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The potential protective effects of malacca (Phyllanthus emblica L.) extract against doxorubicin-induced cardiotoxicity in male Wistar rats ETRINA MELINDA; ERMI GIRSANG; ALI NAPIAH NASUTION
Jurnal Natural Volume 21 Number 2, June 2021
Publisher : Universitas Syiah Kuala

Doxorubicin as a chemotherapy agent is most widely used in cancer treatment. Long-term use at a predetermined dose has a side effect, namely cardiotoxicity. Doxorubicin-induced cardiotoxicity is considered to be caused by reactive oxygen species (ROS), which is also characterized by increasing CK-MB enzyme levels in the blood. To reduce the impact of doxorubin-induced toxicity, a study was conducted on natural antioxidant sources with cardioprotective capabilities in vivo. Phyllanthus emblica L. fruit was used as a sample for a natural source of antioxidants extracted using ethanol. Then performed a phytochemical screening of secondary metabolites contained in it. This extract was administered orally in various doses to the experimental animal Wistar rats and the induced doxorubicin to these animals. The CK-MB enzyme levels were measured, and the heart organ histopathology test was performed. The results of this study indicate that P. emblica L. fruit extract contains alkaloids, tannins, flavonoids, terpenoids, phenolics, and triterpenoids compounds. Extract treatment at a 400 mg/kg BW dose showed the best reduction in CK-MB levels with great improvements in regular arrangement and shape of myocardial muscle cells of cardiac tissue. The sample extract at a 400 mg/kg BW dose showed remarkably decreasing of CK-MB great improvements of heart tissue on doxorubicin-induced cardiotoxicity. This study showed the potential protective effect of P. emblica L. against doxorubicin-induced cardiotoxicity.

The effect of organic fertilizers on the leaf morphology and stomatal density of Pogostemon cablin Benth MEUTIA ZAHARA; SUWARNIATI SUWARNIATI; QURRATU AINI; MUSLIM MUSLIM
Jurnal Natural Volume 21 Number 2, June 2021
Publisher : Universitas Syiah Kuala

Pogostemon cablin Benth is one of the most important crops grown in Indonesia, especially in Aceh province. It is well known as Patchouli belongs to Lamiaceae family and shows a great demand for perfume, luxury products, food and beverage industry. This study conducted to determine the effect of organic fertilizers application on the leaf morphology and stomatal density on the Pogostemon cablin Benth. The seedlings were transplanted for three months on the soil mixed either with manure or compost. The results obtained that was no significant different in affecting the leaf morphology of Pogostemon cablin Benth. The treatment with manure application showed the highest leaf length (15.23 cm) and the highest leaf width (10.5 cm), the leaf color is green. While the stomatal density obtained the significant difference among the treatments, the highest stomatal density in both side of the leaf surface showed in the application of manure, 663.5 mm-2 for adaxial part and 486.38 mm-2 for abaxial part. Stomatal type is anisocytic and on the leaf surface was found glandular and non-glandular trichomes.

Reduction mechanisms of Ag(I) and Au(III) in the synthesis of silver and gold nanoparticles using leaf extract of Terminalia catappa MUHAMMAD ZAKIR; MAMING MAMING; MISKA SANDA LEMBANG; ESTY YURNITA LEMBANG
Jurnal Natural Volume 21 Number 2, June 2021
Publisher : Universitas Syiah Kuala

Synthesis of silver nanoparticles (AgNP) and gold nanoparticles (AuNP) was carried out by the reduction method with leaf extract of Ketapang (Terminalia catappa). The biomolecules present in the extract generated the reduction of Ag+ and Au3+ ions from AgNO3 and HAuCl4, respectively. The growth of nanoparticles was monitored by UV-Vis spectrophotometer. The maximum absorption of biosynthesis of AgNP and AuNP were observed in the respective range of 421-431nm and 530-535nm. Those peaks correspond to surface plasmon absorbance of AgNP and AuNP, respectively. Analysis on the functional groups change of the extract by Fourier Transform Infra Red (FTIR) Spectroscopy showed the formation of carbonyl- from hydroxyl-groups which suggested the oxidation and reduction processes involved in the formation of both nanoparticles. The average size distributions determined by PSA (Particle Size Analyzer) are 55-71nm and 18-44nm for AgNP and AuNP, respectively. Morphology of the silver nanoparticles was observed by Scanning Electron Microscope (SEM) and the structure of the compounds was characterized using X-ray Diffraction (XRD). The shape of AgNP varied from triangular, cubic and hexagonal polyshaped, while AuNP were spherical. XRD studies showed that the nanoparticles obtained were crystalline gold and silver.

Natural Decomposer (MOL) developed from various banana waste and different storage times DEWI YUNITA; IRFAN IRFAN; MARLINA MARLINA
Jurnal Natural Volume 21 Number 2, June 2021
Publisher : Universitas Syiah Kuala

MOL is a local microorganism or natural decomposer that is used as a starter culture in production of organic fertilizers which is known as bokashi. The advantage of using MOL is that it can be made from cheap materials or by utilizing agricultural waste so that it can increase the added value of waste as well as reduce the environmental pollution. The use of MOL as a biodecomposer in production of bokashi can accelerate the fermentation process. This study aimed to produce MOL where the characteristic is similar with commercial Effective Microorganism (EM4). This study used a factorial randomized block design (RBD) with 2 factors. First factor was the types of banana (J) consisted of three levels, namely awak banana (Musa paradisiacal var. Awak; J1), barangan banana (Musa acuminate Colla; J2), and kepok banana (Musa acuminata balbisiana Colla; J3). Second factor was the storage times consisted of three levels, namely 0 weeks after fermentation (L1), 2 weeks after fermentation (L2), and 4 weeks after fermentation (L3). The analysis carried out after fermentation included total cell counts (TCC), pH value, temperature, and organoleptic test in the form of hedonic test for color and description test for aroma. The best sample was determined based on the highest TCC, the lowest pH value and aroma using a ranking test. The best treatment was obtained from J1L2 treatment (awak banana and 2 weeks after fermentation) with 1.8 × 109 CFU/ml of TCC, 3.17 of pH and medium tapai aroma.

Diversity and population structure of Dipterocarpaceae species in Weh Island Nature Tourism Park, Indonesia RIDHA UL FAHMI; SAIDA RASNOVI; ESSY HARNELLY
Jurnal Natural Volume 21 Number 2, June 2021
Publisher : Universitas Syiah Kuala

The Dipterocarpaceae family is one of the identified plant groups with high conservation value that exist in Weh Island Nature Tourism Park. However, the data availability on the species diversity and population structure of Dipterocarpaceae in Weh island in particular and Aceh in general is still very limited. Thus, it is necessary to conduct studies on species diversity and population structure of Dipterocarpaceae from Weh Island. This study aims to obtain data on species abundance and diversity, species composition of each stratum, population structure, and stand structure of Dipterocarpaceae in Weh Island Nature Tourism Park. This research utilized transect method with randomly selected plots according to topographic conditions. We found two Dipterocarpaceae species: Shorea sumatrana (Slooten) Desch and Dipterocarpus hasseltii Blume. Shorea sumatrana (Slooten) Desch has the greatest abundance of all types and strata. The diversity of Dipterocarpaceae species in Weh Island Nature Tourism Park is categorized as low because the diversity index value is in the range of H'1. This means that the presence of seedling and sapling strata from each species has a major effect on the survival of the Dipterocarpaceae family in the future. The stand structure of the Dipterocarpaceae family in normal conditions is indicated by an inverted “J” shaped diagram.

Detection of qnrS and tetA resistance coding genes in Pseudomonas aeruginosaof egg-laying hens farmin Cianjur Regency, West Java FAUZAN ARISANDI; SAFIKA . SAFIKA; FACHRIYAN HASMI PASARIBU
Jurnal Natural Volume 21 Number 2, June 2021
Publisher : Universitas Syiah Kuala

The use of antibiotics is an alternative to reduce disease incidence and is used to increase egg-laying hens. This study aims to detect the presence of antibiotic resistance to resistance coding genes in Pseudomonas aeruginosa bacteria. The cloacal swab samples were collected randomly as many 66 samples from several egg-laying hens farms in Cianjur Regency, West Java. The collected isolates were examined bacteriologically. The results of the antibiotic sensitivity test of 8 samples (12.1%) of the Pseudomonas aeruginosa showed the resistance level of antibiotics class tetracycline (tetracycline50%, oxytetracycline75%, and doxycycline50%), fluoroquinolone (enrofloxacin 12.5%), and phenicol (chloramphenicol 12.5%). Pseudomonas aeruginosa was resistant to tetracyclines, oxytetracyclines, doxycycline, enrofloxacin and is sensitive to chloramphenicol. The detection of resistance coding genes showed the genes amount of tetA (62.5%) and qnrS (75%). Efforts to determine the level of resistance and use of antibiotics in farms need regular surveillance and monitoring to ensure the wise use of antibiotics.

Indigenous Rhizobacteria treatment in controlling diseases Phytophthora palmivora and increasing the viability and growth of cocoa seedling SYAMSUDDIN SYAMSUDDIN; MARLINA MARLINA; TJUT CHAMZURNI; VINA MAULIDIA
Jurnal Natural Volume 21 Number 2, June 2021
Publisher : Universitas Syiah Kuala

Rhizobacteria play a positive role as biocontrol agents as well as Plant Growth Promoting Rhizobacteria (PGPR) agents. The research objective was to obtain indigenous rhizobacteria isolates on cocoa plants that have the potential to inhibit the attack of P. palmivora fungal pathogens, and act as PGPR in vitro and in vivo. The results of the study concluded that isolates TRI 7/1, TRI 8/8, GM 7/9 and GM 7/10 had the highest ability to inhibit the growth of pathogen. The lowest disease severity (20%) was obtained in the seedlings treated using isolates TRI 7/1 and TRI 8/8. Rhizobacterial isolates GM 3/6, GM 5/6, GM 7/9 and GM 8/8 produce high amounts of IAA. Rhizobacteria isolates GM 5/6, GM 7/9 and GM 8/8 has very high peroxidase enzyme activity. High production of HCN compounds was obtained in rhizobacteria isolates TRI 3/3, TRI 4/10 and TRI GM 8/11. All rhizobacterial isolates gave an increase in the value of maximum growth potential, germination and vigor values for growth strength compared with the control. The rizobacteria treatments using isolates TRI 7/1, TRI 8/8, GM 7/9 and GM 7/10 were able to increase plant height, stem diameter and number of leaves at 30, 40, 50, 60, and 70 DAP compared to control treatment.

A generalized linear mixed model for understanding determinant factors of student's interest in pursuing bachelor's degree at Universitas Syiah Kuala ASEP RUSYANA; KHAIRIL ANWAR NOTODIPUTRO; BAGUS SARTONO
Jurnal Natural Volume 21 Number 2, June 2021
Publisher : Universitas Syiah Kuala

Generalized Linear Mixed Model (GLMM) is a framework that has a response variable, fixed effects, and random effects. The response variable comes from an exponential family, whereas random effects have a normal distribution. Estimating parameters can be calculated using the maximum likelihood method using the Laplace approach or the Gauss-Hermite Quadrature (GHQ) approach. The purpose of this study was to identify factors that trigger student's interest to continue studying at Universitas Syiah Kuala (USK) using both techniques. The GLMM is suitable for the data because the variable response has a Bernoulli distribution, and the random effects are assumed to be having a normal distribution. Also, the model helps identify the relationship between the dependent variable and the predictors. This study utilizes data from six high schools in Banda Aceh city drawn using a two-stage sampling technique. Stage 1, we randomly chose six out of sixteen public senior high schools in Banda Aceh. Stage 2, we selected students from each school from four different major classes. The GLMM model includes one binary response variable, five numerical fixed-effects, and two random effects. The response variable is the interest of high school students to continue study at USK (yes or no). The five fixed effects in the model including scores of collaboration (C), Action (A), Emotion (E), Purposes (P), and Hope (H). Finally, the random effects are schools (S) and majors (M). In this study, both Laplace and GHQ techniques produce identical results. The predictors that can explain student interest are A, E, and H. These predictors have a positive effect. The random effects of schools and majors are not significantly different from zero. The model with three significant predictors is better than the complete predictor model.

A generalized linear mixed model for understanding determinant factors of student's interest in pursuing bachelor's degree at Universitas Syiah Kuala ASEP RUSYANA; KHAIRIL ANWAR NOTODIPUTRO; BAGUS SARTONO
Jurnal Natural Volume 21 Number 2, June 2021
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v21i2.19325

Generalized Linear Mixed Model (GLMM) is a framework that has a response variable, fixed effects, and random effects. The response variable comes from an exponential family, whereas random effects have a normal distribution. Estimating parameters can be calculated using the maximum likelihood method using the Laplace approach or the Gauss-Hermite Quadrature (GHQ) approach. The purpose of this study was to identify factors that trigger student's interest to continue studying at Universitas Syiah Kuala (USK) using both techniques. The GLMM is suitable for the data because the variable response has a Bernoulli distribution, and the random effects are assumed to be having a normal distribution. Also, the model helps identify the relationship between the dependent variable and the predictors. This study utilizes data from six high schools in Banda Aceh city drawn using a two-stage sampling technique. Stage 1, we randomly chose six out of sixteen public senior high schools in Banda Aceh. Stage 2, we selected students from each school from four different major classes. The GLMM model includes one binary response variable, five numerical fixed-effects, and two random effects. The response variable is the interest of high school students to continue study at USK (yes or no). The five fixed effects in the model including scores of collaboration (C), Action (A), Emotion (E), Purposes (P), and Hope (H). Finally, the random effects are schools (S) and majors (M). In this study, both Laplace and GHQ techniques produce identical results. The predictors that can explain student interest are A, E, and H. These predictors have a positive effect. The random effects of schools and majors are not significantly different from zero. The model with three significant predictors is better than the complete predictor model.

The potential protective effects of malacca (Phyllanthus emblica L.) extract against doxorubicin-induced cardiotoxicity in male Wistar rats ETRINA MELINDA; ERMI GIRSANG; ALI NAPIAH NASUTION
Jurnal Natural Volume 21 Number 2, June 2021
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v21i2.19699

Doxorubicin as a chemotherapy agent is most widely used in cancer treatment. Long-term use at a predetermined dose has a side effect, namely cardiotoxicity. Doxorubicin-induced cardiotoxicity is considered to be caused by reactive oxygen species (ROS), which is also characterized by increasing CK-MB enzyme levels in the blood. To reduce the impact of doxorubin-induced toxicity, a study was conducted on natural antioxidant sources with cardioprotective capabilities in vivo. Phyllanthus emblica L. fruit was used as a sample for a natural source of antioxidants extracted using ethanol. Then performed a phytochemical screening of secondary metabolites contained in it. This extract was administered orally in various doses to the experimental animal Wistar rats and the induced doxorubicin to these animals. The CK-MB enzyme levels were measured, and the heart organ histopathology test was performed. The results of this study indicate that P. emblica L. fruit extract contains alkaloids, tannins, flavonoids, terpenoids, phenolics, and triterpenoids compounds. Extract treatment at a 400 mg/kg BW dose showed the best reduction in CK-MB levels with great improvements in regular arrangement and shape of myocardial muscle cells of cardiac tissue. The sample extract at a 400 mg/kg BW dose showed remarkably decreasing of CK-MB great improvements of heart tissue on doxorubicin-induced cardiotoxicity. This study showed the potential protective effect of P. emblica L. against doxorubicin-induced cardiotoxicity.

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Contact Name
Suhartono

Contact Email
suhartono@usk.ac.id

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Journal Mail Official
jurnal.natural@fmipa.unsyiah.ac.id

Editorial Address
Block A 2nd Floor FMIPA USK Jl. Tegk. Syech Abdurrauf No. 3, Banda Aceh, 23111, Indonesia

Location
Kab. aceh besar,

Aceh

INDONESIA

Abstract

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Suhartono

Contact Email suhartono@usk.ac.id

Phone -

Journal Mail Official jurnal.natural@fmipa.unsyiah.ac.id

Editorial Address Block A 2nd Floor FMIPA USK Jl. Tegk. Syech Abdurrauf No. 3, Banda Aceh, 23111, Indonesia

Location Kab. aceh besar, Aceh INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Suhartono

Contact Email
suhartono@usk.ac.id

Phone
-

Journal Mail Official
jurnal.natural@fmipa.unsyiah.ac.id

Editorial Address
Block A 2nd Floor FMIPA USK Jl. Tegk. Syech Abdurrauf No. 3, Banda Aceh, 23111, Indonesia

Location
Kab. aceh besar,

Aceh

INDONESIA