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Jurnal Natural

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Published by Universitas Syiah Kuala

ISSN : 14118513 EISSN : 25414062 DOI : https://doi.org/10.24815/jn

Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Energy Immunology & microbiology Neuroscience Physics

Jurnal Natural (JN) aims to publish original research results and reviews on sciences and mathematics. Jurnal Natural (JN) encompasses a broad range of research topics in chemistry, pharmacy, biology, physics, mathematics, statistics, informatic and electronic.

Arjuna Subject : Matematika - Matematika (Lain-Lain)

Articles 457 Documents

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ANTIDIABETIC ACTIVITY FROM ETHANOL EXTRACT OF KLUWIH’S LEAF (Artocarpus camansi) Marianne Marianne; Yuandani Yuandani; Rosnani Rosnani
Jurnal Natural Volume 11, Number 2, September 2011
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (153.426 KB)

Research on antidiabetic activity of ethanol leaf extracts Kluwih (Artocarpus camansi) has been carried out to determine the antidiabetic activity of ethanol extract of leaves kluwih (EELK) of mice using glucose tolerance test. The study began by dividing the mice into 6 groups. Group 1 was given 1% CMC, group 2 to group 4, given EELK 50, 100, 200, 400 mg / kg bw, respectively, and group 6 administered with glibenclamide 0.45 mg/kg bw. Thirty minutes later each group was given glucose 30 mg/kg bw. After 30 min of glucose loading, blood glucose levels of mice were measured, and measured again at minute 60, 90, 120 and 150 minutes. The results showed that the glucose tolerance test EELK a significant effect in lowering blood glucose levels compared to controls at 30 and 60 minutes after administration of glucose. At minute 90 to 150, the effect of blood glucose levels EELK restore back to normal. EELK demonstrated ability to reduce blood glucose levels, and EELK doses of 50 and 100 mg/kg bw showed antidiabetic effects better than a dose of 200 and 400 mg/kg bw. Increasing doses showed antagonistic effects: the ability to increase blood glucose levels.

The potential protective effects of malacca (Phyllanthus emblica L.) extract against doxorubicin-induced cardiotoxicity in male Wistar rats ETRINA MELINDA; ERMI GIRSANG; ALI NAPIAH NASUTION
Jurnal Natural Volume 21 Number 2, June 2021
Publisher : Universitas Syiah Kuala

Doxorubicin as a chemotherapy agent is most widely used in cancer treatment. Long-term use at a predetermined dose has a side effect, namely cardiotoxicity. Doxorubicin-induced cardiotoxicity is considered to be caused by reactive oxygen species (ROS), which is also characterized by increasing CK-MB enzyme levels in the blood. To reduce the impact of doxorubin-induced toxicity, a study was conducted on natural antioxidant sources with cardioprotective capabilities in vivo. Phyllanthus emblica L. fruit was used as a sample for a natural source of antioxidants extracted using ethanol. Then performed a phytochemical screening of secondary metabolites contained in it. This extract was administered orally in various doses to the experimental animal Wistar rats and the induced doxorubicin to these animals. The CK-MB enzyme levels were measured, and the heart organ histopathology test was performed. The results of this study indicate that P. emblica L. fruit extract contains alkaloids, tannins, flavonoids, terpenoids, phenolics, and triterpenoids compounds. Extract treatment at a 400 mg/kg BW dose showed the best reduction in CK-MB levels with great improvements in regular arrangement and shape of myocardial muscle cells of cardiac tissue. The sample extract at a 400 mg/kg BW dose showed remarkably decreasing of CK-MB great improvements of heart tissue on doxorubicin-induced cardiotoxicity. This study showed the potential protective effect of P. emblica L. against doxorubicin-induced cardiotoxicity.

ANTIMICROBIAL ACTIVITY OF METHANOL EXTRACT FROM STEM BARK OF Cinnamomum sintoc Nurdin Saidi; Hira Helwati; Lailatul Qhadariah Lubis; Muhammad Bahi
Jurnal Natural Volume 17, Number 2, September 2017
Publisher : Universitas Syiah Kuala

Antimicrobial activity of methanol extract from stem bark of Cinnamomum sintoc has been evaluated against Candida albicans, Staphylococcus aureus and Escherichia coli. The extraction of compound was carried out by maceration, then isolation by column chromatograph, which yielded five (5) subfractions (A-E). Activity against fungus C. albicans, S. aureus bacteria dan E. coli using agar dilution method in paper disk. Methanol extract was not potent against antifungal activity but shows antibacterial activity with medium category. Subfraction C showed that antibacterial activity against S. aureus and E. coli with weak category, but subfractions D and E did not show any activity.

SOLUSI PERMASALAHAN KOMPUTASI SKALA BESAR PADA SOFTWARE ADOBE FLASH DALAM PERANCANGAN MEDIA PEMBELAJARAN PENCARIAN EULERIAN CIRCUIT Reza Wafdan; Mahyus Ihsan; Marwan Ramli; Hafnani Hafnani
Jurnal Natural Volume 16, Number 1, March 2016
Publisher : Universitas Syiah Kuala

Adobe Flash is a software that is used to build an interactive contents that can be attached in other things, such as presentations, games and e-learning. The Eulerian Circuit Search Instructional Media is one of examples in using Adobe Flash in building an interactive instructional media to solve graph theory problems. Visually, Adobe Flash is better than other programming software in general and it is the most suitable one for graph theory, as it uses graphics and visuals to solve problems. The weakness of Adobe Flash is when doing large scale calculations; such as when testing algorithms to find Eulerian circuits. Then an idea came about to complete the large scale calculations in Adobe Flash, which is commonly known as script time limit, with using other methodologies by changing script time limit on the settings, algorithms, partition the processes, and utulize the timers within the objects in the actionscript that handles the search algorithms of searching Eulerian circuit.

Yield potential and resistance of corn (Zea mays L.) S5 generation SITI HAFSAH; BAKHTIAR BAKHTIAR; NUR ROSLINI; FIRDAUS FIRDAUS
Jurnal Natural Volume 21 Number 1, February 2021
Publisher : Universitas Syiah Kuala

. Maize S5 generation was obtained and assembled through open pollination, from its parents possessing high yield potential and resistant to downy mildew disease, where the parents were obtained through mass selection. The objective of this research was to evaluate the yield potential and resistance of maize S5 generation against downy mildew disease. The research was conducted at Syngenta Seed Indonesia, Kediri Field Station, Kedungmalang Village, Papat District, Kediri Regency, East Java, from May to October 2019. The research was employed Randomized Block Design (RBD) non Factorial with the only factor observed, 24 genotypes of maize, 5 genotypes for disease resistance assay and 4 genotypes for yield potential assay with 2 replications. The results showed that there were 5 resistant genotypes, 18ID010125, 18ID010141, 18ID010158, 18ID010134, 18ID010118 and 18ID010122 and 7 potential genotypes to have high yield, 18ID010144, 18ID010123, 18ID006020, 18ID010135, 18ID010125, 18ID007419 and 18ID010148. The results also exhibited 3 genotypes with the highest yield and possessed high resistance against downy mildew (18ID010125, 18ID010123 and 18ID010148).

INHIBITION TEST OF METHANOL EXTRACT FROM SOURSOP LEAF (Annona muricata Linn.) AGAINST Streptococcus mutans BACTERIA* Raudhatul Jannah; Muhammad Ali Husni; Risa Nursanty
Jurnal Natural Volume 17, Number 1, March 2017
Publisher : Universitas Syiah Kuala

Abstract. Dental caries is a disease with a high prevalence of caries in Indonesia is caused by the bacterium Streptococcus mutans. The leaves of the soursop (Annona muricata Linn.) is one of the herbs that can remove dental plaque. This study aims to determine the chemical content and measure the inhibitory antibacterial soursop leaft methanol extractin inhibiting the growth of Streptococcus mutans bacteria. Phytochemical screening stated that the leaf of the soursop contains flavonoids, alkaloids, tannins, steroids, glycosides and saponins. Test of inhibition were measured using paper disc diffusion method with variation concentrations of 5, 10, 15 20, and 25%, positive control is tetrasilkin 30 µg, and a negative control is methanol. Antibacterial test results showed that the methanol extract of soursop leaves have antibacterial activity against Streptococcus mutans at concentrations of 5, 10, 15, 20 and 25% with inhibitory diameter of 9,1; 10,57; 11,53; 12,01 and 13,75 mm respectively. Keywords: Soursop leaves, Dental caries, Streptococcus mutans, Methanol.*Judul ini telah dipresentasikan pada Seminar Nasional: Indonesian Students Conference on Science and Mathematics (ISCSM) 11-12 November 2015, Banda Aceh Indonesia

Interpretasi Potensi Massa Longsoran Dengan Metoda Geolistrik(Studi Kasus Daerah Gayo Lues) Muchlis Muchlis
Jurnal Natural Volume 15, Number 1, March 2015
Publisher : Universitas Syiah Kuala

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One indication of a potential landslide area is a formation along the slip field slope. The slope is formed due to the difference between the cover layers (top soil) with a layer beneath it. The top layer is usually a layer of soil that passes the water so that it could be easily infiltrated into the slope. However, rain water infiltrated into the soil or are often not able to enter deeper into the ground because there is an impermeable layer which forms the slope area. Geoelectric resistivity method is generally used for shallow exploration, approximately to depth of 300 to 500 meter. The principle of the method is that the electrical current injected into the earth through two current electrodes, while the potential difference that occurs is measured through two potential electrodes. From the results of measurements of currents and electric potential difference can be obtained by variation of value of electrical resistivity in the layer below the measuring point. The resistivity value can show the bedding soils and on which one is the layer of slip field. From this study we expected the resistivity 2D cross section that shows the depth and dimensions of the field of slip on the slope studied so as to provide recommendations on the appropriate method of stabilizing slopes.

The blood glucose lowering effect of Malaysian Tinospora crispa in rats SARAH FIRDAUSA; MAUNG MAUNG CHO; KHIN MAUNG MAUNG; NILAR AUNG; NORSIDAH KUZAIFAH; SURYAWATI SURYAWATI
Jurnal Natural Volume 20 Number 1, February 2020
Publisher : Universitas Syiah Kuala

Diabetes is defined as a chronic hyperglycemia which should be countered by the effective, safe and readily available hypoglycemic agents. Herbal is among alternatives that has been used by society for years but lacks of documented evidences. Tinospora crispa (TC) is enriched by phytochemicals which potentially reduce blood glucose thus is useful for diabetic patients. This study aimed to investigate the potency of TC inreducing blood sugar and body weight. It involved 30 healthy rats divided into 5 groups namely: normal control, normal fed with TC extract, diabetic, TC-treated diabetic (dose 500 mg/kg w/w), and vitamin E-traeted diabetic rats (60 IU). The body weight and fasting blood glucose were measured each week for 1 month. The administration of TC extract 500 mg/kg (w/w) helps to maintain body weight in diabetic rats and reduce the fasting blood glucose. TC is highly potent as hypoglycemic agents therefore needed to be explored further.

XRD ANALYSIS OF Bi-2212 SUPERCONDUCTORS: PREPARED BY THE SELF-FLUX METHOD Nurmalita Nurmalita; Nailul Amani; Fauzi Fauzi
Jurnal Natural Volume 13, Number 1, March 2013
Publisher : Universitas Syiah Kuala

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An experiment had been carried out on formation of Bi-2212 crystals with the self-flux method. Flux was used and derived from CuO and CaCO3. The process of synthesis was equipped with the melting process at temperature 890 °C with time variation of melting 35 minutes and 40 minutes, followed by slow cooling at a rate of 1°C/hour for 70 hours. The results were obtained and characterized by XRD test. This research aimed to produce superconducting materials with self-flux method, calculate the percentage of the value of the volume fraction, the percentage of oriented phase and impurities. Samples generated from XRD measurements were made to match with the XRD Strobell’s pattern of the superconducting Bi-2212 standards. The results showed that the value of the volume fraction of 2212 phase and the phase of the highest oriented melting at 40 minutes were equal to 67.68% and 38.89%, while the smallest impurity phase of 32.32% were obtained at the same time melting.

Anticancer activity and apoptotic induction of Chromolaena odorata Linn leaves extract and fractions on hepatocellular carcinoma cell lines (HepG2) HANIFAH YUSUF; MARHAMI FAHRIANI
Jurnal Natural Volume 22 Number 1, February 2022
Publisher : Universitas Syiah Kuala

The purpose of this study is to screen and to evaluate anticancer activity and apoptosis induction of Chromolaena odorata (C. odorata) leaves extract and its fractions on HepG2 cancer cell lines. The C. odorata leaves were extracted by maceration using ethanol 80% then fractionated by using n-hexane, ethyl acetate and ethanol. MTT assay method was used to evaluate anticancer activity and flowcytometri method used to evaluate the induction of apoptosis. The phytochemical analysis and characterization of the major compound of the extract and the fractions were done by using Liquid Chromatography-Mass Spectroscopy (LCMS). The phytochemical analyis showed that the crude ethanolic extract and fractions of C. odorata leaves contains alkaloid, flavonoids, phenolic, steroids, tannin and saponin. The result of LCMS shown the major compounds of the extract and fractions are 5,7,8,3′,4′-Pentamethoxyflavonone, 1-Carboethoxy-β-carboline, 3-Methylcanthin-2, 6- dion, Canthin-6-one. In the n-hexane fraction obtained 5,7,8,3′,4′-Pentamethoxyflavonone, Methyl ophiopogonanone A and Pd-C-Ⅱ. Meanwhile, in the ethyl acetate fraction contained, 3-(3′,4′-Dihydroxybenzyl)-7-hydroxychroman-4-one, 3-(4'-Hydroxy-benzyl)-5,7-dihydroxy-6-methyl-8- methoxy-chroman-4-one, Methyl opiopogonanone A and Sinensetin. The ethanol fraction, contained the compound 3-(3′,4′-Dihydroxybenzyl)-7-hydroxychroman-4-one, 3-(4'-Hydroxy-benzyl)-5,7-dihydroxy-6-methyl-8- methoxy-chroman-4-one and Methyl opiopogonanone A. The crude ethanolic extract, n-hexane fraction, ethyl acetate and ethanol fraction extract have anticancer activities with IC50 value of 23.44 mg/mL, 84.52mg/mL; 88.51mg/mL; and 167.49 mg/mL respectively. This research suggests the crude ethanolic extract of Chromolaena odorata leaves has a potential candidate for hepatocarcinoma treatment.

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Contact Name
Suhartono

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suhartono@usk.ac.id

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Journal Mail Official
jurnal.natural@fmipa.unsyiah.ac.id

Editorial Address
Block A 2nd Floor FMIPA USK Jl. Tegk. Syech Abdurrauf No. 3, Banda Aceh, 23111, Indonesia

Location
Kab. aceh besar,

Aceh

INDONESIA