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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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The Effectiveness of the Strategy (SCAMPER) to Generate Ideas in Learning the Skill of the Service is Facing from the Top and Down in the Volleyball for Students Saeed Gheni Noori
Journal of Global Pharma Technology .
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Abstract

The study objective to identify the effectiveness of the (SCAMPER) strategy to generate ideas in learning the skills of the service is facing from the top and down in the volleyball, the experimental society was used, while the research society was identified by students in the fifth grade preparatory class (scientific and biological) for the Secondary School of Civilizations for Boys in Misan Governorate / Iraq for the academic year 2017-2018, which reached (64) students, and distribution into two groups, the control group's branch of biological (28) students applied the experimental branch's group (28) students either the rest of the students excluded from the sample for their participation experience reconnaissance. The parity of the two groups has been carried out in the accuracy of the skill of service is facing from the top, it has been applied (12) and the educational unit for both groups in accordance with the program unified distributed according to two units per week of educational duration of the unit per (45) minutes, researchers have concluded that the effectiveness of the program prepared in accordance with the strategy (SCAMPER) to generate ideas in learning the skills of the service is facing from the top and down in volleyball the experimental group, as well as students interact with the strategic development of creative thinking.Keywords: Strategy (SCAMPER) for generating ideas, Service is facing top and down in the volleyball.
Efficiency of a High-dose Intravenous Immunoglobulin Therapy in Children with Autism Spectrum Disorders Associated with Genetic Deficiency of Folate Cycle Enzymes Dmitry V. Maltsev
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Previously, it has been repeatedly reported on the effectiveness of intravenous immunoglobulin therapy in some children with autism spectrum disorders without specifying selection criteria of potential responders to immunotherapy. Objective: to evaluate high-dose immunoglobulin therapy efficacy and safety in children with autism spectrum disorders and genetic deficiency of folate cycle. The studied group consisted of 78 children aged 2 to 10 years who have been on intravenous immunoglobulin at a dose of 2 g/kg per month for 6 months. The control group included children of similar age and gender distribution, which received only non-drug rehabilitation support. The dynamics of psychiatric symptoms were assessed using the Aberrant Behavior Checklist scale. Complete elimination of the phenotype of autism spectrum disorders has been obtained in 21 patients and an improvement was marked in 33 children of study group. In parallel, positive dynamic of other clinical manifestations of folate cycle deficiency phenotype was evaluated: PANDAS (19 out of 21), epilepsy (29 out of 36) and gastrointestinal (in 49 out of 68 children) syndromes.  Intravenous immunoglobulin has a complex positive impact on the manifestation of a genetic deficiency of folate cycle, including autism spectrum disorders, extrapyramidal disturbances, bowel syndrome, epileptiform brain activity, immune deficiency, and leukoencephalopathy.Keywords: Folate cycle, Intravenous immunoglobulin, Autism spectrum disorder.
Influence of Osmotic Dehydration in Processing of Tamarindus indica Jam N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Tamarind (Tamarindus indica L.) has long been used as a spice, food component and traditional medicine. It has high content of total phenols, proanthocyanidin and tannins Tamarindus indica has a high commercial value affordable functional foods. Howeever it has short shelf-life during post-harvest handling owing to high moisture content. It’s necessary to preserve this valuable fruit for long-term use. Objective of this research focused on the effectiveness of various processing parameters such as pretreatment with KMS solution, sugar concentration, immersion time, and agitation speed during the osmotic dehydration of Tamarindus indica into jam. Our results showed that the optimal dehydration process should be pre-treated with 0.25% KMS solution, sugar 60oBrix, immersion in 75 min, agitation 500 rpm. From this approach, the added value of Tamarindus indica fruits would be enhanced. Osmotic dehydration showed minimum heat degradation to nutritional components owing to low temperature moisture removal. It contributed some advantages such as limiting the thermal damage to the aroma, color, preventing the browning of enzymes and decreasing the energy consumption.Keywords: Tamarindus indica, Osmotic dehydration, Pretreatment, Immersion, Agitation, Sugar.
Evaluation of Anti-Ulcer Activity of Ethanolic Extract of Leaves of Calophyllum Inophyllum (Calophyllaceae) in Rats J. Banu Rekha
Journal of Global Pharma Technology Volume 11 Issue 02 (2019) Feb. 2019
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Abstract

Calophyllum inophyllum (CI) (Linn.) has been used to treat gastric ulcer in Indian folk medicine, but its efficacy has not been validated. The present study was carried out to evaluate the anti-ulcer activity of 80% ethanol leaf extract of Calophyllum inophyllum in rats. The effect of its extract on gastric ulcer in rats in pylorus ligation-induced and ethanol-induced models were studied using single dosing (200,400 mg/kg) and repeated dosing (200 mg/kg for 10 and 20 days) approaches. Ranitidine (50 mg/kg) and Sucralfate (100 mg/kg) were used as the standard drugs. Depending on the model, outcome measures were volume and pH of gastric fluid, total acidity, ulcer score, percent inhibition of ulcer score, ulcer index as well as percent inhibition of ulcer index. The extract possesses both dose-dependent and time-dependent anti-ulcer effect in the two models. The oral median lethal dose (LD50) is estimated to be higher than 2000 mg/kg for the alcoholic extract and secondary metabolites such as flavonoids, terpenoids, tannins and saponins were present. The findings of this study confirmed that the extract has anti-ulcer pharmacologic activity due to one or more of the secondary metabolites present in it. Therefore, this study validates its anti-ulcer use in Indian folk medicine. Further investigations on isolation of specific phytoconstituents and elucidating mechanisms of action are needed.Keywords: Antiulcer activity, Calophyllum inophyllun, Ranitidine, in vivo, Ethanolic Extract.
Estimation of Some Immunological Parameters Levels in Giardiasis Patients in Al- Najaf Province Jameel Jerri Yousif
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The current study was conducted during the period from August 2017 to April 2018 in the Department of Biology - Faculty of Education for Girls - University of Kufa to measure the level of some cytokines and immunoglobulins in patients with Giardia lamblia parasite in Al- Najaf Province. A total of 923 stool samples from patients, with diarrhea ranging in age from 1 to 60 years were examined with a direct smear and sedimentation methods. The results of the immunological examination were shown using the enzyme linked immunosorbent assay (ELISA) and single radial immunodiffusion (SRID) Plate. IgA, IgE, IgG and IgM concentrations were increased in patients with Giardiasis as 276 ± 32.3 mg / dl, 260 ± 39.3 IU / ml, 576 ± 42.4 mg / dL and 73 ± 17.8 mg / dL , respectively, compared with the control group of 65 ± 22.7 mg / dl, 175 ± 23.3 IU / ml, 365 ± 27.3 mg / dl and 47 ± 14.4 mg / dl, respectively, with a statistically significant difference P <0.05.As well as an increase in concentrations of IFN-γ , IL-4 and TNF-α (284 ± 21.4, 395 ± 27.1 and 443 ± 29.2) pg / mL respectively compared to control group (131 ± 18.7, 345 ± 22.6 and 191 ± 26.6) pg / ml, respectively, with a statistically significant difference P <0.05.Keywords: Giardia lamblia; Cytokines; Immunoglobulins.
Serum Tumor Necrosis Factor Alpha and Gene Polymorphisms in Rheumatoid Arthritis Patients in Babylon Province, Iraq Abdulsamie H. Alta&#039;ee
Journal of Global Pharma Technology .
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Abstract

Background: Rheumatoid arthritis (RA) is a systemic autoimmune disease affects 0.5-1% of the worldwide population, of unknown etiology, characterized by chronic inflammation of the synovial joints, hyperplasia, and overgrowth of synoviocytes, with the destruction of articular cartilage that can cause serious weakness and inability to work. Objective: The present study aims to investigate the possible association between tumor necrosis factor alpha (TNF-α) levels and (-308 G/A) TNF-α promoter polymorphism in patients with RA in Babylon Province. Patients and Methods: This study was designed as a case control. Forty-five (10 males, 35 females) patients with RA and forty-five (9 males, 36 females) apparently healthy persons as control with the compatible age and sex were enrolled in this study. Serum level of TNF-α and anti-cyclic citrullinated peptide antibodies (ACCPA) were measured using enzyme-linked immunosorbent assay (ELISA) method. Disease activity of RA patients was assessed using the Disease Activity Score-28 (DAS28). The frequency of TNF-α -308 G/A gene polymorphism was determined using polymerase chain reaction, restriction fragment length polymorphism (PCR-RFLP) technique. Results: Present study finds significant high levels of serum TNF-α and ACCPA in patients with RA in comparison with healthy controls. The genotype of (-308 G/A) TNF-α gene promoter polymorphisms the GG genotype was 60% in RA patients and 42.2% in control group, while the GA genotype was 40% in RA patients and 53.3% in control group, whereas, the AA genotype was 0% in RA patients and 4.4% in control group. Correlation between TNF-α levels with both of DAS-28 and ACCPA in RA patients found to be a significant positive correlation proposes a probable role of TNF-α in RA pathogenesis. Statistical analysis showed no significant difference in the genotype frequency of the TNF-α (-308 G/A) gene promoter polymorphisms between two groups. Conclusions: The results of the present study were shown that TNF-α (-308G/A) gene polymorphism had not associated with a risk factor of RA in Babylon patients and this SNP do not affect the serum level of TNF-α in RA patients.Keywords: Rheumatoid arthritis, TNF-α, -308 G/A gene polymorphism, ACCP Antibody, PCR-RFLP , Iraq.
An Investigation of Ground Water Resources Quality in Sistan and Baluchistan Province, 2015 Mojtaba Afsharnia
Journal of Global Pharma Technology .
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Abstract

Sistan and Baluchistan province with an area of 187.500 km2, accounts for 11.4% of the total area of the country as the biggest province. Considering the population density, it is one of the lowest populated provinces in Iran. Quality of the ground water is determined by its chemical, physical, and biological properties. Since chemical elements play a significant role in the type and amount of the usage of these resources, in this work, it's been aimed to determine and interpret the dominant type of water and critical points by measuring the important and influential physical and chemical properties including the concentrations of sulfate, fluoride, calcium, chloride, magnesium, and sodium ions, as well as other physical and chemical parameter in 800 samples from different areas of the province in 2015. The final goal is to contribute to solving the current water crisis of the country by gaining the knowledge for better management of these water resources, now and in the future. The results demonstrated that, in all cities of the province, all parameters were within the limited range, except for sodium, which was revealed to be higher than the limited range in majority of the cities. Among these cities, the quality of the water in Zahedan and Chabahar was obtained to be comparatively worse. Furthermore, the dominant type in Sistan and Baluchistan province was detected to be sodium sulfate and then sodium bicarbonate.Keywords: Chemical elements, water quality, ground water, GIS, Sistan and Baluchistan
Evaluation of Water Quality in Purification Plants (Al-Baladiat and Al-Jadria) Within Rusafa District in Baghdad City Miami Abdulaleem Abdulzahra
Journal of Global Pharma Technology .
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This study was established to evaluate the quality of drinking water in two water purification plants in addition to four residential neighborhoods within the scope of these plants by measuring a number of physical and chemical properties per month and during the period from February until August 2017. The samples were collected from two outlets within the filter plant (River outlet and collection tanks of sterile water after adding chlorine). The results showed that the values of trihlomethane rise with rising temperature, pH, free chlorine and total organic carbon. The highest value of (83.324) μg/ L was recorded in Al-Jadria area during the month of July. Also, four heavy metals (Pb, Zn, Al, Fe) were investigated and the results show that the concentrations of both aluminum and zinc were not exceed the international and Iraqi standard specifications, while the concentration of iron and lead exceeded these limits in some locations during the months of July and August. Also, Total organic carbon was measured, and Aerobic Plate Count, Coli and Streptococci were detected. In addition to measuring the pH, water temperature, electrical conductivity, total organic solids, turbidity, total hardness, the concentration of sulphate, chlorides and nitrates, and the results showed that the total organic carbon values were exceeded the Iraqi and international standards limits in some locations, and the highest value is 1.70 mg /l During the month of July while the other factors did not exceed the standard limits.Keywords: Drinking water, Tri-halo methane, Lead, Gas Chromatography, Least significant difference
Interleukin-1 beta (IL-1β) and interleukin-6 (IL-6) as proinflammatory cytokines in traumatic brain injury (TBI) of rat (Sprague-Dawley) : A study of propofol administration Riyadh Firdaus; Franciscus Dhyana Giri Suyatna; Aida Rosita Tantri; Yetty Ramli; Ekowati Handharyani; Arni Diana Fitri
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

The increase in the prevalence of traumatic brain injury (TBI) followed by increased morbidity and mortality challenges anesthetists to perform the treatment patients with TBI. Menwhile, interleukin-1 beta (IL-1β) and interleukin-6 (IL-6) are the first pro-inflammatory markers expressed after secondary injury occurs. In addition, propofol (2,6-disopropylphenol) is a short-acting intravenous agent that reported to play role in inflammatory process. This study aims to determine the effects of propofol administration on the neuroinflammatory pathway. Thirty adult female Sprague Dawley rats were randomly assigned as TBI rats (T), rats that received propofol infusion (P), or TBI rats that received propofol infusion (TP). The rat model of TBI was developed using the Marmarou Weight Drop method. Clinical assessment was performed using the Neurobehavioral Severity Score-Revised (NSS-R). Brain tissues were taken 24 h after TBI and the levels of interleukin-1 (IL-1) and interleukin-6 (IL-6) mRNA expression levels were examined using qRT-PCR, while the concentration were examined using ELISA and immunohistochemistry. On clinical examination, a decrease in the median value of NSS-R in the TP group was found from 30th minute to 120th minute. 24 hours after the occurrence of TBI, there was a decrease in both the TP and T groups. However, the NSS-R values in the TP group were lower than those in the T group. The expression of IL-1β was found in the nuclei and cytosol, while IL-6 was found in the axons and cytosol. The expression and concentration of IL-1β and IL-6 were the highest in the TP group, followed by the P and then the T group. Propofol can improve neurological function in rats with TBI, probably through the mechanism involves neuroinflammatory pathways, particularly IL-1β and IL-6.
Sequencing of Proteus Toxic Agglutinin (Pta) Gene in Proteus Mirablis and Cytotoxic Effect of Pta on Human Colon Cancer Cell and Human Kidney Cell Lamees A. Abdul-Lateef
Journal of Global Pharma Technology .
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Objective study the sequencing of Pta gene and the cytotoxic effect of pta gene on SW480 and ACHN cell line Material and method detection of pta gene by using PCR technique, detection of mutation in the Pta gene by used automated sequencing. Also the cytotoxic effect of Pta toxin on cell lines of SW480 and ACHN cell were used in vitro. Results the result was revealed that the Pta gene is present in 17 isolates (15 isolated from urine and 2 isolates from stool).  Sequencing of Pta gene from isolates of Proteus mirablis reveals of 43 mutations in five isolates and gives identity in percentage (92-95%) with standard strand in NCBI web site. However, the cytotoxic effect of Pta on cells line of SW480 and ACHN were used in vitro was also investigated. The result was shown that the effect of Pta toxin on SW480 lead to the proliferation of cell was significantly elevated when Pta toxin at 12.5%, 25%, and 50% concentrations. The concentration 50% of Pta toxin a significantly better effect on cell growth On the other hand, ACHN  cell  was gradually increase in growth at concentrations (6.25%, 12.5%%, 25%, and 50%)Keywords: Proteus toxic agglutinin gene, Sequencing, Human colon cancer cell line, Human kidney cell line.

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