Objective: To evaluate the antihyperglycemic activity of ethanol extract of M. calabura fruit in alloxan-induced hyperglycemic mice. Method: An in vivo experimental study used 30 mice divided into normal control, diabetic control, and extract treatment groups receiving 10%, 15%, or 20% extract orally for 14 days. Hyperglycemia was induced using alloxan at 150 mg/kg body weight. Blood glucose levels were measured before induction and on days 7 and 14. Phytochemical screening was performed qualitatively. Data were assessed using Shapiro-Wilk and Levene’s tests, followed by one-way ANOVA and Tukey’s HSD test. Results: The extract yield was 24.25%, and phytochemical screening identified flavonoids, alkaloids, tannins, and saponins. Alloxan successfully induced hyperglycemia, with diabetic-control blood glucose levels reaching approximately 299 mg/dL on day 14. Extract treatment produced a dose-dependent reduction in blood glucose. The 20% extract group showed the greatest effect, with a mean final blood glucose level of approximately 116 mg/dL and no significant difference from the normal control group (p=0.209). One-way ANOVA showed significant differences among groups (p<0.001). Conclusion: Ethanol extract of M. calabura fruit demonstrated significant antihyperglycemic activity in alloxan-induced mice, with the 20% concentration providing the most effective glucose-lowering response.
The Effect of Triethanolamine Variations on The Evaluation of Physical Properties of Papaya Leaf Ethanol Extract Lotion (Carica Papaya L.) Susi Endrawati; Anom Parmadi; Sri Saptuti Wahyuningsih
Duta Pharma Journal Vol. 6 No. 1 (2026): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/gkajqf73

Abstract

Background: Papaya leaves (Carica papaya L.) contain papain, flavonoids, and vitamin C, which have antioxidant potential. Objective: This study aimed to formulate papaya leaf ethanol extract as a lotion and to determine the effect of triethanolamine (TEA) concentration on its physical properties. Methods: This experimental study used 96% ethanol for maceration. Papaya leaf extract was incorporated at a concentration of 15%, while TEA concentrations were varied at 2% (F1), 3% (F2), and 4% (F3). The formulations were evaluated for organoleptic properties, pH, homogeneity, spreadability, adhesion, protective ability, lotion type, physical stability, preference, and viscosity. Results: The extract yield was 8.79% w/w. F1 and F2 were medium-viscosity liquids, whereas F3 was a low-viscosity liquid. All formulations were bright brownish-green, had a rose fragrance, were homogeneous, had a pH of 6, and formed oil-in-water (O/W) lotions. The highest mean spreadability under a 100 g load was 25.53 cm² in F2 and F3, whereas F1 showed the lowest value of 18.10 cm². The mean adhesion times were 1.56 s, 1.66 s, and 1.88 s for F1, F2, and F3, respectively. F3 was the most preferred formula, selected by 45% of respondents. All formulas remained stable during four weeks of storage. One-way ANOVA showed that TEA concentration significantly affected spreadability (p = 0.000) but did not significantly affect adhesion (p = 0.788). Conclusion: Papaya leaf ethanol extract can be formulated into a stable O/W lotion. Increasing the TEA concentration reduced viscosity and increased spreadability; however, the difference in adhesion was not statistically significant.
Characteristics and Hedonic Evaluation of “Microgum” Chewable Gummy containing Moringa oleifera and Cucurbita moschata as a Potential Micronutrient Supplement Arika Nur Insani; Adelia Widianti; Najwa Aulia Putri; Salsabiela Dwiyudrisa Suyudi
Duta Pharma Journal Vol. 6 No. 1 (2026): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/apn68611

Abstract

Background: Malnutrition and micronutrient deficiencies remain major public health problems, the the low acception of conventional supplements is one of contributing factor. Natural ingredients such as Moringa oleifera leaves and pumpkin seeds (Cucurbita moschata) contain bioactive compounds that may support the development of functional supplement products. Objective: This study aimed to formulate and evaluate chewable gummies (microgummy) containing Moringa oleifera leaf extract and Cucurbita moschata seed extract through physical, hedonic, and stability evaluations. Methods This quantitative experimental study used three formulations containing different concentrations of Moringa oleifera leaf extract (5%, 10%, and 15%). Extraction was performed by maceration using distilled water as the solvent. Evaluations included phytochemical screening, pH, swelling ratio, syneresis, dispersion time, weight uniformity, accelerated stability, and hedonic testing involving 15 panelists. Data were analyzed using One-Way ANOVA followed by Duncan’s post hoc test. Results: showed that Moringa oleifera leaf extract contained flavonoids, tannins, and saponins, while pumpkin seed extract showed positive results for alkaloids. All formulations had a pH value of 5. Swelling ratio values for F1, F2, and F3 were 2.00%, 2.02%, and 2.90%, while syneresis values were 3.125%, 2.752%, and 12.12%, respectively. Dispersion times were 16.59, 13.37, and 2.55 minutes. Only F1 met the weight uniformity requirement and dispersion standard (15-30 minutes). Accelerated stability testing at 40°C caused visible melting and deformation in all formulations. Hedonic evaluation showed that only aroma differed significantly among formulations (p<0.05). Formula F3 obtained the highest hedonic scores for color (4.20±0.41), taste (4.20±0.51), and texture (4.13±0.51). Conclusion: each formulation demonstrated different physicochemical characteristics which can vary because of the moringa leaves and pumpkin seed composition. The hedonic test shows that F3 achieved higher hedonic preference scores.
Clinicopathologic Characteristics, Pathological Response and Safety Profile of Triple-Negative Breast Cancer (TNBC) Patients: A Retrospective Study in Yogyakarta Rommy; Clara Ritawany Sinaga; Annafiatuzakiah
Duta Pharma Journal Vol. 6 No. 1 (2026): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/hy4h0v48

Abstract

Background: Triple-negative breast cancer (TNBC) is a uniquely aggressive molecular subtype associated with poor prognosis, high proliferation rates, and significant genomic instability. Objective: This study aimed to determine the clinicopathologic characteristics, pathological response, and safety profile of TNBC patients in a local clinical setting. Method: A retrospective cohort study was conducted on 50 female patients at a private hospital in Yogyakarta (2019–2022). Chemotherapy regimens were categorized into platinum-based (carboplatin and taxane) and non-platinum-based (anthracycline-taxane, capecitabine, or methotrexate) groups. Pathological complete response (pCR) was defined as the total absence of residual invasive carcinoma in both the breast tissue and sampled regional lymph nodes (ypT0/Tis ypN0). Data were extracted from medical records and analyzed using bivariate statistical tests. Results: The mean age was 48.48 years (95% CI: 46.24–50.72), with 76% of patients aged 40-59. Most patients presented with cT2 tumor size (38%) and cN0 nodal status (58%). The mean Ki67 index was 24.96 (95% CI: 19.29–30.63), with 44% of patients exhibiting high proliferation (? 30%). The overall pCR rate was 20% (10/50). The platinum group achieved a higher numerical pCR rate (25%, 6/24) compared to the non-platinum group (15.4%, 4/26), though the difference was not statistically significant (OR = 1.833, 95% CI: 0.448–7.511, p = 0.490). A high Ki67 index (? 30%) was significantly associated with superior pCR achievement (OR = 7.428, 95% CI: 1.365–40.413, p = 0.014). Adverse drug reactions (ADRs) occurred in 66% (33/50) of patients, predominantly chemotherapy-induced nausea and vomiting (22%) and neurological disorders (20%). Conclusion: High Ki67 expression was associated with therapeutic response in this cohort. No statistically significant difference in pCR or total ADR incidence was observed between regimens in this sample. The study is limited by its single-center design and small sample size (n=50)

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